A Clinical Trial and Extension Study of Infliximab in Korean Patients with Active Rheumatoid Arthritis despite Methotrexate Treatment.
Abstract Currently, infliximab is given for disease control for active rheumatoid arthritis (RA) patients despite methotrexate treatment. However, the efficacy and safety of infliximab in Korean patients has not been assessed appropriately. Therefore, we performed placebo-controlled, double-blind, randomized study and extension study. One-hundred forty-three patients with active RA were randomized to receive placebo or infliximab 3 mg/kg intravenously at week 0, 2, 6, 14, and 22 with methotrexate maintenance. Primary endpoint was American College of Rheumatology 20% improvement criteria (ACR20) at 30 week. After t...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kim J, Ryu H, Yoo DH, Park SH, Song GG, Park W, Cho CS, Song YW Tags: J Korean Med Sci Source Type: research

Role of regulatory T cells in transferable immunological tolerance to bone marrow donor in murine mixed chimerism model.
In this study, we explored the mechanism of mixed chimerism supplemented with depletion of Natural Killer cells. Mixed chimerism with C57BL/6 bone marrow cells was induced in recipient BALB/c mice which were given 450 cGy of γ-ray irradiation (n = 16). As revealed by reduced proliferation and cytokine production in mixed leukocyte reaction and ELISpot assay (24.6 vs 265.5), the allo-immune response to bone marrow donor was reduced. Furthermore, the induction of transferable immunological tolerance was confirmed by adoptive transfer and subsequent acceptance of C57BL/6 skin graft (n = 4). CD4(+)FoxP3(+) regulatory T c...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Yoon IH, Kim YH, Kim YS, Shin JS, Park CG Tags: J Korean Med Sci Source Type: research

Application of the multiplex cytokine analysis to monitor xenogeneic immune responses to the porcine islet graft in non-human primate.
This study aimed to assess the feasibility of this multiplex cytokine assay in the development of immune-modulatory regimen. Using this assay, we were able to detect different cytokines with a minimal usage of blood samples, and this allowed us to detect various immunological situations in the recipients. Detection of TNF-α surge (347.8 pg/mL) guided us to block TNF-α in the early phase of transplantation. Supportive information for in vivo efficacy of cytokine neutralizing antibody could be speculated by in vitro neutralization assay (1,250 pg/mL → 0 pg/mL). In addition, periodic monitoring of cytokines i...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kim YH, Kim JS, Yoon IH, Shin JS, Kim JM, Kim SJ, Park CG Tags: J Korean Med Sci Source Type: research

The association between the socioeconomic status and thyroid cancer prevalence; based on the korean national health and nutrition examination survey 2010-2011.
Abstract The incidence of thyroid cancer has recently increased in most industrialized countries, including Korea. To date, few studies have examined the association between thyroid cancer and socioeconomic status (SES). The current study was based on data collected from a total of 12,276 subjects (5,277 men and 6,999 women) by the Korean National Health and Nutrition Examination Survey (KNHANES) between 2010 and 2011. Univariate and multivariate logistic regression analysis revealed that older age (odds ration [OR], 1.03; 95% confidence interval [CI], 1.00-1.05), being female (OR, 8.16; 95%CI, 2.99-22.24), being ...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Choi SW, Ryu SY, Han MA, Park J Tags: J Korean Med Sci Source Type: research

Proactive Multifactorial Intervention Strategy Reduces the Risk of Cardiovascular Disease Estimated with Region-Specific Risk Assessment Models in Pacific Asian Patients Participating in the CRUCIAL Trial.
Abstract Despite race, ethnic, and regional differences in cardiovascular disease risk, many worldwide hypertension management guidelines recommend the use of the Framingham coronary heart disease (CHD) risk equation to guide treatment decisions. This subanalysis of the recently published CRUCIAL trial compared the treatment-related reductions in calculated CHD and stroke risk among Pacific Asian (PA) patients using a variety of region-specific risk assessment models. As a result, greater reductions in systolic and diastolic blood pressure, low-density lipoprotein cholesterol, and triglycerides were observed in th...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Cho EJ, Kim JH, Sutradhar S, Yunis C, Westergaard M, CRUCIAL Trial Investigators Tags: J Korean Med Sci Source Type: research

Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction.
This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). ...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kim HL, Kang SH, Yoon CH, Cho YS, Youn TJ, Cho GY, Chae IH, Kim HS, Chae SC, Cho MC, Kim YJ, Kim JH, Ahn Y, Jeong MH, Choi DJ, Other Korea Acute Myocardial Infarction Registry (KAMIR) and Korea Working Group on Myocardial Infarction (KorMI) Investigators Tags: J Korean Med Sci Source Type: research

De vega annuloplasty for functional tricupsid regurgitation: concept of tricuspid valve orifice index to optimize tricuspid valve annular reduction.
Abstract We evaluated long-term results of De Vega annuloplasty measured by cylindrical sizers for functional tricuspid regurgitation (FTR) and analyzed the impact of measured annular size on the late recurrence of tricuspid valve regurgitation. Between 2001 and 2011, 177 patients (57.9±10.5 yr) underwent De Vega annuloplasty for FTR. Three cylindrical sizers (actual diameters of 29.5, 31.5, and 33.5 mm) were used to reproducibly reduce the tricuspid annulus. Long-term outcomes were evaluated and risk factor analyses for the recurrence of FTR ≥3+ were performed. Measured annular diameter indexed by patie...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Hwang HY, Chang HW, Jeong DS, Ahn H Tags: J Korean Med Sci Source Type: research

A Prospective Study of Epicardial Adipose Tissue and Incident Metabolic Syndrome: The ARIRANG Study.
Abstract Increased epicardial adipose tissue (EAT) may be closely associated with the development of metabolic abnormalities. We investigated whether EAT predicts the incident metabolic syndrome in a community-based, middle-aged population. The study subjects were comprised of 354 adults (134 men and 220 women) aged 40 to 70 yr without metabolic syndrome. Baseline EAT thickness, measured by echocardiography, was compared between subjects who developed new-onset metabolic syndrome at follow-up survey and those who did not. After an average of 2.2 yr of follow-up, 32 men (23.9%) and 37 women (16.8%) developed metabo...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Lee JH, Kim JY, Kim KM, Lee JW, Youn YJ, Ahn MS, Yoo BS, Lee SH, Yoon J, Choe KH, Ahn SV, Koh SB, Park JK, Ahn SG Tags: J Korean Med Sci Source Type: research

Incidence of Metabolic Syndrome and Relative Importance of Five Components as a Predictor of Metabolic Syndrome: 5-Year Follow-up Study in Korea.
Abstract The aim of this study was to describe the incidence of metabolic syndrome and to identify five components as metabolic syndrome predictors. The final study included 1,095 subjects enrolled in a rural part of Daegu Metropolitan City, Korea for a cohort study in 2003. Of these, 762 (69.6%) subjects had participated in the repeat survey. During the five-year follow-up, incidence density was significantly higher for women than for men (men, 30.0/1,000 person-years; women, 46.4/1,000 person-years). In both men and women, incidence of metabolic syndrome showed a significant increase with increasing number of me...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Hwang JH, Kam S, Shin JY, Kim JY, Lee KE, Kwon GH, Chun BY, Chae SC, Yang DH, Park HS, Hwang TY Tags: J Korean Med Sci Source Type: research

Change in Somatostatinergic Tone of Acromegalic Patients according to the Size of Growth Hormone-Producing Pituitary Tumors.
In conclusion, as the size of the pituitary tumor increases, the effect of glucose on SST appears to be attenuated. Macroadenomas that are non-responders to the OST possess a portion of GH secretion exceeding the range of regulation by SST. PMID: 24339708 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Chin SO, Chon S, Hwang YC, Jeong IK, Oh S, Kim SW Tags: J Korean Med Sci Source Type: research

Comparison of Complications between Endoscopic and Percutaneous Replacement of Percutaneous Endoscopic Gastrostomy Tubes.
Abstract When replacing percutaneous endoscopic gastrostomy (PEG) tubes, an internal bolster may be retrieved either percutaneously or endoscopically. The aim of this study was to compare the complications of percutaneous and endoscopic method during PEG tube replacement. The medical records of 330 patients who received PEG tube replacement were retrospectively analyzed. According to the removal method of internal bolster, we categorized as endoscopic group and percutaneous group. Demographic data, procedure-related complications and risk factors were investigated. There were 176 cases (53.3%) in endoscopic group ...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Lee CG, Kang HW, Lim YJ, Lee JK, Koh MS, Lee JH, Yang CH, Kim JH Tags: J Korean Med Sci Source Type: research

Cross-cultural adaptation of the korean version of the minneapolis-manchester quality of life instrument-adolescent form.
Abstract We verified the reliability and validity of the Korean version of the Minneapolis-Manchester Quality of Life Instrument-Adolescent Form (KMMQL-AF) among Korean childhood cancer survivors. A total of 107 childhood cancer patients undergoing cancer treatment and 98 childhood cancer survivors who completed cancer treatment were recruited. To assess the internal structure of the KMMQL-AF, we performed multi-trait scaling analyses and exploratory factor analysis. Additionally, we compared each domains of the KMMQL-AF with those of the Karnofsky Performance Status Scale and the Revised Children's Manifest Anxie...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Park HJ, Yang HK, Shin DW, Kim YY, Kim YA, Yun YH, Nam BH, Bhatia S, Park BK, Ghim TT, Kang HJ, Park KD, Shin HY, Ahn HS Tags: J Korean Med Sci Source Type: research

Diagnostic role of prostate resection in the elderly patients who experience significant co-morbidity with a high clinical suspicion of prostate cancer.
Abstract The necessity of routine prostate biopsy prior to transurethral resection of the prostate (TURP) in elderly comorbid patients with a high prostate specific antigen (PSA) level remains controversial. We assessed the role of TURP in prostate cancer diagnosis in these individuals. A total of 197 patients underwent TURP in conjunction with prostatic needle biopsy. Pathologic reviews of specimens of TUR chips and biopsy cores were analyzed. Overall, prostate cancer (CaP) was detected in 114 patients (57.6%). Ninety-eight cancers (86%) were detected with TURP and biopsy, and seven cancers (6.1%) with only TURP....
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kang HW, Yang JB, Kwon WA, Lee YS, Kim WT, Kim YJ, Yun SJ, Lee SC, Kim IY, Kim WJ Tags: J Korean Med Sci Source Type: research

Antibodies to Interferon beta in Patients with Multiple Sclerosis Receiving CinnoVex, Rebif, and Betaferon.
In conclusion, the three IFN-β preparations have different degrees of immunogenicity. PMID: 24339712 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Zare N, Zarkesh-Esfahani SH, Gharagozloo M, Shaygannejad V Tags: J Korean Med Sci Source Type: research

Knee pain and its severity in elderly koreans: prevalence, risk factors and impact on quality of life.
This study investigated the epidemiology (prevalence, risk factors, and impact on quality of life) of knee pain and its severity in elderly Koreans. The subjects (n=3,054) were participants aged ≥50 yr from the fifth Korea National Health and Nutrition Examination Survey, conducted in 2010. Knee pain was defined as pain in the knee lasting ≥30 days during the most recent 3 months; severity was categorized as mild, moderate, or severe. EQ-5D was used to measure quality of life. The prevalence of knee pain was 23.1% (11.7% in men, 31.9% in women). The prevalences of mild, moderate, and severe knee pain were 4.3%, 9.1%,...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Jhun HJ, Sung NJ, Kim SY Tags: J Korean Med Sci Source Type: research

Injuries Associated with the 580 km University Student Grand Voluntary Road March: Focus on Foot Injuries.
Abstract College student volunteers (n = 142) completed a 580 km road march for 21 consecutive days. Each volunteer carried a backpack that weighed 14.1 ± 1.4 kg on the average. We investigated the incidence and location of blisters associated with the road march using a foot map along with other injuries. Overall, 95.1% of the subjects (135 of 142) sustained one or more injuries. All injured subjects had foot blisters, and 18% had other foot injuries. The most common locations of blister development were the right 5th toe (61%) and the left 5th toe (57%). The little toes seem to have been subjected to the ...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Choi SC, Min YG, Lee IS, Yoon GH, Kang BR, Jung YS, Cho JP, Kim GW Tags: J Korean Med Sci Source Type: research

Performance Assessment of the SOFA, APACHE II Scoring System, and SAPS II in Intensive Care Unit Organophosphate Poisoned Patients.
In conclusion, the SOFA, APACHE II, and SAPS II have different capability to discriminate and estimate early in-hospital mortality of organophosphate poisoned patients. The SOFA score is more useful in predicting mortality, and easier and simpler than the APACHE II and SAPS II. PMID: 24339715 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kim YH, Yeo JH, Kang MJ, Lee JH, Cho KW, Hwang S, Hong CK, Lee YH, Kim YW Tags: J Korean Med Sci Source Type: research

Hemolytic anemia case caused by an inverted inner felt after bentall operation.
Abstract A 26-yr-old male patient reported worsened dyspnea, dizziness one year after an emergency Bentall operation for type A aortic dissection. There was evidence of hemolytic anemia and aortogram revealed a significant stenosis at the distal anastomosis site. During the reoperation, we found the inner felt at the distal anastomosis was inverted causing a significant stenosis. The reoperation successfully resolved this problem. Here, we report a rare case of hemolytic anemia caused by an inverted inner felt after Bentall operation. PMID: 24339716 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kang H, Choe JW, Cho DY, Sohn DS, Kim SW, Hong J Tags: J Korean Med Sci Source Type: research

Immunoglobulin g4 non-related sclerosing disease with intracardiac mass mimicking mitral stenosis: case report.
We describe the multimodal imaging used to diagnose IgG4 non-related systemic multifocal fibrosclerosis and a positive response to steroid treatment. There have been no previous case reports of IgG4 non-related systemic multifocal fibrosclerosis with intracardiac involvement. Here, we report a case of IgG4 non-related systemic multifocal fibrosclerosis mimicking mitral stenosis. PMID: 24339717 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Hwang JW, Park SJ, Gwag HB, Ha JM, Lee WJ, Kim E, Yune S, Kim JS, Park YJ, Kim DK Tags: J Korean Med Sci Source Type: research

A case of liver fibrosis with splenomegaly after oxaliplatin-based adjuvant chemotherapy for colon cancer.
We report a case of 45-yr-old Korean man in whom liver fibrosis with splenomegaly developed after 12 cycles of oxaliplatin based adjuvant chemotherapy for colon cancer (T4N2M0). Thorough history taking and serological examination revealed no evidence of chronic liver disease. Restaging CT scans demonstrated a good response to chemotherapy. Five month after chemotherapy, he underwent right hepatectomy due to isolated metastatic lesion. The liver parenchyma showed diffuse sinusoidal dilatation and centrilobular vein fibrosis with necrosis without steatosis. We could conclude that splenomegaly was due to perisinusoidal liver ...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Kang GH, Moon HS, Lee ES, Kim SH, Sung JK, Lee BS, Jeong HY, Lee HY, Kang DY Tags: J Korean Med Sci Source Type: research

A case of acute motor and sensory axonal neuropathy following hepatitis a infection.
Abstract Acute motor and sensory axonal neuropathy (AMSAN) are recently described subtypes of Guillain-Barre syndrome characterized by acute onset of distal weakness, loss of deep tendon reflexes, and sensory symptoms. A 21-yr-old male was transferred to our hospital due to respiration difficulties and progressive weakness. In laboratory findings, immunoglobulin M antibodies against hepatitis A were detected in blood and cerebrospinal fluid. The findings of motor nerve conduction studies showed markedly reduced amplitudes of compound muscle action potentials in bilateral peroneal, and posterior tibial nerves, with...
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Jo YS, Han SD, Choi JY, Kim IH, Kim YD, Na SJ Tags: J Korean Med Sci Source Type: research

Erratum: Correction of Title. Longitudinal Standards for Height and Height Velocity in Korean Children and Adolescents: the Kangwha Cohort Study.
Abstract [This corrects the article on p. 1512 in vol. 28, PMID: 24133358.]. PMID: 24339720 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2013 Category: Journals (General) Authors: Chae HW, Suh I, Kwon AR, Kim YJ, Kim YH, Kang DR, Kim HY, Oh SM, Kim HC, Kim DH, Kim HS Tags: J Korean Med Sci Source Type: research

Urinary Incontinence and Physician's Attitude.
PMID: 24265515 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Park WH Tags: J Korean Med Sci Source Type: research

Brilliant hallyu and plastic surgery.
PMID: 24265516 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Eun SC Tags: J Korean Med Sci Source Type: research

Korean guideline for iron chelation therapy in transfusion-induced iron overload.
Abstract Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. Deferasirox (DFX), a once-daily oral iron chelator for both adult and pediatric patients with transfusion-induced iron overload, is now available in Korea. The effectiveness of deferasirox in reducing or maintaining body iron has been demonstrated in many studies of patients with a variety of transfusion-induced ...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Jang JH, Lee JH, Yoon SS, Jo DY, Kim HJ, Chung J, Lee JW Tags: J Korean Med Sci Source Type: research

Trends of breastfeeding rate in Korea (1994-2012): comparison with OECD and other countries.
In conclusion, BRs were lowest in 2000, and there have been remarkable increases in BRs over the past 10 yr in Korea. Although BRs have been increasing, further efforts to increase BRs should be made continuously. PMID: 24265518 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Chung SH, Kim HR, Choi YS, Bae CW Tags: J Korean Med Sci Source Type: research

Return-to-Work According to Impairment Type Among Occupationally Injured Workers in Korea.
This study examined the association between return-to-work and impairment type. Database of the Korea Workers' Compensation and Welfare Service was used to identify disabled persons; and return-to-work information was obtained from the Korea Employment Information Services database. The study participants were 79,328 persons who received Workers' compensation and who were confirmed as disabled during 2009-2011. Logistic regression was used to analyze the association between return-to-work and impairment type, adjusted by age, sex, impairment severity, pre-injury businesses size, and pre-injury occupational category. Compar...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Rhie J, Jeong I, Won JU Tags: J Korean Med Sci Source Type: research

Intron 4 VNTR (4a/b) Polymorphism of the Endothelial Nitric Oxide Synthase Gene Is Associated with Breast Cancer in Mexican Women.
We examined the role of the eNOS4 a/b polymorphism by comparing the genotypes of 281 healthy Mexican women with the genotypes of 429 Mexican women with breast cancer (BC). The observed genotype frequencies for control and BC patients were 0.6% and 0.7% for a/a (polymorphic); 87% and 77% for a/a (wild type); and 12% and 22% for a/b respectively. We found that the odds ratio (OR) was 1.9, with a 95% confidence interval (95%CI) of 1.29-2.95, P = 0.001 for genotypes a/a-a/b, b/c. The association was also evident when comparing the distribution of the a/a-a/b genotypes in patients with high levels of glutamate-oxaloacetate tran...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Ramírez-Patiño R, Figuera LE, Puebla-Pérez AM, Delgado-Saucedo JI, Legazpí-Macias MM, Mariaud-Schmidt RP, Ramos-Silva A, Gutiérrez-Hurtado IA, Gómez Flores-Ramos L, Zúñiga-González GM, Gallegos-Arreola MP Tags: J Korean Med Sci Source Type: research

Post-progression survival in patients with non-small cell lung cancer with clinically acquired resistance to gefitinib.
Abstract Most patients with tyrosine kinase inhibitor (TKI)-sensitive non-small cell lung cancer (NSCLC) eventually develop acquired resistance to TKIs. Factors that affect TKI-sensitive patient survival after progression during TKI treatment remain unknown. We attempted to identify factors that affected post-progression survival. We retrospectively reviewed 81 advanced NSCLC patients with disease progression following tumor response and durable (≥ 6 months) disease stabilization with first-line or second-line gefitinib. Post-progression survival (PPS) and characteristics were investigated and compared in patie...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kim H, Yun T, Lee YJ, Han JY, Kim HT, Lee GK Tags: J Korean Med Sci Source Type: research

Association of Serum γ-Glutamyltransferase Level and Incident Prehypertension in Korean Men.
Association of Serum γ-Glutamyltransferase Level and Incident Prehypertension in Korean Men. J Korean Med Sci. 2013 Nov;28(11):1603-8 Authors: Chun H, Park SK, Ryoo JH Abstract Several lines of evidence indicate that prehypertension is more atherogenic than normal blood pressure. Serum γ-glutamyltransferase (GGT) is known to be positively associated with prehypertensive status and the progression of hypertension. However, there have been no prospective studies of serum GGT level as a predictor of prehypertension. Apparently 13,435 healthy men (mean age 42.0 ± 6.6 yr) with normal blood pr...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Chun H, Park SK, Ryoo JH Tags: J Korean Med Sci Source Type: research

A Prospective, Randomized Comparison of Promus Everolimus-Eluting and TAXUS Liberte Paclitaxel-Eluting Stent Systems in Patients with Coronary Artery Disease Eligible for Percutaneous Coronary Intervention: The PROMISE Study.
Abstract We aimed comparing two-year clinical outcomes of the Everolimus-Eluting Promus and Paclitaxel-Eluting TAXUS Liberte stents used in routine clinical practice. Patients with objective evidence of ischemia and coronary artery disease eligible for PCI were prospectively randomized to everolimus-eluting stent (EES) or paclitaxel-eluting stent (PES) groups. The primary end-point was ischemia-driven target vessel revascularization (TVR) at 2 yr after intervention, and the secondary end-point was a major adverse cardiac event (MACE), such as death, myocardial infarction (MI), target lesion revascularization (TLR)...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kim U, Lee CH, Jo JH, Lee HW, Choi YJ, Son JW, Lee SH, Park JS, Shin DG, Kim YJ, Jeong MH, Cho MC, Bae JH, Lee JH, Kang TS, Jung KT, Jung KH, Lee SW, Cho JH, Kim W, Hur SH, Kim KS, Park HS, Kim MH, Hwang JY, Kim DI, Kim TI Tags: J Korean Med Sci Source Type: research

Decreased renal function is an independent predictor of severity of coronary artery disease: an application of gensini score.
In this study, we investigate the association between renal function and the severity of CAD. We retrospectively reviewed the medical records of 1,192 patients who underwent elective coronary angiography (CAG). The severity of CAD was evaluated by Gensini score according to the degree of luminal narrowing and location(s) of obstruction in the involved main coronary artery. In all patients, the estimated glomerular filtration rate (eGFR) was independently associated with Gensini score (β=-0.27, P
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kim IY, Hwang IH, Lee KN, Lee DW, Lee SB, Shin MJ, Rhee H, Yang B, Song SH, Seong EY, Kwak IS Tags: J Korean Med Sci Source Type: research

Prospective observation of 5-year clinical course of subclinical hypothyroidism in korean population.
Abstract Subclinical hypothyroidism (SCH) is a common clinical condition, whereas it's natural course has not been identified distinctly. We evaluated the natural history of 169 SCH patients over 5-yr and the prognostic factors including thyroid autoantibodies and thyroid ultrasonographic (USG) findings related to develop overt hypothyroidism. After 5 yr, 47.3% of patients showed normalization of TSH, while 36.7% of patients remained persistence of high level of TSH, and overt hypothyroidism developed in 11.2% of patients. There were painless thyroiditis (2.9%) and hyperthyroidism (1.7%) during 5 yr follow-up. The...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Park WR, Oh TK, Jeon HJ Tags: J Korean Med Sci Source Type: research

Risk Factors for Long-term Outcomes after Initial Treatment in Hepatolithiasis.
In conclusion, several long-term hepatobiliary complications occur after hepatolithiasis treatment, and regular observation is necessary in patients with concomitant biliary stricture or residual stones. PMID: 24265526 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Park JS, Jeong S, Lee DH, Bang BW, Lee JI, Lee JW, Kwon KS, Kim HK, Shin YW, Kim YS, Park SG Tags: J Korean Med Sci Source Type: research

Factors related to decreased bone mineral density in childhood cancer survivors.
Abstract The risk of osteoporosis or osteopenia is known to increase after childhood cancer treatment. The purpose of this study was to evaluate patterns of bone mineral density (BMD) and to identify factors related to the decreased BMD in childhood cancer survivors. We studied 78 patients (34 boys, 44 girls) treated for childhood cancer. Twenty (25.7%) patients had lumbar BMD (LBMD) standard deviation score (SDS) lower than -2. Nineteen (24.4%) patients had femur neck BMD (FNBMD) SDS lower than -2. The patients treated with hematopoietic stem cell transplantation had lower LBMD SDS (-1.17 ± 1.39 vs -0.43 &...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Choi YJ, Park SY, Cho WK, Lee JW, Cho KS, Park SH, Hahn SH, Jung MH, Chung NG, Cho B, Suh BK, Kim HK Tags: J Korean Med Sci Source Type: research

Fever phobia in korean caregivers and its clinical implications.
Abstract Fever is the most common complaint among children brought into the emergency department (ED). 'Fever phobia' is a descriptive term for an unrealistic concern about the consequences of fever. 'Fever phobia' is prevalent among parents and even healthcare providers, worldwide. The aim of this study was to determine the implications of fever-phobic ideas in Korean caregivers. A prospective, multi-center survey was conducted on Korean caregivers who visited the EDs with febrile children. In total, 746 caregivers were enrolled. The mean age of the subjects was 34.7 yr (SD±5.0). Three hundred sixty respon...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kwak YH, Kim do K, Jang HY, Kim JJ, Ryu JM, Oh SB, Lee EJ, Lee JS, Lee JH, Jung JH, Han SB Tags: J Korean Med Sci Source Type: research

Clinical characteristics of pediatric thalassemia in Korea: a single institute experience.
Abstract Few literatures have elaborated on the clinical characteristics of children with thalassemia from low-prevalence areas. A retrospective analysis was conducted on children genetically confirmed with thalassemia at Seoul National University Children's Hospital in Korea. Nine children (1α thalassemia trait, 6β thalassemia minor, 2β thalassemia intermedia) were diagnosed with thalassemia at median age of 4.3 yr old with median hemoglobin of 9.7 g/dL. Seven (78%) children were incidentally found to be anemic and only 2 with β thalassemia intermedia had presenting symptoms. Five children (5...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Hong CR, Kang HJ, Lee JW, Kim H, Kim NH, Park KD, Park JD, Seong MW, Park SS, Shin HY, Ahn HS Tags: J Korean Med Sci Source Type: research

Clinical Features of Congenital Adrenal Insufficiency Including Growth Patterns and Significance of ACTH Stimulation Test.
This study was designed to understand the clinical manifestations including growth patterns and to find the usefulness of ACTH stimulation test. Sixteen patients with confirmed genotyping were subdivided into three groups according to the genetic study results: congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH, n=11), congenital lipoid adrenal hyperplasia (n=3) and X-linked adrenal hypoplasia congenita (n=2). Bone age advancement was prominent in patients with CAH especially after 60 months of chronologic age (n=6, 67%). They were diagnosed in older ages in group with bone age advancement (P
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Koh JW, Kim GH, Yoo HW, Yu J Tags: J Korean Med Sci Source Type: research

Long-term Outcomes of Endoscopic Variceal Ligation to Prevent Rebleeding in Children with Esophageal Varices.
Abstract After an episode of acute bleeding from esophageal varices, patients are at a high risk for recurrent bleeding and death. However, there are few reports regarding the long-term results of secondary prophylaxis using endoscopic variceal ligation (EVL) against variceal rebleeding in pediatrics. Thirty-seven, who were followed for over 3 yr post-eradication, were included in the study. The mean duration of follow up after esophageal variceal eradication was 6.4±1.9 yr. The mean time required to achieve the eradication of varices was 3.25 months. The mean number of sessions and O-bands needed to eradic...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kang KS, Yang HR, Ko JS, Seo JK Tags: J Korean Med Sci Source Type: research

Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism.
Abstract Sporadic spastic paraplegia (SSP) and hereditary spastic paraplegia (HSP) belong to a clinical and genetically heterogeneous group of disorders characterized by progressive spasticity and weakness in the lower extremities. The symptoms are associated with pyramidal tract dysfunction and degeneration of the corticospinal tracts. Parkinsonism is uncommon in SSP/HSP patients. However, both disorders are associated with damage to the nigrostriatal dopaminergic system. In the present study, the clinical features of patients with SSP/HSP were investigated, and nigrostriatal dopaminergic binding potential was as...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kim JS, Kim JM, Kim YK, Kim SE, Yun JY, Jeon BS Tags: J Korean Med Sci Source Type: research

Early Risk Factors for Depressive Symptoms among Korean Adolescents: A 6-to-8 Year Follow-up Study.
This study aimed to identify childhood emotional and behavioral risk factors related to depressive symptoms in Korean adolescents through a longitudinal study. The first survey took place from 1998 to 2000, and a follow-up assessment conducted in 2006, as the original participants reached 13-15 yr of age. The first assessment used the Korean version of Child Behavior Checklist and a general questionnaire on family structure, parental education, and economic status to evaluate the participants. The follow-up assessment administered the Korean Children's Depression Inventory. Multiple regression analysis revealed that childh...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Shin KM, Cho SM, Shin YM, Park KS Tags: J Korean Med Sci Source Type: research

Psychometric properties of the korean version of stanford acute stress reaction questionnaire.
Abstract The present study aimed to examine the psychometric properties of the Korean version of Stanford Acute Stress Reaction Questionnaire (SASRQ). A Korean version of the SASRQ was produced through forward translation, reconciliation, and back translation. A total of 100 healthy, non-clinical participants were selected through screening and clinical interview, and they each were given a set of questionnaires including SASRQ. Psychometric properties of SASRQ were then examined through statistical analyses. Full-scale and subscales of SASRQ yielded excellent internal consistency (Cronbach's alpha=0.98 and 0.78-0...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kweon YS, Jung NY, Wang SM, Rauch SA, Chae JH, Lee HK, Lee CT, Lee KU Tags: J Korean Med Sci Source Type: research

An outbreak of food borne illness due to methomyl pesticide intoxication in Korea.
Abstract On February 21, 2013, 6 elderly people collapsed abruptly after eating bean sprout bibimbab (boiled rice mixed with bean sprouts and seasoned with soybean sauce) at a countryside restaurant in the Chungbuk Province, Korea. Minutes after eating the meal, all of the patients lapsed into a state of stupor. Respiratory arrest developed in 2 patients; and one of two patients died of cardiac arrest. The autopsy identified methomyl and methanol in the deceased patient's gastric contents and in the remaining soybeanbean sauce seasoning. Five of the 6 patients ingested one spoonful of the soybeanbean sauce seasoni...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Gil HW, Jeong MH, Park JS, Choi HW, Kim SY, Hong SY Tags: J Korean Med Sci Source Type: research

An unusual presentation of diabetic ketoacidosis in familial hajdu-cheney syndrome: a case report.
Abstract A 21-year-old man with diabetic ketoacidosis (DKA) displayed short and clubbed fingers and marked eyebrow, which are typical of Hajdu-Cheney Syndrome (HCS). Laboratory findings confirmed type 1 diabetes mellitus (DM). After conservative care with hydration and insulin supply, metabolic impairment was improved. Examinations of bone and metabolism revealed osteoporosis and craniofacial abnormalities. The mutation (c.6443T>G) of the NOTCH2 gene was found. The patient was diagnosed with HCS and DM. There may be a relationship between HCS and DM, with development of pancreatic symptoms related to the NOTCH2...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Lee GH, An SY, Sohn YB, Jeong SY, Chung YS Tags: J Korean Med Sci Source Type: research

Glufosinate herbicide intoxication causing unconsciousness, convulsion, and 6th cranial nerve palsy.
Abstract Although glufosinate ammonium herbicides are considered safe when used properly, ingestion of the undiluted form can cause grave outcomes. Recently, we treated a 34-yr-old man who ingested glufosinate ammonium herbicide. In the course of treatment, the patient developed apnea, mental deterioration, and sixth cranial nerve palsy; he has since been discharged with full recovery after intensive care. This case report describes the clinical features of glufosinate intoxication with a focus on sixth cranial nerve palsy. Our observation suggests that neurologic manifestations after ingestion of a "low-grad...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Park JS, Kwak SJ, Gil HW, Kim SY, Hong SY Tags: J Korean Med Sci Source Type: research

ANCA-Negative Wegener's Granulomatosis with Multiple Lower Cranial Nerve Palsies.
Abstract Wegener's granulomatosis (WG) is a systemic vasculitis affecting small and medium-sized vessels with granulomatous formation. Though it is known for respiratory tract and kidney involvement, neurologic manifestation has been also reported. Herein we report a patient who suffered pansinusitis with multiple lower cranial nerve palsies but reached remission by immunosuppressant after the diagnosis of WG. A 54-yr-old female visited with headache, hearing difficulty, and progressive bulbar symptoms. She experienced endoscopic sinus surgeries due to refractory sinusitis. Neurologic examination revealed multiple...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Kim SH, Park J, Bae JH, Cho MS, Park KD, Jeong JH Tags: J Korean Med Sci Source Type: research

Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy.
Abstract Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%...
Source: J Korean Med Sci - November 1, 2013 Category: Journals (General) Authors: Nam YH, Hwang EK, Jin HJ, Lee JM, Shin YS, Ye YM, Palacin A, Salcedo G, Lee SY, Park HS Tags: J Korean Med Sci Source Type: research

Lesson of the seventh international congress on peer review and biomedical publication.
PMID: 24133342 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 1, 2013 Category: Journals (General) Authors: Hong ST Tags: J Korean Med Sci Source Type: research

NLRP3 Inflammasome and Host Protection against Bacterial Infection.
Abstract The inflammasome is a multi-protein complex that induces maturation of inflammatory cytokines interleukin (IL)-1β and IL-18 through activation of caspase-1. Several nucleotide binding oligomerization domain-like receptor family members, including NLRP3, recognize unique microbial and danger components and play a central role in inflammasome activation. The NLRP3 inflammasome is critical for maintenance of homeostasis against pathogenic infections. However, inflammasome activation acts as a double-edged sword for various bacterial infections. When the IL-1 family of cytokines is secreted excessively, ...
Source: J Korean Med Sci - October 1, 2013 Category: Journals (General) Authors: Kim JJ, Jo EK Tags: J Korean Med Sci Source Type: research

Comparative analysis of acute toxic poisoning in 2003 and 2011: analysis of 3 academic hospitals.
In conclusion, the average patient age and psychotic drug poisoning has increased over time, and the use of lavage treatment has decreased. PMID: 24133344 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 1, 2013 Category: Journals (General) Authors: Jang HS, Kim JY, Choi SH, Yoon YH, Moon SW, Hong YS, Lee SW Tags: J Korean Med Sci Source Type: research