Evaluation of the reciprocal interaction between hepatic steatosis and type 2 diabetes: a comparative analysis with respect to anti-diabetic treatment, glycemic control, renal and hepatic function
This study aimed to evaluate reciprocal interaction between hepatic steatosis (HS) and type 2 diabetes (T2D) through comparative analysis of anti-diabetic treatment, glycemic control, and renal and hepatic function in T2D patients with versus without concomitant HS.MethodsA total of 102 T2D patients were included in this cross-sectional single-center study, and patients were divided into two groups including those with HS (n = 58) and those without HS (n = 44). Data on patient demographics, current anti-diabetic treatment, and serum levels for fasting blood glucose (FBG), HbA1c (%), urea, creati...
Source: International Journal of Diabetes in Developing Countries - September 18, 2021 Category: Endocrinology Source Type: research

Prevalence of dysglycemia and its associations with age and body mass index among community dwelling adults in a developing country
AbstractIntroductionDysglycemia includes prediabetes and diabetes. We aimed to study the prevalence of dysglycemia, and its associations with age and body mass index (BMI) among community dwelling adults in Sri Lanka.MethodsThe prevalence of dysglycemic state (FPG  >  100 mg/dL) and its associations with age and BMI in males and females were estimated. The association between gender and glycemic status in different BMI ranges and age groups were estimated. The optimal cut-off points of BMI to determine the risk of dysglycemia in both genders were calculated.ResultsPrevalence of prediabetes and diabete...
Source: International Journal of Diabetes in Developing Countries - September 18, 2021 Category: Endocrinology Source Type: research

Renal outcomes in Asian patients with type 2 diabetes mellitus treated with SGLT2 inhibitors: a systematic review and meta-analysis of randomized controlled trials
This study investigated the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on renal outcomes in Asian patients with type 2 diabetes mellitus (T2DM).Materials and methodsWe searched Medline, EMBASE, and the Cochrane Library to identify randomized controlled trials published up to April 2020 that compared SGLT2 inhibitors with placebo or active comparator and reported any renal outcomes in Asian patients with T2DM. Random effects models and inverse variance weighting were used to calculate relative risks with 95% confidence intervals (CIs).ResultsWe included 14 studies, totaling 3792 patients, in the analysis. ...
Source: International Journal of Diabetes in Developing Countries - September 14, 2021 Category: Endocrinology Source Type: research

Liraglutide may affect visceral fat accumulation in diabetic rats via changes in FTO, AMPK, and AKT expression
AbstractPurposeThe aim of this study is to explore the effects of liraglutide (LRG) on the expression of FTO, AMPK, and AKT in the visceral adipose tissues of obese and diabetic rats and the underlying mechanisms thereof.MethodsThirty SPF-grade, male SD rats were randomly divided into the healthy control, diabetic model (DM), and DM  + LRG groups. The DM and DM + LRG groups were administered normal saline and LRG (0.6 mg/kg/d), respectively. After 12 weeks, the body weight of the rats was measured, and their visceral adipose tissues were collected and weighed; the levels of serum bioch...
Source: International Journal of Diabetes in Developing Countries - September 14, 2021 Category: Endocrinology Source Type: research

Evaluation of the prevalence of inappropriate hba1c examination requests at the General Hospital of Dokter Saiful Anwar Malang
ConclusionThis may not only be caused by the lack of communication between clinicians and laboratory personnel, but also the presence of hemoglobinopathies, causing unreliable results. Requesting HbA1c test too early can result in inaccurate measurements. As a consequence, there is a need for better communication between clinicians and laboratory personnel. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - September 11, 2021 Category: Endocrinology Source Type: research

How the COVID-19 outbreak affected patients with diabetes mellitus?
ConclusionsIt is important to be aware of the possibility of acute stress, depression, and anxiety after pandemic in patients with DM whose glycemic control is impaired. Psychological problems should not be ignored beyond physical inactivity and worsening eating habits. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - September 10, 2021 Category: Endocrinology Source Type: research

Isolation and characterization of bacteria from diabetic foot ulcer: amputation, antibiotic resistance and mortality rate
ConclusionsMortality of diabetic patients with DFU was associated with nephropathy and Acinetobacter orE. coli infections. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - September 10, 2021 Category: Endocrinology Source Type: research

Neutrophil lymphocyte ratio: a reliable biomarker for diabetic nephropathy?
The objective was to evaluate NLR as a predictive and prognostic marker for DN.Material and methodsIt was an observational cross-sectional study. A total of 324 T2DM patients and 212 healthy controls (HC) were selected by consecutive sampling between June 2019 and June 2020. Complete blood count, erythrocyte sedimentation rate (ESR), renal function parameters, 24-h urinary protein, and fundoscopy were done. Appropriate statistical analysis was applied using SPSS software.ResultsOf 324 T2DM patients, 146 (45%) had DN and 178 (55%) did not. Mean NLR ( ± SD) for T2DM without DN, T2DM, with DN and HC was 2.73&thi...
Source: International Journal of Diabetes in Developing Countries - September 5, 2021 Category: Endocrinology Source Type: research

Sarcopenia in patients with type 2 diabetes mellitus: a case –control study in Maracaibo city, Venezuela
AbstractBackground/purpose of the studySeveral studies implicate  skeletal muscle as a physio-pathological target among the metabolic disturbances of diabetes, or with the mechanisms shared by sarcopenia and type 2 diabetes mellitus (T2DM). The present study aimed to determine the relationship between sarcopenia and T2DM in outpatients of the Zulian Diabetes Ins titute, Maracaibo, Venezuela.MethodsA case –control study was performed on patients diagnosed with T2DM that went to the Zulian Diabetes Institute between January and June 2019. After obtaining a final sample of 131 patients with T2DM, control subjects w...
Source: International Journal of Diabetes in Developing Countries - August 27, 2021 Category: Endocrinology Source Type: research

Long-term persistent symptoms of COVID-19 infection in patients with diabetes mellitus
ConclusionLong-term persistent symptoms of COVID-19 infection are common among patients with DM. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 24, 2021 Category: Endocrinology Source Type: research

Evaluation of treatment strategies and pregnancy outcome among GDM twin versus GDM singleton pregnancy
AbstractObjectiveTo compare the treatment strategies and pregnancy outcomes between women with gestational diabetes mellitus carrying twin and singleton pregnancies.MethodWe conducted a retrospective chart review of women with singleton and twin pregnancy; those visited Sunil ’s Diabetes Care n’ Research Centre, Nagpur, and Gupte Hospital Pune, between 2006 and 2019, for the treatment of gestational diabetes mellitus (GDM). Propensity scores for baseline characteristics were used to assemble a matched-pairs cohort of women with twin and singleton pregnancies.ResultsA subset of 132 singleton cases was obtained f...
Source: International Journal of Diabetes in Developing Countries - August 22, 2021 Category: Endocrinology Source Type: research

Utilization of Indian diabetes risk score (IDRS) in steroid-induced diabetes
AbstractIntroductionSteroid-induced diabetes (SID) can be defined as the occurrence of hyperglycemic state in non-diabetic individuals following steroid therapy. The traditional risk factors for type 2 DM, such as age, abdominal obesity, family history, and physical activity, have been incorporated in the Indian diabetes risk score (IDRS). We conducted this study to determine the use of IDRS in the prediction of SID.Materials and methodsA prospective observational, cohort study on non-diabetic subjects, aged between 18 and 70  years, on oral or parenteral steroid therapy for different diseases was conducted. Anthropom...
Source: International Journal of Diabetes in Developing Countries - August 21, 2021 Category: Endocrinology Source Type: research

SMOTE-SMO-based expert system for type II diabetes detection using PIMA dataset
ConclusionThe output of the study confirms that the proposed integrated approach of DM could be used as an expert system for diagnosing diabetes in patients at an early stage. The extracted features from this study will be used for the development of a prognostic tool in the form of a mobile application for early diabetes detection. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 17, 2021 Category: Endocrinology Source Type: research

The effect of using a reminder diabetic foot mirror on foot checking frequency and development of diabetic foot in people with diabetes
In this study, 133 people with diabetes were included and assigned to groups randomly. A reminder diabetic foot mirror was given to the experimental group 1, while the diabetic foot mirror was given to the experimental group 2. Diabetic foot examinations were performed at the beginning of the study and every 3  months. For 9 months, foot examination frequency data were recorded by interviewing the participants at the end of each month.ResultsAt the beginning of the study, the participants in all the groups had similar characteristics. However, at the end, it was found that the frequency of foot checking was highe...
Source: International Journal of Diabetes in Developing Countries - August 16, 2021 Category: Endocrinology Source Type: research

The role of pharmacists in diabetes management in Abu Dhabi, United Arab Emirates
AbstractObjectiveTo evaluate the services rendered by pharmacists, including the education offered, and the counseling barriers that are involved in providing necessary pharmaceutical care to patients with diabetes.MethodsA cross-sectional survey was conducted among a representative sample of licensed pharmacists from Abu Dhabi. A self-administered questionnaire was designed and validated through pilot study and consisted of the demographics, counseling services, education provided, and barriers involved in providing pharmaceutical care to patients with diabetes. A total of 68 questions (20 closed-ended and 48 open-ended),...
Source: International Journal of Diabetes in Developing Countries - August 16, 2021 Category: Endocrinology Source Type: research

Effects of fasting proinsulin/fasting insulin, proinsulin/insulin, vitamin D3, and waistline on diabetes prediction among the Chinese Han population
AbstractBackgroundFasting proinsulin/fasting insulin, proinsulin/insulin, vitamin D3, and waistline are each associated with the risk of diabetes. The aim of this study was to explore the effects of fasting proinsulin/fasting insulin, proinsulin/insulin, vitamin D3, and waistline on diabetes prediction in the Chinese Han population.MethodsOur study consisted of 490 subjects with glucose metabolism dysfunction (GMD) and 770 healthy subjects. Spearman ’s correlation analysis was used to assess the relationship of clinical characteristics with prediabetes. Receiver operation characteristic (ROC) curve analysis was used ...
Source: International Journal of Diabetes in Developing Countries - August 16, 2021 Category: Endocrinology Source Type: research

Triple challenge of diabetes, COVID-19, and mucormycosis
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 13, 2021 Category: Endocrinology Source Type: research

Youth-onset type 2 diabetes mellitus —a distinct entity?
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 13, 2021 Category: Endocrinology Source Type: research

The Notch pathway regulates KLF4 in podocyte injury induced by high glucose
AbstractBackgroundDiabetic nephropathy (DN) is a common complication of diabetes. The Notch pathway plays an important role in podocyte injury and decreases the expression of podocyte-specific proteins in DN. However, the exact mechanisms are still elusive.ObjectiveThe purpose of this study was to investigate the effect of the Notch pathway on podocyte injury by regulating Kr üppel-like factor 4 (KLF4) in high glucose (HG)-induced podocytes.MethodsThe expression of the Notch pathway and KLF4 was regulated in HG-induced podocytes. Western blotting was used to detect the protein expression of Notch1, Notch intracellular...
Source: International Journal of Diabetes in Developing Countries - August 12, 2021 Category: Endocrinology Source Type: research

Genetic polymorphisms in ABCA1 (rs2230806 and rs1800977) and LIPC (rs2070895) genes and their association with the risk of type 2 diabetes: a case control study
ConclusionIt can be concluded that A allele ofABCA1 variant G656A andLIPC variant G-250A might serve as risk factors in the development of T2DM in the North Indian population. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 10, 2021 Category: Endocrinology Source Type: research

Comparative analysis of the transcriptome of T2DM Bama mini-pigs with T2DM patients
ConclusionThis study represents the first RNAseq transcriptome analysis in T2D Bama mini-pigs and provided a new perspective for the study on the human T2DM pathogenesis by using the T2DM model of Bama mini-pigs. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 4, 2021 Category: Endocrinology Source Type: research

Rapidly progressive diabetic kidney disease: South Asian experience
ConclusionYounger age, higher body mass index, coexisting hypertension, overt proteinuria, and suboptimal glycemic and blood pressure control with underutilization of RAS inhibitors were prevalent in rapid decliners in DKD. Rapidly progressive diabetic kidney disease is a globally under-recognized entity, and this is the first experience shared from the South Asian region. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 30, 2021 Category: Endocrinology Source Type: research

Dietary self-care and hospital readmission among individuals with diabetes mellitus
ConclusionsAfter hospital discharge, individuals with DM presented poor adherence to self-care, especially regarding diet. However, when these individuals adhered to nutritional guidance, there were fewer hospital readmissions. These results reinforce the importance of interdisciplinary educational actions for DM management. However, due to the small sample size because of the high mortality, further studies for this purpose should be conducted. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 29, 2021 Category: Endocrinology Source Type: research

Protective effect and mechanism of Schistosoma japonicum soluble egg antigen against type 1 diabetes in NOD mice
ConclusionsThese results demonstrated that SEA can prevent type 1 diabetes by enhancing regulatory T cells and the T helper 2 cell immune response in NOD mice. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 29, 2021 Category: Endocrinology Source Type: research

Factors associated with influenza vaccine coverage among patients with diabetes: Korea National Health and Nutrition Examination Survey 2016 –2018
AbstractBackgroundAlthough the influenza vaccine has been proven to be effective, this common disease has high morbidity and mortality rates. Moreover, adults with diabetes are at a high risk of influenza-mediated morbidity and mortality.Purpose  of the studyWith the increasing prevalence of diabetes, influenza is more lethal in diabetics; thus, we aimed to investigate the factors associated with influenza vaccination coverage in patients with diabetes.MethodsCross-sectional data were obtained from the Korea National Health and Nutrition Examination Survey (2016 –2018). We retrospectively analyzed whether sociod...
Source: International Journal of Diabetes in Developing Countries - July 27, 2021 Category: Endocrinology Source Type: research

What drives glycemic control in a person living with diabetes?
ConclusionPatient behavior and activation-related factors are predominant drivers of glycemic control. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 24, 2021 Category: Endocrinology Source Type: research

Therapeutic outcome of dapagliflozin on various parameters in non-alcoholic fatty liver disease (NAFLD) patients
ConclusionDapagliflozin has a strong potential to reverse NAFLD-associated changes in type 2 diabetic patients. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 23, 2021 Category: Endocrinology Source Type: research

Correction to: Barriers to postpartum follow-up of mothers with gestational diabetes mellitus and its implications: a mixed method study
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 22, 2021 Category: Endocrinology Source Type: research

Resistin, TNF- α, and microRNA 124-3p expressions in peripheral blood mononuclear cells are associated with diabetic nephropathy
AbstractIntroductionDiabetic nephropathy causes chronic kidney disease and renal failure globally. We investigated the mRNA expression of resistin, TNF- α, and microRNA 124-3p (miR-124-3p) in peripheral blood mononuclear cells (PBMCs) of diabetic patients with and without nephropathy.MethodsThe mRNA expression of target genes in isolated PBMCs from whole blood was determined using real-time quantitative reverse transcription (RT) polymerase chain reaction (qRT-PCR). Demographic and clinical characteristics of study patients were also measured by standard methods.ResultsRelative expression of resistin and TNF- α...
Source: International Journal of Diabetes in Developing Countries - July 21, 2021 Category: Endocrinology Source Type: research

WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus
This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM).MethodsA total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine  aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta...
Source: International Journal of Diabetes in Developing Countries - July 21, 2021 Category: Endocrinology Source Type: research

Increased of fasting active glucagon-like peptide-1 is associated with insulin resistance in patients with hypertriglyceridemia
AbstractBackgroundGlucagon-like peptide-1 (GLP-1) is an incretin hormone that facilitates insulin secretion and preserves β cell function. hypertriglyceridemia plays an important role in the pathogenesis of insulin resistance and T2DM. The purpose of this study was to measure fasting active GLP-1 levels in hypertriglyceridemia subjects and analyse the relationship between GLP-1 and insulin resistance.MethodsWe recruited 146 subjects including 38 diabetes patients with hypertriglyceridemia, 33 diabetes patients without hypertriglyceridemia, 35 hypertriglyceridemia subjects, and 40 healthy subjects as the normal control...
Source: International Journal of Diabetes in Developing Countries - July 21, 2021 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus and the risk of hip and vertebral fractures: a systematic review and meta-analysis of cohort studies
ConclusionT2DM was positively associated with an increased risk of hip fracture but not with vertebral fracture. Bone health in patients with T2DM requires more attention, and further research is warranted. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 13, 2021 Category: Endocrinology Source Type: research

Resveratrol exerts antiproliferative effects on high-glucose-cultured vascular smooth muscle cells via inhibition of STAT3 and upregulation of mitochondrial gene GRIM-19 which is responsible for STAT3 activation
ConclusionThe results of the study suggest that Resv has an antiproliferative effect in high-glucose-cultured VSMCs partly through inhibiting STAT3 function and upregulating mitochondrial biogenesis. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 10, 2021 Category: Endocrinology Source Type: research

Glycemic control among children and adolescents with type 1 diabetes during COVID-19 pandemic in Egypt: a pilot study
AbstractBackgroundThe COVID-19 pandemic and the consequences of lockdown significantly impacted glycemic control.AimTo evaluate the impact of the pandemic and lockdown on glycemic control among Egyptian children and adolescents with type 1 diabetes.MethodsCross-sectional study conducted through an online questionnaire. The participants were patients with type 1 diabetes and/or their caregiversResultsA total of 115 valid responses to the questionnaire were received. During the lockdown, almost 64% of patients showed worsening of their HbA1C with significant increment of HbA1c after the lockdown (p  
Source: International Journal of Diabetes in Developing Countries - July 9, 2021 Category: Endocrinology Source Type: research

Association between neutrophil –lymphocyte ratio on arterial stiffness in type-2 diabetes mellitus patients: a part of DiORS Study
This study is part of the Diabetic Ocular Renal Surabaya Study (DiORS Study). Participants were measured for their NLR count by dividing absolute neutrophil count with absolute lymphocyte count in peripheral blood and measuring of arterial stiffness with baPWV. The statistical analysis in use included independent t-test, Mann –Whitney test, Pearson correlation test, or Spearman correlation test. The results of the statistical analysis were significant ifp   1.65). The mean of baPWV was 15.19 ± 2.72 m/s with a range of 10.20–23.30 m/s, and 75.0% of them saw an increas...
Source: International Journal of Diabetes in Developing Countries - July 9, 2021 Category: Endocrinology Source Type: research

Effect of constructing doctor-pharmacist joint pharmacy clinic for outpatients on the comprehensive management of type 2 diabetes mellitus: a pilot RCT
This study was designed to investigate the effectiveness of pharmacists participating in the comprehensive management of T2DM patients in the form of building doctor-pharmacist joint pharmacy clinic in the National Metabolic Management Center (MMC).MethodsA total of 204 patients with type 2 diabetes mellitus were enrolled and randomly divided into control group and intervention group. During the 3-month study period, both groups received standardized MMC diagnosis and treatment, and clinical pharmacists provided pharmaceutical care for the intervention group. Observation indicators include drug compliance, fasting blood gl...
Source: International Journal of Diabetes in Developing Countries - July 2, 2021 Category: Endocrinology Source Type: research

To study the awareness of gestational diabetes mellitus in antenatal women, and medical and paramedical trainees in teaching hospital in North India
AbstractIntroductionGestational diabetes mellitus (GDM) increases pregnancy complications and future development of diabetes. Success of initiatives to increase GDM awareness depends upon the knowledge level of healthcare providers and antenatal women.Materials and methodIt is a descriptive, cross-sectional study done in a teaching hospital in North India. Two pre-tested, semi-structured questionnaires assessing the basic and advanced knowledge on GDM were used. Participants included antenatal women, undergraduate trainees who filled the level 1 questionnaire, and postgraduate residents, MBBS 3rd professional students, who...
Source: International Journal of Diabetes in Developing Countries - June 25, 2021 Category: Endocrinology Source Type: research

In-hospital fasting hyperglycemia and increased risk of mortality after acute coronary syndrome: a systematic overview and meta-analysis
AbstractBackgroundSeveral studies noted that increased fasting blood glucose in hospital is associated with increasing mortality of acute coronary syndrome (ACS). We conducted a meta-analysis to assess the risk of mortality after ACS in patients who had fasting hyperglycemia (FH) in hospital.MethodsWe conducted searches on PubMed, Cochrane Library, Web of Science, and Embase for relevant studies published before August 31, 2019. We pooled odds ratios (OR) from individual studies using a random effects model. Data abstraction was conducted by two independent reviewers, and the meta-analysis was performed using Review Manage...
Source: International Journal of Diabetes in Developing Countries - June 23, 2021 Category: Endocrinology Source Type: research

Obesity and dyslipidemia among Bhil tribal population: A cross-sectional study from India
ConclusionThe observed high prevalence of obesity and dyslipidemia, particularly low HDL-C and hypertriglyceridemia, warrants a public health concern. This study emphasizes the need for population-specific disease documentation to highlight underlying mechanisms of risk factors and to set forth a targeted approach to disease treatment and management. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 23, 2021 Category: Endocrinology Source Type: research

Two nested syndromes: fibromyalgia and neuropathic pain in prediabetes —a pilot study
This study aimed to determine the prevalence of neuropathic pain (NeP) and fibromyalgia syndrome (FMS) in prediabetics and to compare them with normoglycemic controls, to disclose the impact of NeP and FMS in disease burden.MethodsPeople, 18 –65 years old, who were admitted to a tertiary hospital’s internal medicine outpatient clinic for routine health check-ups and then those who were newly diagnosed with prediabetes were recruited as a prediabetic group and those who were normoglycemic were recruited as a control group. Participa nts’ demographics and clinical data were recorded. The ShortForm-36 a...
Source: International Journal of Diabetes in Developing Countries - June 16, 2021 Category: Endocrinology Source Type: research

Effect of vitamin D on arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease
AbstractPurposeTo evaluate the association between serum 25-hydroxy vitamin D level and arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease (CKD).MethodsThe serum 25-hydroxy vitamin D level and various parameters of vascular functions were assessed in type 2 diabetes patients with intermediate CKD (stages 3a and 3b). The carotid-femoral pulse wave velocity (cfPWV) among vitamin D-deficient, -insufficient, and normal patients was compared.ResultsOne hundred and twenty-one patients were included. The cfPWV in the vitamin D-deficient group (1190.32  ± 256.95 cm/s) ...
Source: International Journal of Diabetes in Developing Countries - June 15, 2021 Category: Endocrinology Source Type: research

Effects of comprehensive nursing intervention on maternal and infant outcomes for gestational diabetes mellitus patients
This study aimed to investigate the effects of comprehensive nursing intervention on maternal and infant outcomes for GDM patients.MethodsNinety-three GDM patients were randomly divided into intervention group (45 cases) and control group (48 cases). During the perinatal period, the control group received the routine nursing (one-off health education and nutrition and exercise guidance, regular pregnancy monitoring, regular postpartum care, etc.). The intervention group received the comprehensive nursing intervention including psychological intervention, health education, diet control, exercise intervention, pregnancy moni...
Source: International Journal of Diabetes in Developing Countries - June 8, 2021 Category: Endocrinology Source Type: research

Diabetes Mellitus and Heart Failure: A Consensus Statement
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 4, 2021 Category: Endocrinology Source Type: research

Predictive low-glucose suspend system and glycemic variability
ConclusionWith PLGS therapy, TIR was> 70% and the time spent in hypoglycemia was very low. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 3, 2021 Category: Endocrinology Source Type: research

Diabetic nephropathy with and without retinopathy: comparison between urine and serum vascular endothelial growth factor
ConclusionThe occurrence of DR in patients with DN is associated with higher mean serum than urine VEGF levels, as compared to lower serum to urine ratio of VEGF levels in DN patients without DR. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 2, 2021 Category: Endocrinology Source Type: research

Genetic association of vascular endothelial growth factor (VEGF) gene variants with the risk for diabetic retinopathy: a meta-analysis
ConclusionThe meta-analysis suggested the substantial role ofVEGF polymorphism rs3025039 as a possible biomarker for the assessment of DR risk. However, genome-wide association study (GWAS) is required in future to elucidate the multi-SNP effect of these polymorphisms inVEGF gene. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 1, 2021 Category: Endocrinology Source Type: research

Post-liver transplantation diabetes mellitus — a clinical challenge for diabetologists?
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 26, 2021 Category: Endocrinology Source Type: research

Add-on therapy with dapagliflozin in routine outpatient care of type 2 diabetes patients from Turkey: a retrospective cohort study on HbA1c, body weight, and blood pressure outcomes
This study aimed to evaluate HbA1c, blood pressure (BP), and weight outcomes in dapagliflozin-treated patients with type 2 diabetes (T2D) treated in a real-world setting.MethodsA total of 1683 T2D patients (mean (SD) age: 54.6 years (9.1), 56.6% were females) initiating dapagliflozin were included in this multicenter retrospective observational cohort study. Data on patient demographics, comorbidities, duration of diabetes, and concomitant antidiabetic treatment were recorded. Change in glycated hemoglobin (HbA1c), body weight, body mass index (BMI), and BP levels with dapagliflozin treatment and dapagliflozin discontinuat...
Source: International Journal of Diabetes in Developing Countries - May 4, 2021 Category: Endocrinology Source Type: research

Association between rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 with type 2 diabetes susceptibility among the Isfahan population in Iran
AbstractBackground and aimType 2 diabetes mellitus (T2DM) is a global human disease that affects millions of people. Long non-coding RNAs (LncRNAs) are transcripts with more than two-hundred nucleotides that play essential roles in the management of mRNAs. In the present study, we examined whether the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 is associated with the susceptibility to T2DM among the Isfahan population, Iran.MethodsTo this end, a case-control study was conducted on 200 healthy persons and 200 patients with T2DM. The genomic DNA was extracted from blood samples to strengthen the intended f...
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research

Dietary supplementation of mustard oil reduces blood glucose levels by triggering insulin receptor signaling pathway
ConclusionsMustard oil inclusion in the diet reduces blood glucose levels by increased insulin receptor signaling, thereby partially reversing diabetic state in experimentally induced diabetic rats. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research