A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc
CONCLUSION: Zygosids demonstrated robust therapeutic efficacy in treatment of T2DM. Importantly, no adverse effects were detected, in all the experiments, indicating high safety profile.PMID:38173374 | DOI:10.4093/dmj.2022.0292 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Vladimir Vinokur Eduard Berenshtein Mordechai Chevion Dror Chevion Source Type: research
Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0115. Online ahead of print.ABSTRACTMitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPRmt) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response and UPRmt, are crucial mediators of inter-organ communication and influence systemic metabolic and physiological processes. In this review, we provide a comprehensive overview of mitokines, including their regulation by exercise and lifestyle interventions and their implicati...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Benyuan Zhang Joon Young Chang Min Hee Lee Sang-Hyeon Ju Hyon-Seung Yi Minho Shong Source Type: research
Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0110. Online ahead of print.ABSTRACTInsulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of D...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Yajie Fan Zhipeng Yan Tingting Li Aolin Li Xinbiao Fan Zhongwen Qi Junping Zhang Source Type: research
Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0193. Online ahead of print.ABSTRACTNovel strategies are required to reduce the risk of developing diabetes and/or clinical outcomes and complications of diabetes. In this regard, the role of the circadian system may be a potential candidate for the prevention of diabetes. We reviewed evidence from animal, clinical, and epidemiological studies linking the circadian system to various aspects of the pathophysiology and clinical outcomes of diabetes. The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events thro...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Da Young Lee Inha Jung So Young Park Ji Hee Yu Ji A Seo Kyeong Jin Kim Nam Hoon Kim Hye Jin Yoo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Nan Hee Kim Source Type: research
Alantolactone Attenuates Renal Fibrosis via Inhibition of Transforming Growth Factor β/Smad3 Signaling Pathway
CONCLUSION: Alantolactone improves renal fibrosis by inhibiting the TGF-β/Smad3 signaling pathway in obstructive nephropathy. Thus, alantolactone is a potential therapeutic agent for chronic kidney disease.PMID:38173367 | DOI:10.4093/dmj.2022.0231 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Kyeong-Min Lee Yeo Jin Hwang Gwon-Soo Jung Source Type: research
Association of Muscle Mass Loss with Diabetes Development in Liver Transplantation Recipients
CONCLUSION: Muscle depletion after liver transplantation is associated with increased risk of PTDM development.PMID:38173368 | DOI:10.4093/dmj.2022.0100 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Sejeong Lee Minyoung Lee Young-Eun Kim Hae Kyung Kim Sook Jung Lee Jiwon Kim Yurim Yang Chul Hoon Kim Hyangkyu Lee Dong Jin Joo Myoung Soo Kim Eun Seok Kang Source Type: research
Association of Measures of Glucose Metabolism with Colorectal Cancer Risk in Older Chinese: A 13-Year Follow-up of the Guangzhou Biobank Cohort Study-Cardiovascular Disease Substudy and Meta-Analysis
CONCLUSION: Higher HbA1c was a significant predictor of CRC in the general population. Our findings shed light on the pathology of glucose metabolism and CRC, which warrants more in-depth investigation.PMID:38173369 | DOI:10.4093/dmj.2022.0383 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Shu Yi Wang Wei Sen Zhang Chao Qiang Jiang Ya Li Jin Tong Zhu Feng Zhu Lin Xu Source Type: research
Psychotic Disorders and the Risk of Type 2 Diabetes Mellitus, Atherosclerotic Cardiovascular Diseases, and All-Cause Mortality: A Population-Based Matched Cohort Study
CONCLUSION: Patients with psychotic disorders treated with antipsychotics were associated with increased risk of premature allcause mortality and cardiometabolic outcomes in an Asian population. This relationship was more pronounced in younger individuals, especially aged 18 to 39 years.PMID:38173370 | DOI:10.4093/dmj.2022.0431 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: You-Bin Lee Hyewon Kim Jungkuk Lee Dongwoo Kang Gyuri Kim Sang-Man Jin Jae Hyeon Kim Hong Jin Jeon Kyu Yeon Hur Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
DWN12088, A Prolyl-tRNA Synthetase Inhibitor, Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis
CONCLUSION: Our findings provide new insights about DWN12088, namely that it plays an important role in the overall improvement of NASH. Hence, DWN12088 shows great potential to be developed as a new integrated therapeutic agent for NASH.PMID:38173372 | DOI:10.4093/dmj.2022.0367 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Dong-Keon Lee Su Ho Jo Eun Soo Lee Kyung Bong Ha Na Won Park Deok-Hoon Kong Sang-In Park Joon Seok Park Choon Hee Chung Source Type: research
Glucagon-Like Peptide Receptor Agonist Inhibits Angiotensin II-Induced Proliferation and Migration in Vascular Smooth Muscle Cells and Ameliorates Phosphate-Induced Vascular Smooth Muscle Cells Calcification
CONCLUSION: These data show that GLP-1RAs ameliorate aberrant proliferation and migration in VSMCs through both GLP-1Rdependent and independent pathways and inhibit Pi-induced vascular calcification.PMID:38173373 | DOI:10.4093/dmj.2022.0363 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Jinmi Lee Seok-Woo Hong Min-Jeong Kim Sun Joon Moon Hyemi Kwon Se Eun Park Eun-Jung Rhee Won-Young Lee Source Type: research
A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc
CONCLUSION: Zygosids demonstrated robust therapeutic efficacy in treatment of T2DM. Importantly, no adverse effects were detected, in all the experiments, indicating high safety profile.PMID:38173374 | DOI:10.4093/dmj.2022.0292 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Vladimir Vinokur Eduard Berenshtein Mordechai Chevion Dror Chevion Source Type: research
Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0115. Online ahead of print.ABSTRACTMitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPRmt) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response and UPRmt, are crucial mediators of inter-organ communication and influence systemic metabolic and physiological processes. In this review, we provide a comprehensive overview of mitokines, including their regulation by exercise and lifestyle interventions and their implicati...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Benyuan Zhang Joon Young Chang Min Hee Lee Sang-Hyeon Ju Hyon-Seung Yi Minho Shong Source Type: research
Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0110. Online ahead of print.ABSTRACTInsulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of D...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Yajie Fan Zhipeng Yan Tingting Li Aolin Li Xinbiao Fan Zhongwen Qi Junping Zhang Source Type: research
Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Diabetes Metab J. 2024 Jan 3. doi: 10.4093/dmj.2023.0193. Online ahead of print.ABSTRACTNovel strategies are required to reduce the risk of developing diabetes and/or clinical outcomes and complications of diabetes. In this regard, the role of the circadian system may be a potential candidate for the prevention of diabetes. We reviewed evidence from animal, clinical, and epidemiological studies linking the circadian system to various aspects of the pathophysiology and clinical outcomes of diabetes. The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events thro...
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Da Young Lee Inha Jung So Young Park Ji Hee Yu Ji A Seo Kyeong Jin Kim Nam Hoon Kim Hye Jin Yoo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Nan Hee Kim Source Type: research
