Bed sharing deaths in infancy - sids or asphyxia?
PMID: 24015053 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2013 Category: Journals (General) Authors: Byard RW Tags: J Korean Med Sci Source Type: research

Resolution of UTIs Post Deflux Injections for VUR May Be due to the Cure of BBD.
PMID: 24015054 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2013 Category: Journals (General) Authors: de Jesus LE Tags: J Korean Med Sci Source Type: research

Erratum: Correction of Figure. Sarcopenia and Obesity: Gender-Different Relationship with Functional Limitation in Older Persons.
Abstract [This corrects the article on p. 1041 in vol. 28, PMID: 23853487.]. PMID: 24015055 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2013 Category: Journals (General) Authors: Kim JH, Choi SH, Lim S, Yoon JW, Kang SM, Kim KW, Lim JY, Cho NH, Jang HC Tags: J Korean Med Sci Source Type: research

Choosing the target journal: do authors need a comprehensive approach?
PMID: 23960434 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Gasparyan AY Tags: J Korean Med Sci Source Type: research

Global trends in medical journal publishing.
PMID: 23960435 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Chi Y Tags: J Korean Med Sci Source Type: research

Associations between Cigarette Smoking and Total Mortality Differ Depending on Serum Concentrations of Persistent Organic Pollutants among the Elderly.
Abstract There are substantial variations of relative risks (RR) in smoking-related mortality by country and time. We hypothesized the RRs in smoking-related mortality might differ depending on serum concentrations of persistent organic pollutants (POPs). We evaluated the associations of cigarette smoking with total mortality in 610 elderly (aged ≥ 70 yr) (702 elderly for organochlorine pesticides [OCPs]) after stratification by serum concentration of POPs, in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 followed through 2006. Summary measures of POPs subclasses showed significant or ...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee YM, Bae SG, Lee SH, Jacobs DR, Lee DH Tags: J Korean Med Sci Source Type: research

Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups.
Abstract Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution of DPYD, we directly sequenced 288 subjects from five ethnic groups (96 Koreans, 48 Japanese, 48 Han Chinese, 48 African Americans, and 48 European Americans). As a result, 56 polymorphisms were observed, including 6 core polymorphisms and 18 novel polymorphisms. Allele frequencies were nearly the same across the Asian populations, Korean, Han Chinese and Japanese, where...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Shin JG, Cheong HS, Kim JY, Kim LH, Han CS, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD Tags: J Korean Med Sci Source Type: research

Tofacitinib prevents radiographic progression in rheumatoid arthritis.
Abstract Tofacitinib, a novel Janus kinase inhibitor, may prevent structural damage in rheumatoid arthritis (RA). In this cohort study, we compared radiographic progression of hand joints between 21 RA patients who took tofacitinb for 18 months in a phase IIb and its extension study and 42 patients who took conventional disease modifying antirheumatic drugs (DMARDs), using simple erosion narrowing score. For tofacitinib group, changes before and after the treatment were also compared. The changes of erosion and sum scores were significantly less in tofacitinib than DMARDs group (for erosion, -0.60 ± 1.83 vs...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kim JW, Choi IA, Lee EY, Song YW, Lee EB Tags: J Korean Med Sci Source Type: research

The effects of antihypertensive drugs on bone mineral density in ovariectomized mice.
Abstract The effects of several antihypertensive drugs on bone mineral density (BMD) and micro-architectural changes in ovariectomized (OVX) mice were investigated. Eight-week-old female C57/BL6 mice were used for this study. Three days after ovariectomy, mice were treated intraperitoneally with nifedipine (15 mg/kg), telmisartan (5 mg/kg), enalapril (20 mg/kg), propranolol (1 mg/kg) or hydrochlorothiazide (12.5 mg/kg) for 35 consecutive days. Uterine atrophy of all mice was confirmed to evaluate estrogen deficiency state. BMD and micro-architectural analyses were performed on tibial proximal ends by micro-compute...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kang KY, Kang Y, Kim M, Kim Y, Yi H, Kim J, Jung HR, Park SH, Kim HY, Ju JH, Hong YS Tags: J Korean Med Sci Source Type: research

Serum Level of Interleukin-33 and Soluble ST2 and Their Association with Disease Activity in Patients with Behcet's Disease.
Abstract Interleukin (IL)-33 is an important mediator of innate immunity. Behcet's disease (BD) is an autoinflammatory disorder characterized by hyperactivity of the innate immune response. We measured serum levels of IL-33 and its receptor soluble ST2 (sST2) in patients with BD to investigate their association with disease activity. Serum levels of both IL-33 and sST2 were higher in patients with BD compared with those in normal controls (IL-33: 594.48±175.04 pg/mL in BD and 224.23±56.64 pg/mL in normal controls [P=0.048], sST2: 99.01±15.92 pg/mL in BD and 23.56±3.25 pg/mL in normal controls [P
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kim DJ, Baek SY, Park MK, Park KS, Lee JH, Park SH, Kim HY, Kwok SK Tags: J Korean Med Sci Source Type: research

15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Abstract 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa as a biomarker for predicting colorectal neoplasms. We obtained paired tumor and normal tissues from the surgical specimens of 32 sporadic colorectal cancer patients. mRNA expression of 15-PGDH was measured using a quantitative real-time PCR assay. We evaluated the association between 15-PGDH mRNA expression in normal-appearing mucosa, the presence of synchronous adenoma, an...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee HJ, Yang DH, Ryu YM, Song M, Song HJ, Jung KW, Kim KJ, Ye BD, Byeon JS, Choi EK, Yang SK, Kim JH, Myung SJ Tags: J Korean Med Sci Source Type: research

An integrative model of the cardiovascular system coupling heart cellular mechanics with arterial network hemodynamics.
Abstract The current study proposes a model of the cardiovascular system that couples heart cell mechanics with arterial hemodynamics to examine the physiological role of arterial blood pressure (BP) in left ventricular hypertrophy (LVH). We developed a comprehensive multiphysics and multiscale cardiovascular model of the cardiovascular system that simulates physiological events, from membrane excitation and the contraction of a cardiac cell to heart mechanics and arterial blood hemodynamics. Using this model, we delineated the relationship between arterial BP or pulse wave velocity and LVH. Computed results were ...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kim YT, Lee JS, Youn CH, Choi JS, Shim EB Tags: J Korean Med Sci Source Type: research

Evaluation of cardiovascular anomalies in patients with asymptomatic turner syndrome using multidetector computed tomography.
This study found cardiovascular abnormalities in 65% of asymptomatic Turner syndrome patients using MDCT. Even though, there are no cardiac symptoms in Turner syndrome patients, a complete evaluation of the heart with echocardiography or MDCT at transition period to adults must be performed. PMID: 23960443 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee SH, Jung JM, Song MS, Choi SJ, Chung WY Tags: J Korean Med Sci Source Type: research

Risk Factors between Patients with Lone and Non-Lone Atrial Fibrillation.
Abstract Clinical factors such as tall stature, lean body mass, obstructive sleep apnea, alcohol or caffeine, smoking, endurance sports, and genetic factors are proposed as risk factors for lone atrial fibrillation (LAF). The KORAF (KORean Atrial Fibrillation) study is a retrospective multicenter registry that enrolled 3,570 consecutive atrial fibrillation (AF) patients. Data on risk factors were available for 2,133 patients, of whom 398 (18.7%) were identified as having LAF. In univariate analysis, patients with LAF were more likely to be men (82.4% vs 59.8%, P
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee SH, Park SJ, Byeon K, On YK, Kim JS, Shin DG, Cho JG, Kim YN, Kim YH, KORAF Investigators Tags: J Korean Med Sci Source Type: research

Urinary biomarkers for early detection of recovery in patients with acute kidney injury.
Abstract Urinary biomarkers of acute kidney injury (AKI) have been revealed recently to be useful for prior prediction of AKI. However, it is unclear whether these urinary biomarkers can also detect recovery from established AKI. Urinary biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C, were measured every 2 days for 8 days in 66 patients with AKI. At day 0, there were no significant differences in plasma creatinine, BUN, and urine cystatin C between AKI patients in the recovery (n = 33) and non-recovery (n = 33) groups. Plasma creatinine concentrations were significantly lowe...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Moon SJ, Park HB, Yoon SY, Lee SC Tags: J Korean Med Sci Source Type: research

Higher Prevalence of Klebsiella pneumoniae Extended-Spectrum β-Lactamase in Patients on Renal Replacement Therapy.
In conclusion, RRT can be a risk factor for KP(+) in patients with pneumonia. PMID: 23960446 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee HL, Whang DH, Park DW, Lee YJ, Kim YH, Chin HJ, Kim S, Koo HS Tags: J Korean Med Sci Source Type: research

Incidence, etiology, and outcomes of rhabdomyolysis in a single tertiary referral center.
Abstract We have encountered numerous cases of rhabdomyolysis associated with acute pesticide intoxication; however, the cause, incidence, and treatment outcomes of rhabdomyolysis have not been studied. The current study involved 2,125 patients hospitalized with acute chemical poisoning. Based on clinical and laboratory parameters and treatment outcomes, we found that overall incidence of rhabdomyolysis in our hospital was 0.06% (93 of 143,830 patients admitted), but the incidence associated with acute pesticide intoxication was 1.8% (33 of 1,793 cases). The incidence of rhabdomyolysis after pesticide intoxication...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Park JS, Seo MS, Gil HW, Yang JO, Lee EY, Hong SY Tags: J Korean Med Sci Source Type: research

Systematic review and meta-analysis of pulmonary hypertension specific therapy for exercise capacity in chronic obstructive pulmonary disease.
Abstract Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an effect for stable COPD. Data sources were Medline, EMBASE, Cochrane Central Register of Controlled Trials, Korea med and references from relevant publications. Randomized prospective trials that compared PH specific therapy in COPD for more than 6 weeks with placebo were included. The outcomes were the exercise capacity and adverse events. Four randomized controlled trials involvi...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Park J, Song JH, Park DA, Lee JS, Lee SD, Oh YM Tags: J Korean Med Sci Source Type: research

The Model for End-Stage Liver Disease Score-Based System Predicts Short Term Mortality Better Than the Current Child-Turcotte-Pugh Score-Based Allocation System during Waiting for Deceased Liver Transplantation.
In conclusion, MELD score-based system can predict short term mortality better and select more number of high risk patients in Korean population. PMID: 23960449 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Hong G, Lee KW, Suh S, Yoo T, Kim H, Park MS, Choi Y, Yi NJ, Suh KS Tags: J Korean Med Sci Source Type: research

The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in korean.
In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR. PMID: 23960450 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kim JS, Ahn SM, Jung YK, Kwon OS, Kim YS, Choi DJ, Kim JH Tags: J Korean Med Sci Source Type: research

Optimal duration of medical treatment in superior mesenteric artery syndrome in children.
Abstract The aim of this study was to investigate the outcome, and optimal duration of medical treatment in children with superior mesenteric artery syndrome (SMAS). Eighteen children with SMAS were retrospectively studied. The data reviewed included demographics, presenting symptoms, co-morbid conditions, clinical courses, nutritional status, treatments, and outcomes. The three most common symptoms were postprandial discomfort (67.7%), abdominal pain (61.1%), and early satiety (50%). The median duration of symptoms before diagnosis was 68 days. The most common co-morbid condition was weight loss (50%), followed b...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Shin MS, Kim JY Tags: J Korean Med Sci Source Type: research

Intra-amniotic infection/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor.
Abstract The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI) was associated with subsequent ruptured membranes in women with preterm labor and intact membranes who had a clinically indicated amniocentesis. This retrospective cohort study included 237 consecutive women with preterm labor (20-34.6 weeks) who underwent amniocentesis. The clinical and laboratory parameters evaluated included demographic variables, gestational age, C-reactive protein (CRP) and amniotic fluid (AF) white blood cell, interleukin-6 (IL-6) and culture results. IAI was defined as a positive AF culture a...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Lee SY, Park KH, Jeong EH, Oh KJ, Ryu A, Kim A Tags: J Korean Med Sci Source Type: research

Interfractional variation of radiation target and adaptive radiotherapy for totally resected glioblastoma.
This study aimed to evaluate the effects of volume adapted re-planning for radiotherapy (RT) after gross total resection (GTR) for glioblastoma. Nineteen patients with glioblastoma who underwent GTR and postoperative RT were analyzed. The volumes of the surgical cavity on computed tomography (CT) obtained one day after GTR (CT0), the first RT simulation CT (sim-CT1), and the second simulation CT for the boost RT plan (sim-CT2) were compared. The boost RT plan was based on the surgical cavity observed on the sim-CT2 (boost RTP2) and was compared with that based on the surgical cavity observed on the sim-CT1 (boost RTP1). Th...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kim TG, Lim do H Tags: J Korean Med Sci Source Type: research

Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats.
In this study, we investigated the effect of the intrathecal amiloride and benzamil in neuropathic pain model, and also examined the role of ASICs on modulation of neuropathic pain. Neuropathic pain was induced by L4-5 spinal nerve ligation in male Sprague-Dawley rats weighing 100-120 g, and intrathecal catheterization was performed for drug administration. The effects of amiloride and benzamil were measured by the paw-withdrawal threshold to a mechanical stimulus using the up and down method. The expression of ASICs in the spinal cord dorsal horn was also analyzed by RT-PCR. Intrathecal amiloride and benzamil significantl...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Jeong S, Lee SH, Kim YO, Yoon MH Tags: J Korean Med Sci Source Type: research

Effectiveness of mechanical embolectomy for septic embolus in the cerebral artery complicated with infective endocarditis.
This report shows that the early retrieve of septic cerebral emboli can be a helpful treatment of acute stroke associated with endocarditis. PMID: 23960455 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Kang G, Yang TK, Choi JH, Heo ST Tags: J Korean Med Sci Source Type: research

Imatinib plasma monitoring-guided dose modification for managing imatinib-related toxicities in gastrointestinal stromal tumor patients.
We present two cases of advanced GIST patients in whom we managed imatinib-related toxicities through dose modifications guided by imatinib plasma level monitoring. Imatinib blood level testing may be a promising approach for fine-tuning imatinib dosage for better tolerability and optimal clinical outcomes in patients with advanced GIST. PMID: 23960456 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Yoon S, Ryu MH, Yoo C, Beck MY, Ryoo BY, Kang YK Tags: J Korean Med Sci Source Type: research

Intramedullary spinal cord metastasis in renal cell carcinoma: a case report of the surgical experience.
We report the first published Korean case of ISCM from RCC confirmed pathologically and describe our surgical experience and his clinical characteristics. PMID: 23960457 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Park J, Chung SW, Kim KT, Cho DC, Hwang JH, Sung JK, Lee D Tags: J Korean Med Sci Source Type: research

Therapeutic hypothermia following emergent coronary artery bypass grafting after failed percutaneous coronary intervention in a comatose post-cardiac arrest patient.
We report the case of 60-yr-old female in which therapeutic hypothermia (TH) was successfully induced maintaining the target temperature of 34℃ for 12 hr despite a risk of hypothermia-induced coagulation abnormalities following an emergent coronary artery bypass grafting (CABG) due to failed percutaneous coronary intervention, who suffered a cardiac arrest. Emergent CABG may be a relative contraindication for TH in post-cardiac arrest patients because hypothermia may increase the risk of infection and bleeding. However, the possibility of an improved neurologic outcome outweighs the risk of bleeding, although major surge...
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Choi SP, Wee JH, Park JH, Park KN, Hong SJ, Lee SH Tags: J Korean Med Sci Source Type: research

Erratum: Addition of a Co-Author.
Abstract [This corrects the article on p. 983 in vol. 28, PMID: 23853479.]. PMID: 23960459 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2013 Category: Journals (General) Authors: Moon S, Kwak W, Lee S, Kim W, Oh J, Youn SK Tags: J Korean Med Sci Source Type: research

Over the journal impact factor.
PMID: 23853473 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Hong ST Tags: J Korean Med Sci Source Type: research

Peer Review in Scholarly Biomedical Journals: a Few Things that Make a Big Difference.
PMID: 23853474 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Gasparyan AY Tags: J Korean Med Sci Source Type: research

Selecting your editorial board: maintaining standards.
PMID: 23853475 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Gasparyan AY Tags: J Korean Med Sci Source Type: research

Recent Increase in Autism and ADHD: True or Inflated?
PMID: 23853476 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Yoo HJ Tags: J Korean Med Sci Source Type: research

Osteoporotic hip fracture in the elderly patients: physicians' views.
PMID: 23853477 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Lee YK, Koo KH Tags: J Korean Med Sci Source Type: research

Current levels of conflict of interest disclosure in medical publications from Korea.
Abstract Medical research should be fully transparent. The aims of this study were to determine the prevalence of author-related conflict of interest (COI) policies and evaluate the actual state of COI disclosure in Korean medical journals. To determine the prevalence of author-related COI policies, we examined the 198 medical journals listed in the KoreaMed database. To investigate the actual state of COI disclosures in published papers, we analyzed the publications in a representative medical journal, the Journal of the Korean Medical Science, from the perspective of the relevance of the ethics of COI disclosure...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Kang BH, Moon JY, Chang Y, Koo YM, Koh Y Tags: J Korean Med Sci Source Type: research

Epidemiological characteristics of the first water-borne outbreak of cryptosporidiosis in seoul, Korea.
In conclusion, Cryptosporidium parvum was the key causal pathogen of this outbreak. It is presumed that the tap water was contaminated by a sewage leak from the aged pipelines. PMID: 23853479 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Moon S, Kwak W, Lee S, Kim W, Oh J, Youn SK Tags: J Korean Med Sci Source Type: research

Causes of Death and Risk Factors for Mortality among HIV-Infected Patients Receiving Antiretroviral Therapy in Korea.
Abstract A retrospective study was conducted to determine the mortality, causes and risk factors for death among HIV-infected patients receiving antiretroviral therapy (ART) in Korea. The outcomes were determined by time periods, during the first year of ART and during 1-5 yr after ART initiation, respectively. Patients lost to follow-up were traced to ascertain survival status. Among 327 patients initiating ART during 1998-2006, 68 patients (20.8%) died during 5-yr follow-up periods. Mortality rate per 100 person-years was 8.69 (95% confidence interval, 5.68-12.73) during the first year of ART, which was higher t...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Lee SH, Kim KH, Lee SG, Cho H, Chen DH, Chung JS, Kwak IS, Cho GJ Tags: J Korean Med Sci Source Type: research

Clinical and Molecular Epidemiology of Community-Onset Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli over a 6-Year Period.
Clinical and Molecular Epidemiology of Community-Onset Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli over a 6-Year Period. J Korean Med Sci. 2013 Jul;28(7):998-1004 Authors: Kang CI, Cha MK, Kim SH, Ko KS, Wi YM, Chung DR, Peck KR, Lee NY, Song JH Abstract Although extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) has emerged as a significant community-acquired pathogen, there is little epidemiological information regarding community-onset bacteremia due to ESBL-EC. A retrospective observational study from 2006 through 2011 was performed to evaluat...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Kang CI, Cha MK, Kim SH, Ko KS, Wi YM, Chung DR, Peck KR, Lee NY, Song JH Tags: J Korean Med Sci Source Type: research

Transglutaminase 2 expression predicts progression free survival in non-small cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitor.
Abstract Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-κB). We investigated the association of non-small cell lung cancer (NSCLC) treatment efficacy with TG2 and NF-κB expression in 120 patients: 102 with adenocarcinoma and 18 with other histologic types. All patients underwent surgery; 88 received adjuvant chemotherapy, with 28 receiving platinum-based doublet chemotherapy as first-line treatment and 29 receiving epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy. Patients' ...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Jeong JH, Cho BC, Shim HS, Kim HR, Lim SM, Kim SK, Chung KY, Islam SM, Song JJ, Kim SY, Kim JH Tags: J Korean Med Sci Source Type: research

Changes in body composition predict homocysteine changes and hyperhomocysteinemia in Korea.
Abstract Cardiovascular disease (CVD) is the primary cause of death in Korea. Hyperhomocysteinemia confers an independent risk for CVD comparable to the risk of smoking and hyperlipidemia. The purpose of this study was to assess the effect of cardiovascular risk factors and body composition change on homocysteine (Hcy) levels in Korean men and women. The association between body composition and Hcy levels was investigated in a 2-yr prospective cohort study of 2,590 Koreans (mean age 45.5±9.6 yr). There were 293 cases of hyperhomocysteinemia (>14 µM/L) at follow-up. Increases in total body fat propo...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Park SB, Georgiades A Tags: J Korean Med Sci Source Type: research

Genetic mutation in korean patients of sudden cardiac arrest as a surrogating marker of idiopathic ventricular arrhythmia.
This study aimed to find mutations in cardiac ion channel genes of Korean sudden cardiac arrest patients with structurally normal heart and to verify association between common genetic variation in cardiac ion channel and sudden cardiac arrest by idiopathic ventricular tachyarrhythmia in Koreans. Study participants were Korean survivors of sudden cardiac arrest caused by idiopathic ventricular tachycardia or fibrillation. All coding exons of the SCN5A, KCNQ1, and KCNH2 genes were analyzed by Sanger sequencing. Fifteen survivors of sudden cardiac arrest were included. Three male patients had mutations in SCN5A gene and none...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Son MK, Ki CS, Park SJ, Huh J, Kim JS, On YK Tags: J Korean Med Sci Source Type: research

Percutaneous coronary intervention for acute myocardial infarction in elderly patients with renal dysfunction: results from the Korea acute myocardial infarction registry.
This study aimed to evaluate the effects of percutaneous coronary intervention (PCI) on short- and long-term major adverse cardiac events (MACE) in elderly (>75 yr old) acute myocardial infarction (AMI) patients with renal dysfunction. As part of Korea AMI Registry (KAMIR), elderly patients with AMI and renal dysfunction (GFR
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Lim SY, Bae EH, Choi JS, Kim CS, Ma SK, Ahn Y, Jeong MH, Kim W, Woo JS, Kim YJ, Cho MC, Kim CJ, Kim SW, Korea Acute Myocardial Infarction Registry Investigators Tags: J Korean Med Sci Source Type: research

Small increases in plasma sodium are associated with higher risk of mortality in a healthy population.
Abstract Elevated blood pressure (BP) is the most common cause of cardiovascular disease. Salt intake has a strong influence on BP, and plasma sodium (pNa) is increased with progressive increases in salt intake. However, the associations with pNa and BP had been reported inconsistently. We evaluated the association between pNa and BP, and estimated the risks of all-cause-mortality according to pNa levels. On the basis of data collected from health checkups during 1995-2009, 97,009 adult subjects were included. Positive correlations between pNa and systolic BP, diastolic BP, and pulse pressure (PP) were noted in pa...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Oh SW, Baek SH, An JN, Goo HS, Kim S, Na KY, Chae DW, Kim S, Chin HJ Tags: J Korean Med Sci Source Type: research

Sarcopenia and obesity: gender-different relationship with functional limitation in older persons.
Abstract Age-related body composition changes such as sarcopenia and obesity affect functional decline in the elderly. We investigated the relationship between body composition parameters and functional limitation in older Korean adults. We enrolled 242 men and 231 women aged ≥ 65 yr from the Korean elderly cohort. We used appendicular skeletal muscle mass (ASM) divided by height(2) (ASM/Ht(2)) and ASM divided by weight (ASM/Wt). The isokinetic strength of knee extensor muscles were measured using an isokinetic device. Functional limitations were assessed using the Short Physical Performance Battery (SPPB) scor...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Kim JH, Choi SH, Lim S, Yoon JW, Kang SM, Kim KW, Lim JY, Cho NH, Jang HC Tags: J Korean Med Sci Source Type: research

Chronic obstructive pulmonary disease assessment test can predict depression: a prospective multi-center study.
This study was conducted to investigate the association between the chronic obstructive pulmonary disease (COPD) assessment test (CAT) and depression in COPD patients. The Korean versions of the CAT and patient health questionnaire-9 (PHQ-9) were used to assess COPD symptoms and depressive disorder, respectively. In total, 803 patients with COPD were enrolled from 32 hospitals and the prevalence of depression was 23.8%. The CAT score correlated well with the PHQ-9 score (r=0.631; P
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Lee YS, Park S, Oh YM, Lee SD, Park SW, Kim YS, In KH, Jung BH, Lee KH, Ra SW, Hwang YI, Park YB, Jung KS, Korean COPD Study Group Tags: J Korean Med Sci Source Type: research

Avoidable causes of delayed enteral nutrition in critically ill children.
Abstract To evaluate the incidence of delayed enteral nutrition (EN) and identify avoidable causes of delay, we retrospectively reviewed medical records of 200 children (median age [range]; 37.5 [1-216] months) who stayed in the intensive care unit (ICU) for a minimum of 3 days. Among 200 children, 115 received EN following ICU admission with a median time of EN initiation of 5 days after admission. Of these, only 22 patients achieved the estimated energy requirement. A significant decrease in the final z score of weight for age from the initial assessment was observed in the non-EN group only (-1.3±2.17 to...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Lee H, Koh SO, Kim H, Sohn MH, Kim KE, Kim KW Tags: J Korean Med Sci Source Type: research

Clinical value of persistent but downgraded vesicoureteral reflux after dextranomer/hyaluronic Acid injection in children.
Abstract We aimed to investigate the clinical value of persistent but downgraded vesicoureteral reflux (VUR) after dextranomer/hyaluronic acid (Dx/HA) injection in children. The medical records of 128 children (195 ureters) who underwent Dx/HA injections for VUR were reviewed. The incidences of pre- and post-operative febrile urinary tract infections (UTIs) were analyzed in children with or without persistent VUR on voiding cystourethrography (VCUG) 3 months postoperatively. The surgical results of VUR persistent children who underwent a single additional injection were assessed. The VUR resolved completely in 100...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Baek M, Kang MY, Lee HE, Park K, Choi H Tags: J Korean Med Sci Source Type: research

A nationwide epidemiological study of nocturnal enuresis in korean adolescents and adults: population based cross sectional study.
Abstract We performed a nationwide epidemiological study to evaluate the prevalence and characteristics of nocturnal enuresis (NE) in Korean adolescents and adults. A questionnaire was sent via e-mail to 51,073 people aged 16-40 yr by stratified sampling according to age, sex, and region among a 200,000 internet survey panel pool. The questionnaire included following information; presence or absence of NE, frequency of NE, possible risk factors for NE, self-esteem scale score and depression score results, and measures for the treatment of NE. Among the 2,117 responders, 54 (2.6%) had NE (≥1 enuretic episode wit...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Baek M, Park K, Lee HE, Kang JH, Suh HJ, Kim JH, Lee SD, Pai KS, Han SW, Park YH, Kim KD, Korean Children's Continence and Enuresis Society Tags: J Korean Med Sci Source Type: research

Quantitative in Vivo Detection of Brain Cell Death after Hypoxia Ischemia Using the Lipid Peak at 1.3 ppm of Proton Magnetic Resonance Spectroscopy in Neonatal Rats.
This study was performed to determine the accuracy of proton magnetic spectroscopy ((1)H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old Sprague Dawley rats were subjected to 8% oxygen following a unilateral carotid artery ligation. For treatment, cycloheximide was given immediately after hypoxic ischemia (HI). Lipid peak was measured using (1)H-MRS at 24 hr after HI, and then brains were harvested for fluorocytometric analyses with annexin V/propidium iodide (PI) and fluorescent probe JC-1, and for adenosine-5'-triphosphate (ATP) and lactate. Increased lipid peak...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Ahn SY, Yoo HS, Lee JH, Sung DK, Jung YJ, Sung SI, Lim KH, Chang YS, Lee JH, Kim KS, Park WS Tags: J Korean Med Sci Source Type: research

Print media coverage of post-traumatic stress disorder: content analysis of three major korean newspapers.
Abstract The print media is still one of major sources for health-related information. To shed light on how the media accurately delivers information for post-traumatic stress disorder (PTSD), we searched the newspaper articles and analyzed their contents for accuracy in the description of symptoms, causes, and treatment of PTSD. The articles featuring PSTD were searched from the very first available to 2010 at on-line search systems of three major Korean newspapers. A total of 123 articles appeared and the first article appeared in 1984. The number of articles steadily increased till the early 2000s but we found ...
Source: J Korean Med Sci - July 1, 2013 Category: Journals (General) Authors: Jeong Y, Kim D, Oh HY, Park YC Tags: J Korean Med Sci Source Type: research