Interaction Effect between Weight Perception and Comorbidities on Weight Control Behavior in Overweight and Obese Adults: Is There a Sex Difference?
Abstract We investigated the interaction effect between body weight perception and chronic disease comorbidities on body weight control behavior in overweight/obese Korean adults. We analyzed data from 9,138 overweight/obese adults ≥20 yr of age from a nationally representative cross-sectional survey. Multiple logistic regression using an interaction model was performed to estimate the effect of chronic disease comorbidities on weight control behavior regarding weight perception. Adjusted odds ratios for weight control behavior tended to increase significantly with an increasing number of comorbidities in men r...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Hwang JH, Ryu DH, Park SW Tags: J Korean Med Sci Source Type: research

Computational Discrimination of Breast Cancer for Korean Women Based on Epidemiologic Data Only.
In this study, breast cancer discrimination models for Korean women are developed using only epidemiological case-control data (n = 4,574). The models are configured by different classification techniques: support vector machine, artificial neural network, and Bayesian network. A 1,000-time repeated random sub-sampling validation is performed for diverse parameter conditions, respectively. The performance is evaluated and compared as an area under the receiver operating characteristic curve (AUC). According to age group and classification techniques, AUC, accuracy, sensitivity, specificity, and calculation time of all mode...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Lee C, Lee JC, Park B, Bae J, Lim MH, Kang D, Yoo KY, Park SK, Kim Y, Kim S Tags: J Korean Med Sci Source Type: research

Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.
Abstract Gastric cancer is one of the most common cancers in the world. The aims of this study were to evaluate the association between polymorphisms in TFF gene family, TFF1, TFF2, and TFF3 and the risk of gastric cancer (GC) and GC subgroups in a Korean population via a case-control study. The eight polymorphisms in TFF gene family were identified by sequencing and genotyped with 377 GC patients and 396 controls by using TaqMan genotyping assay. The rs184432 TT genotype of TFF1 was significantly associated with a reduced risk of GC (odds ratio, [OR) = 0.45; 95% confidence interval, [CI] = 0.25-0.82; P = 0.009), ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Jin EH, Lee SI, Kim J, Seo EY, Lee SY, Hur GM, Shin S, Hong JH Tags: J Korean Med Sci Source Type: research

Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients.
Abstract The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or i...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Ban GY, Ye YM, Lee Y, Kim JE, Nam YH, Lee SK, Kim JH, Jung KS, Kim SH, Park HS, Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group Tags: J Korean Med Sci Source Type: research

The Effect of Asthma Clinical Guideline for Adults on Inhaled Corticosteroids PrescriptionTrend: A Quasi-Experimental Study.
Abstract In order to increase inhaled corticosteroid (ICS) use and to reduce hospitalization, emergency department visits and ultimately the economic burden of asthma, "Korean Asthma Management Guideline for Adults 2007" was developed. To assess the guideline effects on physician's ICS prescription for asthma, we conducted segmented regression and multilevel logistic regression using National Health Insurance claims database of outpatient visits from 2003 to 2010. We set each quarter of a year as a time unit and compared ICS prescription between before and after guideline dissemination. A total of 624,30...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kim SH, Cho BL, Shin DW, Hwang SS, Lee H, Ahn EM, Yun JM, Chung YH, Nam YS Tags: J Korean Med Sci Source Type: research

Low Hepatic Toxicity in Primary and Metastatic Liver Cancers after Stereotactic Ablative Radiotherapy Using 3 Fractions.
This study evaluated the incidence of hepatic toxicity after stereotactic ablative radiotherapy (SABR) using 3 fractions to the liver, and identified the predictors for hepatic toxicity. We retrospectively reviewed 78 patients with primary and metastatic liver cancers, who underwent SABR using 3 fractions between 2003 and 2011. To examine the incidence of hepatic toxicity, we defined newly developed hepatic toxicity≥grade 2 according to the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 within 3 months after the end of SABR as a significant adverse event. To identify the predictors for hep...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Bae SH, Kim MS, Jang WI, Cho CK, Yoo HJ, Kim KB, Han CJ, Park SC, Lee DH Tags: J Korean Med Sci Source Type: research

Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma.
Abstract The records of 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed. All patients received nine cycles of induction chemotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT). Follow-up BM examination was performed every three cycles during induction chemotherapy and every three months for one year after the second HDCT/auto-SCT. BM tumor cells persisted in 48.4%, 37.7%, 23.3%, and 20.4% of patients after three, six, and nine cycles of induction chemotherapy and three months after the second HDCT/au...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Choi YB, Bae GE, Lee NH, Kim JS, Lee SH, Yoo KH, Sung KW, Koo HH Tags: J Korean Med Sci Source Type: research

Clinical Significance of Substaging and HER2 Expression in Papillary Nonmuscle Invasive Urothelial Cancers of the Urinary Bladder.
Abstract The study aimed to verify the prognostic utility, therapeutic application and clinical benefits of tumor substaging and HER2 status in papillary non-muscle invasive bladder cancer (NMIBC). Select NMIBC transurethral resection specimens from 141 patients were used to construct tissue microarrays for assessing the substaging, HER2 protein expression by immunohistochemistry (HER2-IHC) and gene amplification by dual-color silver in situ hybridization (HER2-SISH). Substages were identified by the differing depth of tumor invasion (pTa / pT1a / pT1b / pT1c). HER2 protein expression was semiquantitatively analyz...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Lim SD, Cho YM, Choi GS, Park HK, Paick SH, Kim WY, Kim SN, Yoon G Tags: J Korean Med Sci Source Type: research

Prevalence of Atrial Fibrillation and Relation to Echocardiographic Parameters in a Healthy Asymptomatic Rural Korean Population.
This study aimed to determine the prevalence of AF in a population-based sample of adults in a rural region of Korea. Between January 2005 and December 2009, 4,067 individuals (60.2 ± 11.2 yr old, M: F = 1,582:2,485) over 21 who were residents of the county of Yangpyeong, Korea, participated in the study. AF was assessed on a resting 12-lead electrocardiogram (ECG) in 4,053 of the participants. Blood tests and transthoracic echocardiography (TTE) were also performed to investigate the relationship between left ventricular mass and AF in the study group. Fifty-four cases (32 men) were diagnosed as AF among the 4,053 ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Park HC, Park JK, Choi SI, Kim SG, Kim MK, Choi BY, Shin J Tags: J Korean Med Sci Source Type: research

Exuberant Vasculoconnective Component in Mediastinal Mixed Germ Cell Tumors.
Abstract We aimed to evaluate the histologic components of primary mediastinal mixed germ cell tumors. A total of 221 patients diagnosed with a mediastinal germ cell tumor (GCT) were retrospectively reviewed. Among them, 14 patients underwent surgical resection after chemotherapy and 8 patients were diagnosed with mixed GCT, who were then selected for further evaluation. Clinical chart review and histologic review of biopsy and surgical specimens of 8 patients were performed. All 8 patients were young males and showed a mature teratoma or a mature teratoma with a focal immature teratoma in the resected specimens. ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Cha YJ, Han J, Lee KS, Shim YM Tags: J Korean Med Sci Source Type: research

Routine Screening and Consultation Facilitate Improvement of Metabolic Syndrome.
Abstract This randomized controlled trial study aimed to investigate the effects of a lifestyle intervention on metabolic syndrome (MetS) among middle-aged Koreans. A total of 243 middle-aged Koreans with MetS were randomly assigned to either of 2 types of lifestyle intervention for MetS and followed for 12 months. Health examinations and interventions were implemented at 16 regional branch facilities of a Korean medical institution from 2010, following the NCEP-ATP III criteria and recommendations. Lifestyle intervention (LI) group (n = 137) participated in a 12-week multi-component intervention including individ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Yoon NH, Yoo S, Kim H, Han Y Tags: J Korean Med Sci Source Type: research

Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.
Abstract Contribution of genetic predisposition to risk prediction of type 2 diabetes mellitus (T2DM) was investigated using a prospective study in middle-aged adults in Korea. From a community cohort of 6,257 subjects with 8 yr' follow-up, genetic predisposition score with subsets of 3, 18, 36 selected single nucleotide polymorphisms (SNPs) (genetic predisposition score; GPS-3, GPS-18, GPS-36) in association with T2DM were determined, and their effect was evaluated using risk prediction models. Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score inc...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Park HY, Choi HJ, Hong YC Tags: J Korean Med Sci Source Type: research

Lifestyle and Dietary Factors Associated with Serum 25-Hydroxyvitamin D Levels in Korean Young Adults.
This study aimed to investigate potentially modifiable determinants of vitamin D levels in young adults in Korea. This cross-sectional study was based on health check-up data from 3,450 healthy male and female university students aged 18-29 yr in Seoul between April and May 2013. Serum 25-hydroxyvitamin D [25(OH)D] levels were determined using chemiluminescent immunoassay. Anthropometric data were measured, and lifestyle, dietary, and sociodemographic factors were obtained through self-administered questionnaires. General linear regression was used to assess correlates of serum 25(OH)D levels. The mean serum 25(OH)D level ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Joh HK, Lim CS, Cho B Tags: J Korean Med Sci Source Type: research

Clinical Features and Prognosis of Invasive Pulmonary Aspergillosis in Korean Children with Hematologic/Oncologic Diseases.
This study was designed to characterize IPA in Korean children with hematologic/oncologic diseases. Medical records of children with hematologic/oncologic diseases receiving antifungal therapy were reviewed. The enrolled children were divided into the IPA group (proven and probable IPA) and non-IPA group, and the clinical characteristics and prognosis were compared between the two groups. During the study period, 265 courses of antifungal therapy were administered to 166 children. Among them, two (0.8%) episodes of proven IPA, 35 (13.2%) of probable IPA, and 52 (19.6%) of possible IPA were diagnosed. More children in the I...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Han SB, Kim SK, Bae EY, Lee JW, Yoon JS, Chung NG, Cho B, Jeong DC, Kang JH, Kim HK, Lee DG, Lee HS, Im SA Tags: J Korean Med Sci Source Type: research

Differences in Features and Course of Mucosal Type Eosinophilic Gastroenteritis between Korean Infants and Children.
This study aimed to evaluate the characteristics of EGE in infants and children. A total of 22 patients were diagnosed with histologic EGE (hEGE) or possible EGE (pEGE). Serum specific IgE levels, peripheral eosinophil counts, and endoscopic biopsies were carried out. In the hEGE group (n = 13), initial symptoms included hematemesis, abdominal pain, and vomiting. Three of the subjects had normal endoscopic findings. Eight patients were categorized into the infant group and 5 into the child group. All patients in the infant group showed clinical improvement after switching from cow's milk feeding to special formula or breas...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Choi BS, Hong SJ, Park SH, Kim HM, Choe BH Tags: J Korean Med Sci Source Type: research

Establishment of Reference Ranges for Prostate Volume and Annual Prostate Volume Change Rate in Korean Adult Men: Analyses of a Nationwide Screening Population.
Abstract We aimed to determine normal reference ranges for prostate volume (PV) and annual PV change rate in a Korean nationwide screening population. Data from men who underwent a routine health check-up were collected from 13 university hospitals. The cohort comprised men aged ≥40 yr who had undergone 2 or more serial transrectal ultrasonographies. Men with initial PV>100 mL; serum PSA level>10 ng/mL; PV reduction>20% compared with initial PV, or who had history of prostate cancer or prostate surgery, were excluded. Linear regression and mixed effects regression analyses were used to predict mean PV ...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Park J, Lee DG, Suh B, Cho SY, Chang IH, Paick SH, Lee HL Tags: J Korean Med Sci Source Type: research

Survival Outcomes and Predictive Factors for Female Urethral Cancer: Long-term Experience with Korean Patients.
Abstract The aim of this study was to evaluate female urethral cancer (UCa) patients treated and followed-up during a time period spanning more than 20 yr at single institution in Korea. We reviewed medical records of 21 consecutive patients diagnosed with female UCa at our institution between 1991 and 2012. After exclusion of two patients due to undefined histology, we examined clinicopathological variables, as well as survival outcomes of 19 patients with female UCa. A Cox proportional hazards ratio model was used to identify significant predictors of prognosis according to variables. The median age at diagnosis...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kang M, Jeong CW, Kwak C, Kim HH, Ku JH Tags: J Korean Med Sci Source Type: research

Trends in the Use of Chemotherapy before and after Radical Cystectomy in Patients with Muscle-invasive Bladder Cancer in Korea.
Abstract We investigated trends in perioperative chemotherapy use, and determined factors associated with neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC) use in Korean patients with muscle-invasive bladder cancer (MIBC). We recruited 1,324 patients who had MIBC without nodal invasion or metastases and had undergone radical cystectomies (RC) between 2003 and 2013. The study's cut-off time for AC was three months after surgery, and the study's timespan was divided into three periods based on NAC use, namely, 2003-2005, 2006-2009, and 2010-2013. Complete remission was defined as histologically confirmed...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kim SH, Seo HK, Shin HC, Chang SJ, Yun S, Joo J, Ku JH, Kim HS, Jeon HG, Jeong BC, Jeong IG, Kang SH, Hong B, UCART (urothelial cancer-advanced research and treatment group in Korea) group Tags: J Korean Med Sci Source Type: research

Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.
This study aimed to determine the prognostic values of certain apoptosis-associated factors, and examine the role of histone modification on apoptosis in AMs. The medical records of 67 patients with AMs, as diagnosed during recent 13 yr, were reviewed retrospectively. Immunohistochemical staining was performed on archived paraffin-embedded tissues for pro-apoptotic factors (CASP3, IGFBP, TRAIL-R1, BAX, and XAF1), anti-apoptotic factors (survivin, ERK, RAF1, MDM2, and BCL2), and the histone modifying enzymes (MLL2, RIZ, EZH1, NSD2, KDM5c, JMJD2a, UTX, and JMJD5). Twenty-six (38.8%) patients recurred during the follow-up per...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Lee SH, Lee EH, Lee SH, Lee YM, Kim HD, Kim YZ Tags: J Korean Med Sci Source Type: research

The Korean Version of the Pediatric Symptom Checklist: Psychometric Properties in Korean School-aged Children.
Abstract Psychosocial problems increase the risk for mental health problems and increase the need for health care services in children and adolescents. Primary care practice is a valuable avenue for identifying the need for more specialized mental health care. We hypothesized that Korean version of the pediatric symptom checklist (PSC) would be a useful tool for early detection of psychosocial problems in children and adolescents in Korea and we aimed to suggest cut-off scores for detecting meaningful psychosocial problems. A total of 397 children with their parents and 97 child patients with their parents were as...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Han DH, Woo J, Jeong JH, Hwang S, Chung US Tags: J Korean Med Sci Source Type: research

Analysis of Predisposing Factors for Hearing Loss in Adults.
We examined data from 13,369 participants collected between 2009 and 2011. Average hearing thresholds at low (0.5, 1, and 2 kHz) and high frequencies (3, 4, and 6 kHz), were investigated in accordance with various known risk factors via multiple regression analysis featuring complex sampling. We additionally evaluated data from 4,810 participants who completed a questionnaire concerned with different types of noise exposure. Low body mass index, absence of hyperlipidemia, history of diabetes mellitus, low incomes, low educational status, and smoking were associated with elevated low frequency hearing thresholds. In additio...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Lee JS, Choi HG, Jang JH, Sim S, Hong SK, Lee HJ, Park B, Kim HJ Tags: J Korean Med Sci Source Type: research

Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss.
In this study, we demonstrated for the first time that the Dicer mRNA expression level was down-regulated in patients with SSNHL, suggesting its important role in pathobiology of SSNHL development. PMID: 26240498 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kim S, Lee JH, Nam SI Tags: J Korean Med Sci Source Type: research

Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model.
In conclusion, intrathecal nefopam reduced mechanical allodynia in a rat neuropathic pain model. Its mechanical antiallodynic effect is associated with inhibition of glial activation and suppression of the transcription factors' mitogen-activated protein kinases in the spinal cord. PMID: 26240499 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kim KH, Byeon GJ, Kim HY, Baek SH, Shin SW, Koo ST Tags: J Korean Med Sci Source Type: research

Randomized Comparison of Actual and Ideal Body Weight for Size Selection of the Laryngeal Mask Airway Classic in Overweight Patients.
Abstract Size selection of the laryngeal mask airway (LMA) Classic based on actual body weight remains a common practice. However, ideal body weight might allow for a better size selection in obese patients. The purpose of our study was to compare the utility of ideal body weight and actual body weight when choosing the appropriate size of the LMA Classic by a randomized clinical trial. One hundred patients with age 20 to 70 yr, body mass index ≥25 kg/m(2), and the difference between LMA sizes based on actual weight and ideal weight were allocated to insert the LMA Classic using either actual body weight or ide...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kim MS, Lee JS, Nam SB, Kang HJ, Kim JE Tags: J Korean Med Sci Source Type: research

Neonatal Iliopsoas Abscess: The First Korean Case.
We present a case of neonatal IPA that was initially believed to bean inguinal hernia. A 20-day-old male infant was referred to our hospital for herniorrhaphy after a 2-day history of swelling and bluish discoloration of the left inguinal area and leg without limitation of motion. Abdominal and pelvic ultrasonography suggested a femoral hernia, but the anatomy was unclear. Abdominal computed tomography revealed a multi-septated cystic mass extending into the psoas muscle from the lower pole of the left kidney to the femur neck. Broad spectrum antibiotics were initiated, and prompt surgical exploration was planned. After op...
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Han YM, Kim AY, Lim RK, Park KH, Byun SY, Kim SH, Kim HY Tags: J Korean Med Sci Source Type: research

An Appropriate Lower Respiratory Tract Specimen Is Essential for Diagnosis of Middle East Respiratory Syndrome (MERS).
PMID: 26240502 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Lee JH, Lee CS, Lee HB Tags: J Korean Med Sci Source Type: research

Letter to the editor: Knowledge and Attitude of Nursing Personnel towards Depression in General Hospitals: The Korean Perspective.
PMID: 26240503 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2015 Category: Journals (General) Authors: Kosai N, Rajan R, Das S Tags: J Korean Med Sci Source Type: research

Combined Rewarding Mechanisms Can be Implemented to Incentivize the Best Reviewers.
Combined Rewarding Mechanisms Can be Implemented to Incentivize the Best Reviewers. J Korean Med Sci. 2015 Jun;30(6):832-3 Authors: Gasparyan AY, Gerasimov AN, Voronov AA, Kitas GD PMID: 26213737 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2015 Category: Journals (General) Authors: Gasparyan AY, Gerasimov AN, Voronov AA, Kitas GD Tags: J Korean Med Sci Source Type: research

Erratum: Optical Coherence Tomography for the Diagnosis and Evaluation of Human Otitis Media.
Abstract [This corrects the article on p. 328 in vol. 30, PMID: 25729258.]. PMID: 26019479 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 29, 2015 Category: Journals (General) Authors: Cho NH, Lee SH, Jung W, Jang JH, Boppart SA, Kim J Tags: J Korean Med Sci Source Type: research

Stem Cell Therapy for Bronchopulmonary Dysplasia: Bench to Bedside Translation.
Abstract Bronchopulmonary dysplasia (BPD), a chronic lung disease affecting very premature infants, is a major cause of mortality and long-term morbidities despite of current progress in neonatal intensive care medicine. Though there has not been any effective treatment or preventive strategy for BPD, recent stem cell research seems to support the assumption that stem cell therapy could be a promising and novel therapeutic modality for attenuating BPD severity. This review summarizes the recent advances in stem cell research for treating BPD. In particular, we focused on the preclinical data about stem cell transp...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Ahn SY, Chang YS, Park WS Tags: J Korean Med Sci Source Type: research

Perforator Flap versus Conventional Flap.
Abstract The introduction of perforator flaps represented a significant advance in microsurgical reconstruction. However, confusion has developed due to the erroneous belief that perforator flaps are different from conventional flaps. The concept of the perforator is not new, but is an idea that evolved from the conventional flap. In fact, some of the flaps used by microsurgeons were perforator flaps. The only difference is the anatomical level of the blood vessels involved; the perforator concept is focused on the distal circulation, so-called 'perforator'. Therefore, thinner sections of tissue can be taken from ...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim JT, Kim SW Tags: J Korean Med Sci Source Type: research

General internists' perspectives regarding primary care and currently related issues in Korea.
In this study, we conducted a questionnaire survey of general internists to investigate their perspectives regarding primary care, and which included the evaluation of current primary care, perception of the five, key attributes of primary care, and their opinions regarding the management system of chronic diseases. A total of 466 general internists' responses were used in this analysis. The results showed that primary care is considered to have an important role, according to general internists, although their evaluation of the overall status of primary care in Korea indicated that it is poor. The respondents also indicat...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee JY, Eun SJ, Ock M, Kim HJ, Lee HJ, Son WS, Jo MW Tags: J Korean Med Sci Source Type: research

Expression of Peroxisome Proliferator Activated Receptor gamma in Prostatic Adenocarcinoma.
Abstract Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-γ ligands are anti-tumorigenic in prostate cancer due to anti-proliferative and pro-differentiation effects. The aim of this study was to validate PPAR-γ expression in malignant and benign prostate tissues by immunohistochemistry and quantitative real-time polymerase chain reaction (PCR). A total of 730 prostatic adenocarcinomas (PCAs) including 63 whole sectio...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Park HK, Kim H, Kim HG, Cho YM, Jung WY, Han HS, Hwang TS, Kwon GY, Lim SD Tags: J Korean Med Sci Source Type: research

Risks of Lung Cancer due to Radon Exposure among the Regions of Korea.
Abstract Radon is likely the second most common cause of lung cancer after smoking. We estimated the lung cancer risk due to radon using common risk models. Based on national radon survey data, we estimated the population-attributable fraction (PAF) and the number of lung cancer deaths attributable to radon. The exposure-age duration (EAD) and exposure-age concentration (EAC) models were used. The regional average indoor radon concentration was 37.5 95 Bq/m(3). The PAF for lung cancer was 8.3% (European Pooling Study model), 13.5% in males and 20.4% in females by EAD model, and 19.5% in males and 28.2% in females ...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee HA, Lee WK, Lim D, Park SH, Baik SJ, Kong KA, Jung-Choi K, Park H Tags: J Korean Med Sci Source Type: research

Cross-reactivity of Toxocariasis with Crude Antigen of Toxascaris leonina Larvae by ELISA.
In conclusion, there is a partial cross reaction between serum specimens of toxocariasis and TLLA. PMID: 25931784 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Jin Y, Shen C, Huh S, Choi MH, Hong ST Tags: J Korean Med Sci Source Type: research

Infliximab partially alleviates the bite force reduction in a mouse model of temporomandibular joint pain.
In this study, we investigated the effect of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for evaluating the changes in bite force (BF). The mice were randomly divided into three groups (7 mice per group): the control group, the complete Freund's adjuvant (CFA) group, and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the baseline BF, CFA or incomplete Freund's adjuvant was injected into both TMJs and then the changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For measuring the BF, we used a custom-built BF transducer. Control...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim SH, Son CN, Lee HJ, Cho HC, Jung SW, Hur JA, Baek WK, Jung HR, Hong JH Tags: J Korean Med Sci Source Type: research

A Novel Angiotensin Type I Receptor Antagonist, Fimasartan, Prevents Doxorubicin-induced Cardiotoxicity in Rats.
Abstract Angiotensin receptor blockers (ARBs) have organ-protective effects in heart failure and may be also effective in doxorubicin-induced cardiomyopathy (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, fimasartan, in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle (DOX-only group, n=22), 5 mg/kg of fimasartan (Low-fima group, n=22), and 10 mg/kg of fimasartan (High-fima group, n=19). DOX was injected onc...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Chang SA, Lim BK, Lee YJ, Hong MK, Choi JO, Jeon ES Tags: J Korean Med Sci Source Type: research

Role of Soluble ST2 as a Prognostic Marker in Patients with Acute Heart Failure and Renal Insufficiency.
This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in patients hospitalized with acute heart failure (HF) and renal insufficiency. sST2 was measured at admission and discharge in 66 patients hospitalized with acute decompensated HF and renal insufficiency (estimated glomerular filtration rate [eGFR]
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim MS, Jeong TD, Han SB, Min WK, Kim JJ Tags: J Korean Med Sci Source Type: research

The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats.
Abstract Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) placed in the correct place in the lung and research on changes of hemodynamics, pulmonary pathology, immunomodulation and several gene expressions in monocrotaline (MCT)-induced PAH rat models after hUCB-MSCs transfusion. The rats were grouped as follows: the control (C) group; the M group (MCT 60 mg/kg); the U group (hUCB-MSCs transfusion). They receive...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee H, Lee JC, Kwon JH, Kim KC, Cho MS, Yang YS, Oh W, Choi SJ, Seo ES, Lee SJ, Wang TJ, Hong YM Tags: J Korean Med Sci Source Type: research

Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
Abstract The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 ...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim WJ, Kim SS, Lee HC, Song SH, Bae MJ, Yi YS, Jeon YK, Kim BH, Kim YK, Kim IJ Tags: J Korean Med Sci Source Type: research

Radiological findings and outcomes of bronchial artery embolization in cryptogenic hemoptysis.
This study aimed to investigate the radiologic findings and bronchial artery embolization outcomes in cryptogenic hemoptysis, and to compare the results with non-cryptogenic hemoptysis. We evaluated 26 patients with cryptogenic hemoptysis and 152 patients with non-cryptogenic hemoptysis. A comparison of the bronchial artery abnormalities between the cryptogenic and non-cryptogenic hemoptysis groups showed that only extravasation was more statistically significant in the cryptogenic hemoptysis group than in the non-cryptogenic hemoptysis group, while the other bronchial artery abnormalities, such as bronchial artery dilatat...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kervancioglu S, Bayram N, Gelebek Yilmaz F, Sanli M, Sirikci A Tags: J Korean Med Sci Source Type: research

Clinical characteristics and prognostic impact of bacterial infection in hospitalized patients with alcoholic liver disease.
Abstract Bacterial infection is an important cause of death in patients with liver cirrhosis. The aim of this study was to investigate the clinical characteristics and prognostic impact of bacterial infection in hospitalized patients with alcoholic liver disease (ALD). We retrospectively analyzed data from 409 patients consecutively admitted to a tertiary referral center with ALD diagnosis. Of a total of 544 admissions, 133 (24.4%) cases presented with bacterial infection, of which 116 were community-acquired whereas 17 were hospital-acquired. The common types of infection were pneumonia (38%), biliary tract infec...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Park JK, Lee CH, Kim IH, Kim SM, Jang JW, Kim SH, Kim SW, Lee SO, Lee ST, Kim DG Tags: J Korean Med Sci Source Type: research

Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Acute Cholecystitis.
Abstract Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play crucial roles in a variety of diseases, including autoimmunity, infectious diseases, and cancers. However, little is known about the roles of these invariant T cells in acute cholecystitis. The purposes of this study were to examine the levels of MAIT cells and NKT cells in patients with acute cholecystitis and to investigate potential relationships between clinical parameters and these cell levels. Thirty patients with pathologically proven acute cholecystitis and 47 age- and sex-matched healthy controls were e...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim JC, Jin HM, Cho YN, Kwon YS, Kee SJ, Park YW Tags: J Korean Med Sci Source Type: research

The Immunogenicity and Safety of the Live-attenuated SA 14-14-2 Japanese Encephalitis Vaccine Given with a Two-dose Primary Schedule in Children.
Abstract Effective and tolerable vaccination is an essential strategy to prevent Japanese encephalitis (JE) in endemic areas. Although the live attenuated SA 14-14-2 JE vaccine (LAJEV) has been widely used since its introduction, the systemic data of LAJEV was very rarely available in Korea. We conducted the open-label, prospective cohort study to assess the immunogenicity and safety of this vaccine. Ninety subjects were enrolled, and LAJEV in a 2-dose primary series was given with a 12-month interval. Neutralizing antibody titers were measured before and after each vaccination, and active monitoring for adverse e...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kwon HJ, Lee SY, Kim KH, Kim DS, Cha SH, Jo DS, Kang JH Tags: J Korean Med Sci Source Type: research

Prevalence of antibiotic use for pediatric acute upper respiratory tract infections in Korea.
This study was conducted to estimate the prevalence of antimicrobial prescribing for acute upper respiratory tract infections (URI) among pediatric outpatients and to identify the national patterns of its use from 2009 to 2011 in Korea. Using National Patients Sample database from 2009 to 2011, we estimated the frequency of antibiotics prescribing for URI in pediatric outpatients with diagnoses of acute nasopharyngitis (common cold), acute sinusitis, acute pharyngitis, acute tonsillitis, acute laryngitis/tracheitis, acute obstructive laryngitis/epiglottitis, and acute upper respiratory infections of multiple and unspecifie...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Shin SM, Shin JY, Kim MH, Lee SH, Choi S, Park BJ Tags: J Korean Med Sci Source Type: research

Functional magnetic resonance imaging of motor cortex activation in schizophrenia.
This study can serve as a baseline measurement of schizophrenic dysfunction in other cognitive processes. PMID: 25931795 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee HJ, Preda A, Ford JM, Mathalon DH, Keator DB, van Erp TG, Turner JA, Potkin SG Tags: J Korean Med Sci Source Type: research

A korean survey on qualities and definition of a good psychiatrist.
Abstract The definition of a "good" psychiatrist has varied over the past decades due to changing roles of psychiatrists. Studies on the qualities of "good" psychiatrists have been completed in many countries. However, no such study has been undertaken in Korea. In Korea, recent growing interest in psychiatry demands the identification of qualities for a good psychiatrist. The purpose of this study was to define the qualities of a good psychiatrist in Korea, subsequently facilitating the improvement of psychiatric training programs. The questionnaire was based on a Singaporean survey with the p...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Kim JH, Tor PC, King J, Seo JS Tags: J Korean Med Sci Source Type: research

Increasing Prevalence of Trichophyton rubrum Identified through an Analysis of 115,846 Cases over the Last 37 Years.
Abstract Trichophyton rubrum is the most common dermatophyte in the world with the highest prevalence in Korea. There are few reports about epidemiological and mycological characteristics of T. rubrum based on long-term, large-scale studies. The purpose of this study was to investigate the clinical and epidemiological characteristics of T. rubrum infections in Korea. We retrospectively investigated with patients' records about the epidemiological and mycological status of 115,846 cases with T. rubrum infection that was mycologically diagnosed at Catholic Skin Disease Clinic from 1979 to 2013. Direct microscopy in ...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee WJ, Kim SL, Jang YH, Lee SJ, Kim do W, Bang YJ, Jun JB Tags: J Korean Med Sci Source Type: research

Inpatient stroke rehabilitation outcomes in Korea derived from the korean brain rehabilitation centers' online database system for the years 2007 to 2011.
This report shows that LOS and transfer time after onset has been decreased over time and initial functional status and shorter transfer after onset are predictors of better functional outcome at discharge. PMID: 25931798 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Joa KL, Han TR, Pyun SB, Rah UW, Park JH, Kim YH, Chun MH, Paik NJ, Yoo SD, Lee SG, Park SW, Im SH, Jung HY Tags: J Korean Med Sci Source Type: research

Effects of ยต-Opioid Receptor Gene Polymorphism on Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia with Remifentanil: Double Blinded Randomized Trial.
Effects of µ-Opioid Receptor Gene Polymorphism on Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia with Remifentanil: Double Blinded Randomized Trial. J Korean Med Sci. 2015 May;30(5):651-7 Authors: Lee SH, Kim JD, Park SA, Oh CS, Kim SH Abstract Association between postoperative nausea and vomiting (PONV) and µ-opioid receptor A118G single nucleotide polymorphism (SNP) is undefined and might underlie inconsistent results of studies on PONV occurrence in patients undergoing general anesthesia with the opioid, remifentanil. Four hundred and sixteen Korean women un...
Source: J Korean Med Sci - May 1, 2015 Category: Journals (General) Authors: Lee SH, Kim JD, Park SA, Oh CS, Kim SH Tags: J Korean Med Sci Source Type: research