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On Improving Donor Lung Usage Rate for Transplantation.
Authors: Park SI, Choi S PMID: 29115066 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Area-level Socioeconomic Deprivation Affect Individual Cancer Mortality in Korea.
Authors: Nam HS PMID: 29115067 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Hip Fracture in Chronic Kidney Disease Patients: Necessity of Multidisciplinary Approach.
Authors: Yoon BH, Koo KH PMID: 29115068 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Editorial Abuses.
Authors: Rivera H PMID: 29115069 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Legislative Issues in Disclosing Financial Conflicts of Interest to Participants in Biomedical Research: Effectiveness and Methodology.
Authors: Kim JS Abstract This research focuses on the analysis regarding disclosure of financial conflicts of interest (FCOI) after Gelsinger v. University of Pennsylvania (Penn). The main legal issue was that the participants did not have enough opportunity to make an autonomous decision about participating in the research because he was not informed about the researchers' and the institution's substantial FCOI. The disclosure system was adopted by the Code of Federal Regulations. Under the regulation, researchers and institutions need to report FCOI over $5,000 to the institution, and the internal review boards h...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

An Acute Medical Unit in a Korean Tertiary Care Hospital Reduces the Length of Stay and Waiting Time in the Emergency Department.
Authors: Ohn JH, Kim NH, Kim ES, Baek SH, Lim Y, Hur J, Lee YJ, Kim ES, Jang HC Abstract A hospitalist-run acute medical unit (AMU) opened at a tertiary care hospital on August 2015 for the first time in Korea. Patients visiting the emergency department (ED) with acute medical problems are admitted to the AMU. They stay in that unit for less than 72 hours and are discharged or transferred to specialty wards if longer treatment is necessary. We reviewed 19,450 medical admissions through the ED from January 2014 to September 2016. The median length of stay (LOS) significantly decreased from 10.0 days (interquartile r...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Emergency Department Visits Can Be Reduced by Having a Regular Doctor for Adults with Diabetes Mellitus: Secondary Analysis of 2013 Korea Health Panel Data.
In conclusion, health care policies that promote having a RD who delivers high-quality primary care could decrease unnecessary ED visits by diabetic adults. This can partly reduce ED overcrowding in Korea. PMID: 29115072 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Assessment of Competence in Emergency Medicine among Healthcare Professionals in Cameroon.
This study aimed to develop competence assessment tools in emergency medicine and use it to assess competence of Cameroonian healthcare professionals. This was a cross-sectional, descriptive study. Through literature review, expert survey, and discrimination tests, we developed a self-survey questionnaire and a scenario-based competence assessment tool for assessing clinical knowledge and self-confidence to perform clinical practices or procedures. The self-survey consisted of 23 domains and 94 questionnaires on a 5-point Likert scale. Objective scenario-based competence assessment tool was used to validate the self-survey...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Adapter-based Safety Injection System for Prevention of Wrong Route and Wrong Patient Medication Errors.
In this study, we suggest a safety injection system that can help to prevent an injection when a mismatch exists between the drug and route or patient. For this, we prepared two distinct adapters with key and keyhole patterns specifically assigned to a pair of drug and route or patient. When connected to a syringe tip and its counterpart, a catheter injection-port, respectively, the adapters allowed for a seamless connection only with their matching patterns. In this study, each of the adapters possessed a specific key and keyhole pattern at one end and the other end was shaped to be a universal fit for syringe tips or cat...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Unobtrusive Estimation of Cardiorespiratory Fitness with Daily Activity in Healthy Young Men.
Authors: Ahn JW, Hwang SH, Yoon C, Lee J, Kim HC, Yoon HJ Abstract Despite the importance of cardiorespiratory fitness, no practical method exists to estimate maximal oxygen consumption (VO₂max) without a specific exercise protocol. We developed an estimation model of VO₂max, using maximal activity energy expenditure (aEEmax) as a new feature to represent the level of physical activity. Electrocardiogram (ECG) and acceleration data were recorded for 4 days in 24 healthy young men, and reference VO₂max levels were measured using the maximal exercise test. aEE was calculated using the measured acceleration data...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Current Status and Future of Lung Donation in Korea.
Authors: Yeo HJ, Yoon SH, Lee SE, Jeon D, Kim YS, Cho WH, Kim DH Abstract Lung transplantation is the only effective treatment option for patients with end-stage lung disease. However, donor organ shortage makes timely transplant not possible for all patients, especially in Korea. We investigated the number and utilization of donor lungs by retrospectively reviewing all donor organs registered in the Korea Network for Organ Sharing database from March 2012 to March 2016. The donors were stratified into 4 groups by donor acceptability criteria. A total of 1,304 donors were included. Of those, 295 brain-dead donors (...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Identification of Epstein-Barr Virus in the Human Placenta and Its Pathologic Characteristics.
In this study, we proved the expression of latent EBV genes in the endometrial glandular epithelial cells of the placenta and investigated the cytological characteristics of these cells. Sixty-eight placentas were obtained from pregnant women. Tissue microarray was constructed. EBV latent genes including EBV-encoding RNA-1 (EBER1), Epstein-Barr virus nuclear antigen 1 (EBNA1), late membrane antigen (LMP1), and RPMS1 were detected with silver in situ hybridization and/or mRNA in situ hybridization. Nuclear features of EBV-positive cells in EBV-infected placenta were compared with those of EBV-negative cells via image analys...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Elderly Patients Exhibit Stronger Inflammatory Responses during Gout Attacks.
Authors: Lee JH, Yang JA, Shin K, Lee GH, Lee WW, Lee EY, Song YW, Lee EB, Park JK Abstract Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Patients in three age groups were compared in terms of presence of fever (> 37.8°C), C-reactive protein (CRP) ...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Disparities by Age, Sex, Tumor Stage, Diagnosis Path, and Area-level Socioeconomic Status in Survival Time for Major Cancers: Results from the Busan Cancer Registry.
Authors: Kwak M, Kim C Abstract Our goal was to examine the effect of area-level deprivation on patient survival time for seven major cancers - stomach, colon, liver, lung, breast, cervix, and thyroid cancer. Data on 10,902 subjects who were diagnosed with major cancers from 2010 and 2011 in Busan were collected regarding the survival time along with several important prognostic factors and an area-level deprivation index was constructed from education, income, unemployment, and welfare assistance, to assess the comprehensive area-level socioeconomic status. A multilevel Cox proportional hazard model was used to in...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prevalences and Management of Diabetes and Pre-diabetes among Korean Teenagers and Young Adults: Results from the Korea National Health and Nutrition Examination Survey 2005-2014.
Authors: Cho EH, Shin D, Cho KH, Hur J Abstract The rapid increases in childhood obesity and physical inactivity are linked to the incidence of diabetes among young individuals. However, few studies have evaluated the prevalence of diabetes among this population. Therefore, we used Korea National Health and Nutrition Examination Survey (KNHANES) data to evaluate the prevalence and management of diabetes and pre-diabetes among young Koreans. We evaluated KNHANES data (2005-2014) from 10-29-year-old individuals. Individuals were considered eligible if they had completed the health examination and the health interview...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Verification of Current Risk Scores for Kawasaki Disease in Korean Children.
Authors: Shin J, Lee H, Eun L Abstract The purpose of this study was to evaluate and assess the compatibility of current risk scoring systems from Japan that were developed to predict intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD). The authors previously investigated another prediction model for patients with refractory KD in Korea. A retrospective study involving 350 patients with KD who were admitted between January 2014 and December 2015 was performed. Patients younger than 2 years were excluded for the propensity score matching in this study. Patients were classified into IV...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Genetic Contributions to Childhood Obesity: Association of Candidate Gene Polymorphisms and Overweight/Obesity in Korean Preschool Children.
This study was aimed to investigate the association of candidate gene polymorphisms and obesity or overweight in young Korean children. A total of 190 Korean preschool children (96 control, 48 overweight, and 46 obese children) were genotyped for the angiotensin converting enzyme (ACE) insertion (I)/deletion (D), angiotensin II type 2 receptor (AT2) C3123A, transforming growth factor (TGF)-β1 T869C, vascular endothelial growth factor (VEGF) T460C, and tumor necrosis factor (TNF)-α G308A polymorphisms. No differences were found among the groups with respect to age, sex, birth weight, blood pressure levels, and se...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Clinical Evaluation of Techniques for Measuring Nasal-Specific Immunoglobulin E in Pediatric Patients.
This study included 82 patients who visited Kyungpook National University Children's Hospital from December 2014 to July 2016 with rhinitis symptoms. Thirty patients used the spray method, and 52 patients used the swab method. We examined nasal-specific IgE to Dermatophagoides farinae, Dermatophagoides pteronyssinus, Alternaria, birch, and weed mix. Thirty patients had nasal-specific IgE concentrations of ≥ 0.35 kIU/L. There was a positive correlation between nasal-specific IgE and serum-specific IgE to D. farinae and D. pteronyssinus (r = 0.548, P
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Cardiac Magnetic Resonance Predictor of Ventricular Function after Surgical Coronary Revascularization.
In conclusion, the number of viable myocardial segments (≥ 14) in preoperative CMR predicted LV function improvement after CABG in patients with LV dysfunction. PMID: 29115084 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prediction of Amnionicity Using the Number of Yolk Sacs in Monochorionic Multifetal Pregnancy.
Authors: Park SY, Chung JH, Han YJ, Lee SW, Kim MY Abstract The purpose of this article was to evaluate the accuracy of predicting amnionicity using the number of yolk sacs by diagnostic ultrasound examination in monochorionic (MC) multifetal pregnancies between 7 + 0 and 9 + 6 gestational weeks. A total of 97 patients with MC multifetal pregnancies underwent early ultrasound examination from 2004 to 2014 at Cheil General Hospital and Women's Healthcare Center. All patients for whom the number of yolk sacs was reported were included in this study. We compared the number of yolk sacs with amnionicity confirmed by an...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Long-Term Survival Analysis of Intraperitoneal versus Intravenous Chemotherapy for Primary Ovarian Cancer and Comparison between Carboplatin- and Cisplatin-based Intraperitoneal Chemotherapy.
Authors: Eoh KJ, Lee JY, Nam EJ, Kim S, Kim YT, Kim SW Abstract In epithelial ovarian cancer (EOC), intraperitoneal (IP) administration of chemotherapy is an effective first-line treatment and may improve outcomes, compared with intravenous (IV) chemotherapy. We used Kaplan-Meier survival analysis to compare long-term survival between propensity score-matched patients with advanced EOC receiving IP (n = 34) vs. IV (n = 68) chemotherapy. Additionally, clinical features associated with carboplatin-based (n = 21) and cisplatin-based (n = 16) IP chemotherapy were analyzed and compared with those associated with IV chem...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study.
Authors: Hwang KR, Choi YM, Kim JJ, Lee SK, Yang KM, Paik EC, Jeong HJ, Jun JK, Yoon SH, Hong MA Abstract The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of MTHFR single nucleotide polymorphisms (SNPs), C677T and A1298C, in Korean patients with recurrent pregnancy loss (RPL). ...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Survivorship and Complications after Hip Fracture Surgery in Patients with Chronic Kidney Disease.
Authors: Suh YS, Won SH, Choi HS, Lee JC, Chun DI, Nho JH, Lee HW, Kim JH Abstract The aim of this study was to investigate survival rate, complications and associated risk factors after hip fracture surgery in patients with chronic kidney disease (CKD) by comparing to non-CKD patients. A total of 119 patients (130 hips, 63 hips CKD group, 67 hips non-CKD) who underwent hip fracture surgery were included. We assessed variables including age, gender, CKD, comorbidities, operation delay and operation time as risk factors for survival and complications after hip fracture surgery. The survival rate was 55.8% at 1-year,...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Poisoning-induced Out-of-Hospital Cardiac Arrest and Outcomes according to Poison Agent.
Authors: Kim M, Shin SD, Jeong S, Kwak YH, Suh GJ Abstract It is unclear whether specific agent groups are associated with outcomes in cases of poisoning-induced out-of-hospital cardiac arrest (P-OHCA). The study population comprised cases of confirmed P-OHCA drawn from the national out-of-hospital cardiac arrest (OHCA) registry (2008-2013). Exposures were categorized into five groups according to the International Classification of Disease, 10th version: group 1, prescribed drugs; group 2, vapors and gases; group 3, pesticides; group 4, alcohol and organic solvents; and group 5, other poisons. The outcome was surv...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Urine Methyl Hippuric Acid Levels in Acute Pesticide Poisoning: Estimation of Ingested Xylene Volume and Association with Clinical Outcome Parameters.
Authors: Choi CY, Cho N, Park SY, Park S, Gil HW, Hong SY Abstract To determine the relationship between the oral ingestion volume of xylene and methyl hippuric acid (MHA) in urine, we measured MHA in 11 patients whose ingested xylene volume was identified. The best-fit equation between urine MHA and ingested amount of xylene was as follows: y (ingested amount of xylene, mL/kg) = -0.052x² + 0.756x (x = MHA in urine in g/g creatinine). From this equation, we estimated the ingested xylene volume in 194 patients who had ingested pesticide of which the formulation was not available. Our results demonstrated that o...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Efficacy of Uncross-Matched Type O Packed Red Blood Cell Transfusion to Traumatic Shock Patients: a Propensity Score Match Study.
Authors: Kang BH, Choi D, Cho J, Kwon J, Huh Y, Moon J, Kim Y, Jung K, Lee JCJ Abstract A new blood bank system was established in our trauma bay, which allowed immediate utilization of uncross-matched type O packed red blood cells (UORBCs). We investigated the efficacy of UORBC compared to that of the ABO type-specific packed red blood cells (ABO RBCs) from before the bank was installed. From March 2016 to February 2017, data from trauma patients who received UORBCs in the trauma bay were compared with those of trauma patients who received ABO RBCs from January 2013 to December 2015. Propensity matching was used t...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Hypocomplementemic Urticarial Vasculitis Syndrome with Membranous Nephropathy: Case Report.
We present the case of a teenage boy with hypocomplementemic urticarial vasculitis syndrome (HUVS) that occurred shortly following swine-origin influenza A virus infection in 2009. Afterwards, HUVS was systemically complicated with myositis and membranous nephropathy that developed several months and about 2 years after its onset, respectively. A combination of glucocorticoid and immunosuppressive agents has been used to effectively control disease activity. PMID: 29115092 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult.
We reported the first case of situs solitus dextrocardia coexisting with persistent left SVC, PA sling and right tracheal bronchus presented with WPW and PSVT in a middle-aged adult. In patients with a cardiovascular anomaly, clinicians should consider thorough evaluation of possibly combined cardiovascular and airway malformations and cardiac dysrhythmia. PMID: 29115093 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The First Successful Lung Transplantation in a Korean Child with Cystic Fibrosis.
We report the case of a 12-year-old girl with respiratory failure due to CF who underwent lung transplantation. She had been diagnosed with CF 8 years previously after being treated for recurrent Pseudomonas aeruginosa pneumonia and malnutrition based on sweat chloride concentrations and the CFTR protein gene mutation test. Progression to end-stage lung disease and respiratory failure led to registration with the Korean Network for Organ Sharing. She underwent successful double lung transplantation in 2014. Although she has diabetes mellitus and chronic kidney disease, she has a better quality of life and a prolonged life ...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Radiologic Findings in Extrapancreatic Solid Pseudopapillary Tumor with Aggressive Behavior: a Case Report.
We report a case of a 61-year-old woman who complained abdominal pain with diffuse tenderness. She was diagnosed with extrapancreatic SPT with extensive peritoneal dissemination and hepatic metastases. Although a few cases have reported imaging findings of extrapancreatic SPT, there have been no reports of extrapancreatic SPT with aggressive tumor behavior and dismal prognosis. Although imaging features closely resembled those of classical pancreatic SPTs, malignant transformation of extrapancreatic SPT should be considered when focal discontinuity of the tumor capsule with ill-defined margin and invasion of adjacent struc...
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Letter to the Editor: Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia.
Authors: Özbek E PMID: 29115096 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 9, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Lactate Parameters Predict Clinical Outcomes in Patients with Nonvariceal Upper Gastrointestinal Bleeding.
Authors: Kwon YH PMID: 28960020 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Myopathy, Drugs, and Mitochondria.
Authors: Kim JM PMID: 28960021 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Plagiarism: a Viewpoint from India.
Authors: Misra DP, Ravindran V, Wakhlu A, Sharma A, Agarwal V, Negi VS PMID: 28960022 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Bilateral Emphysematous Pyelonephritis.
Authors: Kim CS, Ma SK, Kim SW PMID: 28960023 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

New Aspects of Vascular Calcification: Histone Deacetylases and Beyond.
Authors: Kwon DH, Kim YK, Kook H Abstract Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases, vascular or valvular diseases, or even aging. However, now calcification is recognized as a highly-regulated consequence, like bone formation, and many clinical trials have been carried out to elucidate the correlation between vascular calcification and cardiovascular events and mortality. As a result, vascular calcification has been implicated as an independ...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Researcher and Author Profiles: Opportunities, Advantages, and Limitations.
This article overviews some of the widely used and emerging profiling platforms, highlighting their tools for sharing scholarly items, crediting individuals, and facilitating networking. Global bibliographic databases and search platforms, such as Scopus, Web of Science, PubMed, and Google Scholar, are widely used for profiling authors with indexed publications. Scholarly networking websites, such as ResearchGate and Academia.edu, provide indispensable services for researchers poorly visible elsewhere on the Internet. Several specialized platforms are designed to offer profiling along with their main functionalities, such ...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Analysis of the Factors Affecting Consumer Acceptance of Accredited Online Health Information.
Authors: Jo HS, Song TM, Kim BG Abstract With the increasing use of the internet and the spread of smartphones, health information seekers obtain considerable information through the internet. As the amount of online health information increases, the need for quality management of health information has been emphasized. The purpose of this study was to investigate the factors affecting the intention of using accredited online health information by applying the extended technology acceptance model (Extended-TAM). An online survey was conducted from September 15, 2016 to October 3, 2016, on 500 men and women aged 19-...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Using the National Health Information Database of the National Health Insurance Service in Korea for Monitoring Mortality and Life Expectancy at National and Local Levels.
This study explores whether the National Health Information Database (NHID) can be used to monitor health status of entire population in Korea. We calculated the crude mortality rate and life expectancy (LE) at birth across the national, provincial, and municipal levels using the NHID eligibility database from 2004 to 2015, and compared the results with the corresponding values obtained from the Korean Statistical Information Service (KOSIS) of Statistics Korea. The study results showed that the ratio of crude mortality rate between the two data was 0.99. The absolute difference between the LE of the two data was not more ...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prevalence of and Risk Factors for Sexually Transmitted Infections among Korean Adolescents under Probation.
In conclusion, the prevalence of STIs among adolescents under probation was high. Systematic screening programs, more practical sexual education, and adequate provision of treatment are essential for the prevention and management of STIs among adolescents, especially those under probation. PMID: 28960028 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Submillisievert Computed Tomography of the Chest in Contact Investigation for Drug-Resistant Tuberculosis.
In conclusion, early identification of secondary MDR-TB is feasible with submillisievert chest CT scans in contact investigations of MDR-TB, minimizing of MDR-TB transmission and offering a favorable treatment outcome. This was a clinical trial study and was registered at www.ClinicalTrials.gov (Identifier: NCT02454738). PMID: 28960029 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers.
We examined the frequency of copy number changes according to the smoking status (non-smoker [n = 8] or smoker [n = 11]). We identified 16 significantly altered regions from ArrayCGH data, three gain and four loss regions overlapped with the TCGA lung squamous cell carcinoma (LUSC) patients. Within these overlapped significant regions, we detected 15 genes that have been reported in the Cancer Gene census. We also found that the proto-oncogene GAB2 (11q14.1) was significantly amplified in non-smokers patients and vice versa in both ArrayCGH and TCGA data. Immunohistochemical analyses showed that GAB2 protein was relatively...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Validation Study for the Korean Version of Fear of Cancer Recurrence Inventory.
This study aimed to confirm the cultural equivalence, reliability, and validity of the Korean version of Fear of Cancer Recurrence Inventory (K-FCRI). We conducted a forward-backward translation of the English version FCRI to Korean version through meticulous process including transcultural equivalence test. The psychometric property of the K-FCRI was then validated in 444 survivors from cancers at various sites. The Korean translation was accepted well by participants. There was a good cultural equivalence between the Korean version and the English version of FCRI. Confirmatory factor analysis supported the original seven...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Is Frailty a Modifiable Risk Factor of Future Adverse Outcomes in Elderly Patients with Incident End-Stage Renal Disease?
Authors: Lee SW, Lee A, Yu MY, Kim SW, Kim KI, Na KY, Chae DW, Kim CH, Chin HJ Abstract Little is known about the clinical significance of frailty and changes of frailty after dialysis initiation in elderly patients with end-stage renal disease (ESRD). We prospectively enrolled 46 elderly patients with incident ESRD at a dialysis center of a tertiary hospital between May 2013 and March 2015. Frailty was assessed by using a comprehensive geriatric assessment protocol and defined as a multidimensional frailty score of ≥ 10. The main outcome was the composite of all-cause death or cardiovascular hospitalization, as...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study.
This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) wer...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prediction of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Using 4-Hour Post-Endoscopic Retrograde Cholangiopancreatography Serum Amylase and Lipase Levels.
In conclusion, 4-hour post-ERCP amylase and lipase levels are useful early predictors of PEP that can ensure safe discharge or prompt resuscitation after ERCP. PMID: 28960034 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Lactate Parameters Predict Clinical Outcomes in Patients with Nonvariceal Upper Gastrointestinal Bleeding.
In conclusion, lactate parameters have a prognostic role in patients with NVUGIB. However, they do not increase the predictive power of AIMS65 when combined. PMID: 28960035 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Measurement of Fluid Status Using Bioimpedance Methods in Korean Pediatric Patients on Hemodialysis.
Authors: Yang EM, Park E, Ahn YH, Choi HJ, Kang HG, Cheong HI, Ha IS Abstract Adequate fluid management is an important therapeutic goal of dialysis. Recently, bioelectrical impedance methods have been used to determine body fluid status, but pediatric reports are rare. To determine the accuracy of bioelectrical impedance methods in the assessment of body fluid statusof children undergoing hemodialysis (HD), 12 children on HD were studied. A multi-frequency bioimpedance analysis device (Inbody S10) and bioimpedance spectroscopy device (BCM) were used to evaluate fluid status. Fluid removal during a HD session (asse...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Myocardial Assessment in School-Aged Children with Past Kawasaki Disease.
Authors: Lee H, Shin J, Eun L Abstract Coronary artery involvement remains the most important complication with Kawasaki disease (KD). Additional myocardial injury can be caused by inflammatory response and ischemic event. However, the long-term outcome of myocardial function has not been fully known in KD. The purpose of this study is to evaluate myocardial function in school-aged children who had the past history of KD. Sixty-seven children in the second grade of elementary schools, who had the past history of KD, were included. Echocardiographic measurements of each coronary artery and myocardial function were o...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prevalence and Clinical Characteristics of Metabolically Healthy Obesity in Korean Children and Adolescents: Data from the Korea National Health and Nutrition Examination Survey.
This study aimed to evaluate the prevalence and clinical characteristics of MHO in Korean children and adolescents and to investigate the anthropometric, laboratory, and lifestyle predictors of MHO. This study included data from 530 obese subjects, aged 10-19 years, obtained from the Fourth Korea National Health and Nutrition Examination Survey. Subjects were classified into MHO and MUO groups according to the presence of CMRF (MHO(CMRF)/MUO(CMRF)) and degree of IR (MHO(IR)/MUO(IR)). Demographic, anthropometric, cardiometabolic, and lifestyle factors were compared between the groups. Logistic regression analysis and receiv...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research