Neuropathic Pain Model of Peripheral Neuropathies Mediated by Mutations of Glycyl-tRNA Synthetase.
Abstract Charcot-Marie-Tooth disease (CMT) is the most common inherited motor and sensory neuropathy. Previous studies have found that, according to CMT patients, neuropathic pain is an occasional symptom of CMT. However, neuropathic pain is not considered to be a significant symptom associated with CMT and, as a result, no studies have investigated the pathophysiology underlying neuropathic pain in this disorder. Thus, the first animal model of neuropathic pain was developed by our laboratory using an adenovirus vector system to study neuropathic pain in CMT. To this end, glycyl-tRNA synthetase (GARS) fusion prot...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Lee SJ, Seo AJ, Park BS, Jo HW, Huh Y Tags: J Korean Med Sci Source Type: research

The influence of depression, anxiety and somatization on the clinical symptoms and treatment response in patients with symptoms of lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
Abstract This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (≤ 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whol...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Yang YJ, Koh JS, Ko HJ, Cho KJ, Kim JC, Lee SJ, Pae CU Tags: J Korean Med Sci Source Type: research

Association between Bone Mineral Density and Clinical Consequences: Cross-Sectional Study of Korean Postmenopausal Women in an Orthopaedic Outpatient Clinic.
This study is to identify the characteristics of BMD and the related clinical consequences through a nationwide, consecutive, cross-sectional study. A total of 1,281 postmenopausal women was enrolled nationwide and underwent measurement for BMD using dual energy x-ray absorptiometry. Following the T-spine and L-spine plane radiography, they were evaluated for vertebral fracture by a semi-quantitative method using the Genant's method. Relationship between BMD and osteoporotic fracture and a degree of deformity in vertebral fracture, treatment history in osteoporosis and the EQ-5D was analyzed. The distribution of the normal...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Lee JH, Lee YH, Moon SH, TOP Study Group Tags: J Korean Med Sci Source Type: research

Aminophylline Partially Prevents the Decrease of Body Temperature during Laparoscopic Abdominal Surgery.
Abstract Aminophylline can elicit thermogenesis in rats or increase metabolic rate during cold stress in lambs. We tested the hypothesis that aminophylline would reduce the change in core body temperature during laparoscopic abdominal surgery requiring pneumoperitoneum. Fifty patients were randomly divided into an aminophylline group (n=25) and a saline control group (n=25). Esophageal temperature, index finger temperature, and hemodynamic variables, such as mean blood pressure and heart rate, were measured every 15 min during sevoflurane anesthesia. In the aminophylline group, esophageal temperatures at T45 (36.1...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kim DW, Lee JA, Jung HS, Joo JD, In JH, Jeon YS, Chun GY, Choi JW Tags: J Korean Med Sci Source Type: research

Transplantation of a horseshoe kidney found during harvest operation of a cadaveric donor: a case report.
Abstract A 34-yr-old female was diagnosed as being brain dead. Preoperative ultrasound revealed no abnormal focal lesions. However, the horseshoe kidney was identified during organ harvest. En bloc nephrectomy was performed. The kidney was divided at the midline of isthmus. The divided right kidney was discarded due to numerous arteries and veins. The divided left kidney was transplanted. After declamping, the kidney was well perfused and started clearing. Resistive index was 0.72. Glomerular filtration ratio was 84.69 mL/min on postoperative day 14. The horseshoe kidney can be successfully transplanted and could ...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Yun S, Woo HD, Doo SW, Kwon SH, Noh H, Song D Tags: J Korean Med Sci Source Type: research

Acute pancreatitis induced by methimazole treatment in a 51-year-old korean man: a case report.
Abstract Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute p...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Jung JH, Hahm JR, Jung J, Kim SK, Kim S, Kim KY, Kim BR, Kim HJ, Jeong YY, Kim SJ Tags: J Korean Med Sci Source Type: research

Trends and Risk Factors of the Epidemic of Charcoal Burning Suicide in a Recent Decade among Korean People.
Abstract The aims of this study were to analyze annual trends of charcoal burning (CB) suicide, 2000 to 2011, and to examine the risk factors of CB suicide in Korea. Data on suicides (n=138,938) were obtained from the Statistics Korea. The proportion of CB suicides among all suicide deaths reported was 0.7% (84 cases) in 2007, and since 2008 it has rapidly increased to 7.9% (1,251 cases) in 2011. Of significant risk factors of CB suicide, the presence of the media report of Ahn's suicide was the greatest risk factor (adjusted odds ratio, 11.69; 95% CI, 10.30-13.23) of the initial phase of the continuing CB suicide...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Ji NJ, Hong YP, Stack SJ, Lee WY Tags: J Korean Med Sci Source Type: research

Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea.
In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Seo MR, Kim SJ, Kim Y, Kim J, Choi TY, Kang JO, Wie SH, Ki M, Cho YK, Lim SK, Lee JS, Kwon KT, Lee H, Cheong HJ, Park DW, Ryu SY, Chung MH, Pai H Tags: J Korean Med Sci Source Type: research

Erratum: Addition of Author's Affiliated Institute and Correction of the Author's Name. Corrected: Safety and Immunogenicity Assessment of an Oral Cholera Vaccine through Phase I Clinical Trial in Korea.
Abstract [This corrects the article on p. 494 in vol. 29, PMID: 24753695.]. PMID: 25120334 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Baik YO, Choi SK, Kim JW, Yang JS, Kim IY, Kim CW, Hong JH Tags: J Korean Med Sci Source Type: research

Erratum: Correction of the Author's Name. Risk Factors between Patients with Lone and Non-Lone Atrial Fibrillation by Lee SH, et al. (J Korean Med Sci. 2013;28:1174-80.).
Authors: Abstract [This corrects the article on p. 1174 in vol. 28, PMID: 23960444.]. PMID: 25120335 [PubMed - as supplied by publisher] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Tags: J Korean Med Sci Source Type: research

Increasing burden of Alzheimer's disease by aging.
PMID: 25045218 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Han SH Tags: J Korean Med Sci Source Type: research

Primary Prevention of Alzheimer's Disease: Is It an Attainable Goal?
Abstract Alzheimer's disease (AD) is the leading cause of dementia, and the most prevalent neurodegenerative disease in the elderly. The prevalence of AD is predicted to rise as life expectancy grows across populations. The exact cause of this devastating disease is still unknown; however, it is an aging-related multi-factorial disorder, and growing evidence supports the contribution of modifiable environmental factors to unmodifiable factors such as gene and ageing itself. The recent advancement of methodologies and techniques for early diagnosis of AD facilitates the investigation of strategies to reduce the ris...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Han JY, Han SH Tags: J Korean Med Sci Source Type: research

Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease.
Abstract Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid β (Aβ) and neurofibrillary tangles. The lack of early diagnostic biomarker and therapeutic remedy hinders the prevention of increasing population of AD patients every year. In spite of accumulated scientific information, numerous clinical trials for candidate drug targets have failed to be preceded into therapeutic development, therefore, AD-related sufferers including patients and caregivers, are desperate to seek the solution. Also, effective AD intervention is des...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Han SH, Mook-Jung I Tags: J Korean Med Sci Source Type: research

Prevalence and Trends of Dementia in Korea: A Systematic Review and Meta-Analysis.
Abstract Through a systematic review and meta-analysis of epidemiological studies on dementia, we assessed the prevalence of dementia and its subtypes-Alzheimer' disease (AD) and vascular dementia (VaD)-in Korea. We searched for epidemiological studies on dementia published in 1990-2013 using PubMed, Scopus, EMBASE, KoreaMed, KISS, and RiCH. Dementia prevalence in elderly patients (aged≥65 yr) was 9.2% (95% confidence interval [CI], 8.2%-10.4%) from 11 studies, which was higher than those from Western and other Asian countries. AD was the most prevalent dementia type, with a prevalence of 5.7% (95% CI, 5.0%-6.4...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Kim YJ, Han JW, So YS, Seo JY, Kim KY, Kim KW Tags: J Korean Med Sci Source Type: research

The Recent Decline in Prevalence of Dementia in Developed Countries: Implications for Prevention in the Republic of Korea.
Abstract With the rapid aging of the population in Korea, the number of older people with dementia is projected to increase, forecasting an epidemic of dementia. Recent trends in dementia in several western countries, however, depict a gradual decline in prevalence and incidence. This decrease has been attributed to an improvement in education and living environments, engagement in healthy behaviors, and reduction in the prevalence of vascular risk factors. In Korea, however, trends in modifiable risk factors do not favor an optimistic outlook due to the continuous increase in the prevalence of hypertension, diabe...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Lee Y Tags: J Korean Med Sci Source Type: research

Moving toward Universal Coverage of Health Insurance in Vietnam: Barriers, Facilitating Factors, and Lessons from Korea.
Abstract Vietnam has pursued universal health insurance coverage for two decades but has yet to fully achieve this goal. This paper investigates the barriers to achieve universal coverage and examines the validity of facilitating factors to shorten the transitional period in Vietnam. A comparative study of facilitating factors toward universal coverage of Vietnam and Korea reveals significant internal forces for Vietnam to further develop the National Health Insurance Program. Korea in 1977 and Vietnam in 2009 have common characteristics to be favorable of achieving universal coverage with similarities of level of...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Do N, Oh J, Lee JS Tags: J Korean Med Sci Source Type: research

Clinical Significance of Previously Cryptic Copy Number Alterations and Loss of Heterozygosity in Pediatric Acute Myeloid Leukemia and Myelodysplastic Syndrome Determined Using Combined Array Comparative Genomic Hybridization plus Single-Nucleotide Polymorphism Microarray Analyses.
This study demonstrates that CGH+SNP microarray can simultaneously detect previously cryptic CNAs and LOH, which may demonstrate prognostic implications. PMID: 25045224 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Koh KN, Lee JO, Seo EJ, Lee SW, Suh JK, Im HJ, Seo JJ Tags: J Korean Med Sci Source Type: research

Imaging mass spectrometry in papillary thyroid carcinoma for the identification and validation of biomarker proteins.
Abstract Direct tissue imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization and time-of-flight (MALDI-TOF) mass spectrometry has become increasingly important in biology and medicine, because this technology can detect the relative abundance and spatial distribution of interesting proteins in tissues. Five thyroid cancer samples, along with normal tissue, were sliced and transferred onto conductive glass slides. After laser scanning by MALDI-TOF equipped with a smart beam laser, images were created for individual masses and proteins were classified at 200-µm spatial resolution. Base...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Min KW, Bang JY, Kim KP, Kim WS, Lee SH, Shanta SR, Lee JH, Hong JH, Lim SD, Yoo YB, Na CH Tags: J Korean Med Sci Source Type: research

Elevated brachial-ankle pulse wave velocity is independently associated with microalbuminuria in a rural population.
This study included 1,648 individuals aged over 40 who participated in the baseline Multi-Rural Cohort Study conducted in Korean rural communities between 2005 and 2006. Participants were classified into less than 30 mg/g as normoalbuminuria or 30-300 mg/g as microalbuminuriausing urinary albumin creatinine ratio (UACR). The median and Q1-Q3 baPWV values were significantly higher in the microalbuminuric group both in men (1,538, 1,370-1,777 cm/s vs. 1,776, 1,552-2,027 cm/s, P
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Seo JY, Kim MK, Choi BY, Kim YM, Cho SI, Shin J Tags: J Korean Med Sci Source Type: research

Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis.
Abstract The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR≤2.73 [n=370]) vs. high NLR group (NLR>2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9±149.7 µL vs. 192.5±127.7 µL, P=0.001, and 32.7&pl...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Choi YH, Hong YJ, Ahn Y, Park IH, Jeong MH Tags: J Korean Med Sci Source Type: research

The clinical association of the blood pressure variability with the target organ damage in hypertensive patients with chronic kidney disease.
Abstract It is known that blood pressure variability (BPV) can independently affect target organ damage (TOD), even with normal blood pressure. There have been few studieson chronic kidney disease (CKD) patients. We evaluated the relationship between BPV and TOD in a cross-sectional, multicenter study on hypertensive CKD patients. We evaluated 1,173 patients using 24-hr ambulatory blood pressure monitoring. BPV was defined as the average real variability, with a mean value of the absolute differences between consecutive readings of systolic blood pressure. TOD was defined as left ventricular hypertrophy (LVH) (by ...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Ryu J, Cha RH, Kim DK, Lee JH, Yoon SA, Ryu DR, Oh JE, Kim S, Han SY, Lee EY, Kim YS, APrODiTe investigators Tags: J Korean Med Sci Source Type: research

Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes.
Abstract We evaluated the prevalence of vitamin B12 deficiency and associated factors in type 2 diabetes patients using metformin. A total of 799 type 2 diabetes patients using metformin was enrolled. Vitamin B12 and folate levels were quantified by chemiluminescent enzyme immunoassay. Vitamin B12 deficiency was defined as vitamin B12 ≤ 300 pg/mL without folate deficiency (folate> 4 ng/mL). The prevalence of vitamin B12 deficiency in metformin-treated type 2 diabetes patients was 9.5% (n = 76), and the mean vitamin B12 level was 662.5 ± 246.7 pg/mL. Vitamin B12 deficient patients had longer duration of metformin use (P
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Ko SH, Ko SH, Ahn YB, Song KH, Han KD, Park YM, Ko SH, Kim HS Tags: J Korean Med Sci Source Type: research

Clinical significance of non-alcoholic Fatty liver disease as a risk factor for prehypertension.
Abstract Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between NAFLD and prehypertension. A prospective cohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and Cox proportional hazard model was used to measure the hazard ratios (HRs) for the development of prehypertension ...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Ryoo JH, Ham WT, Choi JM, Kang MA, An SH, Lee JK, Shin HC, Park SK Tags: J Korean Med Sci Source Type: research

Toxicity profile of temozolomide in the treatment of 300 malignant glioma patients in Korea.
This study evaluated the toxicity profiles of temozolomide in the treatment of malignant glioma as either concurrent or adjuvant chemotherapy. We retrospectively reviewed the medical records of 300 malignant glioma patients treated with temozolomide in two medical institutions in Korea between 2004 and 2010. Two hundred nine patients experienced a total of 618 toxicities during temozolomide therapy. A total of 84.8% of the 618 toxicities were Common Terminology Criteria for Adverse Events (CTCAE) grade 1 or 2, while 15.2% were grade 3 or 4. Among the hematologic toxicities, thrombocytopenia (13.7%), anemia (11.0%), and AST...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Bae SH, Park MJ, Lee MM, Kim TM, Lee SH, Cho SY, Kim YH, Kim YJ, Park CK, Kim CY Tags: J Korean Med Sci Source Type: research

Comparison of Epidemiology, Emergency Care, and Outcomes of Acute Ischemic Stroke between Young Adults and Elderly in Korean Population: A Multicenter Observational Study.
Abstract Stroke in young adults has been known to show a lower incidence and a better prognosis. Only a few studies have examined the epidemiology and outcomes of ischemic stroke in young adults and compared them with the elderly in Korean population. All consecutive patients with ischemic stroke visiting 29 participating emergency departments were enrolled from November 2007 to October 2009. Patients with less than 15 yr of age and unknown information on age and confirmed diagnosis were excluded. We categorized the patients into young adults (15 to 45 yr) and elderly (46 yr and older) groups. Of 39,156 enrolled a...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Park WB, Cho JS, Shin SD, Kong SY, Kim JJ, Lim YS, Yang HJ, Lee G Tags: J Korean Med Sci Source Type: research

Incidence and risk factors of subsequent hip fractures in Korea: multicenter study.
This study analyzes the incidence of subsequent hip fractures and its risk factors in the northwestern region of Korea. We analyzed hip fracture patients who visited any of the 5 teaching hospitals in the Bucheon and Incheon area from January 2000 to December 2010. Medical records were reviewed and presence of subsequent hip fractures, alcohol history, marital status, live in solitude, dementia, dizziness, American society of anesthesiologists score, osteoporosis treatment after fracture, body mass index (BMI) and initial bone mineral density were analyzed. The average follow-up period was 12 months (range 1-130 months). A...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Lee KH, Kim JY, Yim SJ, Moon do H, Choi GH, Moon KH Tags: J Korean Med Sci Source Type: research

The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People.
This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positi...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Kim S, Won CW, Kim BS, Choi HR, Moon MY Tags: J Korean Med Sci Source Type: research

Does intravenous ketamine enhance analgesia after arthroscopic shoulder surgery with ultrasound guided single-injection interscalene block?: a randomized, prospective, double-blind trial.
Abstract Ketamine has anti-inflammatory, analgesic and antihyperalgesic effect and prevents pain associated with wind-up. We investigated whether low doses of ketamine infusion during general anesthesia combined with single-shot interscalene nerve block (SSISB) would potentiate analgesic effect of SSISB. Forty adult patients scheduled for elective arthroscopic shoulder surgery were enrolled and randomized to either the control group or the ketamine group. All patients underwent SSISB and followed by general anesthesia. During an operation, intravenous ketamine was infused to the patients of ketamine group continuo...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Woo JH, Kim YJ, Baik HJ, Han JI, Chung RK Tags: J Korean Med Sci Source Type: research

Application of damage control resuscitation strategies to patients with severe traumatic hemorrhage: review of plasma to packed red blood cell ratios at a single institution.
Abstract When treating trauma patients with severe hemorrhage, massive transfusions are often needed. Damage control resuscitation strategies can be used for such patients, but an adequate fresh frozen plasma: packed red blood cell (FFP:PRBC) administration ratio must be established. We retrospectively reviewed the medical records of 100 trauma patients treated with massive transfusions from March 2010 to October 2012. We divided the patients into 2 groups according to the FFP:PRBC ratio: a high-ratio (≥0.5) and a low-ratio group (
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Kim Y, Lee K, Kim J, Kim J, Heo Y, Wang H, Lee K, Jung K Tags: J Korean Med Sci Source Type: research

A Case Report of Preoperative and Postoperative 7.0T Brain MRI in a Patient with a Small Cell Glioblastoma.
Abstract A 45-yr-old female patient was admitted with one-month history of headache and progressive left hemiparesis. Brain magnetic resonance imaging (MRI) demonstrated a mass lesion in her right frontal lobe. Her brain tumor was confirmed as a small cell glioblastoma. Her follow-up brain MRI, taken at 8 months after her initial surgery demonstrated tumor recurrence in the right frontal lobe. Contrast-enhanced 7.0T brain magnetic resonance imaging (MRI) was safely performed before surgery and at the time of recurrence. Compared with 1.5T and 3.0T brain MRI, 7.0T MRI showed sharpened images of the brain tumor cont...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Paek SH, Hwang JH, Kim DG, Choi SH, Sohn CH, Park SH, Son YD, Kim YB, Cho ZH Tags: J Korean Med Sci Source Type: research

A case report of testicular sparganosis misdiagnosed as testicular tumor.
Abstract Sparganosis is a parasitic infestation of human by plerocercoid larvae. Sparganum is usually reported to be found in the subcutaneous tissues as well as other organs, including scrotum. However, testicular sparganosis is extremely rare, because of strong capsule of tunica albuginea. An urban-living 54-yr-old Korean man presented with left scrotal pain for 6 yr. Both testes look normal physically. Ultrasonography revealed poorly defined, heterogeneous mass with increased echogenicity in the left testis. This case was misdiagnosed as testicular tumor and underwent orchiectomy, but was diagnosed as testicula...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Park WH, Shin TY, Yoon SM, Park SH, Kang YJ, Kim do K, Han JY, Seong do H Tags: J Korean Med Sci Source Type: research

The significance of clinical and laboratory features in the diagnosis of glycogen storage disease type v: a case report.
Abstract Glycogen storage disease type V (GSD-V) is the most common disorder of muscle glycogenosis with characteristic clinical and laboratory findings. A 32-yr-old woman complained of exercise intolerance and myoglobulinuria since early adolescence. She reported several episodes of second-wind phenomenon. Physical examination did not show any neurological abnormality, including fixed muscle weakness or atrophy. Serum creatine kinase level was 1,161 IU/L at rest. The result of the non-ischemic forearm exercise test was compatible with GSD-V. Mutation analysis identified the compound heterozygous mutations of the ...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Park HJ, Shin HY, Cho YN, Kim SM, Choi YC Tags: J Korean Med Sci Source Type: research

Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients.
In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of S...
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Kim MA, Yoon MG, Jin HJ, Shin YS, Park HS Tags: J Korean Med Sci Source Type: research

Patient preference and satisfaction in decision-making process.
PMID: 25045241 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - July 1, 2014 Category: Journals (General) Authors: Pae CU Tags: J Korean Med Sci Source Type: research

EDITOR'S NOTE - About This Supplement.
PMID: 25006317 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Hong ST Tags: J Korean Med Sci Source Type: research

Compensation for Work-Related Cerebrocardiovascular Diseases.
Abstract The purpose of this study was to discuss the history of, and concerns regarding, the newly amended criteria of occupational cerebrovascular or cardiovascular diseases (CCVDs). Since the early 1990s, CCVDs have been the second most common occupational disease, despite fluctuations in their criteria. The first issue was the deletion of cerebral hemorrhage on duty as a recognized occupational disease in 2008. The second issue was the obscurity regarding definitions of an acute stressful event (within 24 hr before disease occurrence), short-term overwork (within 1 week), and chronic overwork (for 3 or more mo...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Won JU, Kim I Tags: J Korean Med Sci Source Type: research

Work-related musculoskeletal diseases and the workers' compensation.
Abstract The Industrial Accident Compensation Insurance Act (IACIA) regulates the workers' compensation insurance system and the standards for the recognition of occupational diseases (ODs). Since its establishment in 1994, the IACIA has been amended several times. Before 2008, the approval of compensation for work-related musculoskeletal diseases (WMSDs) was decided based on the recommendation of consultants of the Korea Workers' Compensation and Welfare Service (COMWEL). The IACIA was amended in 2008, and since then, the approval of compensation for occupational injuries has been decided based on the recommendat...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Jang TW, Koo JW, Kwon SC, Song J Tags: J Korean Med Sci Source Type: research

Compensation for Occupational Injuries and Diseases in Special Populations: Farmers and Soldiers.
Abstract Some types of workers such as farmers and soldiers are at a higher risk of work-related injury and illness than workers from other occupations. Despite this fact, they are not covered under the Industrial Safety Health (ISH) Act or the Industrial Accident Compensation Insurance (IACI) Act. The Safety Aid System for Farmers (SASF) is a voluntary insurance scheme, and it is the only public compensation plan for self-employed farmers. Fifty percent of SASF premiums are subsidized by the Korean government. Soldiers are compensated by the Veterans' Pension (VP) Act. The approval standard of and procedure for t...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kwon YJ, Lee SJ Tags: J Korean Med Sci Source Type: research

The administrative process for recognition and compensation for occupational diseases in Korea.
Abstract In the Workers' Compensation Insurance (WCI) system in Korea, occupational diseases (ODs) are approved through deliberation meetings of the Committee on Occupational Disease Judgment (CODJ) after disease investigations when workers or medical institutions requested the Korea Workers' Compensation and Welfare Service (COMWEL) for medical care benefits. Insufficient data presented by employers or workers or lack of objective evidence may increase the possibility of disapproval. The expertise of accident investigation staff members should be reinforced and employers' and related institutions' obligations to ...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kwon SC, Kim HR, Kwon YJ Tags: J Korean Med Sci Source Type: research

The scope and specific criteria of compensation for occupational diseases in Korea.
Abstract The range of diseases covered by workers' compensation is constantly expanding. However, new regulations are required for the recognition of occupational diseases (ODs) because OD types evolve with changes in industrial structures and working conditions. OD criteria are usually based on medical relevance, but they vary depending on the social security system and laws of each country. In addition, the proposed range and extent of work-relatedness vary depending on the socio-economic conditions of each country. The Labor Standards Act (LSA) and the Industrial Accident Compensation Insurance Act (IACIA) of K...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Song J, Kim I, Choi BS Tags: J Korean Med Sci Source Type: research

Compensation for occupational cancer.
Abstract The legal scope and criteria for occupational cancer in Korea was out of date. The aim of this study was to review the current criteria for occupational cancer and amend the existent criteria on the basis of recent scientific evidence. The scientific evidence and the legal list of occupational cancer were analyzed to identify the causes of occupational cancer on a global scale. The relationship between compensated occupational cancer cases and carcinogen exposure in Korea was examined. The factors associated with specific causes and target cancers were determined to produce additional criteria. Five-hundr...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim I, Kim EA, Kim JY Tags: J Korean Med Sci Source Type: research

Workers' compensation for occupational respiratory diseases.
Abstract The respiratory system is one of the most important body systems particularly from the viewpoint of occupational medicine because it is the major route of occupational exposure. In 2013, there were significant changes in the specific criteria for the recognition of occupational diseases, which were established by the Enforcement Decree of the Industrial Accident Compensation Insurance Act (IACIA). In this article, the authors deal with the former criteria, implications of the revision, and changes in the specific criteria in Korea by focusing on the 2013 amendment to the IACIA. Before the 2013 amendment t...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Park SY, Kim HR, Song J Tags: J Korean Med Sci Source Type: research

Compensation for occupational skin diseases.
Abstract The Korean list of occupational skin diseases was amended in July 2013. The past list was constructed according to the causative agent and the target organ, and the items of that list had not been reviewed for a long period. The revised list was reconstructed to include diseases classified by the International Classification of Diseases (10th version). Therefore, the items of compensable occupational skin diseases in the amended list in Korea comprise contact dermatitis; chemical burns; Stevens-Johnson syndrome; tar-related skin diseases; infectious skin diseases; skin injury-induced cellulitis; and skin ...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Song HS, Ryou HC Tags: J Korean Med Sci Source Type: research

Compensation for occupational neurological and mental disorders.
Abstract Standards for the recognition of occupational diseases (ODs) in Korea were established in 1954 and have been amended several times. In 2013, there was a significant change in these standards. On the basis of scientific evidence and causality, the International Labour Organization list, European Commission schedule, and compensated cases in Korea were reviewed to revise the previous standards for the recognition of ODs in Korea. A disease-based approach using the International Classification of Diseases (10th version) was added on the previous standards, which were agent-specific approaches. The amended co...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kang DM, Kim I Tags: J Korean Med Sci Source Type: research

Compensation for work-related hematologic, liver, and infectious diseases.
Abstract Occupational diseases may be defined only medically or scientifically, and even then, their definition is not simple. However, compensable occupational diseases involve the additional layer of legal systems and social welfare policies as well. Their multifaceted nature makes determining the work-relatedness of these diseases more complex. Korea has established standards for the recognition of occupational diseases in Schedule 5 of the Enforcement Decree of the Labor Standards Act, and specific criteria for the recognition of occupational diseases are listed in Schedule 3 of the Enforcement Decree of the I...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim JW, Kang DM Tags: J Korean Med Sci Source Type: research

Physical agents and occupational disease compensation: noise, vibration, radiation, and other physical agents.
Abstract The context of specific criteria for the recognition of occupational diseases (ODs) due to physical agents in the Enforcement Decree of the Industrial Accident Compensation Insurance Act (ED-IACIA) and the Labor Standard Act (LSA) does not describe definite disease along with the agents but listed symptoms or obscure clinical conditions. Moreover, the needs for an amendment of these Acts have recently attracted renewed interest. To establish agreed criteria for compensable ODs due to physical agents, we reviewed the criteria for recognizing ODs on the basis of International Labor Organization (ILO) docume...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Lee J, Kim J Tags: J Korean Med Sci Source Type: research

Compensation for occupational diseases by chemical agents in Korea.
Abstract Investigation into the frequency of compensation for occupational diseases (ODs) caused by hazardous chemicals revealed an important opportunity for the improvement and further development of occupational health and safety systems in Korea. In response to concerns after outbreaks of disease due to chemical exposure, specific criteria for recognition of ODs were established and included in the Enforcement Decree of the Labor Standard Act (LSA) and the Industrial Accident Compensation Insurance Act (IACIA) on June 28, 2013. However, the original versions of the LSA and IACIA contain several limitations. Fir...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kwon SC, Roh SY, Lee JH, Kim EA Tags: J Korean Med Sci Source Type: research

HPV Vaccine, Is It Really Harmful?
PMID: 24932072 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim S Tags: J Korean Med Sci Source Type: research

Overview of Surgical Scar Prevention and Management.
Abstract Management of incisional scar is intimately connected to stages of wound healing. The management of an elective surgery patient begins with a thorough informed consent process in which the patient is made aware of personal and clinical circumstances that cannot be modified, such as age, ethnicity, and previous history of hypertrophic scars. In scar prevention, the single most important modifiable factor is wound tension during the proliferative and remodeling phases, and this is determined by the choice of incision design. Traditional incisions most often follow relaxed skin tension lines, but no such lin...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Son D, Harijan A Tags: J Korean Med Sci Source Type: research

Development and Evaluation of Korean Version of Quality of Sexual Function (QSF-K) in Healthy Korean Women.
This study was done to develop a Korean version of the Quality of Sexual Function (QSF-K) and evaluate the validity and reliability of the QSF-K. The participants were 220 women who visited the Center for Uterine Cancer at the National Cancer Center in Korea. Participants completed the scale once and then again at a two to four week interval. The QSF-K, Female Sexual Function Index (FSFI) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30) were used in this study. Receiver operating characteristics (ROC) curve, area under the ROC curve (AUC), intraclass corre...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Lee Y, Lim MC, Son Y, Joo J, Park K, Kim JS, Lee DO, Park SY Tags: J Korean Med Sci Source Type: research