Statement on Publication Ethics for Editors and Publishers.
Abstract The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the l...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Gasparyan AY, Yessirkepov M, Voronov AA, Gorin SV, Koroleva AM, Kitas GD Tags: J Korean Med Sci Source Type: research

Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database.
In conclusion, we detected 12 new signals of amoxicillin which were not listed on the labels of 9 countries. Therefore, it should be followed by signal evaluation including causal association, clinical significance, and preventability. PMID: 27510377 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Soukavong M, Kim J, Park K, Yang BR, Lee J, Jin XM, Park BJ Tags: J Korean Med Sci Source Type: research

Affecting Factors of Secondhand Smoke Exposure in Korea: Focused on Different Exposure Locations.
In this study, we described and compared the factors related to SHS exposure according to location in Korea. Regarding individual factors related to SHS exposure, a common individual variable model and location-specific variable model was used to evaluate SHS exposure at home/work/public locations based on sex. In common individual variables, such as age, and smoking status showed different relationships with SHS exposure in different locations. Among home-related variables, housing type and family with a single father and unmarried children showed the strongest positive relationships with SHS exposure in both males and fe...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Sun LY, Cheong HK, Lee EW, Kang KJ, Park JH Tags: J Korean Med Sci Source Type: research

Transplantation of Mesenchymal Stem Cells for Acute Spinal Cord Injury in Rats: Comparative Study between Intralesional Injection and Scaffold Based Transplantation.
Abstract Experimental stem cell therapy for spinal cord injury (SCI) has been extensively investigated. The selection of effective cell transplantation route is also an important issue. Although various types of scaffold have been widely tried as a carrier of stem cells to the injured spinal cord, there was little comparative study to investigate the efficacy of transplantation comparing with conventional transplantation route. A total of 48 Sprague-Dawley rats were subjected to standardized SCI, followed by transplantation of allogeneic mesenchymal stem cells (MSCs), either via intralesional injection (IL group),...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kim YC, Kim YH, Kim JW, Ha KY Tags: J Korean Med Sci Source Type: research

The Immunogenicity and Safety of a Combined DTaP-IPV//Hib Vaccine Compared with Individual DTaP-IPV and Hib (PRP~T) Vaccines: a Randomized Clinical Trial in South Korean Infants.
Abstract Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination vaccine (Pentaxim™) compared with licensed DTaP-IPV and Hib (PRP~T) vaccines. We enrolled 418 healthy Korean infants to receive either separate DTaP-IPV and Hib vaccines (n = 206) or the pentavalent DTaP-IPV//Hib (n = 208) vaccine at 2, 4, 6 months of age. Antibodies to all components were measured before the first vaccination and one month after the third, ...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kang JH, Lee HJ, Kim KH, Oh SH, Cha SH, Lee J, Kim NH, Eun BW, Kim CH, Hong YJ, Kim HH, Lee KY, Kim YJ, Cho EY, Kim HS, Guitton F, Ortiz E Tags: J Korean Med Sci Source Type: research

Detection of MYCN Amplification in Serum DNA Using Conventional Polymerase Chain Reaction.
Abstract Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and is characterized by a wide range of clinical behaviors. Amplification of MYCN is a well-known poor prognostic factor in NB patients. As the MYCN amplification status is usually tested using tumor specimens, lengthy and invasive procedures are unavoidable. To evaluate the possibility of detecting MYCN amplification without invasive procedure, we performed conventional polymerase chain reaction (PCR) analysis to identify MYCN amplification using the preserved serum DNA. PCR of serum DNA was done in 105 NB patients whose MYCN st...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Ma Y, Lee JW, Park SJ, Yi ES, Choi YB, Yoo KH, Sung KW, Koo HH Tags: J Korean Med Sci Source Type: research

Complications of Cardiac Perforation and Lead Dislodgement with an MRI-Conditional Pacing Lead: a Korean Multi-Center Experience.
This study aimed to compare the incidence of cardiac perforation and lead dislodgement within 30 days after pacemaker implantation between 5086 MRI lead and previous Medtronic CapSureFix Novus 5076 non-MRI pacing lead. This was a nationwide, multicenter retrospective study in which we compared the incidence of adverse events between 277 patients implanted with 5086 lead and 205 patients implanted with 5076 lead between March 2009 and September 2014. Cardiac perforation within 30 days of pacemaker implantation occurred in 4 patients (1.4%) with the 5086 lead and in no patient with the 5076 lead (P = 0.084). Lead dislodgemen...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kwon CH, Choi JH, Kim J, Jo U, Lee JH, Lee WS, Kim YR, Lee SY, Whang KW, Yang J, Kim SH, Oh YS, Park KM, Nam GB, Choi KJ, Kim YH Tags: J Korean Med Sci Source Type: research

Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy.
In conclusion, our results suggest that LJ1888 has a renoprotective effect in ADX-induced nephropathy, which might be associated with podocyte injury through oxidative stress. Therefore, LJ1888, a selective A3AR antagonist, could be considered as a potential therapeutic agent in renal glomerular diseases which include podocyte injury and proteinuria. PMID: 27510383 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS Tags: J Korean Med Sci Source Type: research

Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.
Abstract We investigated an association between serum Growth Differentiation Factor 15 (GDF15) level and cardiovascular risk in patients with newly diagnosed type 2 diabetes mellitus (T2D). A total of 107 participants were screened for T2D and divided into a T2D group and a control group (without diabetes). We used the Framingham risk score (FRS) and the New Pooled Cohort Equation score to estimate the 10-year risk of atherosclerotic cardiovascular disease. Serum GDF15 levels were measured using an enzyme-linked immunosorbent assay. Correlation analyses were performed to evaluate the associations between GDF15 lev...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Shin MY, Kim JM, Kang YE, Kim MK, Joung KH, Lee JH, Kim KS, Kim HJ, Ku BJ, Shong M Tags: J Korean Med Sci Source Type: research

Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice.
Abstract Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided into 5 groups: control, metformin (100 mg/kg), BLM, and BLM with metformin (50 mg/kg or 100 mg/kg). Metformin was administered to the mice orally once a day from day 1. We sacrificed half of the mice on day 10 and collected the bronchoalveolar lavage fluid (BALF) from their left lungs. The remaining mice were sacrificed and analyzed on day 21. The right lungs were harvested for histological ana...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Choi SM, Jang AH, Kim H, Lee KH, Kim YW Tags: J Korean Med Sci Source Type: research

Risk Factors of Advanced Adenoma in Small and Diminutive Colorectal Polyp.
Abstract The aims of this study were to review the clinicopathological characteristics of diminutive (≤ 5 mm) and small polyps (> 5 mm but
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Jeong YH, Kim KO, Park CS, Kim SB, Lee SH, Jang BI Tags: J Korean Med Sci Source Type: research

Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C.
Abstract Hepatitis C virus core antigen (HCV Ag) is a recently developed marker of hepatitis C virus (HCV) infection. We investigated the clinical utility of the new HCV Ag assay for prediction of treatment response in HCV infection. We analyzed serum from 92 patients with HCV infection who had been treated with pegylated interferon and ribavirin. HCV Ag levels were determined at baseline in all enrolled patients and at week 4 in 15 patients. Baseline HCV Ag levels showed good correlations with HCV RNA (r = 0.79, P
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kim MN, Kim HS, Kim JK, Kim BK, Kim SU, Park JY, Kim do Y, Ahn SH, Han KH Tags: J Korean Med Sci Source Type: research

Development of a Swine Benign Biliary Stricture Model Using Endoscopic Biliary Radiofrequency Ablation.
This study conducted to establish a clinically relevant porcine BBS model by means of endobiliary radiofrequency ablation (RFA). Endoscopic retrograde cholangiography (ERC) was performed on 12 swine. The animals were allocated to three groups (60, 80, and 100 W) according to the electrical power level of RFA electrode. Endobiliary RFA was applied to the common bile duct for 60 seconds using an RFA catheter that was endoscopically inserted. ERC was repeated two and four weeks, respectively, after the RFA to identify BBS. After the strictures were identified, histologic evaluations were performed. On the follow-up ERC two we...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Park JS, Jeong S, Kim JM, Park SS, Lee DH Tags: J Korean Med Sci Source Type: research

Epidemiologic Study on Kawasaki Disease in Korea, 2007-2014: Based on Health Insurance Review & Assessment Service Claims.
Epidemiologic Study on Kawasaki Disease in Korea, 2007-2014: Based on Health Insurance Review & Assessment Service Claims. J Korean Med Sci. 2016 Sep;31(9):1445-9 Authors: Ha S, Seo GH, Kim KY, Kim DS Abstract The aim of this study is to assess the actual epidemiologic features of Kawasaki disease (KD) in Korea using the data from Health Insurance Review & Assessment Service (HIRA) claims from 2007 to 2014. We investigated HIRA claims of patients who had KD (International Classification of Diseases-10, M30.3) as a major diagnosis and were given intravenous immunoglobulin (IVIG) from 2007 to 20...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Ha S, Seo GH, Kim KY, Kim DS Tags: J Korean Med Sci Source Type: research

Neonatal and Infant Mortality in Korea, Japan, and the U.S.: Effect of Birth Weight Distribution and Birth Weight-Specific Mortality Rates.
Abstract Difference in crude neonatal and infant mortality rates (NMR and IMR) among different countries is due to the differences in its two determinants: birth weight distribution (BWD) and birth weight-specific mortality rates (BW-SMRs). We aimed to determine impact of BWD and BW-SMRs on differences in crude NMR and IMR among Korea, Japan, and the U.S. Our study used the live birth data of the period 2009 through 2010. Crude NMR/IMR are the lowest in Japan, 1.1/2.1, compared to 1.8/3.2, in Korea, and 4.1/6.2, in the U.S., respectively. Japanese had the best BW-SMRs of all birth weight groups compared to the Kor...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kim do H, Jeon J, Park CG, Sriram S, Lee KS Tags: J Korean Med Sci Source Type: research

Ten Triangles around Cavernous Sinus for Surgical Approach, Described by Schematic Diagram and Three Dimensional Models with the Sectioned Images.
Abstract For the surgical approach to lesions around the cavernous sinus (CS), triangular spaces around CS have been devised. However, educational materials for learning the triangles were insufficient. The purpose of this study is to present educational materials about the triangles, consisting of a schematic diagram and 3-dimensional (3D) models with sectioned images. To achieve the purposes, other studies were analyzed to establish new definitions and names of the triangular spaces. Learning materials including schematic diagrams and 3D models with cadaver's sectioned images were manufactured. Our new definitio...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Chung BS, Ahn YH, Park JS Tags: J Korean Med Sci Source Type: research

Impact of Glycemic Control and Metformin Use on the Recurrence and Progression of Non-Muscle Invasive Bladder Cancer in Patients with Diabetes Mellitus.
In conclusion, poor baseline and post-operative glycemic control was related with shorter progression-free survival of patients with non-muscle invasive bladder cancer. Use of metformin had no impact on the recurrence and progression. Therefore, tight glycemic control and close follow-up for bladder tumor may be beneficial in patients with poor glycemic control. PMID: 27510392 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Ahn JH, Jung SI, Yim SU, Kim SW, Hwang EC, Kwon DD Tags: J Korean Med Sci Source Type: research

Ultrasound Dimensions of the Rotator Cuff and Other Associated Structures in Korean Healthy Adults.
This report suggests normative values of ultrasound dimensions of healthy Korean population with varying age, and can be useful as reference values in evaluating shoulder pathology, especially in rotator cuff tendon pathology. PMID: 27510393 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Kim K, Kim HG, Song D, Yoon JY, Chung ME Tags: J Korean Med Sci Source Type: research

High Prevalence of Sarcopenia in Korean Patients after Hip Fracture: a Case-Control Study.
Abstract Sarcopenia-related falls and fractures are increasing worldwide due to the aging population. The purpose of this study was to 1) evaluate anthropometric characteristics related to hip fracture in Korean patients, 2) investigate sarcopenia prevalence in hip fracture (HF) and non-hip fracture (NF) groups, and 3) investigate the correlation between sarcopenia and osteoporosis. This case-control study examined 359 HF and 1,614 NF normal populations using Korea National Health and Nutrition Examination Survey data. We performed whole-body dual energy X-ray absorptiometry to analyze body composition using the s...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Yoo JI, Ha YC, Kwon HB, Lee YK, Koo KH, Yoo MJ Tags: J Korean Med Sci Source Type: research

Comparison of an Intraoperative Infusion of Dexmedetomidine, Fentanyl, and Remifentanil on Perioperative Hemodynamics, Sedation Quality, and Postoperative Pain Control.
Abstract We aimed to compare fentanyl, remifentanil and dexmedetomidine with respect to hemodynamic stability, postoperative pain control and achievement of sedation at the postanesthetic care unit (PACU). In this randomized double-blind study, 90 consecutive total laparoscopic hysterectomy patients scheduled for elective surgery were randomly assigned to receive fentanyl (1.0 μg/kg) over 1 minute followed by a 0.4 μg/kg/hr infusion (FK group, n = 30), or remifentanil (1.0 μg/kg) over 1 minute followed by a 0.08 μg/kg/min infusion (RK group, n = 30), or dexmedetomidine (1 μg/kg) over 10 minutes foll...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Choi JW, Joo JD, Kim DW, In JH, Kwon SY, Seo K, Han D, Cheon GY, Jung HS Tags: J Korean Med Sci Source Type: research

A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation.
The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month ...
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Hwang SO, Cha KC, Kim K, Jo YH, Chung SP, You JS, Shin J, Lee HJ, Park YS, Kim S, Choi SC, Park EJ, Kim WY, Seo DW, Moon S, Han G, Choi HS, Kang H, Park SM, Kwon WY, Choi E Tags: J Korean Med Sci Source Type: research

Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury.
We report a case of severe acute renal failure associated with delayed diagnosis of falciparum malaria, and primary use of supportive treatment rather than antimalarial medicine. The present case suggests that early diagnosis and treatment is important because untreated tropical malaria can be associated with severe acute renal failure and fatality. Physicians must be alert for correct diagnosis and proper management of imported tropical malaria when patients have travel history of endemic areas. PMID: 27510397 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Choi IH, Hwang PH, Choi SI, Lee DY, Kim MS Tags: J Korean Med Sci Source Type: research

Letter to the Editor: Objective Assessment of Surgical Restaging after Concurrent Chemoradiation for Locally Advanced Pancreatic Cancer.
PMID: 27510398 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Karabicak I Tags: J Korean Med Sci Source Type: research

The Author's Response: Objective Assessment of Surgical Restaging after Concurrent Chemoradiation for Locally Advanced Pancreatic Cancer.
PMID: 27510399 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 12, 2016 Category: Journals (General) Authors: Paik WH, Kim YT Tags: J Korean Med Sci Source Type: research

Forecasting Cause-Specific Mortality in Korea up to Year 2032.
Abstract Forecasting cause-specific mortality can help estimate the future burden of diseases and provide a clue for preventing diseases. Our objective was to forecast the mortality for causes of death in the future (2013-2032) based on the past trends (1983-2012) in Korea. The death data consisted of 12 major causes of death from 1983 to 2012 and the population data consisted of the observed and estimated populations (1983-2032) in Korea. The modified age-period-cohort model with an R-based program, nordpred software, was used to forecast future mortality. Although the age-standardized rates for the world standar...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Yun JW, Son M Tags: J Korean Med Sci Source Type: research

Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance.
Abstract Diagnosis of scrub typhus is challenging due to its more than twenty serotypes and the similar clinical symptoms with other acute febrile illnesses including leptospirosis, murine typhus and hemorrhagic fever with renal syndrome. Accuracy and rapidity of a diagnostic test to Orientia tsutsugamushi is an important step to diagnose this disease. To discriminate scrub typhus from other diseases, the improved ImmuneMed Scrub Typhus Rapid Diagnostic Test (RDT) was evaluated in Korea and Sri Lanka. The sensitivity at the base of each IgM and IgG indirect immunofluorescent assay (IFA) in Korean patients was 98.6...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Kim YJ, Park S, Premaratna R, Selvaraj S, Park SJ, Kim S, Kim D, Kim MS, Shin DH, Choi KC, Kwon SH, Seo W, Lee NT, Kim SH, Kang HK, Kim YW Tags: J Korean Med Sci Source Type: research

IgE Sensitization Patterns to Commonly Consumed Foods Determined by Skin Prick Test in Korean Adults.
In this study, we analysed sensitization rates to commonly consumed foods in Korean adults suspected of having food allergy. One hundred and thirty four subjects underwent a skin prick test (SPT) with 55 food allergens, of which 13 were made by our laboratory and the rest were commercially purchased. Of the 134 patients, 73 (54.5%) were sensitized to one or more food allergens. Sensitization to chrysalis was detected most frequently, at a rate of 25.4%. Sensitization rates to other food allergens were as follows: maize grain (13.4%), shrimp (11.9%), almond (11.1%), wheat flour (8.2%), lobster (8.2%), buckwheat (8.2%), mack...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Kim SR, Park HJ, Park KH, Lee JH, Park JW Tags: J Korean Med Sci Source Type: research

Cross-Reactivity between Oak and Birch Pollens in Korean Tree Pollinosis.
Abstract Oak and birch trees belong to Fagales order. Specific IgE to pollen allergens of both trees are frequently found in Korea pollinosis patients. Oak trees which comprise 40% of forest area are common in Korea. However, birch trees are sparse. We compared the allergenicity of pollen extracts of white oak, sawtooth and Mongolian oaks which are prevalent species in Korea, with the pollen extract of birch. The cross-reactivity of four pollen extracts was examined with pooled sera of 12 patients by ELISA, immunoblotting and CAP inhibitions. A protein of 17 kDa, putatively homologous to a major birch allergen Bet...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Jeong KY, Son M, Park JH, Park KH, Park HJ, Lee JH, Hong CS, Park JW Tags: J Korean Med Sci Source Type: research

Immunohistochemical Analysis of ATRX, IDH1 and p53 in Glioblastoma and Their Correlations with Patient Survival.
In conclusion, in the case of single protein expression, the patients with each IDH1+, or ATRX-, or p53- GBMs showed better survival than patients with counterparts protein expressed GBMs. In the case of double protein pairs, the patients with ATRX-/p53-, ATRX-/IDH1+, and IDH1+/p53- GBMs revealed better survival than the patients with GBMs with the remained pairs. In the case of triple protein combinations, the patients with ATRX-/p53-/IDH+ showed statistically significant survival gain than the patients with remained combination of proteins-expression status. Therefore, these three biomarkers, individually and as a combin...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Chaurasia A, Park SH, Seo JW, Park CK Tags: J Korean Med Sci Source Type: research

OTX1 Contributes to Hepatocellular Carcinoma Progression by Regulation of ERK/MAPK Pathway.
In conclusion, OTX1 contributes to HCC progression possibly by regulation of ERK/MAPK pathway. OTX1 may be a novel target for molecular therapy towards HCC. PMID: 27478331 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Li H, Miao Q, Xu CW, Huang JH, Zhou YF, Wu MJ Tags: J Korean Med Sci Source Type: research

Detection of EGFR and KRAS Mutation by Pyrosequencing Analysis in Cytologic Samples of Non-Small Cell Lung Cancer.
In this study, we aimed to evaluate the testing for EGFR and KRAS mutations by pyrosequencing method, and compared the yield of cytology versus histology specimens in a consecutive series of patients with lung cancer. We retrospectively reviewed EGFR and KRAS mutation results of 399 (patients with EGFR mutation test) and 323 patients (patients with KRAS mutation test) diagnosed with lung cancer in Konkuk University Medical Center from 2008 to 2014. Among them, 60 patients had received both EGFR and KRAS mutation studies. We compared the detection rate of EGFR and KRAS tests in cytology, biopsy, and resection specimens. EGF...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Lee SE, Lee SY, Park HK, Oh SY, Kim HJ, Lee KY, Kim WS Tags: J Korean Med Sci Source Type: research

News Portrayal of Cancer: Content Analysis of Threat and Efficacy by Cancer Type and Comparison with Incidence and Mortality in Korea.
Abstract How the news media cover cancer may have profound significance for cancer prevention and control; however, little is known about the actual content of cancer news coverage in Korea. This research thus aimed to examine news portrayal of specific cancer types with respect to threat and efficacy, and to investigate whether news portrayal corresponds to actual cancer statistics. A content analysis of 1,138 cancer news stories was conducted, using a representative sample from 23 news outlets (television, newspapers, and other news media) in Korea over a 5-year period from 2008 to 2012. Cancer incidence and mor...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Shim M, Kim YC, Kye SY, Park K Tags: J Korean Med Sci Source Type: research

The Impact of Hemodialysis and Arteriovenous Access Flow on Extracranial Hemodynamic Changes in End-Stage Renal Disease Patients.
In this study, we characterized cerebral blood flow changes by assessment of blood flow parameters in neck arteries using carotid duplex ultrasonography and predictive factors for these hemodynamic changes. Hemodynamic variables were measured before and during hemodialysis in 81 patients with an arteriovenous access in their arm. Hemodialysis produced significant lowering in peak systolic velocity and flow volume of neck arteries and calculated total cerebral blood flow (1,221.9 ± 344.9 [before hemodialysis] vs. 1,085.8 ± 319.2 [during hemodialysis], P
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Chung S, Jeong HS, Choi DE, Song HJ, Lim YG, Ham JY, Na KR, Lee KW Tags: J Korean Med Sci Source Type: research

Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis.
Abstract Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant ...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Kim BJ, Kim HS, Song HJ, Chung IK, Kim GH, Kim BW, Shim KN, Jeon SW, Jung YJ, Yang CH, Kim JH, Kim TH, Kim SG, Shin WG, Kim SM, Han SW, Lee JH, Kim KH, Park SK, Park BJ, Lee J, Kim JG, Korean College of Helicobacter and Upper Gastrointestinal Research Tags: J Korean Med Sci Source Type: research

Characteristics and Outcomes of Second Malignant Neoplasms after Childhood Cancer Treatment: Multi-Center Retrospective Survey.
Abstract This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MN...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Koh KN, Yoo KH, Im HJ, Sung KW, Koo HH, Kim HS, Han JW, Yoon JH, Park HJ, Park BK, Baek HJ, Kook H, Lee JA, Lee JM, Lee KC, Kim SK, Park M, Lee YH, Lyu CJ, Seo JJ Tags: J Korean Med Sci Source Type: research

Risk Factors for Functional Constipation in Young Children Attending Daycare Centers.
Abstract Our objective was to determine the risk factors associated with the development of functional constipation (FC) in young children attending daycare centers. A cross-sectional survey using a questionnaire based on the Rome III criteria was conducted in children aged 25 to 84 months from 3 randomly selected daycare centers in January 2016. The items in a questionnaire were statistically compared in the constipated and non-constipated groups. A total of 212 children were included and FC was found in 8.5%. Multivariate logistic regression analyses revealed that maternal history of constipation (odds ratio [OR...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Park M, Bang YG, Cho KY Tags: J Korean Med Sci Source Type: research

Clinical Outcomes of Cryopreserved Arterial Allograft Used as a Vascular Conduit for Hemodialysis.
Abstract This single center cohort study aimed to test the hypothesis that use of a cryopreserved arterial allograft could avoid the maturation or healing process of a new vascular access and to evaluate the patency of this technique compared with that of vascular access using a prosthetic graft. Between April 2012 and March 2013, 20 patients underwent an upper arm vascular access using a cryopreserved arterial allograft for failed or failing vascular accesses and 53 using a prosthetic graft were included in this study. The mean duration of catheter dependence, calculated as the time interval from upper arm access...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Ha TY, Kim YH, Chang JW, Park Y, Han Y, Kwon H, Kwon TW, Han DJ, Cho YP, Lee SG Tags: J Korean Med Sci Source Type: research

Simvastatin Reduces Capsular Fibrosis around Silicone Implants.
Abstract Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various models. Peri-implant capsular formation is the result of tissue fibrosis development in irradiated breasts. The purpose of this study was to examine the effect of simvastatin on peri-implant fibrosis in rats. Eighteen male Sprague-Dawley rats were allocated to an experimental group (9 rats, 18 implants) or a control group (9 rats, 18 implants). Two hemispherical silicone implants, 10 mm in...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Chung KJ, Park KR, Lee JH, Kim TG, Kim YH Tags: J Korean Med Sci Source Type: research

Effects of High-Intensity-Focused Ultrasound Treatment on Benign Uterine Tumor.
This study showed that HIFU treatments for uterine fibroid and adenomyosis is an effective non-invasive therapy via reducing the benign uterine tumor volume. Therefore, the HIFU method might replace other conventional treatment methods. PMID: 27478340 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Park J, Lee JS, Cho JH, Kim S Tags: J Korean Med Sci Source Type: research

Differences in Utilization Patterns among Medications in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: a 36-Month Retrospective Study Using the Korean Health Insurance Review and Assessment Claims Database.
Abstract We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010. Data were followed up from the initiation of treatment with ADHD medications in 2010 to Decembe...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Bhang SY, Hwang JW, Kwak YS, Joung YS, Lee S, Kim B, Sohn SH, Chung US, Yang J, Hong M, Bahn GH, Choi HY, Oh IH, Lee YJ Tags: J Korean Med Sci Source Type: research

The Degree of Diabetic Retinopathy in Patients with Type 2 Diabetes Correlates with the Presence and Severity of Coronary Heart Disease.
Abstract Both diabetic retinopathy (DR) and coronary heart disease (CHD) are clinically significant in diabetic patients. We investigated the correlation between the severity of DR and the presence and severity of CHD among type 2 diabetic patients. A total of 175 patients who were examined at the DR clinic and underwent dual-source computed tomography (DSCT) angiography within 6 months were included. The degree of DR was graded as no DR, nonproliferative DR (NPDR), and proliferative DR (PDR). The severity of CHD and the numbers of significant stenotic coronary artery on DSCT angiography according to DR grade were...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Um T, Lee DH, Kang JW, Kim EY, Yoon YH Tags: J Korean Med Sci Source Type: research

Is There Any Age Cutoff to Treat Elderly Patients with Head and Neck Cancer? Comparing with Septuagenarians and Octogenarians.
Abstract With the increase in life expectancy, age is no longer considered as a limitation for treatment. Nevertheless, the treatment of elderly patients with head and neck cancer (HNC) remains controversial. Here, we aimed to review our experience with the treatment for elderly patients, while particularly focusing on the differences among older old patients (septuagenarians vs. octogenarians). We retrospectively reviewed the records of 260 elderly patients who were assigned to 3 groups according to age: 70 years old ≤ group 1
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Kim H, Kim SD, Shim YJ, Lee SY, Sung MW, Kim KH, Hah JH Tags: J Korean Med Sci Source Type: research

Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization.
Abstract X-linked ichthyosis (XLI) is a recessively inherited ichthyosis. Skin barrier function of XLI patients reported in Western countries presented minimally abnormal or normal. Here, we evaluated the skin barrier properties and a skin barrier-related gene mutation in 16 Korean XLI patients who were diagnosed by fluorescence in situ hybridization and array comparative genomic hybridization analysis. Skin barrier properties were measured, cytokine expression levels in the stratum corneum (SC) were evaluated with the tape stripped specimen from skin surface, and a genetic test was done on blood. XLI patients sho...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Lee NR, Yoon NY, Jung M, Kim JY, Seo SJ, Wang HY, Lee H, Sohn YB, Choi EH Tags: J Korean Med Sci Source Type: research

Preventing Venous Thromboembolism with Use of Intermittent Pneumatic Compression after Total Hip Arthroplasty in Korean Patients.
This study investigated the effectiveness of IPC device. We evaluated incidences of deep vein thrombosis (DVT) and pulmonary embolism (PE) in total hip arthroplasty (THA) patients after use of IPC device, and compared with historical incidences from our institution. We applied IPC device in 741 patients who underwent 870 elective primary THAs from January 2010 to December 2013, DVT was detected in 3 patients (0.3%) by sonography, and one (0.1%) of them was symptomatic. Symptomatic PE occurred in 1 patient (0.1%) and there were no cases of fatal PE. The incidence of symptomatic DVT was significantly lower than the historica...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Jo WL, Lee YK, Ha YC, Lee KM, Kang BJ, Koo KH Tags: J Korean Med Sci Source Type: research

Comparative Effectivenesses of Pulsed Radiofrequency and Transforaminal Steroid Injection for Radicular Pain due to Disc Herniation: a Prospective Randomized Trial.
Abstract Transforaminal Epidural steroid injections (TFESI) have been widely adopted to alleviate and control radicular pain in accord with current guidelines. However, sometimes repeated steroid injections have adverse effects, and thus, this prospective randomized trial was undertaken to compare the effectivenesses of pulsed radiofrequency (PRF) administered to a targeted dorsal root ganglion (DRG) and TFESI for the treatment of radicular pain due to disc herniation. Subjects were recruited when first proved unsuccessful (defined as a score of> 4 on a visual analogue scale (VAS; 0-10 mm) and of> 30% accord...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Lee DG, Ahn SH, Lee J Tags: J Korean Med Sci Source Type: research

Emergency Department Crowding Disparity: a Nationwide Cross-Sectional Study.
In this study, we evaluated national differences in emergency department (ED) crowding to identify factors significantly associated with crowding in institutes and communities across Korea. This was a cross-sectional nationwide observational study using data abstracted from the National Emergency Department Information System (NEDIS). We calculated mean occupancy rates to quantify ED crowding status and divided EDs into three groups according to their occupancy rates (cutoffs: 0.5 and 1.0). Factors potentially related to ED crowding were collected from the NEDIS. We performed a multivariate regression analysis to identify ...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Cha WC, Ahn KO, Shin SD, Park JH, Cho JS Tags: J Korean Med Sci Source Type: research

Influence of Daily Fluid Balance prior to Continuous Renal Replacement Therapy on Outcomes in Critically Ill Patients.
This study investigated the impacts of daily fluid balance prior to CRRT on organ dysfunction, as well as mortality in critically ill patients. We identified daily fluid balance between intensive care unit (ICU) admission and CRRT initiation. According to daily fluid balance, the time to CRRT initiation and the rate of organ failure based on the sequential organ failure assessment (SOFA) score were assessed. We recruited 100 patients who experienced CRRT for acute kidney injury. CRRT was initiated within 2 [0, 4] days. The time to CRRT initiation was shortened in proportion to daily fluid balance, even after the adjustment...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Han MJ, Park KH, Shin JH, Kim SH Tags: J Korean Med Sci Source Type: research

Hypopituitarism Presenting as Adrenal Insufficiency and Hypothyroidism in a Patient with Wilson's Disease: a Case Report.
We report an unprecedented case of hypopituitarism in a patient with Wilson's disease. A 40-year-old woman presented with depression, general weakness and anorexia. Laboratory tests and imaging studies were compatible with liver cirrhosis due to Wilson's disease. Basal hormone levels and pituitary function tests indicated secondary hypothyroidism and adrenal insufficiency due to hypopituitarism. Brain MRI showed T2 hyperintense signals in both basal ganglia and midbrain but the pituitary imaging was normal. She is currently receiving chelation therapy along with thyroid hormone and steroid replacement. There may be a relat...
Source: J Korean Med Sci - August 1, 2016 Category: Journals (General) Authors: Lee HW, Kang JD, Yeo CW, Yoon SW, Lee KJ, Choi MK Tags: J Korean Med Sci Source Type: research

Erratum: Mutations in SLC12A3 and CLCNKB and Their Correlation with Clinical Phenotype in Patients with Gitelman and Gitelman-like Syndrome.
Abstract [This corrects the article on p. 47 in vol. 31, PMID: 26770037.]. PMID: 27103762 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2016 Category: Journals (General) Authors: Han JS Tags: J Korean Med Sci Source Type: research

WMA Guidelines on Promotional Mass Media Appearances by Physicians.
Authors: PMID: 26713043 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - December 1, 2015 Category: Journals (General) Tags: J Korean Med Sci Source Type: research