A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs.
Authors: Chen Y, Ohara T, Xing B, Qi J, Noma K, Matsukawa A Abstract Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Ten-Year Outcomes of Total Hip Arthroplasty Using Fit-and-Fill Type Cementless Collared Straight Stem Implants: Relationship between the Initial Contact Status and Stress Shielding.
Authors: Sanki T, Endo H, Tetsunaga T, Furumatsu T, Yamada K, Ozaki T Abstract We investigated the relationship between the initial contact status and stress shielding in total hip arthroplasty (THA) using fit-and-fill type straight-stem implants. In addition we evaluated the clinical and radiographic outcomes. Subjects were 100 hips of 94 patients who underwent THA and were followed-up for ≥10 years. Contact areas with the femoral cortical bone were investigated according to the zonal distribution of Gruen using postoperative CT images. Depending on the number of contact areas, the patients were classified into...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Relationship between a High-inspired Oxygen Concentration and Dorsal Atelectasis in High-energy Trauma Patients.
Authors: Ishii K, Morimatsu H, Ono K, Miyasho K Abstract We performed a retrospective cohort study of 911 high-energy trauma patients who underwent chest CT scans at least twice after admission. We hypothesized that in high-energy trauma patients, a high-inspired oxygen concentration delivered after admission results in dorsal atelectasis. The study's primary outcome was dorsal atelectasis formation diagnosed based on CT images. We defined dorsal atelectasis as the presence of atelectasis at ≥ 10 mm thick on CT images. We defined high-inspired oxygen concentration as>60% oxygen delivered between two CT scans....
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Minimally Invasive Surgery for Unstable Pelvic Ring Fractures: Transiliac Rod and Screw Fixation.
We describe a surgical transiliac rod and screw fixation (TIF) procedure that provides minimally invasive fixation using a spinal implant for unstable pelvic ring fractures, and we retrospectively analyzed the procedure's outcomes in 27 patients with type B or C1 fractures (based on the AO/ATO classification system). Small skin incisions are made above the posterior superior iliac spines on both sides. The ilium is partially resected, and two iliac screws are inserted on each side. The spinous process of the sacral spine is then shaved, and the iliac screws are connected to 2 rods, one placed caudal to the other. Correctiv...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus.
Authors: Honda H, Hanayama Y, Obika M, Hasegawa K, Hamahara J, Kishida M, Hagiya H, Ogawa H, Kataoka H, Otsuka F Abstract A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients' gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) s...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

The Prevalence and Characteristics of Older Japanese Adults with Polypharmacy, Based on Regionally Representative Health Insurance Claims Data.
We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Alcohol Consumption or Excessive Use of Psychotropic Medication Prior to Suicidal Self-injury in Patients with Adjustment Disorder, Depression, and Schizophrenia: A Cross-sectional Study.
Authors: Takeuchi T, Okumura Y, Ichikura K Abstract The use of alcohol or drug(s) prior to self-injury is a possible inducing factor for suicidal self-injuries among patients with adjustment disorder. We analyzed the cases of 175 individuals who were admitted to the intensive care unit (ICU) of Tokyo Medical and Dental University Medical Hospital for suicidal self-injury to determine whether alcohol consumption or an excessive use of prescribed psychotropic medications prior to self-injury is more common in patients with adjustment disorder. During a 7-year period (July 2006 to June 2013) following their deliberate...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Robotic Renal Autotransplantation: A Feasibility Study in a Porcine Model.
Authors: Kubota R, Araki M, Wada K, Kawamura K, Maruyama Y, Mitsui Y, Sadahira T, Ariyoshi Y, Iwata T, Nishimura S, Takamoto A, Sako T, Edamura K, Kobayashi Y, Kano Y, Kitagawa M, Tanabe K, Sugiyama H, Wada J, Watanabe M, Watanabe T, Nasu Y Abstract We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken o...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Examination of the Causality Relationship between Psychological Distress and Social Participation in Elderly People: A Pilot Study.
Authors: Owari Y, Miyatake N, Suzuki H Abstract Few studies have considered the causal relationship between psychological distress and social participation in elderly people. Here we investigated this relationship based on an initial survey and a follow-up survey. In 2016, a survey was distributed to 86 participants. A follow-up survey of 80 of those participants was performed in 2017. We adopted the following variables: psychological distress and social participation as represented by the Kessler psychological distress scale and social participation scores, respectively. By using cross-lagged and synchronous effec...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy.
Authors: Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K Abstract To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years ...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A Surgical Instructor Training Course for the Next Generation.
Authors: Yamane M, Mandai Y, Ino H, Matsukawa A, Toyooka S Abstract In 2016, Gunma University Hospital's Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Idiopathic Chondrolysis of the Hip Treated by Immunosuppressive Therapy and Arthroscopic Intervention.
We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. PMID: 32099253 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

The Novel Eryngii Method of Nipple Reduction for Female-to-Male Transsexuals.
Authors: Sakurai T, Watanabe T, Manako K, Komagoe S, Mukai Y, Kimata Y, Namba Y Abstract Mastectomy is usually the first and most important surgical procedure in female-to-male (FTM) individuals with gender identity disorder. Nipple reduction is also important in the process of reconstructing the chest wall for a more male appearance. If the nipples remain large after a mastectomy, the results may be disappointing to many FTM transsexuals. Nipple reduction enables these individuals to go to the beach or Japanese public baths, where they may go topless in public. We therefore consider that nipple reduction is indica...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A Multicenter, Open-label, Clinical Trial to Assess the Effectiveness and Safety of Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-intensity Conditioning in Relapsed/refractory Anaplastic Large-cell Lymphoma in Children.
This study is a multicenter, open-label trial to examine the effectiveness and safety of transplantation with reduced-intensity conditioning (RIC) for patients under 20 years old with relapsed or refractory ALCL. We defined RIC as the administration of fludarabine (30 mg/m2/day) for five days plus melphalan (70 mg/m2/day) for two days and total body irradiation at 4 Gy, followed by allogeneic hematopoietic stem cell transplantation. PMID: 32099255 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Epileptic High-frequency Oscillations in Scalp Electroencephalography.
Authors: Shibata T, Kobayashi K Abstract Electroencephalography (EEG) examines the functional state of the brain. High-frequency oscillations (HFOs) in the ripple (80-200/250 Hz) and fast ripple (200/250-500/600 Hz) bands have recently been attracting attention, and their recording has been enabled by advancements in digital EEG techniques. The detection of HFOs was previously limited to intracranial EEG, but fast oscillations (FOs) in the gamma (40-80 Hz) and ripple bands can now be detected over the scalp. HFOs and FOs have been shown to be related to epileptogenicity in intracranial EEG and scalp EEG, respective...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Evaluation of Setup Errors at the Skin Surface Position for Whole Breast Radiotherapy of Breast Cancer Patients.
Authors: Miyahara K, Kuroda M, Yoshimura Y, Aoyama H, Oita M, Sugianto I, Matsuzaki H, Ihara H, Katayama N, Katsui K, Kanazawa S, Asaumi J Abstract We used image-processing software to analyze the setup errors at the skin surface position of breast cancer patients (n=66) who underwent post-operative whole breast irradiation at our hospital in 2014-2015. The sixty-six digital reconstructed radiographs (DRR) were created at the treatment planning for each patient. The lineacgraphies (n=377) were taken after the patients' setup during radiotherapy. The lineacgraphies and DRR were superimposed at the skin surface posit...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Relationship between Chronic Low Back Pain, Social Participation, and Psychological Distress in Elderly People : A Pilot Mediation Analysis.
Authors: Owari Y, Miyatake N Abstract Several studies indicated that chronic low back pain (CLBP) worsened psychological distress (PD) and social participation (SP) improved PD. The relationships among CLBP, SP and PD have not been established. Here we investigate whether SP mediates the relationship between CLBP and PD in 96 elderly people. We evaluated CLBP and SP by a self-administered questionnaire and PD by K6 questionnaires. We used simple correlation analyses, the unpaired t-test, and a mediation analysis following the approach outlined by Structural Equation Modeling (SEM) to clarify the relationships among...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan.
Authors: Nishie H, Tetsunaga T, Kanzaki H, Oda K, Inoue S, Ryuo Y, Ota H, Miyawaki T, Arakawa K, Tetsunaga T, Kitamura Y, Sendo T, Morimatsu H, Ozaki T, Nishida K Abstract We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for> 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 a...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan.
In conclusion, these findings provide comprehensive insight into pAEE in Japan. PMID: 30140082 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Upregulation of Angiogenic Factors via Protein Kinase C and Hypoxia-induced Factor-1 α Pathways under High-glucose Conditions in the Placenta.
We examined whether hypoxia-induced factor-1α (HIF-1α) and protein kinase Cβ (PKCβ) are involved in the regulation of placental angiogenic factors under high-glucose conditions in vitro. The human choriocarcinoma cell lines BeWo and JEG-3, and the human trophoblast cell line HTR-8/SVneo were cultured with 10 and 25 mmol/L glucose [control glucose group (CG) and high-glucose group (HG), respectively]. We examined the changes in HIF-1α, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) expression in the CG and HG by real-time...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Hormonal Therapy Resistant Estrogen-receptor Positive Metastatic Breast Cancer Cohort (HORSE-BC) Study : Current Status of Treatment Selection in Japan.
Authors: Iwamoto T, Taira N, Fujisawa T, Araki K, Sakamaki K, Sangai T, Kikawa Y, Shien T, Takao S, Sato M, Goto Y, Yoshida T, Takahashi M, Aihara T, Mukai H Abstract The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data f...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Venous Thromboembolism in Patients with Acute Thoracolumbar Spinal Cord Injury.
Authors: Morita T, Sugimoto Y, Takigawa T, Misawa H, Ito Y, Ozaki T Abstract Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. We retrospectively assessed 75 patients with acute TLSCI (T1 to L1). All patients were surgically treated. VTE of the lower extremity and pelvis was assessed using color Doppler ultrasound regardless of whether symptoms were present. This retrospective study included patients who...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Impact of Polyp Regression on 2-year Outcomes of Intravitreal Aflibercept Injections: A Treat-and-Extend Regimen for Polypoidal Choroidal Vasculopathy.
Authors: Morizane-Hosokawa M, Morizane Y, Kimura S, Shiode Y, Hirano M, Doi S, Toshima S, Hosogi M, Fujiwara A, Shiraga F Abstract We conducted intravitreal aflibercept injections (IVAs) for 37 Japanese patients (28 males, 9 females, mean age 73.4 years) with polypoidal choroidal vasculopathy (PCV), with a treat-and-extend regimen (TER). We evaluated the impact of polyp regression after a loading dose (2-mg IVA 1×/month for 3 months) on the patients' 2-year treatment outcomes. Thirty-seven eyes were treated with IVA by a TER for 2 years. We divided the patients into 2 groups based on their polyp status after ...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Women with Recurrent Pregnancy Loss : Their Psychology During Late Pregnancy and the Supportive Behavior of Their Partners.
Authors: Hada K, Kuse E, Nakatsuka M Abstract To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the contr...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Relationship between Sedentary Behavior and Health-Related Quality of Life in Patients on Chronic Hemodialysis.
Authors: Hishii S, Miyatake N, Nishi H, Katayama A, Ujike K, Koumoto K, Hashimoto H Abstract We explored the relationship between sedentary behavior and the health-related quality of life (HRQOL) in patients on chronic hemodialysis. A total of 60 outpatients, aged 71.1±12.0 years, were enrolled in this cross-sectional study. Sedentary behavior was measured using a tri-accelerometer and HRQOL was evaluated by the Euro-QOL questionnaire (EQ-5D). The relationship between the patients' sedentary behavior and HRQOL was evaluated by simple and multiple correlation analyses. The relative sedentary behavior (%) for ...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy.
Authors: Wada N, Ikeda F, Mori C, Takaguchi K, Fujioka SI, Kobashi H, Morimoto Y, Kariyama K, Sakaguchi K, Hashimoto N, Moriya A, Kawaguchi M, Miyatake H, Hagihara H, Kubota J, Takayama H, Takeuchi Y, Yasunaka T, Takaki A, Iwasaki Y, Okada H Abstract Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolle...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Development of Gait Rehabilitation System Capable of Assisting Pelvic Movement of Normal Walking.
This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. The rehabilitation robot developed in this study, COWALK, is a lower-body exoskeleton system with 15 degrees of freedom (DoFs). The COWALK can generate multi-DoF pelvic movement along with leg movements. To produce natural gait patterns, the actuation of pelvic movement is essential. In the COWALK, the pelvic movement mechanism is designed to help hemiplegic patients regain gait balance during gait training. To verify the effectiveness of the developed system, the gait patterns with and without pelvic movem...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Microseizures Induced by Topiramate.
Authors: Miyake S, Sugita M, Okazaki T, Takenaka M, Kuwabara K, Ogawa K Abstract A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). EEG showed fast activity at the times of eye-opening. The episodes of eye-opening ...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Study Design of a Phase II Clinical Trial to Assess the Efficacy and Safety of Eperisone in Japanese Type 2 Diabetes Patients with Risk and Non-risk Alleles of CDKAL1.
Authors: Sakakida K, Wei FY, Senokuchi T, Shimoda S, Kakuma T, Araki E, Tomizawa K, Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group Abstract Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carr...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Phase II Clinical Trial for Newly Diagnosed Children and Adolescents with Localized Lymphoblastic Lymphoma (Japanese Leukemia/Lymphoma Study Group Trial LLB-NHL03) : Study Protocol for Nationwide Multicenter Trial.
Authors: Sekimizu M, Fujimoto J, Takimoto T, Tsurusawa M, Horibe K, Sunami S Abstract Pediatric patients with lymphoblastic lymphoma are generally treated using the Berlin-Frankfurt-Munster (BFM) 90 protocol, which is the standard treatment strategy for pediatric acute lymphoblastic leukemia, and have a favorable outcome. However, this intense regimen includes high total doses of anthracycline and alkylating agents, and is known to cause late complications. We therefore planned a clinical trial to examine the efficacy and safety of a modified BFM regimen. We expect that this phase II, nationwide multicenter trial w...
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A Phase I/II Study of Crizotinib for Recurrent or Refractory Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma and a Phase I Study of Crizotinib for Recurrent or Refractory Neuroblastoma : Study Protocol for a Multicenter Single-arm Open-label Trial.
The objectives of this trial are to evaluate the tolerability and safety of crizotinib in Japanese patients with recurrent/refractory ALK-positive ALCL or neuroblastoma (phase I) and its efficacy in recurrent/refractory ALK-positive ALCL (phase II). PMID: 30140094 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

The Effect of Interim FDG-PET-guided Response-Adapted Therapy in Pediatric Patients with Hodgkin's Lymphoma (HL-14) : Protocol for a Phase II Study.
Authors: Koga Y, Baba S, Fukano R, Nakamura K, Soejima T, Maeda N, Sunami S, Ueyama J, Mitsui T, Mori T, Osumi T, Sekimizu M, Ohki K, Tanaka F, Kamei M, Fujita N, Mori T, Saito AM, Kada A, Kobayashi R Abstract This trial enrolls patients with untreated Hodgkin's lymphoma aged
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

An Open-label Single-arm Trial of a Novel Extramedullary Guide Coordinated with 3D Surgical Assistive Software for Total Knee Arthroplasty.
In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision. A report releasing study results will be submitted in an appropriate journal. PMID: 30140096 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - August 25, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Cell-based Biological Pacemakers: Progress and Problems.
Authors: Saito Y, Nakamura K, Ito H Abstract The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of s...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A Randomized Controlled Trial of Short-term Toe Resistance Training to Improve Toe Pinch Force in Patients with Type 2 Diabetes.
Authors: Kataoka H, Miyatake N, Murao S, Tanaka S Abstract Resistance training is effective against type 2 diabetes (T2DM), but the effect of resistance training on toe pinch force (TPF) is unknown. Here we investigated the effect of short-term toe resistance training on TPF in patients with T2DM, in a prospective, parallel-group, single-blind, randomized controlled trial. Twelve patients with T2DM who were hospitalized to improve glycemic control were enrolled. The patients were randomly allocated to the intervention (n=6) and control (n=6) groups. The intervention group performed traditional aerobic exercise and ...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Total Hip Arthroplasty for Patients with Residual Poliomyelitis at a Mean Eight Years of Follow-up.
Authors: Sonekatsu M, Sonohata M, Kitajima M, Kawano S, Mawatari M Abstract In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital. We retrospectively...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

A20 (TNFAIP3) Alterations in Primary Intestinal Diffuse Large B-cell Lymphoma.
Authors: Fujii M, Takata K, Chuang SS, Miyata-Takata T, Ando M, Sato Y, Yoshino T Abstract The gastrointestinal (GI) tract is the most frequently involved site of extranodal non-Hodgkin lymphomas, and diffuse large B-cell lymphoma (DLBCL) is the most common subtype occurring in the GI tract. TNFAIP3 (A20) genetic alterations were reported to be involved in DLBCL's pathogenesis and a portion of GI-DLBCL cases harbor this alteration. However, the frequency and clinicopathological relations focusing on small and large intestinal DLBCL are unclear. Here, we examined A20 deletion and protein expression and analyzed the ...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Relationship between Social Participation, Physical Activity and Psychological Distress in Apparently Healthy Elderly People: A Pilot Study.
Authors: Owari Y, Miyatake N, Kataoka H Abstract Few studies examined the relationship between social participation, physical activity and psychological distress in elderly people. Here we examined these relationships in apparently healthy elderly people. After exclusion of subjects who dropped out or did not meet enrollment criteria, the data of 86 subjects (apparently healthy elderly embers at a college health club; 25 males, 61 females) from July 20 to September 10, 2016 were used. We evaluated each subject's psychological distress using the K6 questionnaire, social participation by a self-completed questionnair...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Results of a Treat-and-Eextend Regimen of Intravitreal Ranibizumab Injection for Macular Edema due to Branch Retinal Vein Occlusion.
Authors: Hosogi M, Morizane Y, Shiode Y, Doi S, Kumase F, Kimura S, Hosokawa M, Hirano M, Toshima S, Takahashi K, Fujiwara A, Shiraga F Abstract To investigate the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections (IVR) for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 35 eyes of 35 patients with ME due to BRVO who underwent TAE for 1 year. Patients whose treatment interval extended to 12 weeks were switched to a pro re nata regimen (PRN; TAE to PRN group), while TAE was continued for patients whose treatment interval was less than...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Transcatheter Arterial Chemoembolization to Reduce Size of Hepatocellular Carcinoma before Radiofrequency Ablation.
Authors: Ako S, Nakamura S, Nouso K, Dohi C, Wada N, Morimoto Y, Takeuchi Y, Yasunaka T, Kuwaki K, Onishi H, Ikeda F, Shiraha H, Takaki A, Okada H Abstract Transcatheter arterial chemoembolization (TACE) is often performed before radiofrequency ablation (RFA) for the treatment of early-stage hepatocellular carcinoma (HCC). TACE prior to RFA can expand the ablated area and reduce the tumor size, facilitating complete ablation. However, the factors correlated with size reduction remain uncertain. The aim of this study was to identify the factors associated with size reduction by TACE and develop a formula to predict ...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

The Usefulness of Readout-Segmented Echo-Planar Imaging (RESOLVE) for Bio-phantom Imaging Using 3-Tesla Clinical MRI.
Authors: Yoshimura Y, Kuroda M, Sugiantoc I, Bamgbosec BO, Miyahara K, Ohmura Y, Kurozumi A, Matsushita T, Ohno S, Kanazawa S, Asaumi J Abstract Readout-segmented echo-planar imaging (RESOLVE) is a multi-shot echo-planar imaging (EPI) modality with k-space segmented in the readout direction. We investigated whether RESOLVE decreases the distortion and artifact in the phase direction and increases the signal-to-noise ratio (SNR) in phantoms image taken with 3-tesla (3T) MRI versus conventional EPI. We used a physiological saline phantom and subtraction mapping and observed that RESOLVE's SNR was higher than EPI's. U...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Slow Fetal Heart Rate before Miscarriage in the Early First Trimester Predicts Fetal Aneuploidy in Women with Recurrent Pregnancy Loss.
We examined the relationship between fetal heart rate (FHR) before miscarriage in the early first trimester and fetal karyotype, analyzing 223 pregnant women with recurrent pregnancy loss. Among the pregnancies, 110 resulted in live births regarded as normal karyotype (the Norm-group). The other 113 pregnancies ended in miscarriage, and we categorized them into groups based on fetal karyotype, determined by chorionic villus sampling: the Misc-NK (normal karyotype) group, n=35 euploid cases; the Misc-CA1 (chromosomal abnormality) group, n=18 cases of aneuploidy with trisomies 13/18/21, Turner's syndrome, or Klinefelter's sy...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Differences in Risk Factors for Rotator Cuff Tears between Elderly Patients and Young Patients.
In this study, we examined the risk factors for rotator cuff tears using classification and regression tree analysis as methods of nonlinear regression analysis. There were 65 patients in the rotator cuff tears group and 45 patients in the intact rotator cuff group. Classification and regression tree analysis was performed to predict rotator cuff tears. The target factor was rotator cuff tears; explanatory variables were age, sex, trauma, and critical shoulder angle≥35°. In the results of classification and regression tree analysis, the tree was divided at age 64. For patients aged≥64, the tree was divided at tra...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Spinal Extradural Arachnoid Cyst: Significance of Intrathecal Infusion after Fistula Closure.
Authors: Umakoshi M, Yasuhara T, Toyoshima A, Sasada S, Kusumegi A, Morimoto J, Kin K, Tomita Y, Date I Abstract The spinal extradural arachnoid cyst is a rare entity. Obtaining the correct diagnosis and detecting the fistula location are critical for providing effective treatment. A 41-year-old man had numbness in the soles of his feet for 2 years with accompanying gait disturbance, and a defecation disorder. Computed tomography myelography performed at another hospital revealed an epidural arachnoid cyst from Th11 to L2. He received a subarachnoid-cyst shunt at the rostral part of the cyst. However, his symptoms ...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Tarsal Tunnel Syndrome Caused by a Schwannoma of the Posterior Tibial Nerve.
We report on a 60-year-old man with tarsal tunnel syndrome caused by a schwannoma of the posterior tibial nerve, which was first diagnosed as a ganglion cyst. After enucleation of this tumor, the patient was asymptomatic and had no related sequelae except for minor numbness in the plantar aspects of his digits. Although schwannoma of the posterior tibial nerve is rare, it should be considered even if a ganglion is clinically suspected. PMID: 29463943 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Laparoscopic Surgery for Small Bowel Obstruction due to Paracecal Hernia.
Authors: Otani H, Makihara S Abstract Internal hernia related to paracecal hernia is a rare disease and is difficult to confirm by preoperative diagnosis. We recently encountered a case of an 83-year-old woman who had lower abdominal pain in her right quadrant. Based on physical findings and CT findings she was diagnosed as having small bowel obstruction by internal hernia around the cecum. She underwent emergency operation with laparoscopic surgery and was diagnosed with a paracecal hernia and treated laparoscopically. After we dissected the ventral wall of the hernia sac and enlarged the hernia orifice, we reduce...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Traumatic Globe Luxation with Complete Optic Nerve Transection Caused by Heavy Object Compression.
Authors: Kosaki Y, Yumoto T, Naito H, Tsuboi N, Kameda M, Hirano M, Morizane Y, Senoo T, Tokuyama E, Nakao A Abstract Traumatic eyeball luxation is a rare clinical condition with a dramatic presentation. Here, we describe a unique case of traumatic globe luxation and complete optic nerve transection caused by heavy object compression. A 45-year-old male automobile mechanic was injured when a truck slipped from its supports, crushing his head and face. On arrival, his right eyeball was obviously displaced anteriorly and he had no light perception. Computed tomography revealed complex frontal bone and facial fracture...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Extensive Bilateral Patellar Tendon Ossification in a Spinal Cord Injury Patient.
Authors: Yamamoto N, Miki T, Nishiyama A, Dan'ura T, Matsui Y, Ozaki T Abstract This is the first report of extensive bilateral patellar tendon ossification occurring over a prolonged time after a unilateral knee injury. An 84-year-old Japanese man with a spinal cord injury caused by a burst fracture of the T12 vertebra presented with a bony hard prominence on the left knee, which was injured in a traffic accident when he was 77 years old. Radiography revealed extensive ossification of the bilateral patellar tendons. We review the English literature with a focus on the localization of bilateral heterotopic ossifica...
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Randomized Controlled Trial of Epidural versus Patient-controlled Intravenous Analgesia for Postoperative Pain Control after Laparoscopic Gastrectomy.
This study will clarify the optimal pain management after LG. PMID: 29463947 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - February 24, 2018 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Mesenchymal Stem Cell Therapy for Ischemic Stroke.
Authors: Toyoshima A, Yasuhara T, Date I Abstract  To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an impor...
Source: Acta Medica Okayama - August 22, 2017 Category: General Medicine Tags: Acta Med Okayama Source Type: research