Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study
Acta Med Okayama. 2024 Feb;78(1):29-36. doi: 10.18926/AMO/66668.ABSTRACTThis retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction ...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Takahiro Kitayama Takashi Tanaka Yuichiro Kanie Yohei Marukawa Katsuhide Kojima Takehiro Tanaka Soshi Takao Takao Hiraki Source Type: research

Is Proximal Triangular Fixation Better than the Conventional Method in Adult Spinal Deformity Surgery?
Acta Med Okayama. 2024 Feb;78(1):37-46. doi: 10.18926/AMO/66669.ABSTRACTIn adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 y...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Masato Tanaka Umesh Meena Takuya Taoka Yoshihiro Fujiwara Daiichiro Yokomizo Santosh Kumar Bashyal Naveen Sake Shinya Arataki Source Type: research

Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study
In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.PMID:38419314 | DOI:10.18926/AMO/66670 (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Manabu Shimomura Katsunori Shinozaki Takuya Yano Shintaro Akabane Hideki Ohdan Hiroshima Surgical study group of Clinical Oncology (HiSCO) Source Type: research

Quantitative Assessment of the Heat Transfer Capacity of Ice Bags and their Cooling Effects on the Skin Surface and Core Temperature
This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 1...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Yukiko Ichikawa Tetsuya Ogino Source Type: research

Significance of Continuous Low-Dose Lenvatinib for the Treating of the Patients with Unresectable Thyroid Carcinoma
Acta Med Okayama. 2024 Feb;78(1):63-70. doi: 10.18926/AMO/66672.ABSTRACTThe tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated wi...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Daizo Murakami Kohei Nishimoto Soshi Takao Satoru Miyamaru Tomoka Kadowaki Haruki Saito Hiroki Takeda Momoko Ise Koichi Suyama Yorihisa Orita Source Type: research

High Fracture Rate of AVANTA Silicone Implant Following Arthroplasty of the Thumb MCP Joint of Rheumatoid Arthritis Patients with Boutonniere Deformities
This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoper...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Daisuke Kaneda Keiichiro Nishida Yoshihisa Nasu Ryuichi Nakahara Ryozo Harada Yoshifumi Hotta Shuichi Naniwa Toshifumi Ozaki Source Type: research

Utility of Combined Use of Transabdominal Ultrasonography and Fecal Immunochemical Test Examinations in Ulcerative Colitis
This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful ...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Masahiro Takahara Sakiko Hiraoka Masayasu Ohmori Keiko Takeuchi Kensuke Takei Yuki Aoyama Eriko Yasutomi Shoko Igawa Toshihiro Inokuchi Junki Toyosawa Yasushi Yamasaki Hideaki Kinugasa Keita Harada Hideki Onishi Hiroyuki Okada Source Type: research

A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research

Ectopic Breast Cancer Arising within an Axillary Lymph Node
We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult ...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Kei Toshima Tadahiko Shien Midori Filiz Nishimura Yoko Suzuki Shogo Nakamoto Maya Uno Ryo Yoshioka Takahiro Tsukioki Yuko Takahashi Takayuki Iwamoto Tsuguo Iwatani Hiroyuki Yanai Source Type: research

Role of Macrophages in Liver Fibrosis
Acta Med Okayama. 2024 Feb;78(1):1-8. doi: 10.18926/AMO/66664.ABSTRACTLiver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Cuiming Sun Akihiro Matsukawa Source Type: research

Prostate Biopsy May Not Be Indicated Early after Bacillus Calmette Gu érin Treatment
Acta Med Okayama. 2024 Feb;78(1):9-13. doi: 10.18926/AMO/66665.ABSTRACTBacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion ...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Naoki Akagi Akihiro Kanematsu Koji Shigesaka Kimihiro Shimatani Shingo Yamamoto Source Type: research

Lung Oligometastasis of Breast Cancer: Prospective Cohort Study of Treatment Strategies (SBP-06)
Acta Med Okayama. 2024 Feb;78(1):15-20. doi: 10.18926/AMO/66666.ABSTRACTWhile local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was ove...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Reina Maeda Tadahiko Shien Mina Takahashi Kengo Kawada Yukiko Kajiwara Shinichiro Kubo Daisuke Takabatake Shoichiro Ohtani Kinya Matsuoka Hajime Hikino Yutaka Ogasawara Naruto Taira Shozo Osumi Masahiko Ikeda Hiroyoshi Doihara Source Type: research

Assessing the Frequency and Effectiveness of Various Arthroscopic Treatments in the Management of Symptomatic Isolated Medial Meniscus Injuries Including Medial Meniscus Posterior Root Tear: A Retrospective Observational Cohort Study
Acta Med Okayama. 2024 Feb;78(1):21-27. doi: 10.18926/AMO/66667.ABSTRACTThe use of various strategies for arthroscopic meniscal repairs to save the meniscus and prevent the progression of knee osteoarthritis has gradually increased. We investigated the frequency of various arthroscopic treatments and the short-term clinical outcomes of symptomatic isolated medial meniscus (MM) injuries. This retrospective observational study included 193 patients (197 knees) who underwent arthroscopic meniscal treatment for isolated MM injuries between January 2016 and April 2019. Arthroscopic meniscal repairs were divided into two groups:...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Masanori Tamura Takayuki Furumatsu Yusuke Yokoyama Keisuke Kintaka Naohiro Higashihara Koki Kawada Toshifumi Ozaki Source Type: research

Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study
Acta Med Okayama. 2024 Feb;78(1):29-36. doi: 10.18926/AMO/66668.ABSTRACTThis retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction ...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Takahiro Kitayama Takashi Tanaka Yuichiro Kanie Yohei Marukawa Katsuhide Kojima Takehiro Tanaka Soshi Takao Takao Hiraki Source Type: research

Is Proximal Triangular Fixation Better than the Conventional Method in Adult Spinal Deformity Surgery?
Acta Med Okayama. 2024 Feb;78(1):37-46. doi: 10.18926/AMO/66669.ABSTRACTIn adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 y...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Masato Tanaka Umesh Meena Takuya Taoka Yoshihiro Fujiwara Daiichiro Yokomizo Santosh Kumar Bashyal Naveen Sake Shinya Arataki Source Type: research