An early stage evaluation of the supporting program for obstetric care underserved areas in Korea.
Abstract "The Supporting Program for Obstetric Care Underserved Areas (SPOU)" provides financial aids to rural community (or district) hospitals to reopen prenatal care and delivery services for regions without obstetrics and gynecology clinics or hospitals. The purpose of this study was to evaluate the early stage effect of the SPOU program. The proportion of the number of birth through SPOU was calculated by each region. Also survey was conducted to investigate the extent of overall satisfaction, elements of dissatisfaction, and suggestions for improvement of the program; 209 subjects participated from...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Na BJ, Kim HJ, Lee JY Tags: J Korean Med Sci Source Type: research

Improving the Reliability of Clinical Practice Guideline Appraisals: Effects of the Korean AGREE II Scoring Guide.
This study examines the effects of the Korean AGREE II scoring guide to reduce inter-rater differences. Appraisers were randomly assigned to two groups (Scoring Guide group and Non-Scoring Guide group). The Korean AGREE II instrument was provided to both groups. However, the scoring guide was offered to Scoring Guide group only. Total 14 appraisers were participated and each guideline was assessed by 8 appraisers. To evaluate the reliability of the Korean AGREE II scoring guide, correlation of scores among appraisers and domain-specific intra-class correlation (ICC) were compared. Most scores of two groups were comparable....
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Oh MK, Jo H, Lee YK Tags: J Korean Med Sci Source Type: research

Clinical features of right-sided infective endocarditis occurring in non-drug users.
Abstract Right-sided infective endocarditis (RIE) occurs predominantly in intravenous drug users in western countries, and it has a relatively good prognosis. Clinical features and prognosis of RIE occurring in non-drug users are not well known. We investigated the clinical findings of RIE in non-drug users. We retrospectively reviewed 345 cases diagnosed with IE. Cases with RIE or left-sided infective endocarditis (LIE) defined by the vegetation site were included and cases having no vegetation or both-side vegetation were excluded. Clinical findings and in-hospital outcome of RIE were compared to those of LIE. A...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Lee MR, Chang SA, Choi SH, Lee GY, Kim EK, Peck KR, Park SW Tags: J Korean Med Sci Source Type: research

Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients.
In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27. PMID: 24932078 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim HW, Choe HR, Lee SB, Chang WI, Chae HJ, Moon JY, Kang J, Lee S, Song YW, Lee EY Tags: J Korean Med Sci Source Type: research

Elevated serum homocysteine levels were not correlated with serum uric Acid levels, but with decreased renal function in gouty patients.
In this study, we measured Hcy levels in patients with gout and examined factors associated with the levels of serum Hcy. Ninety-one male patients with gout and 97 age-matched healthy male controls were enrolled in the study. Serum uric acid levels were not significantly different between gout and healthy control groups. However, serum Hcy levels were significantly higher in patients with gout compared to controls (13.96±4.05 µM/L vs 12.67±3.52 µM/L, P=0.035). In gout group, patients with 1-2 stages of chronic kidney disease (CKD) had significantly lower serum Hcy than those with 3-5 stages of CKD...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Choi ST, Kim JS, Song JS Tags: J Korean Med Sci Source Type: research

The effect of body mass index on survival in advanced epithelial ovarian cancer.
This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.30...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Bae HS, Hong JH, Ki KD, Song JY, Shin JW, Lee JM, Lee JK, Lee NW, Lee C, Lee KW, Kim YM Tags: J Korean Med Sci Source Type: research

Determinants of brachial-ankle pulse wave velocity and carotid-femoral pulse wave velocity in healthy koreans.
Abstract The aim of this study was to determine the normal value of brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV) according to age group, gender, and the presence of cardiovascular risk factors in healthy Koreans, and to investigate the association between PWV and risk factors such as prehypertension, dyslipidemia, smoking, and obesity. We measured an arterial stiffness in 110 normal subjects who were 20 to 69 yr-old with no evidence of cardiovascular disease, cerebrovascular accident or diabetes mellitus. The mean values of baPWV and cfPWV were 12.6 (±2.27) m/se...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Jang SY, Ju EY, Huh EH, Kim JH, Kim DK Tags: J Korean Med Sci Source Type: research

Efficacy of hemocontrol biofeedback system in intradialytic hypotension-prone hemodialysis patients.
Abstract We conducted a study to determine whether the hemocontrol biofeedback system (HBS) can improve intradialytic hypotension (IDH) in hypotension-prone hemodialysis (HD) patients compared with conventional HD. In this multicenter prospective crossover study, 60 hypotension-prone patients were serially treated by conventional HD for 8 weeks (period A), by HD with hemoscan blood volume monitoring for 2 weeks (period B0), and by HBS HD for 8 weeks (period B1). The number of sessions complicated by symptomatic IDH during 24 HD sessions (14.9±5.8 sessions, 62.1% in period A vs 9.2±7.2 sessions, 38.4% in period B1, P
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Gil HW, Bang K, Lee SY, Han BG, Kim JK, Kim YO, Song HC, Kwon YJ, Kim YS Tags: J Korean Med Sci Source Type: research

The Effectiveness of Recombinant Human Thyroid-Stimulating Hormone versus Thyroid Hormone Withdrawal Prior to Radioiodine Remnant Ablation in Thyroid Cancer: A Meta-Analysis of Randomized Controlled Trials.
Abstract We evaluated the efficacy of recombinant human thyroid-stimulating hormone (rhTSH) versus thyroid hormone withdrawal (THW) prior to radioiodine remnant ablation (RRA) in thyroid cancer. A systematic search of MEDLINE, EMBASE, the Cochrane Library, and SCOPUS was performed. Randomized controlled trials that compared ablation success between rhTSH and THW at 6 to 12 months following RRA were included in this study. Six trials with a total of 1,660 patients were included. When ablation success was defined as a thyroglobulin (Tg) cutoff of 1 ng/mL (risk ratio, 0.99; 95% confidence interval, 0.96-1.03) or a Tg...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Pak K, Cheon GJ, Kang KW, Kim SJ, Kim IJ, Kim EE, Lee DS, Chung JK Tags: J Korean Med Sci Source Type: research

Diffuse metastasis to the thyroid: unique ultrasonographic finding and clinical correlation.
In conclusion, ultrasonographic finding of diffuse metastasis is a diffusely enlarged heterogeneous thyroid with reticular pattern internal hypoechoic lines. Thyroid function testing should be performed in all patients with diffuse thyroid metastases, especially those with bilateral lobe involvement. PMID: 24932084 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim HK, Kim SS, Oak CY, Kim SJ, Yoon JH, Kang HC Tags: J Korean Med Sci Source Type: research

Prevalence of chronic sputum and associated factors in korean adults.
In conclusion, the prevalence of chronic sputum in Korea was in the intermediate range compared with other countries. Smoking is a preventable risk factor identified in this study, and major respiratory diseases, such as COPD and tuberculosis, should be considered in subjects with chronic sputum. PMID: 24932085 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Lee BR, Kim YI, Kim S, Lee HS, Yoon SH, Yu JY, Ban HJ, Kwon YS, Oh IJ, Kim KS, Kim YC, Lim SC Tags: J Korean Med Sci Source Type: research

A Pilot Prospective Study of the Relationship among Cognitive Factors, Shame, and Guilt Proneness on Posttraumatic Stress Disorder Symptoms in Female Victims of Sexual Violence.
This study prospectively examined the relationships among cognitive factors and severity of Posttraumatic stress disorder (PTSD) symptoms in female victims of sexual violence. Thirty-eight victims of sexual violence recruited from Center for Women Victims of Sexual and Domestic Violence at Ajou University Hospital. Cognitive factors and PTSD symptom were assessed within 4 months of sexual violence and 25 victims were followed-up 1 month after initial assessment. Repeated-measured ANOVA revealed that PTSD incidence and severity decreased over the month (F [1, 21]=6.61). Particularly, avoidant symptoms might decrease earlier...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Shin KM, Cho SM, Lee SH, Chung YK Tags: J Korean Med Sci Source Type: research

The Korean Version of the Trauma Symptom Checklist for Children: Psychometric Properties and the Connection to Trauma among Korean Children and Adolescents.
In conclusion, the Korean version of TSCC has been shown to be a screening instrument with satisfactory psychometric qualities that is capable of identifying trauma symptoms among children and adolescents who have self-reported experiencing trauma or for whom clinicians have identified traumatic experiences. PMID: 24932087 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Chung US Tags: J Korean Med Sci Source Type: research

Evaluation of stem cell components in retrocorneal membranes.
We examined RCMs with hematoxylin and eosin (H&E), periodic acid-Schiff (PAS) staining and immunohistochemical analysis using monoclonal antibodies against hematopoietic stem cells (CD34, CD133, c-kit), mesenchymal stem cells (beta-1-integrin, TGF-β, vimentin, hSTRO-1), fibroblasts (FGF-β, α-smooth muscle actin), and corneal endothelial cells (type IV collagen, CD133, VEGF, VEGFR1). Histologic analysis of RCMs revealed an organized assembly of spindle-shaped cells, pigment-laden cells, and thin collagenous matrix structures. RCMs were positive for markers of mesenchymal stem cells including beta-1-integ...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Lee SH, Kim KW, Kim MK, Chun YS, Kim JC Tags: J Korean Med Sci Source Type: research

Epidemiology of hip replacements in Korea from 2007 to 2011.
Abstract We analyzed national data collected by the Health Insurance Review and Assessment Service in Korea from 2007 to 2011; 1) to document procedural numbers and procedural rate of bipolar hemiarthroplasty (BH), primary and revision total hip arthroplasties (THAs), 2) to stratify the prevalence of each procedure by age, gender, and hospital type, and quantified, 3) to estimate the revision burden and evaluate whether the burden is changed over time. Our final study population included 60,230 BHs, 40,760 primary THAs, and 10,341 revision THAs. From 2007 to 2011, both the number and the rate of BHs, primary THAs ...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Yoon PW, Lee YK, Ahn J, Jang EJ, Kim Y, Kwak HS, Yoon KS, Kim HJ, Yoo JJ Tags: J Korean Med Sci Source Type: research

The influence of vertebral fracture on the functional disability of patients with rheumatoid arthritis.
This study consecutively enrolled 100 female patients aged 50 yr or older with RA. All participants underwent lateral imaging of the thoracolumbar spine by simple radiography to identify any VFs. They also completed questionnaires via interview regarding demographics, medical history, and disease outcomes including functional disability. We used univariate analysis to evaluate associations between functional disability and VF, and made multivariate logistic regression models to test independent effect of the presence of VF, the number of VFs, and the severity of VF on functional disability. Among the 100 RA patients, 47 ha...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Cho SK, Lee JH, Han M, Lee S, Kim JY, Ryu JA, Choi YY, Bae SC, Sung YK Tags: J Korean Med Sci Source Type: research

Clinical demographics and outcomes in mechanically ventilated patients in korean intensive care units.
The objective of the present study was to describe the current status of mechanically ventilated patients in Korea as of 2010. We analyzed the data of Korean patients (275 patients in 12 Korean intensive care units [ICU]) participating in a multinational prospective cohort study on mechanical ventilation. The most common indication for mechanical ventilation was pneumonia (23%). Pressure-limited ventilation modes were preferred over volume-cycled ventilation modes. Non-invasive positive pressure ventilation was used in only seven (2%) patients as the initial ventilatory support. Median duration of mechanical ventilation wa...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Jeong BH, Suh GY, An JY, Park MS, Lee JH, Lee MG, Kim JH, Kim YS, Choi HS, Kim KC, Lee WY, Koh Y Tags: J Korean Med Sci Source Type: research

Percutaneous Retrieval and Redeployment of an Atrial Septal Occluder under Three-Dimensional Transesophageal Echocardiographic Guidance: A Case Report.
We report a case of percutaneous Amplazter Septal Occluder (ASO; St. Jude Medical Inc., St. Paul, Minnesota, USA) device closure for an ASD with a thin and floppy interatrial septum, which immediately migrated into the right atrium and was not pulled back into the delivery sheath. To our knowledge, this is the first report on a successful percutaneous retrieval and redeployment of the device in such a situation, preventing any vascular injury or unplanned emergency open heart surgery. PMID: 24932092 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Ahn J, Kim JH, Choi JH, Oh JH Tags: J Korean Med Sci Source Type: research

Lemmel's Syndrome, an Unusual Cause of Abdominal Pain and Jaundice by Impacted Intradiverticular Enterolith: Case Report.
Abstract Duodenal diverticula are detected in up to 27% of patients undergoing upper gastrointestinal tract evaluation with periampullary diverticula (PAD) being the most common type. Although PAD usually do not cause symptoms, it can serve as a source of obstructive jaundice even when choledocholithiasis or tumor is not present. This duodenal diverticulum obstructive jaundice syndrome is called Lemmel's syndrome. An 81-yr-old woman came to the emergency room with obstructive jaundice and cholangitis. Abdominal CT scan revealed stony opacity on distal CBD with CBD dilatation. ERCP was performed to remove the stone...
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kang HS, Hyun JJ, Kim SY, Jung SW, Koo JS, Yim HJ, Lee SW Tags: J Korean Med Sci Source Type: research

Transient complete atrioventricular block in a preterm neonate with congenital myotonic dystrophy: case report.
We report a floppy infant of 31(+4) weeks gestation with complete AV block at birth, who was diagnosed with CMD by Southern analysis. She recovered from complete AV block 32 hr after temporary transcutaneous pacing was applied. To the best our knowledge, this is the first recorded case of a complete AV block accompanied by CMD during the neonatal period. When a newborn has a complete AV block, the physician should consider the possibility of the CMD and conduct a careful physical examination. PMID: 24932094 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - June 1, 2014 Category: Journals (General) Authors: Kim HN, Cho YK, Cho JH, Yang EM, Song ES, Choi YY Tags: J Korean Med Sci Source Type: research

Does Standard Triple Therapy Still Have a Role in First-Line Helicobacter pylori Eradication in Korea?
PMID: 24851014 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Jeon HK, Kim GH Tags: J Korean Med Sci Source Type: research

Fine, ultrafine, and yellow dust: emerging health problems in Korea.
PMID: 24851015 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kang D, Kim JE Tags: J Korean Med Sci Source Type: research

Genetic Studies in Human Prion Diseases.
Abstract Human prion diseases are fatal neurodegenerative disorders that are characterized by spongiform changes, astrogliosis, and the accumulation of an abnormal prion protein (PrP(Sc)). Approximately 10%-15% of human prion diseases are familial variants that are caused by pathogenic mutations in the prion protein gene (PRNP). Point mutations or the insertions of one or more copies of a 24 bp repeat are associated with familial human prion diseases including familial Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia. These mutations vary significantly in f...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Jeong BH, Kim YS Tags: J Korean Med Sci Source Type: research

Blood Cadmium Concentration of Residents Living near Abandoned Metal Mines in Korea.
This study shows the geometric mean of blood cadmium concentration in abandoned mining areas are higher than in non-mining areas in the general adult Korean population. PMID: 24851017 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Hong YS, Lee BK, Park JD, Sakong J, Choi JW, Moon JD, Kim DS, Kim BG Tags: J Korean Med Sci Source Type: research

Preoperative selective desensitization of live donor liver transplant recipients considering the degree of T lymphocyte cross-match titer, model for end-stage liver disease score, and graft liver volume.
In conclusion, this desensitization protocol for the selected recipients considering the degree of T lymphocyte cross-match titer, MELD score, and graft liver volume is feasible and safe. PMID: 24851018 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Hong G, Yi NJ, Suh SW, Yoo T, Kim H, Park MS, Choi Y, Lee K, Lee KW, Park MH, Suh KS Tags: J Korean Med Sci Source Type: research

Use of bortezomib as anti-humoral therapy in kidney transplantation.
This study aimed to investigate the effect of bortezomib in the desensitization and treatment of acute antibody mediated rejection (AAMR) in kidney transplantation. Nine patients who received bortezomib therapy for desensitization (DSZ group, n = 3) or treatment of AAMR (AAMR group, n = 6) were included in this study. In the DSZ group, 2 patients required DSZ owing to positive cross match and 1 owing to ABO mismatch with high baseline anti-ABO antibody titer (1:1,024). Bortezomib was used at 1, 3, 8, and 11 days from the start of the treatment. In the AAMR group, 3 patients showed full recovery of allograft function after ...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Yang KS, Jeon H, Park Y, Jo IH, Kim JI, Moon IS, Choi BS, Park CW, Yang CW, Kim YS, Chung BH Tags: J Korean Med Sci Source Type: research

Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin g.
This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxin (PT) IgG titers were measured using a commercial ELISA kit. We compared the mean anti-PT IgG titers and seroprevalence of pertussis of the six age groups: 11-20, 21-30, 31-40, 41-50, 51-60, and ≥ 61 yr. A total of 1,192 subjects were enrolled. The mean anti-PT IgG titer and pertussis seroprevalence were 3...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Lee SY, Han SB, Bae EY, Kim JH, Kang JH, Park YJ, Ma SH Tags: J Korean Med Sci Source Type: research

Prevention of comorbidity and acute attack of gout by uric Acid lowering therapy.
Abstract The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Joo K, Kwon SR, Lim MJ, Jung KH, Joo H, Park W Tags: J Korean Med Sci Source Type: research

Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4.
In conclusion, acetaminophen usage may be associated with asthma and BHR in genetically susceptible subjects. This effect may be modified by polymorphism at TLR4. PMID: 24851022 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ Tags: J Korean Med Sci Source Type: research

Long-term oncologic outcomes after radical cystectomy for bladder cancer at a single institution.
Abstract The aim of this study was to evaluate our experience using radical cystectomy to treat patients with bladder cancer and to describe the associations between pathologic features and clinical outcomes. All 701 patients who underwent radical cystectomy for bladder cancer were evaluated. The patient population consisted of 623 men and 78 women. The overall 5 and 10 yr recurrence-free survival (RFS) rates were 61.8% and 57.7%, respectively, and the 5 and 10 yr cancer-specific survival (CSS) rates were 70.8% and 65.1%, respectively. Multivariate analysis showed that factors significantly predictive of RFS and C...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kwon T, Jeong IG, You D, Hong B, Hong JH, Ahn H, Kim CS Tags: J Korean Med Sci Source Type: research

Papillary thyroid microcarcinomas are different from latent papillary thyroid carcinomas at autopsy.
Abstract The aim of this study was to review the literature of latent papillary thyroid carcinomas (PTCs) discovered at autopsy and describe the available pathologic and demographic differences from a group of papillary thyroid microcarcinomas (PTMCs) the reported in a previous publication. We searched the PubMed for published articles describing latent thyroid carcinomas detected at autopsy. Meta-analysis was performed to identify differences between the clinicopathologic features of PTMCs analyzed previously in our institution (Group I) and those of latent PTCs described in autopsy studies (Group II). We identif...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Lee YS, Lim H, Chang HS, Park CS Tags: J Korean Med Sci Source Type: research

Is there any role of positron emission tomography computed tomography for predicting resectability of gallbladder cancer?
Abstract The role of integrated (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography computed tomography (PET-CT) is uncertain in gallbladder cancer. The aim of this study was to show the role of PET-CT in gallbladder cancer patients. Fifty-three patients with gallbladder cancer underwent preoperative computed tomography (CT) and PET-CT scans. Their medical records were retrospectively reviewed. Twenty-six patients underwent resection. Based on the final outcomes, PET-CT was in good agreement (0.61 to 0.80) with resectability whereas CT was in acceptable agreement (0.41 to 0.60) with resectability. When t...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kim J, Ryu JK, Kim C, Paeng JC, Kim YT Tags: J Korean Med Sci Source Type: research

The Relationship Between J Wave on the Surface Electrocardiography and Ventricular Fibrillation during Acute Myocardial Infarction.
This study demonstrated that the presence of J wave on the sECG is significantly related to VF during AMI. PMID: 24851026 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kim SH, Kim DH, Park SD, Baek YS, Woo SI, Shin SH, Kwan J, Park KS Tags: J Korean Med Sci Source Type: research

Alkali Therapy Attenuates the Progression of Kidney Injury via Na/H Exchanger Inhibition in 5/6 Nephrectomized Rats.
Abstract Metabolic acidosis is a cause of renal disease progression, and alkali therapy ameliorates its progression. However, there are few reports on the role of renal acid-base transporters during alkali therapy. We evaluated the effect of sodium bicarbonate therapy and the role of acid-base transporters on renal disease progression in rats with a remnant kidney. Sprague-Dawley rats consumed dietary sodium bicarbonate (NaHCO3) or sodium chloride (NaCl) with 20% casein after a 5/6 nephrectomy. After being provided with a casein diet, the NaHCO3-treated group had higher levels of serum bicarbonate than the control...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kim S, Lee J, Heo NJ, Lee JW, Han JS Tags: J Korean Med Sci Source Type: research

The Clinical Characteristics of Colonic Pseudo-obstruction and the Factors Associated with Medical Treatment Response: A Study Based on a Multicenter Database in Korea.
Abstract Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Lee KJ, Jung KW, Myung SJ, Kim HJ, Kim NY, Yoon YH, Sohn CI, Shin JE, Cho YK, Hong SJ, Lee TH, Park KS, Jung HK, Choi CH, Kim GH, Kim JH, Jo YJ, Lee JS, Park HJ Tags: J Korean Med Sci Source Type: research

Meta-Analysis of First-Line Triple Therapy for Helicobacter pylori Eradication in Korea: Is It Time to Change?
Abstract Proton pump inhibitor (PPI)-based triple therapy consisting of PPI, amoxicillin, and clarithromycin, is the recommended first-line treatment for Helicobacter pylori infection. However, the eradication rate of triple therapy has declined over the past few decades. We analyzed the eradication rate and adverse events of triple therapy to evaluate current practices in Korea. A comprehensive literature search was performed up to August 2013 of 104 relevant studies comprising 42,124 patients. The overall eradication rate was 74.6% (95% confidence interval [CI], 72.1%-77.2%) by intention-to-treat analysis and 82...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Gong EJ, Yun SC, Jung HY, Lim H, Choi KS, Ahn JY, Lee JH, Kim do H, Choi KD, Song HJ, Lee GH, Kim JH Tags: J Korean Med Sci Source Type: research

Difference of the Naltrexone's Effects in Social Drinkers by Spicy Food Preference.
Abstract The purpose of this study was to investigate the differences in subjective acute effects of alcohol and naltrexone among those who prefer spicy food to varying degrees. Acute biphasic alcohol effects scale (BAES), visual analogue scale for craving (VAS-C), blood alcohol concentration (BAC) and food preference scale were measured in 26 men. Repeated measures ANOVA (2 preference groups×4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in naltrexone condition (N+) (P
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Lee JS, Kim SG, Jeong HJ, Kim JH, Yang YH, Jung WY Tags: J Korean Med Sci Source Type: research

Patterns of antipsychotic prescription to patients with schizophrenia in Korea: results from the health insurance review & assessment service-national patient sample.
This study aimed to analyze the patterns of antipsychotic prescription to patients with schizophrenia in Korea. Using the Health Insurance Review & Assessment Service-National Patients Sample (HIRA-NPS), which was a stratified sampling from the entire population under the Korean national health security system (2009), descriptive statistics for the patterns of the monopharmacy and polypharmacy, neuropsychiatric co-medications, and prescribed individual antipsychotic for patients with schizophrenia were performed. Comparisons of socioeconomic and clinical factors were performed among patients prescribed only with first-...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Park SC, Lee MS, Kang SG, Lee SH Tags: J Korean Med Sci Source Type: research

Serum leptin and adiponectin levels in korean patients with psoriasis.
In conclusion, the present study demonstrated that leptin and adiponectin may play a role in the immunopathogenesis of psoriasis and may be useful biomarkers indicating severity of psoriasis in Korean patients. PMID: 24851032 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Oh YJ, Lim HK, Choi JH, Lee JW, Kim NI Tags: J Korean Med Sci Source Type: research

Thrombolytic Therapy Complemented by ECMO: Successful Treatment for A Case of Massive Pulmonary Thromboembolism with Hemodynamic Collapse.
In conclusion, thrombolytic therapy complemented by ECMO may be an effective treatment option for acute massive PTE with hemodynamic instability. PMID: 24851033 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Chon MK, Park YH, Choi JH, Lee SH, Kim JS, Kim J, Kim JH, Chun KJ Tags: J Korean Med Sci Source Type: research

Gastroplasty for esophageal perforation after endoscopic balloon dilatation for achalasia: two cases.
Abstract Esophageal perforation after endoscopic forceful pneumatic dilatation for achalasia is a devastating complication and surgical treatment is necessary. A 65-yr-old man and a 54-yr-old woman referred for esophageal perforation two hours after pneumatic dilatation and during the procedure, respectively. Gastroplasties through thoracotomy were performed in both cases and their recoveries were uneventful. The esophagogram with gastrografin on the post-operative 8th day did not show any passage disturbance or leakage at the anastomosis site. On the follow-up endoscopy 4 to 6 months after operation revealed that...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kim H Tags: J Korean Med Sci Source Type: research

Methylenetetrahydrofolate reductase 677 genotype-specific reference values for plasma homocysteine and serum folate concentrations in korean population aged 45 to 74 years: the namwon study.
Abstract The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in pre...
Source: J Korean Med Sci - May 1, 2014 Category: Journals (General) Authors: Kweon SS, Lee YH, Jeong SK, Nam HS, Park KS, Choi SW, Kim BH, Kim HN, Choi JS, Shin MH Tags: J Korean Med Sci Source Type: research

National academy of medicine of Korea celebrates its 10th anniversary.
PMID: 24753691 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Chi JG Tags: J Korean Med Sci Source Type: research

Clinical Application of Adipose Stem Cells in Plastic Surgery.
Abstract Adipose stem cells (ASCs) are a type of adult stem cells that share common characteristics with typical mesenchymal stem cells. In the last decade, ASCs have been shown to be a useful cell resource for tissue regeneration. The major role of regenerative medicine in this century is based on cell therapy in which ASCs hold a key position. Active research on this new type of adult stem cell has been ongoing and these cells now have several clinical applications, including fat grafting, overcoming wound healing difficulties, recovery from local tissue ischemia, and scar remodeling. The application of cultured...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Kim YJ, Jeong JH Tags: J Korean Med Sci Source Type: research

Evidence-Based, Pharmacological Treatment Guideline for Depression in Korea, Revised Edition.
Abstract This paper aims to introduce, summarize, and emphasize the importance of the 'Evidence-Based, Pharmacological Treatment Guideline for Depression in Korea, Revised Edition'. The guideline broadly covers most aspects of the pharmacological treatment of patients in Korea diagnosed with moderate to severe major depression according to the DSM-IV TR. The guideline establishment process involved determining and answering a number of key questions, searching and selecting publications, evaluating recommendations, preparing guideline drafts, undergoing external expert reviews, and obtaining approval. A guideline ...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Won E, Park SC, Han KM, Sung SH, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS Tags: J Korean Med Sci Source Type: research

The Association between Influenza Treatment and Hospitalization-Associated Outcomes among Korean Children with Laboratory-Confirmed Influenza.
Abstract There are limited data evaluating the relationship between influenza treatment and hospitalization duration. Our purpose assessed the association between different treatments and hospital stay among Korean pediatric influenza patients. Total 770 children ≤ 15 yr-of-age hospitalized with community-acquired laboratory-confirmed influenza at three large urban tertiary care hospitals were identified through a retrospective medical chart review. Demographic, clinical, and cost data were extracted and a multivariable linear regression model was used to assess the associations between influenza treatment type...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Lim JK, Kim TH, Kilgore PE, Aiello AE, Choi BM, Lee KC, Yoo KH, Song YH, Kim YK Tags: J Korean Med Sci Source Type: research

Safety and Immunogenicity Assessment of an Oral Cholera Vaccine through Phase I Clinical Trial in Korea.
Abstract The safety, tolerability and immunogenicity of an oral cholera vaccine (OCV) was assessed in adult Korean male through an open-label, non-comparative clinical study. Two doses of vaccine with an interval of 2 weeks were given to 20 healthy subjects. A total of 7 adverse events occurred in 6 subjects. However, no clinically significant change was observed in electrocardiograms, vital signs, physical examinations, and clinical laboratory tests. The immunogenicity of OCV was evaluated by serum vibriocidal assay where anti-Vibrio cholerae O1 and O139 antibodies were measured at day 0, 14, and 28 of vaccine ad...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Baik YO, Choi SK, Kim JW, Yang JS, Kim IY, Kim CW, Hong JH Tags: J Korean Med Sci Source Type: research

Digital Thermography of the Fingers and Toes in Raynaud's Phenomenon.
Abstract The aim of this study was to determine whether skin temperature measurement by digital thermography on hands and feet is useful for diagnosis of Raynaud's phenomenon (RP). Fifty-seven patients with RP (primary RP, n = 33; secondary RP, n = 24) and 146 healthy volunteers were recruited. After acclimation to room temperature for 30 min, thermal imaging of palmar aspect of hands and dorsal aspect of feet were taken. Temperature differences between palm (center) and the coolest finger and temperature differences between foot dorsum (center) and first toe significantly differed between patients and controls. T...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Lim MJ, Kwon SR, Jung KH, Joo K, Park SG, Park W Tags: J Korean Med Sci Source Type: research

Prognostic significance of initial platelet counts and fibrinogen level in advanced non-small cell lung cancer.
This study aimed to investigate the prevalence and prognostic significance of thrombocytosis and elevated fibrinogen levels in patients with advanced non-small cell lung cancer (NSCLC). Initial platelet counts and fibrinogen levels were reviewed in 854 patients with histologically proven NSCLC. Thrombocytosis was defined as platelet counts> 450 × 10(9)/L. A serum fibrinogen level> 4.5 g/L was considered high. At the time of diagnosis, initial platelet counts and serum fibrinogen levels were evaluated before treatment. Clinicopathologic data including histological type, tumor, node, metastasis (TNM) stage, perfo...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Kim KH, Park TY, Lee JY, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK, Yang SC Tags: J Korean Med Sci Source Type: research

The effect of preceding biopsy on complete endoscopic resection in rectal carcinoid tumor.
The objective of the study was to investigate the effect of preceding biopsy on complete endoscopic resection in rectal carcinoid tumor. It was also determined if rectal carcinoid tumors can be macroscopically distinguished by endoscopy. We reviewed retrospectively the records of patients with rectal carcinoid tumor who had undergone an endoscopic treatment at our hospital, during a 7-yr period. The resection margin was clear in 57 of 98 cases. The preceding biopsy was taken in 57 cases and the biopsy was significantly associated with the risk of incomplete tumor resection (OR, 3.696; 95% CI, 1.528-8.938, P = 0.004). In 95...
Source: J Korean Med Sci - April 1, 2014 Category: Journals (General) Authors: Lee SP, Sung IK, Kim JH, Lee SY, Park HS, Shim CS Tags: J Korean Med Sci Source Type: research