Social and Structural Determinants of Cardiovascular Complications of Diabetes
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of mortality in people who have diabetes. Racial and ethnic minorities with diabetes have suboptimal management of cardiovascular risk factors, leading to higher mortality. Social and structural determinants of health are external factors that influence an individual ’s ability to choose positive health behaviors. In this review, we will discuss cardiovascular complications in people who have diabetes and their relationship to social determinants of health (SDOH).Recent FindingsRecent innovations in diabetes treatment, including new devices and me...
Source: Current Diabetes Reports - May 2, 2024 Category: Endocrinology Source Type: research
Exploring type 2 diabetes self-management practices in rural Bangladesh: facilitators, barriers and expectations--a qualitative study protocol
This study will use an exploratory qualitative approach. 16 focus group discussions, 13 in-depth interviews and 9 key informant interviews will be conducted among multilevel stakeholders, including people with T2DM, their caregivers, healthcare providers, health managers/administrators and policy planners. Interviews will be audio-recorded, transcribed, translated and analysed using thematic analysis.
Ethics and dissemination
This research project has been approved by the Monash University Human Research Ethics Committee (project reference number: 39483) and the Ethical Review Committee of the Centre for Injury Prevention...
Source: BMJ Open - May 2, 2024 Category: General Medicine Authors: Chowdhury, H. A., Joham, A. E., Kabir, A., Rahman, A. K. M. F., Ali, L., Harrison, C. L., Billah, B. Tags: Open access, Diabetes and Endocrinology Source Type: research
Exploring functional abilities and competing risks among stroke patients: a longitudinal and survival analysis study at Felege Hiwot Referral Hospital, Ethiopia
Conclusion
A substantial proportion of patients who had a stroke experienced mortality and drop-out during the study period, highlighting the importance of considering competing risks in stroke research. Age, diabetes, white cell count and stroke complications were significant covariates affecting both longitudinal and survival submodels. Compared with stand-alone models, the joint competing risk modelling technique offers comprehensive insights into the disease’s transition pattern. (Source: BMJ Open)
Source: BMJ Open - May 2, 2024 Category: General Medicine Authors: Berehan, H. B., Dessie, Z. G., Tesfaw, L. M. Tags: Open access, Public health Source Type: research
DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation
Ischemic postconditioning (IPostC) has been reported as a promising method for protecting against myocardial ischemia-reperfusion (MI/R) injury. Our previous study found that the infarct-limiting effect of IPo... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Wei Li, Yan Leng, Yonghong Xiong, Wenyuan Li, Yin Cai, Rui Xue, Rong Chen, Shaoqing Lei, Zhengyuan Xia and Zhongyuan Xia Tags: Research Source Type: research
The comparison of sleep disorders between type-1 diabetic and non-diabetic children and adolescents
ConclusionAccording to the findings of our study, impaired sleep conditions in the T1DM children group were approximately three times the observed ones in the non-diabetic children group. According to our findings, routine evaluation of sleep disorders in diabetic children and adolescents is recommended. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 2, 2024 Category: Endocrinology Source Type: research
A case report of type 1 diabetes mellitus coexistent with Charcot –Marie–Tooth type 1A and a literature review
ConclusionIt is not yet clear whether there is a genetic association between the CMTD and diabetes, the genes causing CMTD are perhaps related to T1D and T2D genes. When CMTD and diabetes coexist, the resulting neuropathy is more severe than that observed with either condition alone. We recommend that such patients should strictly control their blood-glucose level to slow down the progression of the disease. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 2, 2024 Category: Endocrinology Source Type: research
Infographic. All health professionals should talk about physical activity with patients
Regular physical activity contributes to the prevention and management of non-communicable diseases, including cardiovascular disease, stroke, diabetes and cancer, as well as improved mental health, sleep and cognitive function.1 Despite these benefits, populations worldwide are insufficiently active.2 Enabling people with the lowest levels of physical activity to become more active is where the greatest gains to public health will be achieved.3 Researchers, practitioners and policymakers are increasingly advocating for a systems approach to physical activity promotion. This should involve stakeholders across diverse secto...
Source: British Journal of Sports Medicine - May 2, 2024 Category: Sports Medicine Authors: Milton, K., Morris, J. L., McLaughlin, M., Cameron, A., Dewhurst, S., Gardner, S., Gomersall, S., Blackshaw, J. Tags: BJSM Infographic Source Type: research
Predictive factors of post-HoLEP incontinence: differences between stress and urgency urinary incontinence
ConclusionIn the first month post-HoLEP, age is a predictive factor of urgency UI and stress UI. In addition, prostatic volume and the presence of an indwelling urinary catheter are predictive factors of stress UI. (Source: World Journal of Urology)
Source: World Journal of Urology - May 2, 2024 Category: Urology & Nephrology Source Type: research
Deciphering mortality risk of diabetes medications in heart failure patients with diabetes mellitus under triple guideline-directed medical therapy
Scientific evidence regarding the impact of different combinations of diabetes medications in heart failure patients with diabetes mellitus (HFwDM) remains limited. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 2, 2024 Category: Cardiology Authors: İnci Tuğçe Çöllüoğlu, Ahmet Çelik, Naim Ata, Dilek Ural, Anıl Şahin, Mustafa Mahir Ulgu, Emine Arzu Kanık, Şuayip Birinci, Mehmet Birhan Yılmaz Source Type: research
Complement regulation in the eye: implications for age-related macular degeneration
Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision. Dysregulated complement activation contributes to parainflammation, a low level of inflammation triggered by cellular damage that functions to reestablish homeostasis, or outright inflammation that disrupts the visual a...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Georgia A. Wilke, Rajendra S. Apte Source Type: research
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Semaglutide in Patients with HFpEF and Obesity
This study enrolled adult patients with obesity (BMI ≥30 kg/m2), HFpEF (left ventricular ejection fraction ≥45%; and New York Heart Association functional class II, III, or IV), a Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) of less than 90 points, a six-minute walk distance of at least 100 m; and clinical or laboratory evidence of volume-overloaded HF. About 500 participants, median age of 69, were randomized to receive semaglutide 2.4 mg subcutaneously weekly, versus placebo for 52 weeks. In patients randomized to receive semaglutide, there was an improvement in self-reported HF symptoms...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Cardiology In the Literature Pharmacology Source Type: research
Effect of Maternal Pre-Pregnancy Body Mass Index on Longitudinal Fetal Growth and Mediating Role of Maternal Fasting Plasma Glucose: A Retrospective Cohort Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Hypoxia-inducible factor-1 α in myocardial infarction
World J Cardiol. 2024 Apr 26;16(4):181-185. doi: 10.4330/wjc.v16.i4.181.ABSTRACTHypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthe...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Ivana Škrlec Sergey N Kolomeichuk Source Type: research
Event-Related Potential Changes Following 12-week Yoga Practice in T2DM Patients: A Randomized Controlled Trial
Conclusion. The 12-week yoga practice improved cognitive performance by enhancing the processes of conflict monitoring and response inhibition. Further, improved cognitive performance postintervention was facilitated by improved glycemic control.PMID:38689456 | DOI:10.1177/15500594241249511 (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 1, 2024 Category: Neuroscience Authors: Amit Kanthi Singh Deepeshwar Kaligal Chidananda Mahadevappa Vidyashree Dwivedi Krishna Source Type: research
