Drawing Guidelines for Receiver Operating Characteristic Curve in Preparation of Manuscripts.
Abstract The appropriate plot effectively conveys the author's conclusions to the readers. The Journal of Korean Medical Science provides a series of special articles to show you how to make consistent and excellent plots easier. In the second article, drawing receiver operating characteristic (ROC) curve is introduced. A ROC curve is a graphic plot that illustrates the diagnostic ability as its discrimination threshold is varied. It is widely used as logistic regression analysis as machine learning becomes widespread. It has great visual effect in comparing various diagnostic tools. PMID: 32567255 [PubMed - ...
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Kim J, Hwang IC Tags: J Korean Med Sci Source Type: research

Mycophenolic Acid Trough Concentration and Dose Are Associated with Hematologic Abnormalities but Not Rejection in Kidney Transplant Recipients.
CONCLUSION: Either a higher MPA C₀ or dose is associated with an increased risk of cytopenia, but neither a lower MPA C₀ nor dose is associated with BPAR within the first year of transplantation. Hence, a reduced MPA dose with TAC and corticosteroids might be safe in terms of reducing hematologic abnormalities without causing rejection. PMID: 32567256 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Jung HY, Lee S, Jeon Y, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD Tags: J Korean Med Sci Source Type: research

Gap between Perceived eHealth Literacy and Ability to Use Online Cancer-Related Information.
CONCLUSION: There is a gap between perceived eHealth literacy and the actual ability to use online cancer-related information. To fundamentally improve eHealth literacy, it is important to evaluate the actual abilities concerning each eHealth literacy component and to provide customized education. PMID: 32567257 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Kim S, Park K, Jo HS Tags: J Korean Med Sci Source Type: research

The Influence of Renal Dialysis on All-Cause Mortality in Older Patients with Hip Fracture: a Korean Nationwide Cohort Study.
Abstract BACKGROUND: The purpose of this study was to analyze the all-cause mortality rate over time after elderly hip fracture in end-stage renal disease (ESRD) patients with dialysis, using a Korean nationwide claims database. METHODS: This retrospective nationwide study identified subjects from the Korean National Health Insurance Service-Senior cohort (NHIS-Senior). The NHIS-Senior (total of 588,147 participants) was constructed by 10% random sampling and was designed to represent the elderly living in Korea. Subjects were patients aged 65-99 years who underwent surgical treatment for femoral neck fractur...
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Jang SY, Ha YC, Cha Y, Kim KJ, Choy W, Koo KH Tags: J Korean Med Sci Source Type: research

Anti-N-methyl-D-aspartate Receptor Encephalitis: a Rare Complication of Ovarian Teratoma.
Abstract Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a potentially life-threatening but reversible autoimmune disorder characterized by psychiatric symptoms, cognitive dysfunction, speech dysfunction, seizures, movement disorder, decreased level of consciousness, and autonomic dysfunction or central hypoventilation. It occurs predominantly in young women and approximately half of them have underlying tumors, mainly ovarian teratoma. A 24-year old woman was admitted because of fever, headache, abnormal movement and decreased mental status. Five cycles of plasmapheresis improved her neurological ...
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Lee CH, Kim EJ, Lee MH, Yim GW, Kim KJ, Kim KK, Kim EJ, Roh JW Tags: J Korean Med Sci Source Type: research

Financial Burden of Hospitalization of Children with Coronavirus Disease 2019 under the National Health Insurance Service in Korea.
This study revealed the differences in cost among age groups, determined by the type of hospital wherein admission occurred, as a trend of increasing age, increasing hospitalization time, and increasing cost was observed. Tailored COVID-19 treatment strategies by age group may lower costs and increase the effectiveness of resource allocation. PMID: 32567260 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Lee JK, Kwak BO, Choi JH, Choi EH, Kim JH, Kim DH Tags: J Korean Med Sci Source Type: research

Epidemiological Characteristics and Forecast of COVID-19 Outbreak in the Republic of Kazakhstan.
CONCLUSION: The outcomes of our study could be of interest for policymakers as they help to forecast the trends of COVID-19 outbreak, the demands for professional workforce, and to estimate the consequences of quarantine measures. PMID: 32567261 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Semenova Y, Glushkova N, Pivina L, Khismetova Z, Zhunussov Y, Sandybaev M, Ivankov A Tags: J Korean Med Sci Source Type: research

A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance.
We describe a patient, 60-year old Korean woman, with coronavirus disease 2019 (COVID-19) who had been taking hydroxychloroquine for 6 months. Her serum and saliva concentrations of hydroxychloroquine were 280 μg/L and 4,890 μg/L, respectively. The present case raises concerns on hydroxychloroquine's role as a prophylactic agent for COVID-19. PMID: 32567262 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 22, 2020 Category: General Medicine Authors: Ahn BY, Kang CK, Seo JD, Choe PG, Song SH, Park WB, Park SW, Kim NJ, Oh MD Tags: J Korean Med Sci Source Type: research

Tocilizumab Increases Body Weight and Serum Adipokine Levels in Patients with Rheumatoid Arthritis Independently of Their Treatment Response: a Retrospective Cohort Study.
Abstract BACKGROUND: Causes of weight change after tocilizumab treatment are unclear. We aimed to investigate the effects of tocilizumab treatment on body weight and serum adipokine levels in patients with rheumatoid arthritis (RA). METHODS: In this retrospective cohort study, we evaluated weight changes in patients with RA who received methotrexate (Cohort I) or tocilizumab with methotrexate (Cohorts II and III) for 24 weeks. Adipokine concentrations at baseline and 24 weeks were analyzed in Cohorts I and III. Cohorts I and II received tocilizumab therapy for an additional 48 weeks, during which weight chang...
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Choi IA, Sagawa A, Lee EY, Lee EB, Song YW Tags: J Korean Med Sci Source Type: research

Nonalcoholic Fatty Liver Disease Is Associated with Benign Prostate Hyperplasia.
This study aimed to evaluate whether NAFLD is associated with benign prostatic hyperplasia (BPH) independent of other risk factors. METHODS: A total of 3,508 subjects who underwent prostate and hepatic ultrasonography were enrolled. NAFLD was diagnosed and graded by ultrasonographic findings. BPH was defined by total prostate volume. RESULTS: The prevalence of BPH was significantly increased according to NAFLD severity (P
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Chung GE, Yim JY, Kim D, Kwak MS, Yang JI, Park B, An SJ, Kim JS Tags: J Korean Med Sci Source Type: research

Urinary Angiotensinogen in addition to Imaging Classification in the Prediction of Renal Outcome in Autosomal Dominant Polycystic Kidney Disease.
CONCLUSION: Urinary AGT/Cr can be a useful predictive marker in the patients with relatively small ADPKD. Various biomarkers should be considered to define RP when implementing novel treatment in the patients with ADPKD. PMID: 32508065 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Park HC, Kim J, Cho A, Kim DH, Lee YK, Ryu H, Kim H, Oh KH, Oh YK, Hwang YH, Lee KB, Kim SW, Kim YH, Lee J, Ahn C, KNOW-CKD Investigators Group Tags: J Korean Med Sci Source Type: research

The Epidemiology and Trends of Primary Total Ankle Arthroplasty and Revision Procedure in Korea between 2007 and 2017.
CONCLUSION: The incidence of primary TAA and revision procedures steadily increases in Korea during the 11-year study period. PMID: 32508066 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Kim SJ, Sung IH, Song SY, Jo YH Tags: J Korean Med Sci Source Type: research

A Case of Consumptive Hypothyroidism in a 1-Month-Old Boy with Diffuse Infantile Hepatic Hemangiomas.
We report the case of severe consumptive hypothyroidism in a 1-month-old boy with infantile hepatic hemangiomas who presented with cardiac failure and cholestasis. Diffuse infiltration of hepatic hemangiomas was detected on abdominal imaging studies, and thyroid function screening test revealed severe hypothyroidism, which necessitated the administration of higher-than-usual doses of levothyroxine for the normalization of thyroid function. The patient was successfully treated with propranolol, prednisolone, and levothyroxine, and he showed normal thyroid function at 3 months of age and normal neurodevelopment at 9 months o...
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Kim YH, Lee YA, Shin CH, Hong KT, Kim GB, Ko JS, Lee YJ Tags: J Korean Med Sci Source Type: research

Defining Association between COVID-19 and the Multisystem Inflammatory Syndrome in Children through the Pandemic.
PMID: 32508068 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Kim YJ, Park H, Choi YY, Kim YK, Yoon Y, Kim KR, Choi EH Tags: J Korean Med Sci Source Type: research

Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19.
We report a rapidly deteriorating coronavirus disease 2019 (COVID-19) patient, a-58-year-old woman, with severe acute respiratory distress syndrome and shock with hyperpyrexia up to 41.8°C, probably due to the cytokine storm syndrome. Considering extracorporeal membrane oxygenation (ECMO) as the last resort, we applied therapeutic temperature modulation for management of hyperpyrexia. The patient demonstrated rapid improvement in oxygenation and shock after achieving normothermia, and fully recovered from COVID-19 three weeks later. Therapeutic temperature modulation may have successfully offloaded the failing cardiore...
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Jeong HG, Lee Y, Song KH, Hwang IC, Kim ES, Cho YJ Tags: J Korean Med Sci Source Type: research

Psychosocial Support during the COVID-19 Outbreak in Korea: Activities of Multidisciplinary Mental Health Professionals.
This study presented the anecdotal records that provided a detailed process of the multidisciplinary teamwork in mental health during the COVID-19 outbreak in the country. Psychosocial support is no less important than infection control during an epidemic, and collaboration and networking are at the core of disaster management. Thus, a multidisciplinary team of mental health professionals was immediately established and has collaborated effectively with its internal and external stakeholders for psychosocial support during the COVID-19 outbreak. PMID: 32508070 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 8, 2020 Category: General Medicine Authors: Hyun J, You S, Sohn S, Kim SJ, Bae J, Baik M, Cho IH, Choi H, Choi KS, Chung CS, Jeong C, Joo H, Kim E, Kim H, Kim HS, Ko J, Lee JH, Lee SM, Lee SH, Chung US Tags: J Korean Med Sci Source Type: research

Clinical Significance of Segmental Chromosomal Aberrations in Patients with Neuroblastoma: First Report in Korean Population.
CONCLUSION: This is the first study investigating SCAs in Korean neuroblastoma patients. Prognostic significance of SCAs other than MYCN amplification was different from those reported in western countries. Further study with a larger cohort and longer follow-up is needed to confirm our findings. PMID: 32281311 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Lim H, Son MH, Hyun JK, Cho HW, Ju HY, Lee JW, Yoo KH, Sung KW, Koo HH Tags: J Korean Med Sci Source Type: research

Medication-Related Knowledge and Medication Adherence in Pediatric and Adolescent Patients with Inflammatory Bowel Disease.
CONCLUSION: Adolescent IBD patients have lower oral medication adherence. Knowledge of the prescribed medications taken previously, and the adverse effects of these medications are associated with good adherence. IBD specialists should educate the patients regarding the disease and about their medication. PMID: 32281312 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Lim JK, Lee YJ, Park JH Tags: J Korean Med Sci Source Type: research

The First Reported Case of Infant Botulism in Korea: Treatable Infantile Neuromuscular Disease.
We report the first Korean case of infant botulism in an acute progressive floppy infant with poor sucking and a weak cry. No abnormalities were found in all blood, cerebrospinal fluid, genetic test, nerve conduction study, and imaging studies. A stool-toxin test was finally performed under suspicion of infant botulism, and the result was positive. The patient was immediately treated with heptavalent botulism antitoxin. Follow-up after 3 months showed normal development with a complete resolution of all symptoms. Therefore, clinical suspicion of infant botulism, which is a treatable infantile neuromuscular disease, is esse...
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Jang HG, Jang J, Jung HJ, Jung DE Tags: J Korean Med Sci Source Type: research

Trends of Premature and Early Menopause: a Comparative Study of the US National Health and Nutrition Examination Survey and the Korea National Health and Nutrition Examination Survey.
Abstract BACKGROUND: While evidence shows a tendency toward delays in menopause worldwide, whether prevalence of premature (
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Choe SA, Sung J Tags: J Korean Med Sci Source Type: research

Analysis of Associated Anomalies in Anorectal Malformation: Major and Minor Anomalies.
CONCLUSION: A considerable number of patients with ARM had AAs. Our data are useful for predicting AAs in patients with ARM. PMID: 32281315 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Oh C, Youn JK, Han JW, Yang HB, Kim HY, Jung SE Tags: J Korean Med Sci Source Type: research

Determinants of Spontaneous Preterm Labor and Birth Including Gastroesophageal Reflux Disease and Periodontitis.
CONCLUSION: GERD is more important than periodontitis for predicting and preventing preterm birth. For preventing preterm birth, preventive measures for hypertension, GERD and diabetes mellitus would be needed alongside the promotion of effective BMI management and appropriate progesterone and calcium-channel-blocker medications. PMID: 32281316 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Lee KS, Song IS, Kim ES, Ahn KH Tags: J Korean Med Sci Source Type: research

Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea.
We describe two cases of COVID-19 treated with convalescent plasma infusion. Both patients presented severe pneumonia with acute respiratory distress syndrome and showed a favorable outcome after the use of convalescent plasma in addition to systemic corticosteroid. To our knowledge, this is the first report of the use of convalescent plasma therapy for COVID-19 in Korea. PMID: 32281317 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Ahn JY, Sohn Y, Lee SH, Cho Y, Hyun JH, Baek YJ, Jeong SJ, Kim JH, Ku NS, Yeom JS, Roh J, Ahn MY, Chin BS, Kim YS, Lee H, Yong D, Kim HO, Kim S, Choi JY Tags: J Korean Med Sci Source Type: research

Convalescent Plasma Therapy for Corona Virus Disease 2019: a Long Way to Go but Worth Trying.
PMID: 32281318 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 13, 2020 Category: General Medicine Authors: Yoo JH Tags: J Korean Med Sci Source Type: research

Impact of Bronchiectasis on Postoperative Pulmonary Complications after Extra-Pulmonary Surgery in Patients with Airflow Limitation.
Abstract The impact of bronchiectasis on the occurrence of postoperative pulmonary complications (PPC) after extra-pulmonary surgery in patients with airflow limitation is not well elucidated. A retrospective analysis of 437 patients with airflow limitations, including 62 patients with bronchiectasis, was conducted. The analysis revealed that bronchiectasis was associated with increased PPC (adjusted odds ratio [aOR], 2.73; P = 0.001), which was especially significant in patients who did not use bronchodilators (aOR, 3.24; P = 0.002). Our study indicates that bronchiectasis is associated with an increased risk of ...
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Yang B, Choi H, Chung SJ, Shin B, Lee H, Park HY Tags: J Korean Med Sci Source Type: research

Objective Verification of Acute Tinnitus and Validation of Efficacy of Systemic Steroids in Rats.
CONCLUSION: An acute tinnitus model with minimal structural changes by noise exposure was set up, and used to verify tinnitus objectively by measuring the GPIAS value. Steroid therapy for control of tinnitus was validated in this animal model. PMID: 32242342 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Kim YC, Kim H, Kim YS, Jung SK, Park IY, Choung YH, Jang JH Tags: J Korean Med Sci Source Type: research

Analysis of Risk Factors for Myringosclerosis Formation after Ventilation Tube Insertion.
CONCLUSION: Older age, serous effusion, type 2 VT, presence of post-VTI perforation, and frequent VTI may be risk factors for myringosclerosis after VTI; the severity of myringosclerosis may vary based on the duration of effusion and frequency of VTI. PMID: 32242343 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Kim EH, Park KW, Lee SH, Kim BJ, Park YH Tags: J Korean Med Sci Source Type: research

Prevalence and Risk Factors of Peripheral Arterial Disease in Patients with Lumbar Spinal Stenosis and Intermittent Claudication: CT Angiography Study.
CONCLUSION: The current study showed that man gender, diabetes and hypertension were the greatest risk factors for PAD. We conclude that man patients with diabetes and/or hypertension should be put under serious consideration for routine CTA examination when under evaluation for LSS and intermittent claudication. PMID: 32242344 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Park JW, Lee JH Tags: J Korean Med Sci Source Type: research

Recent Decrease in Organ Donation from Brain-Dead Potential Organ Donors in Korea and Possible Causes.
CONCLUSION: Fewer eligible donors in spite of an increase in brain-dead potential organ donors suggests that reduction in these donations resulted mainly from factors associated with family consent. Among such factors, implementation of the Life-sustaining Treatment Act appears to be most important. Abolition of family compensation and the incident in which a brain-dead donor's remains were mistreated may also have influenced family consent. PMID: 32242345 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Park J, Kim CJ Tags: J Korean Med Sci Source Type: research

The Utility of the Random Urine Uric Acid-to-Creatinine Ratio for Patients with Gout Who Need Uricosuric Agents: Retrospective Cross-Sectional Study.
Abstract BACKGROUND: The 24-hour uric acid excretion measurement is important in assessing disease status and helping to select the appropriate uric acid-lowering agent for patients with gout, however, it is inconvenient. The authors investigated the efficacy of the random urine uric acid-to-creatinine (UA/CR) ratio to screen the patients who under-secreted 24-hour urine uric acid. METHODS: This was a retrospective cross-sectional study. Ninety patients with gout, without undergoing uric acid-lowering treatment were enrolled. Twenty-four-hour urine and random urine samples were obtained on the same day. Six h...
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Choi ST, Song JS, Kim SJ, Kim CH, Moon SJ Tags: J Korean Med Sci Source Type: research

Out-of-Hospital Cohort Treatment of Coronavirus Disease 2019 Patients with Mild Symptoms in Korea: an Experience from a Single Community Treatment Center.
Abstract The outbreak of Coronavirus Disease 2019 (COVID-19) caused a worldwide pandemic. Less than 6 weeks after the first confirmed cases in Korea, the patient number exceeded 5,000, which overcrowded limited hospital resources and forced confirmed patients to stay at home. To allocate medical resources efficiently, Korea implemented a novel institution for the purpose of treating patients with cohort isolation out of hospital, namely the Community Treatment Center (CTC). Herein, we report results of the initial management of patients at one of the largest CTC in Korea. A total of 309 patients were admitted to o...
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Park PG, Kim CH, Heo Y, Kim TS, Park CW, Kim CH Tags: J Korean Med Sci Source Type: research

Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.
CONCLUSION: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community. PMID: 32242348 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Kim ES, Chin BS, Kang CK, Kim NJ, Kang YM, Choi JP, Oh DH, Kim JH, Koh B, Kim SE, Yun NR, Lee JH, Kim JY, Kim Y, Bang JH, Song KH, Kim HB, Chung KH, Oh MD, Korea National Committee for Clinical Management of COVID-19 Tags: J Korean Med Sci Source Type: research

School Opening Delay Effect on Transmission Dynamics of Coronavirus Disease 2019 in Korea: Based on Mathematical Modeling and Simulation Study.
CONCLUSION: The simulation results show that the government could reduce at least 200 cases, with two announcements by the Ministry of education. After March 23, although the possibility of massive transmission in the children's age group is lower, group transmission is possible to occur. PMID: 32242349 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Kim S, Kim YJ, Peck KR, Jung E Tags: J Korean Med Sci Source Type: research

A Lesson from Temporary Closing of a Single University-affiliated Hospital owing to In-Hospital Transmission of Coronavirus Disease 2019.
PMID: 32242350 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 4, 2020 Category: General Medicine Authors: Lee H, Heo JW, Kim SW, Lee J, Choi JH Tags: J Korean Med Sci Source Type: research

Effect of Cervical Cerclage on the Risk of Recurrent Preterm Birth after a Twin Spontaneous Preterm Birth.
This study aimed to evaluate the effect of cervical cerclage on the recurrence risk for preterm birth in singleton pregnant women after a twin spontaneous preterm birth (sPTB). METHODS: This multicenter retrospective cohort study included women who had a singleton pregnancy from January 2009 to December 2018 at 10 referral hospitals and a twin sPTB before the current pregnancy. We compared the cervical lengths during pregnancy and pregnancy outcomes, according to the placement of prophylactic or emergency cerclage. We evaluated the independent risk factors for sPTB (
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Kim S, Park HS, Kwon H, Seol HJ, Bae JG, Ahn KH, Na S, Lee SJ, Lee MY, Lee SM, Kwak DW, Park JY, Park IY, Won HS, Kim MY, Ko HS, Hwang HS, Korean Society of Ultrasound in Obstetrics and Gynecology Research Group Tags: J Korean Med Sci Source Type: research

Pretransplant Hepatic Malignancy Increases Risk of De Novo Malignancy after Liver Transplantation.
Abstract BACKGROUND: Hepatocellular carcinoma (HCC) recurrence and development of de novo malignancy (DNM) after liver transplantation (LT) are the major causes of late recipient death. METHODS: We analyzed the incidence of extrahepatic DNM following living donor LT according to the status of pretransplant hepatic malignancy. We selected 2,076 adult patients who underwent primary LDLT during 7 years from January 2010 to December 2016. RESULTS: The pretransplant hepatic malignancy group (n = 1,012) showed 45 cases (4.4%) of the following extrahepatic DNMs: posttransplant lymphoproliferative disease (PTLD)...
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Park GC, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Yoon YI, Cho HD, Kwon JH, Chung YK, Kang SH, Choi JU, Jung IJ, Lee SG Tags: J Korean Med Sci Source Type: research

External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old.
CONCLUSION: The pooled bias and inaccuracy of the pharmacokinetic predictions are clinically acceptable. Therefore, our external validation of the Kim model indicated that the model can be applicable to target-controlled infusion of propofol in children younger than 2 years, with the recommended use of actual bispectral index monitoring in clinical settings that remifentanil is present. Trial Registration Clinical Research Information Service Identifier. TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0001752. PMID: 32193901 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS Tags: J Korean Med Sci Source Type: research

Reflex and Spontaneous Movements in Adult Patients during the Process of Determining Brain Death in Korea.
CONCLUSION: Movements associated with brain dead patients are not rare and thus an awareness of these movements is important to brain death diagnosis. Physicians who perform brain death examinations should understand the frequency and characteristics of these movements to reduce delays in determining brain death. PMID: 32193902 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Kim DH, Kwon OY, Yang TW, Kim M, Lee J, Cho W, Yeom JS, Kim YS Tags: J Korean Med Sci Source Type: research

Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea.
This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. METHODS: Patients aged ≥ 18 years diagnosed with endemic zoonoses during a 3-year period (between January 2015 and December 2017) were retrospectively enrolled from 4 tertiary university hospitals. A prediction score was built based on multivariate logistic regression analyses. RESULTS: Of 84 patients, 35 with SFTS and 49 with other endemic zoonoses were enrolled. In multivariate logistic regression analysis, indep...
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Heo DH, Kang YM, Song KH, Seo JW, Kim JH, Chun JY, Jun KI, Kang CK, Moon SM, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Oh WS, Kim NJ, Oh MD Tags: J Korean Med Sci Source Type: research

Drive-Through Screening Center for COVID-19: a Safe and Efficient Screening System against Massive Community Outbreak.
Abstract As the coronavirus disease 2019 (COVID-19) outbreak is ongoing, the number of individuals to be tested for COVID-19 is rapidly increasing. For safe and efficient screening for COVID-19, drive-through (DT) screening centers have been designed and implemented in Korea. Herein, we present the overall concept, advantages, and limitations of the COVID-19 DT screening centers. The steps of the DT centers include registration, examination, specimen collection, and instructions. The entire service takes about 10 minutes for one testee without leaving his or her cars. Increased testing capacity over 100 tests per ...
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Kwon KT, Ko JH, Shin H, Sung M, Kim JY Tags: J Korean Med Sci Source Type: research

First Pediatric Case of Coronavirus Disease 2019 in Korea.
In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. Lastly, we raise concerns on the optimal strategy of self-quarantine and patient care in a negative isolation room for children. PMID: 32193905 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Park JY, Han MS, Park KU, Kim JY, Choi EH Tags: J Korean Med Sci Source Type: research

Are We Ready for Coronavirus Disease 2019 Arriving at Schools?
PMID: 32193906 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Choe YJ, Choi EH Tags: J Korean Med Sci Source Type: research

Current Situation of Home Oxygen Therapy for Chronic Obstructive Pulmonary Disease Patients in Korea.
CONCLUSION: This study revealed low adherence to home oxygen therapy, poor health-related quality of life, frequent hospitalizations, and a high financial burden among COPD patients using home oxygen therapy. The study highlights the need for adequate strategies to improve the quality of home oxygen therapy. PMID: 31997611 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Kim JK, Jang SH, Park S, Kim JH, Park JY, Yoo KH, Kim YS, Lim SY, Hwang YI Tags: J Korean Med Sci Source Type: research

Independent, Publicly Funded Journals Adhering to Platinum Open Access Are the Future of Responsible Scholarly Publishing.
PMID: 31997612 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Gajović S Tags: J Korean Med Sci Source Type: research

Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008-2017.
CONCLUSION: Although most cutaneous drug eruptions in this study were rash or urticaria, approximately 8% of reports were of severe or life-threatening adverse drug reactions, such as SJS, TEN, or DRESS. When hypersensitivity skin reactions occurred, aromatic AEDs were associated with 4 fold the risk of SJS/TEN/DRESS compared with non-aromatic AEDs. Our findings further emphasize that high risk AEDs should be prescribed under careful monitoring, and early detection and prompt interventions are needed to prevent severe complications. PMID: 31997613 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Kim HK, Kim DY, Bae EK, Kim DW Tags: J Korean Med Sci Source Type: research

Association between Left Ventricular Systolic Dysfunction and Mortality in Patients with Septic Shock.
Abstract BACKGROUND: The impact of myocardial damage on the prognosis of patients with septic shock is not clearly elucidated because complex hemodynamic changes in sepsis obscure the direct relationship. We evaluated left ventricular (LV) conditions that reflect myocardial damage independently from hemodynamic changes in septic shock and their influence on the prognosis of patients. METHODS: We retrospectively enrolled 208 adult patients who were admitted to the intensive care unit and underwent echocardiography within 7 days from the diagnosis of septic shock. Patients who were previously diagnosed with str...
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Kim S, Lee JD, Kim BK, Kim YH, Kim JH Tags: J Korean Med Sci Source Type: research

Disease-Specific Mortality and Prevalence Trends in Korea, 2002-2015.
CONCLUSION: Between 2002 and 2015, overall decreasing trends in the mortality rate and increasing trends in the prevalence rate were observed for all causes in Korea. Especially, NCDs represented an important part of the increasing trends in Korea. For clusters of diseases with unusual trends, proper management must be considered. PMID: 31997615 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Shin Y, Park B, Lee HA, Park B, Han H, Choi EJ, Kim NE, Park H Tags: J Korean Med Sci Source Type: research

A Disclosure Form for Work Submitted to Medical Journals: a Proposal from the International Committee of Medical Journal Editors.
PMID: 31997616 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P Tags: J Korean Med Sci Source Type: research

The Use of Gonadotropin-Releasing Hormone Agonist Does Not Affect the Development of Cardiovascular Disease in Prostate Cancer Patients: a Nationwide Population-Based Cohort Study.
The objective of this study was to investigate whether androgen deprivation therapy (ADT) with gonadotropin-releasing hormone agonist (GnRHa) in prostate cancer (Pca) patients is associated with cardiovascular disease in the cohort based from the entire Korean population. METHODS: Using the Korean National Health Insurance database, we conducted an observational study of 579,377 men who sought treatment for Pca between January 1, 2012 and December 31, 2016. After excluding patients with previously diagnosed cardiovascular disease or who had undergone chemotherapy, we extracted the data from 2,053 patients who started ...
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Shim M, Bang WJ, Oh CY, Lee YS, Jeon SS, Ahn H, Ju YS, Cho JS Tags: J Korean Med Sci Source Type: research

The Fight against the 2019-nCoV Outbreak: an Arduous March Has Just Begun.
PMID: 31997618 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 31, 2020 Category: General Medicine Authors: Yoo JH Tags: J Korean Med Sci Source Type: research