Urinary sodium excretion has positive correlation with activation of urinary Renin Angiotensin system and reactive oxygen species in hypertensive chronic kidney disease.
Abstract It is not well described the pathophysiology of renal injuries caused by a high salt intake in humans. The authors analyzed the relationship between the 24-hr urine sodium-to-creatinine ratio (24HUna/cr) and renal injury parameters such as urine angiotensinogen (uAGT/cr), monocyte chemoattractant peptide-1 (uMCP1/cr), and malondialdehyde-to-creatinine ratio (uMDA/cr) by using the data derived from 226 hypertensive chronic kidney disease patients. At baseline, the 24HUna/cr group or levels had a positive correlation with uAGT/cr and uMDA/cr adjusted for related factors (P
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Ahn SY, Kim S, Kim DK, Park JH, Shin SJ, Lee SH, Choi BS, Lim CS, Kim S, Chin HJ Tags: J Korean Med Sci Source Type: research

Estimated amount of 24-hour urine sodium excretion is positively correlated with stomach and breast cancer prevalence in Korea.
Abstract Stomach cancer is one of the most common cancers in Korea. The aim of this study was to identify the association between the prevalence of cancer, particularly stomach cancer, and the amount of 24-hr urine sodium excretion estimated from spot urine specimens. The study included 19,083 subjects who took part in the Korean National Health and Nutritional Examination Survey between 2009 and 2011. The total amount of urine sodium excreted in a 24-hr period was estimated by using two equations based on the values for spot urine sodium and creatinine. In subjects who had an estimated 24-hr urine sodium excretio...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Park JH, Kim YC, Koo HS, Oh SW, Kim S, Chin HJ Tags: J Korean Med Sci Source Type: research

Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-κB Inhibition in Human Renal Proximal Tubular Epithelial Cells.
Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-κB Inhibition in Human Renal Proximal Tubular Epithelial Cells. J Korean Med Sci. 2014 Sep;29 Suppl 2:S139-45 Authors: Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY Abstract We evaluated the effect of cobalt chloride (CoCl2) on TNF-α and IFN-γ-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2 before the administration of TNF-α/IFN-γ. To regulate hemeoxygenase-1 (HO-1) expression, the cells were treated CoCl2 or HO-1 ...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY Tags: J Korean Med Sci Source Type: research

Bilirubin Activates Transcription of HIF-1α in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content.
Bilirubin Activates Transcription of HIF-1α in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content. J Korean Med Sci. 2014 Sep;29 Suppl 2:S146-54 Authors: Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ Abstract The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue. The human kidney (HK2) cells were cultured in 5%...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ Tags: J Korean Med Sci Source Type: research

Effect of bilirubin on triglyceride synthesis in streptozotocin-induced diabetic nephropathy.
In conclusion, bilirubin attenuates renal dysfunction and dyslipidemia in diabetes by suppressing LXRα and SREBP-1 expression and oxidative stress. PMID: 25317020 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Xu J, Lee ES, Baek SH, Ahn SY, Kim S, Na KY, Chae DW, Chin HJ Tags: J Korean Med Sci Source Type: research

EDITOR'S NOTE - About This Supplement.
PMID: 25317021 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Hong ST Tags: J Korean Med Sci Source Type: research

Estimation of Daily Salt Intake through a 24-Hour Urine Collection in Pohang, Korea.
Abstract There is an established relationship between a high salt diet and public health problems, especially hypertension and cardiovascular disease. We estimated daily salt intake in a group of adults and assessed its association with related variables in Pohang, Korea. We conducted a cross-sectional survey in 2013 with 242 adults. Urine was collected for 24 hr to estimate daily salt intake, and questionnaires about salt preference were administered. The mean daily salt intake was 9.9±4.6 g. There was no difference in salt intake between high systolic blood pressure (SBP) participants and normal SBP parti...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim YC, Koo HS, Kim S, Chin HJ Tags: J Korean Med Sci Source Type: research

Not salt taste perception but self-reported salt eating habit predicts actual salt intake.
In conclusion, a self-reported salt-eating habit, not salt taste threshold predicts actual salt intake. PMID: 25317023 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Lee H, Cho HJ, Bae E, Kim YC, Kim S, Chin HJ Tags: J Korean Med Sci Source Type: research

Estimating 24-hour urine sodium level with spot urine sodium and creatinine.
Abstract The 24-hr urine sodium excretion level was estimated based on the spot urine sodium, and the efficacy of the formula was validated to determine the status of low salt intake
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Koo HS, Kim YC, Ahn SY, Oh SW, Kim S, Chin HJ, Park JH Tags: J Korean Med Sci Source Type: research

Preparedness for prevention of ebola virus disease.
PMID: 25246733 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Hwang ES Tags: J Korean Med Sci Source Type: research

The implications of social rejection and peer victimization: beyond social phenomenon.
PMID: 25246734 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Yoo HJ Tags: J Korean Med Sci Source Type: research

2,3,7,8-tetrachlorodibenzo-p-dioxin induced cell-specific drug transporters with acquired Cisplatin resistance in Cisplatin sensitive cancer cells.
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug transporters induction from cancer cells of various origins. Cell viabilities after treatment of cisplatin were measured to evaluate acquiring cisplatin resistance by TCDD. Acquring cisplatin resistance was found only in cisplatin senstivie cancer cells including gastric SNU601, colon LS180, brain CRT-MG and lymphoma Jurkat cells which showed a significant increase in cell viabili...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Gotovdorj T, Lee E, Lim Y, Cha EJ, Kwon D, Hong E, Kim Y, Oh MY Tags: J Korean Med Sci Source Type: research

Usefulness of serum leucine-rich alpha-2 glycoprotein as a disease activity biomarker in patients with rheumatoid arthritis.
Abstract Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8±14...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Ha YJ, Kang EJ, Lee SW, Lee SK, Park YB, Song JS, Choi ST Tags: J Korean Med Sci Source Type: research

Drug survival rates of tumor necrosis factor inhibitors in patients with rheumatoid arthritis and ankylosing spondylitis.
Abstract We investigated the compliance of Korean patients using tumor necrosis factor (TNF) inhibitors to treat rheumatoid arthritis (RA) and ankylosing spondylitis (AS), and identified potential predictors associated with treatment discontinuation. The study population comprised 114 RA and 310 AS patients treated with TNF inhibitors at a single tertiary center for at least 1 yr from December 2002 to November 2011. Of the 114 RA patients, 64 (56.1%) discontinued their first TNF inhibitors with a mean duration of 18.1 months. By contrast, 65 of 310 patients (21.0%) with AS discontinued their first TNF inhibitors, ...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kang JH, Park DJ, Lee JW, Lee KE, Wen L, Kim TJ, Park YW, Lee SS Tags: J Korean Med Sci Source Type: research

Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy.
Abstract The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score in our institution and compare the result with the preoperative progression predictor, CAPRA score. Data of 130 patients were reviewed who underwent radical prostatectomy for localized prostate cancer from 2008 to 2013. Performance of CAPRA-S score in predicting progression free probabilities was assessed throu...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Seo WI, Kang PM, Kang DI, Yoon JH, Kim W, Chung JI Tags: J Korean Med Sci Source Type: research

Benefits of a continuous ambulatory peritoneal dialysis (CAPD) technique with one icodextrin-containing and two biocompatible glucose-containing dialysates for preservation of residual renal function and biocompatibility in incident CAPD patients.
Abstract In a prospective randomized controlled study, the efficacy and safety of a continuous ambulatory peritoneal dialysis (CAPD) technique has been evaluated using one icodextrin-containing and two glucose-containing dialysates a day. Eighty incident CAPD patients were randomized to two groups; GLU group continuously using four glucose-containing dialysates (n=39) and ICO group using one icodextrin-containing and two glucose-containing dialysates (n=41). Variables related to residual renal function (RRF), metabolic and fluid control, dialysis adequacy, and dialysate effluent cancer antigen 125 (CA125) and inte...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Yoon HE, Chang YK, Shin SJ, Choi BS, Kim BS, Park CW, Song HC, Yoon SA, Jin DC, Kim YS Tags: J Korean Med Sci Source Type: research

Risk Factors for Death during Pulmonary Tuberculosis Treatment in Korea: A Multicenter Retrospective Cohort Study.
Abstract The data regarding risk factors for death during tuberculosis (TB) treatment are inconsistent, and few studies examined this issue in Korea. The purpose of this study was to evaluate baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients who received TB treatment at eight hospitals from January 2009 to December 2010 was performed. Successful treatment included cure (1,129, 45.5%) and treatment completion (1,204, 48.5%) in 2,333 patients (94.0%). Unsuccessful treatment included death (85, 3.4%) and trea...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kwon YS, Kim YH, Song JU, Jeon K, Song J, Ryu YJ, Choi JC, Kim HC, Koh WJ Tags: J Korean Med Sci Source Type: research

Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study.
In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis. PMID: 25246741 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Park S, Lee SH, Seo KH, Shin KC, Park YB, Lee MG, Yoo KH, Kim HJ, Park JS, Cho JH, Ko Y, Lee SK, Cheon KT, Kim do I, Ha JW, Lee JM, Suhr JW, Jeong EH, Jung KS Tags: J Korean Med Sci Source Type: research

Clarithromycin-Based Standard Triple Therapy Can Still Be Effective for Helicobacter pylori Eradication in Some Parts of the Korea.
Abstract We evaluated the antibiotic resistance rates and eradication rates of clarithromycin based triple therapy from 2005 to 2010 retrospectively. In addition, we investigated the mechanism of clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients. Two hundred and twelve strains of H. pylori were isolated from 204 patients. H. pylori ATCC 43504 was used as the standard strain. The eradication rates of H. pylori from 2005 to 2010 were 89.3%, 82.6%, 86.3%, 87.7%, 81.8%, and 84.2%, respectively. Total eradication rate was 84.9%. DNA sequences of the 23S RNA gene in clarithromycin-re...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Yoon KH, Park SW, Lee SW, Kim BJ, Kim JG Tags: J Korean Med Sci Source Type: research

Shifting prevalence of gallbladder polyps in Korea.
In conclusion, GBP prevalence is increasing and risk factors for GBP have changed in Korea. More attention should be paid to this issue in the future. PMID: 25246743 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Lee YJ, Park KS, Cho KB, Kim ES, Jang BK, Chung WJ, Hwang JS Tags: J Korean Med Sci Source Type: research

Sarcopenia as a useful predictor for long-term mortality in cirrhotic patients with ascites.
This study aimed to assess and compare sarcopenia with other prognostic factors for predicting long-term mortality in cirrhotic patients with ascites. Clinical data of 65 among 89 patients with measurement of all parameters were consecutively collected. Sarcopenia was evaluated as right psoas muscle thickness measurement divided by height (PMTH) (mm/m). During a mean follow-up of 20 (range: 1-49) months, 19 (29.2%) of 65 patients died. The values of the area under the receiver operating characteristics curve (AUROC) of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD-Na, and PMTH for predicting 1-yr m...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim TY, Kim MY, Sohn JH, Kim SM, Ryu JA, Lim S, Kim Y Tags: J Korean Med Sci Source Type: research

Results of Surgical Treatment on Benign Anal Diseases in Korean HIV-Positive Patients.
This study aimed to evaluate the outcomes of these surgical procedures in Korean patients, focusing on wound healing and postoperative complications. Retrospective analysis was performed on 72 HIV-positive patients who underwent surgery by a single surgeon for benign anal disease between 1998 and 2011. Of these, 68.1% (49/72) of patients received surgery for condyloma acuminata, 19.4% (14/72) for anal fistulas, 6.9% (5/72) for hemorrhoids, and 5.6% (4/72) for perianal abscesses. Patients with condyloma acuminata received surgical excision with electrical coagulation, and all wounds healed completely within 3 months, though...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Oh HK, Moon SH, Ryoo S, Choe EK, Park KJ Tags: J Korean Med Sci Source Type: research

Anti-müllerian hormone levels in the follicular fluid of the preovulatory follicle: a predictor for oocyte fertilization and quality of embryo.
Anti-müllerian hormone levels in the follicular fluid of the preovulatory follicle: a predictor for oocyte fertilization and quality of embryo. J Korean Med Sci. 2014 Sep;29(9):1266-70 Authors: Kim JH, Lee JR, Chang HJ, Jee BC, Suh CS, Kim SH Abstract This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was collected from the largest preovulatory follicle sized≥20 mm of mean diameter from each ovary. Sample...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim JH, Lee JR, Chang HJ, Jee BC, Suh CS, Kim SH Tags: J Korean Med Sci Source Type: research

A prospective korean multicenter study for infectious complications in patients undergoing prostate surgery: risk factors and efficacy of antibiotic prophylaxis.
Abstract This multicenter study was undertaken to determine the efficacy of antibiotic prophylaxis and identify the risk factors for infectious complications after prostate surgery in Korean patients. A total of 424 patients who underwent surgery of the prostate were reviewed. All patients underwent urinalysis and urine culture preoperatively and postoperatively. Efficacy of antibiotic prophylaxis and risk factors for infectious complications were investigated. Infectious complications were observed in 34.9% of all patients. Factors independently associated with infectious complications were diabetes mellitus (adj...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Hwang EC, Jung SI, Kwon DD, Lee G, Bae JH, Na YG, Min SK, Son H, Lee SJ, Chung JM, Chung H, Cho IR, Kim YH, Kim TH, Chang IH Tags: J Korean Med Sci Source Type: research

Influence of propofol and fentanyl on deep brain stimulation of the subthalamic nucleus.
In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients. PMID: 25246748 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim W, Song IH, Lim YH, Kim MR, Kim YE, Hwang JH, Kim IK, Song SW, Kim JW, Lee WW, Kim HJ, Kim C, Kim HC, Kim IY, Park HP, Kim DG, Jeon BS, Paek SH Tags: J Korean Med Sci Source Type: research

Relationship between Socioeconomic Position and Suicide Attempts among the Korean Adolescents.
In conclusion, the relationship of subjective SEP is important in suicide attempts as much as objective SEP and far more important in the high school students. PMID: 25246749 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Ko MJ, Lee EY, Kim K Tags: J Korean Med Sci Source Type: research

Neural changes associated with emotion processing in children experiencing peer rejection: a functional MRI study.
This study was performed to investigate differences between children who did and did not experience peer rejection in psychological state through surveys and in emotion processing during an interpersonal stress challenge task to reflect naturalistic interpersonal face-to-face relationships. A total of 20 right-handed children, 10 to 12 yr of age, completed self-rating questionnaires inquiring about peer rejection in school, depression, and anxiety. They then underwent an interpersonal stress challenge task simulating conditions of emotional stress, in reaction to positive, negative and neutral facial expression stimuli, us...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Lee HS, Lee JE, Lee KU, Kim YH Tags: J Korean Med Sci Source Type: research

Survival and Neurologic Outcomes of Out-of-Hospital Cardiac Arrest Patients Who Were Transferred after Return of Spontaneous Circulation for Integrated Post-Cardiac Arrest Syndrome Care: The Another Feasibility of the Cardiac Arrest Center.
Abstract It has been proven that safety and efficiency of out-of-hospital cardiac arrest (OHCA) patients is transported to specialized hospitals that have the capability of performing therapeutic hypothermia (TH). However, the outcome of the patients who have been transferred after return of spontaneous circulation (ROSC) has not been well evaluated. We conducted a retrospective observational study between January 2010 to March 2012. There were primary outcomes as good neurofunctional status at 1 month and the secondary outcomes as the survivals at 1 month between Samsung Medical Center (SMC) group and transferred...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kang MJ, Lee TR, Shin TG, Sim MS, Jo IJ, Song KJ, Jeong YK Tags: J Korean Med Sci Source Type: research

Diagnostic imaging utilization in cases of acute appendicitis: multi-center experience.
Abstract The purpose of this cross-sectional study was to measure imaging utilization rates and the negative appendectomy rate (NAR) in metropolitan Seoul, Korea. The study included 2321 adolescents and adults (≥15 yr; median [interquartile range] age, 37 [27-50] yr; 46.7% female) undergoing appendectomy in 2011 at eight tertiary and three secondary hospitals. Imaging utilization rate was 99.7% (95% confidence interval, 99.4%-99.9%). CT and ultrasonography utilization rates as an initial imaging modality were 93.1% (92.0%-94.1%), and 6.5% (5.6%-7.6%), respectively. The NAR in patients undergoing CT only, comple...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Park JH, LOCAT Group Tags: J Korean Med Sci Source Type: research

Extremely Elevated International Normalized Ratio of Warfarin in a Patient with CYP2C9(*)1/(*)3 and Thyrotoxicosis.
Abstract A 73-yr-old Korean man with permanent atrial fibrillation visited outpatient clinic with severely increased International Normalized Ratio (INR) values after taking a usual starting dosage of warfarin to prevent thromboembolism. We found out later from his blood tests that he had hyperthyroidism at the time of treatment initiation. His genetic analysis showed CYP2C9(*)1/(*)3 and VKORC1+1173TT genotypes. We suspect that both hyperthyroidism and genetic variant would have contributed to his extremely increased INR at the beginning of warfarin therapy. From this case, we learned that pharmacogenetic and thyr...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Lee JE, Ryu DH, Jeong HJ, Kim JH, Jun JE, Kim JS, Lee SY Tags: J Korean Med Sci Source Type: research

A case of mental retardation with paraphilia treated with depot leuprorelin.
Abstract Paraphilia is a psychiatric disease that has been difficult to cure. However, recently developed therapeutic methods hold promise. The patient was a 20-yr-old male with chief complaints of continuous masturbation, genital exposure, and aggressive behavior that started 2 yr ago. We administered leuprorelin 3.6 mg intramuscular injection per month, a depot gonadotrophin-releasing hormone analogue, to this patient who a severe mentally retardation with paraphilia. The clinical global impression (CGI)-severity, CGI-improvement and aberrant behavior checklist were performed. After one month, we observed signif...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Park WS, Kim KM, Jung YW, Lim MH Tags: J Korean Med Sci Source Type: research

Seroprevalence of Respiratory Syncytial Virus IgG among Healthy Young Adults in Basic Training for the Republic of Korea Air Force.
Abstract This investigation enrolled 570 healthy young males gathered from all over the country for military service at the Republic of Korea Air Force boot camp. It confirmed RSV IgG seroprevalence by utilizing the enzyme immunoassay method just prior to undergoing basic training. The mean age of this study was 20.25±1.34 yr old. The results of their immunoassay seroprofiles showed that 561 men (98.4%) were positive, 2 (0.4%) were negative and 7 (1.2%) were equivocal belonging to the grey zone. It was confirmed that RSV is a common respiratory virus and RSV infection was encountered by almost all people be...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Park WJ Tags: J Korean Med Sci Source Type: research

The Relationship between Homocysteine and Uric Acid Levels in Gouty Patients.
PMID: 25246756 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Agilli M, Aydin FN, Cayci T, Kurt YG Tags: J Korean Med Sci Source Type: research

Unfounded reports on thyroid cancer.
PMID: 25120309 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Chung JH Tags: J Korean Med Sci Source Type: research

Ten Tips for Authors of Scientific Articles.
g a good quality scientific article takes experience and skill. I propose 'Ten Tips' that may help to improve the quality of manuscripts for scholarly journals. It is advisable to draft first version of manuscript and revise it repeatedly for consistency and accuracy of the writing. During the drafting and revising the following tips can be considered: 1) focus on design to have proper content, conclusion, points compliant with scope of the target journal, appropriate authors and contributors list, and relevant references from widely visible sources; 2) format the manuscript in accordance with instructions to authors of th...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Authors of Scientific Articles. Tags: J Korean Med Sci Source Type: research

Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes.
Abstract The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease,...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Lee MS Tags: J Korean Med Sci Source Type: research

Withaferin A-Caused Production of Intracellular Reactive Oxygen Species Modulates Apoptosis via PI3K/Akt and JNKinase in Rabbit Articular Chondrocytes.
Abstract Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment of osteoarthritis (OA) and has a wide range of biochemical and pharmacologic activities, there are no findings suggesting its properties on chondrocytes or cartilage. The aim of the present study is to investigate the effects of WFA on apoptosis with focus on generation of intracellular reactive oxygen species (ROS). Here we showed that WFA significantly increased the generation of intracellular ROS in a dose-dependent manner....
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Yu SM, Kim SJ Tags: J Korean Med Sci Source Type: research

Clinicopathological Features of Rare BRAF Mutations in Korean Thyroid Cancer Patients.
Abstract The most common BRAF mutation in thyroid cancer is c.1799T>A (p.Val600Glu), and other BRAF mutations are rarely reported. We investigated the clinicopathological features of thyroid cancer with rare BRAF mutations. A total of 2,763 patients with thyroid cancer underwent molecular testing by direct DNA sequencing for mutations in BRAF exon 15. Among them, 2,110 (76.4%) had BRAF mutations. The c.1799T>A mutation was found in 2,093 (76.9%) of 2,722 papillary carcinomas and in one of 7 medullary carcinomas. Sixteen cases (0.76%) harbored rare mutation types. Five cases had single-nucleotide substitution...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Cho U, Oh WJ, Bae JS, Lee S, Lee YS, Park GS, Lee YS, Jung CK Tags: J Korean Med Sci Source Type: research

Influenza Vaccination and Associated Factors among Korean Cancer Survivors : A Cross-Sectional Analysis of the Fourth & Fifth Korea National Health and Nutrition Examination Surveys.
This study was designed to assess influenza vaccination patterns among Korean cancer survivors. In this cross-sectional analysis, data were obtained from standardized questionnaires from 943 cancer survivors and 41,233 non-cancer survivors who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (2007-2011). We identified the adjusted influenza vaccination rates and assessed factors associated with influenza vaccination using multivariate logistic regression. Cancer survivors tended to have a higher adjusted influenza vaccination rate than the general population. The rates for influe...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Choi KH, Park SM, Lee K, Lee JH, Park JS Tags: J Korean Med Sci Source Type: research

Sirolimus conversion efficacy for graft function improvement and histopathology in renal recipients with mild to moderate renal insufficiency.
This study was designed to evaluate whether sirolimus (SRL) conversion effectively improves renal function and histopathology in calcineurin inhibitor (CNI)-treated renal recipients with mild to moderate renal insufficiency. SRL conversion from CNI was performed in patients who underwent kidney transplantation from 6 months to 5 yr prior to screening. Forty-five patients were enrolled. The effect of SRL conversion on graft function was evaluated, and protocol biopsies were performed preconversion and 1 yr after conversion. Overall graft function after SRL conversion gradually improved, and the improvement in renal function...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Joo DJ, Yang CW, Jeong HJ, Lim BJ, Huh KH, Chung BH, Choi YJ, Kang SW, Kim YS Tags: J Korean Med Sci Source Type: research

Four-week effects of allopurinol and febuxostat treatments on blood pressure and serum creatinine level in gouty men.
Abstract The aim of this study was to observe the effects of uric acid lowering therapy (UALT), febuxostat and allopurinol, on blood pressure (BP) and serum creatinine level. Post-hoc data were derived from a phase-III, randomised, double-blind, 4-week trial of male gouty patients that compared the safety and efficacy of febuxostat and allopurinol in adults with gout. The subjects were randomly assigned to one of five groups, 35-37 in each group (febuxostat: 40, 80, 120 mg/d; allopurinol: 300 mg/d; control group: placebo). Blood pressure and serum creatinine level were measured at baseline and at weeks 2 and 4. Di...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kim HA, Seo YI, Song YW Tags: J Korean Med Sci Source Type: research

The Risk of Osteoporotic Fractures According to the FRAX Model in Korean Patients with Rheumatoid Arthritis.
Abstract The aim of the current study is to identify patients without osteoporosis who met the criteria of the fracture risk assessment tool (FRAX) of the National Osteoporosis Foundation (NOF) only. The incidence of fractures was investigated in patients who met only the FRAX criteria of the NOF and patients who presented osteoporosis. Five hundred and forty five patients with rheumatoid arthritis who visited a single center were recruited in Korea. In the follow-up period of median 30 months, the new onset of fractures was investigated. Of 223 patients who have no osteoporosis, 39 (17.4%) satisfied the FRAX crit...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Lee JH, Suh YS, Koh JH, Jung SM, Lee JJ, Kwok SK, Ju JH, Park KS, Park SH Tags: J Korean Med Sci Source Type: research

Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection.
Abstract We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNFα). The study participants (n=127) had a negative IGRA screening before receiving anti-TNFα and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNFα, including type and treatment duration. The ...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Son CN, Jun JB, Kim JH, Sung IH, Yoo DH, Kim TH Tags: J Korean Med Sci Source Type: research

Impact of multimodality approach for patients with leptomeningeal metastases from solid tumors.
Abstract The purpose of this study was to evaluate treatment patterns, outcome and prognosticators for patients with leptomeningeal metastases from solid tumor. Medical records of 80 patients from January 1, 2004 to May 31, 2011 were retrospectively reviewed. Most frequent site of origin was the lung (59%) followed by the breast (25%). Most patients were treated with intrathecal chemotherapy (90%) and/or whole brain radiotherapy (67.5%). Systemic therapy was offered to 27 patients (33.8%). Percentage of patients treated with single, dual, and triple modality were 32.5%, 43.8%, and 23.8%, respectively. Median survi...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kwon J, Chie EK, Kim K, Kim HJ, Wu HG, Kim IH, Oh DY, Lee SH, Kim DW, Im SA, Kim TY, Heo DS, Bang YJ, Ha SW Tags: J Korean Med Sci Source Type: research

Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease.
Abstract Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac cathete...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Hwang YJ, Hyun MC, Choi BS, Chun SY, Cho MH Tags: J Korean Med Sci Source Type: research

Comparison of Korean COPD Guideline and GOLD Initiative Report in Term of Acute Exacerbation: A Validation Study for Korean COPD Guideline.
Abstract The purpose of this study was to compare the Korean COPD guideline to GOLD consensus report in terms of acute exacerbation. A total of 361 patients were enrolled in this study, and 16.9% of them experienced acute exacerbation during the follow-up. A total of 6.3% of patients in GOLD A, 9.5% in GOLD B, 7.7% in GOLD C and 17.0% of GOLD D experienced exacerbation during the first year of follow-up, respectively (P=0.09). There was no one who experienced exacerbation during the first year of follow-up in the Korean group 'ga'. The 12-month exacerbation rates of Korean group 'na' and 'da' were 4.5% and 16.0%, respectively (P
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Hwang YI, Park YB, Oh YM, Lee JH, Kim TH, Yoo KH, Yoon HK, Rhee CK, Kim DK, Shin KC, Lee SY, Jung KS Tags: J Korean Med Sci Source Type: research

Relationship of liver stiffness and controlled attenuation parameter measured by transient elastography with diabetes mellitus in patients with chronic liver disease.
Abstract High prevalence of diabetes mellitus in patients with liver cirrhosis has been reported in many studies. The aim of our study was to evaluate the relationship of hepatic fibrosis and steatosis assessed by transient elastography with diabetes in patients with chronic liver disease. The study population consisted of 979 chronic liver disease patients. Liver fibrosis and steatosis were assessed by liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) on transient elastography. Diabetes was diagnosed in 165 (16.9%) of 979 patients. The prevalence of diabetes had significant difference a...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Ahn JM, Paik YH, Kim SH, Lee JH, Cho JY, Sohn W, Gwak GY, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC Tags: J Korean Med Sci Source Type: research

KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty.
This study was aimed to identify KISS1 gene variations and to investigate the associations between KISS1 gene variations and CPP in Korean girls. All coding exons of KISS1 gene were sequenced in Korean girls with CPP (n = 143) and their healthy controls (n = 101). Nine polymorphisms were identified in KISS1 gene. A novel single-nucleotide polymorphism (SNP), 55648176 T/G, was identified for the first time. SNP 55648184 C/G and 55648186 -/T were detected more frequently in CPP group than in control group. SNP 55648176 T/G was detected less frequently in CPP group than in control group. Haplotype GGGC-ACCC was detected less ...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Rhie YJ, Lee KH, Ko JM, Lee WJ, Kim JH, Kim HS Tags: J Korean Med Sci Source Type: research

Early Prophylactic versus Late Selective Use of Surfactant for Respiratory Distress Syndrome in Very Preterm Infants: A Collaborative Study of 53 Multi-Center Trials in Korea.
Abstract Pulmonary surfactant (PS) therapy was proven to be highly successful for the treatment of respiratory distress syndrome in premature infants. As a results, early prophylactic (EP) PS therapy has been introduced recently in Europe, the US and Korea. However, no multi-center study was compared EP and late selective (LS) PS therapies in Korea. We performed a retrospective multi-center study to compare the outcomes of EP and LS PS therapies in very preterm infants. We analyzed clinical morbidity and mortality for 1,291 infants in 2010 (LS group) and 1,249 infants in 2011 (EP group); the infants were born
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kim SM, Park YJ, Chung SH, Choi YS, Kim CH, Bae CW Tags: J Korean Med Sci Source Type: research

Effect of renal insufficiency on stone recurrence in patients with urolithiasis.
In conclusion, GFR correlates positively with urinary excretion of stone-forming constituents in SF. This finding implies that renal insufficiency is not a risk factor for stone recurrence. PMID: 25120325 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kang HW, Seo SP, Kim WT, Kim YJ, Yun SJ, Lee SC, Kim WJ Tags: J Korean Med Sci Source Type: research