Association between rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 with type 2 diabetes susceptibility among the Isfahan population in Iran
AbstractBackground and aimType 2 diabetes mellitus (T2DM) is a global human disease that affects millions of people. Long non-coding RNAs (LncRNAs) are transcripts with more than two-hundred nucleotides that play essential roles in the management of mRNAs. In the present study, we examined whether the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 is associated with the susceptibility to T2DM among the Isfahan population, Iran.MethodsTo this end, a case-control study was conducted on 200 healthy persons and 200 patients with T2DM. The genomic DNA was extracted from blood samples to strengthen the intended f...
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research

Dietary supplementation of mustard oil reduces blood glucose levels by triggering insulin receptor signaling pathway
ConclusionsMustard oil inclusion in the diet reduces blood glucose levels by increased insulin receptor signaling, thereby partially reversing diabetic state in experimentally induced diabetic rats. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research

The impact of different modes of exercise training on GLP-1: a systematic review and meta-analysis research
ConclusionIn this meta-analysis, it was found that the levels of GLP-1 could be affected by short-term and long-term training with different modes and intensity. As a result, current evidence shows that it may be a good choice for patients with type 2 diabetes to control their blood glucose. The mechanism of this GLP-1 increase has not yet been fully discovered. Further longitudinal studies and exploration into mechanisms of action are required in order to determine the precise role of GLP-1 in insulin responses to an exercise intervention. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 22, 2021 Category: Endocrinology Source Type: research

High expression of lncRNA MALAT1 is associated with decreased insulin secretion under hyperglycemic stress in patients with type 2 diabetes mellitus
This study aimed to explore the expression of lncRNA MALAT1 in patients with T2DM and its clinical significance. A total of 25 normal controls and 69 patients with T2DM were selected.MethodsReal-time polymerase chain reaction was used to determine the expression level of lncRNA MALAT1 in blood leukocytes of the two groups.ResultsThe expression level of lncRNA MALAT1 in patients with T2DM was significantly higher than that in the control group (p
Source: International Journal of Diabetes in Developing Countries - April 21, 2021 Category: Endocrinology Source Type: research

Investigation of extracellular matrix genes associated with Alzheimer ’s disease in the hippocampus of experimental diabetic model rats
ConclusionThese genes encoding proteases that regulate neuronal activity have decreased levels in the T2D model. There may be potential in the adoption of new treatment approaches for Alzheimer ’s and T2D. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 17, 2021 Category: Endocrinology Source Type: research

Predicted HbA1c and fructosaminated HbA1c: evaluating their role as an indicator of glycemic status in diabetes mellitus: a hospital based cross-sectional study
AbstractBackgroundGlycated hemoglobin has been a popular investigation to access the glycemic status. It is a marker for intracellular glycation, and hence, an investigation which can comply with both intracellular and extracellular glycation statuses is preferred.MethodologyIn this regard, fructosaminated HbA1c (FHbA1c), predicted HbA1c (PHbA1c) and glycation gap (GG) were evaluated in 57 cases of diabetes mellitus (DM) without complication and having a normal serum protein and albumin levels. Fifty controls were also evaluated. FHbA1c, PHbA1c and post-prandial predicted HbA1c (PPHbA1c) were plotted using population linea...
Source: International Journal of Diabetes in Developing Countries - April 16, 2021 Category: Endocrinology Source Type: research

Risk factors for diabetes mellitus in patients with gastroesophageal reflux disease
ConclusionWe conclude that DM in patients with GERD should have regular physical examinations that include a thorough patient history, appropriate laboratory tests, and possible endoscopy. We also suggest that patients with either DM or GERD should be evaluated and treated immediately if they have symptoms, including regular physical examinations and lifestyle interventions, to improve health-related quality of life. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 16, 2021 Category: Endocrinology Source Type: research

The effects of in-water and on-land aerobic training on postural sway and balance in patients with type 2 diabetes
AbstractBackgroundBalance and maintaining posture are essential requirements for the daily activities of diabetic patients. The purpose of this study was to investigate the effect of in-water and on-land aerobic training on balance of type 2 diabetic patients.Research questionIs there a difference in the balance of patients between aerobic training environments in water and on land?MethodsFor this, 24 participants were assigned randomly in three eight-person groups of control, aerobics on land, and aerobics in water. Patients performed aerobic protocol in 12 weeks (2 sessions per week) and total of twenty-four 60-min train...
Source: International Journal of Diabetes in Developing Countries - April 14, 2021 Category: Endocrinology Source Type: research

Albuminuria increased the risk of left ventricular hypertrophy in type 2 diabetes patients with early renal insufficiency
ConclusionsAlbuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal insufficiency. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 8, 2021 Category: Endocrinology Source Type: research

Risk factors associated with gestational diabetes mellitus: a retrospective case-control study
This study aims to identify the prevalence of GDM, the risk factors, and the effect on pregnancy outcome based on a retrospective case-control study.MethodsTwo hundred ninety-three parturients with GDM who delivered in a general hospital in Fujian province and met the inclusion criteria were selected as the case group from January to June 2018. Two hundred ninety-three parturients without GDM who delivered in the same period served as the control group. Risk factors for GDM were determined by univariate and binary logistic regression analysis. The prevalence of pregnancy outcomes was determined by a chi-square test.Results...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

High prevalence of prolonged QTc interval among individuals in ambulatory diabetic care in southwestern Uganda
AbstractBackgroundHeart rate-corrected QT (QTc) interval is associated with increased risk for cardiovascular events and mortality among individuals with diabetes mellitus (DM). Little is known about the epidemiology of prolonged QTc among people with DM in resource-limited settings.MethodsWe conducted a cross-sectional study among adults with diabetes in ambulatory care at the Mbarara Regional Referral Hospital, from November 2018 to April 2019. Twelve-lead ECG recordings were performed on all participants. We collected clinical and laboratory data related to diabetes disease status and treatment control. We estimated QTc...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

Knowledge, attitude, and practice towards diabetes mellitus among outpatient diabetic elderly persons: a descriptive study
AbstractObjectiveTo investigate the knowledge, attitude, and practice (KAP) towards diabetes mellitus (DM) among outpatient diabetic elderly persons attending tertiary healthcare facilities in Nigeria and also to verify the null hypotheses of no significant differences within demographic variables.MethodsThe study was based on descriptive research design and was carried out in 36 public tertiary healthcare facilities in Nigeria, from August to December 2019. Using the purposive sampling technique, a total of 360 diabetic elderly persons aged 60 years and above were studied. An adapted KAP questionnaire with 0.86 reliabilit...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

An ultra-rare case of 47,XXY/48,XXXY/49,XXXXY mosaic Klinefelter syndrome associated with diabetic ketosis and foot ulcer
ConclusionsThis case provides information on KS patients with the extremely rare karyotype 47,XXY/48,XXXY/49,XXXXY, and also emphasizes the importance of considering KS in the differential diagnosis of a sterile male with diabetes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 6, 2021 Category: Endocrinology Source Type: research

Elevated levels of fasting serum GIP may be protective factors for diabetic retinopathy in type 2 diabetes mellitus
ConclusionsPrevalence of DR was independently and negatively correlated with fasting serum GIP in T2DM, indicating that elevated levels of fasting serum GIP may act as protective factors for DR. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 17, 2021 Category: Endocrinology Source Type: research

A study on diabetes-related distress among type 2 diabetes mellitus patients using the diabetes distress scale in a tertiary care center in Telangana
ConclusionsDiabetes distress and glycemic control have a strong correlation with each other, and both need to be addressed during management of type 2 DM. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 15, 2021 Category: Endocrinology Source Type: research

Influence of a 12-week physical activity program on leptin resistance in metabolic syndrome: a preliminary study
ConclusionFrom present study, it is concluded that a 12-week physical activity promotion program brought marginal changes in leptin levels and has potential to modify metabolic syndrome parameters and improve physical activity. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 9, 2021 Category: Endocrinology Source Type: research

Stewart (physicochemical) approach versus conventional anion gap approach for resolution of metabolic acidosis in diabetic ketoacidosis
AbstractBackgroundDiabetic ketoacidosis (DKA) frequently requires emergency admission. The anion gap approach is conventionally used for the diagnosis and documenting the resolution of acidosis during treatment. However, it fails to detect hyperchloremic acidosis during the resolution and may result in the prolongation of treatment.ObjectivesTo determine the role of the Stewart approach of acid-base disorder during DKA management for the prediction of an earlier resolution.MethodsA prospective comparative study was conducted between January 2017 and December 2017 at a single academic hospital in north India. Patients aged ...
Source: International Journal of Diabetes in Developing Countries - March 9, 2021 Category: Endocrinology Source Type: research

Doege-Potter syndrome: a case report
ConclusionThis case stresses upon thorough evaluation of patients presenting with non-diabetic hypoglycemia to rule out underlying malignancy. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 8, 2021 Category: Endocrinology Source Type: research

Mauriac syndrome: a rare cause of massive hepatomegaly
We report a 10-year-old boy with poorly controlled type I diabetes mellitus (on pre-mix insulin), hepatomegaly, and extremely high levels of liver transaminases. He underwent a liver biopsy elsewhere which showed glycogen deposits. He was referred to our institution for confirmation of diagnosis of glycogen storage disorder. Clinical examination revealed short stature, moon facies, and protuberant abdomen with hepatomegaly of 8 cm below the right costal margin. After exclusion of other causes of hepatitis, we controlled his sugars using basal bolus insulin regimen. Clinical exome sequencing revealed no abnormal mutations i...
Source: International Journal of Diabetes in Developing Countries - March 6, 2021 Category: Endocrinology Source Type: research

The efficacy of negative pressure wound therapy compared with conventional dressing in treating infected diabetic foot ulcers: a randomized controlled trial
ConclusionNPWT seems to be more efficacious than conventional dressing in treating infected DFUs. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 4, 2021 Category: Endocrinology Source Type: research

Is there a need to reconsider the use of metformin in COVID-19 patients with type 2 diabetes mellitus?
ConclusionsOur findings indicated that metformin may be safely continued in COVID-19 patients. The benefit of metformin therapy with simultaneous continuous monitoring of COVID-19 severity and kidney function may outweigh the risks of lactic acidosis, of which incidence is relatively rare. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 2, 2021 Category: Endocrinology Source Type: research

RSSDI clinical practice recommendations for screening, diagnosis, and treatment in type 2 diabetes mellitus with obstructive sleep apnea
AbstractPurpose of the study Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are closely associated diseases with a significant impact on public health. Both diseases are highly prevalent and the common overlapping risk factors include obesity, old age, and a generally high preponderance in men. A growing body of evidence suggests a bidirectional association between OSA and T2DM; both, in turn, constitute as strong risk factors for cardiovascular diseases, the leading cause of premature deaths and morbidity in India. Several studies have reported a higher prevalence of OSA in Indian patients with T2DM, de...
Source: International Journal of Diabetes in Developing Countries - February 25, 2021 Category: Endocrinology Source Type: research

Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
AbstractBackgroundSeveral studies have been performed to assess the relationship between hyperhomocysteinemia and type 2 diabetes mellitus (T2DM). However, inconsistent results have been obtained. Therefore, we performed this meta-analysis to address this knowledge gap.MethodsWe searched PubMed, Cochrane library, and EMBASE database for studies that evaluated the relationship between blood homocysteine (HCY) level and T2DM from inception to Jun 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). RevMan5.3 and Stata12.0 were used f...
Source: International Journal of Diabetes in Developing Countries - February 23, 2021 Category: Endocrinology Source Type: research

MiRNA expression analysis emphasized the role of miR-424 in diabetic cardiovascular complications
ConclusionCardiovascular risk assessment, supported by emerging circulating biomarkers, such as miRNAs, is important for stratifying high-risk individuals, optimizing treatment strategies, and enhancing our understanding of basic biology. Our study showed the highest increase in expression levels of miR-424-5p in target group and emphasized its role as a biomarker for cardiovascular damage in patients with type 2 diabetes mellitus. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 20, 2021 Category: Endocrinology Source Type: research

Secondary diabetes mellitus in Prader-Willi syndrome
ConclusionsThis case emphasizes the importance of considering PWS in the differential diagnosis of an adolescent with diabetes. Antenatal history of neonatal hypotonia and childhood history of feeding disorder are the keys to the diagnosis of PWS. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients
Conclusions/interpretationIn conclusion, Lys inhibited protein glycation, improved glycemic control, and increased antioxidant markers in type 2 diabetic patients; thus, it could be suggested for combinatorial therapy of diabetes with oral hypoglycemic agents to protect against vascular risk factors and other diabetic complications. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

Evaluation of ultrasound examination combined with intensive injection technique education on insulin-induced lipohypertrophy (LH) management: a prospective cohort study in China
This study was aimed to assess the impact of ultrasound examination combined with intensive injection technique education for LH management.MethodA total of 120 patients with diabetes who were identified as existing clinical LH were enrolled into the study. All patients underwent ultrasound examination and received intensive injection technique education based on ultrasound detection results and Chinese guideline for diabetic injection technology in a prospective single study in China with a follow-up of 3 months. Injection Technique Questionnaire (ITQ) and assessment of glycemic control were used to assess the impact of u...
Source: International Journal of Diabetes in Developing Countries - February 16, 2021 Category: Endocrinology Source Type: research

Sleep: an emerging therapeutic target in diabetes care
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 13, 2021 Category: Endocrinology Source Type: research

Circulating microRNAs associated with prediabetes and geographic location in Latinos
Conclusions/interpretationThis study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. Future studies should consider other microRNAs related to different biological pathways as possible biomarkers for type 2 diabetes in Latinos. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

Correction to: Prevalence of peripheral neuropathy among type 2 diabetes mellitus patients in a rural health centre in South India
A Correction to this paper has been published:https://doi.org/10.1007/s13410-020-00885-6 (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

The self-efficacy improvement in adolescent girls with type 1 diabetes mellitus with self-care education through mobile-based social networking
This study aimed to assess the effectiveness of a self-care educational program provided by mobile-based social networking (MBSN) on the self-efficacy of diabetic adolescent girls.MethodsA quasi-experimental study with 76 Iranian 14- to 18-year-old girls with T1DM was conducted in 2018 –2019. The subjects were selected with aconvenient sampling method and randomly assigned to the experimental and control groups. The MBSN was applied to implement a self-care educational program in the experimental group for 12 weeks. The Diabetes Management Self-Efficacy Scale (DMSES) questionnai re with the main domains of blood suga...
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research

Genetic characterization of suspected MODY patients in Pakistan by next generation sequencing —a pilot study
ConclusionThis study was the first in Pakistan to investigate the MODY using next-generation sequencing for clinical applications. There is huge public health burden of diabetes in the country. The study identified mutation in one known MODY gene. More extensive studies involving large sample size are required in future. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research

Epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic patients
ConclusionDiabetes is associated with increased mortality rate in patients with COVID-19 and is considered as a major risk factor for COVID-19 infection, posing a major public health challenge for health policymakers in managing and controlling the disease. Therefore, development of prevention and treatment strategies aimed at reducing COVID-19 morbidity and mortality in diabetes patients is of significant importance. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 9, 2021 Category: Endocrinology Source Type: research

Arbutin alleviates diabetic symptoms by attenuating oxidative stress in a mouse model of type 1 diabetes
ConclusionsThis investigation demonstrated that arbutin possesses antioxidant activities and can alleviate symptoms of type-1 diabetes mellitus (T1DM) in mice. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 8, 2021 Category: Endocrinology Source Type: research

Effects of anti-CD20 monoclonal antibody and IL-10 on pancreatic β cell regeneration in nonobese diabetic mice
AbstractObjectiveTo investigate the effects of anti-CD20 monoclonal antibody (mAb) combined with IL-10 mediated by adenovirus on the regeneration of pancreatic β cells in nonobese diabetic (NOD) mice.MethodsSerum IL-10, TGF- β, TNF-α, IFN-γ, C-peptide, and insulin were determined using commercial ELISA. Western blot assay and real-time PCR were performed to determine the expression of mRNA and protein expression, respectively. Besides, immunohistochemistry and immunofluorescence were performed.ResultsImmunohistochemisty assay indicated Ngn3 expression showed decrease in the anti-CD20+IL-10 group compa...
Source: International Journal of Diabetes in Developing Countries - January 27, 2021 Category: Endocrinology Source Type: research

Transcription factor 7-like 2 ( TCF7L2 ) rs12255372 variant and the risk of type 2 diabetes mellitus among the Kurdish population in Erbil, Iraq
ConclusionOur results suggest rs12255372 T allele as a putative risk factor that increases the susceptibility of T2D among the Iraqi Kurdish population. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 26, 2021 Category: Endocrinology Source Type: research

The association between dairy products consumption with risk of type 1 diabetes mellitus in children: a meta-analysis of observational studies
AbstractAimThe cornerstone of diabetes management is the diagnosis of its risk factors and then applying appropriate therapy. The aim of the study was to find if dairy consumption increases the risk of T1DM in children.MethodA systematic search of PubMed and Scopus was done up to 22 February 2020. The overall estimates and their 95% confidence intervals were calculated using a random effects model.ResultOur meta-analysis was performed on 7 studies. We extracted 14 effect sizes for T1DM risk. The analysis indicated that dairy consumption increased the risk of T1DM (RR: 1.04, 95% CI: 1.01, 1.08), with high heterogeneity (I2&...
Source: International Journal of Diabetes in Developing Countries - January 26, 2021 Category: Endocrinology Source Type: research

Type 1 diabetes in children: a scientometric assessment of Indian research output from 1990 to 2019
ConclusionsIndian contribution to global scientific output on pediatric T1D is lagging in quantity and quality compared to developed countries but has shown improvement in recent years. There is a need for Indian researchers to focus on collaborative research in pediatric T1D. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 25, 2021 Category: Endocrinology Source Type: research

What makes poor diabetic control worse? A cross-sectional survey of biopsychosocial factors among patients with poorly controlled diabetes mellitus in Malaysia
This study explored what biopsychosocial factors are associated with poor vs. very poor glycemic control among Malaysian patients with sub-optimal glycated hemoglobin (HbA1c) levels.MethodsThis cross-sectional study recruited diabetic patients with poor glycemic control (HbA1c ≥ 7.0%) from the Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia. The Generalized Anxiety Disorder (GAD)-7, Beck Depression Inventory (BDI) and Big Five Inventory (BFI) questionnaires assessed for anxiety, depression and personality traits, respectively. Multivariate logistic regre ssion analysis was performed to evaluate associati...
Source: International Journal of Diabetes in Developing Countries - January 23, 2021 Category: Endocrinology Source Type: research

New-onset diabetes mellitus after liver transplantation in the patients with acute liver failure
ConclusionWe showed that pretransplant hyperglycemia increased NODAT risk by 4 times, but hypoglycemia did not affect. So, pretransplant hyperglycemia should be controlled also in the patients with acute liver failure as in the patients with chronic liver failure. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 22, 2021 Category: Endocrinology Source Type: research

Molecular basis of non-alcoholic fatty liver disease and metabolic syndrome in a subset of South Asians
AbstractBackgroundMetabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) are emerging threats in Pakistan. The prevalence of MetS is reported to be 18 –46% in general population. Adipokines and their genetic polymorphisms are now considered as risk factors for these conditions. Chemerin modulates glucose and lipid homeostasis, nesfatin-1 acts as an anorexigenic peptide, desnutrin regulates adipose tissue fatty acid oxidation, adipocyte fat conte nt, and size. Therefore, this study was designed to identify the molecular and genetic differences in the above-mentioned biomarkers in metabolic syndrome po...
Source: International Journal of Diabetes in Developing Countries - January 14, 2021 Category: Endocrinology Source Type: research

Prevalence and risk factors associated with diabetes in Meru County, Kenya: a cross-sectional study
ConclusionPreventive intervention strategies should aim to address the modifiable correlates so as to reduce the burden of diabetes in rural communities in Kenya. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 14, 2021 Category: Endocrinology Source Type: research

Extremely low HDL and residual cardiovascular risk —a case report
ConclusionSuch cases are infrequent and pose a diagnostic challenge. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 13, 2021 Category: Endocrinology Source Type: research

Comparison of clinical features, complication profile, and achievement of guideline targets in early- and late-onset type 2 diabetes patients from North India
AbstractIntroductionThe prevalence of diabetes in young people is rising in India. The risk factors are high body mass index, lack of physical activity, and a positive family history. Young patients with type 2 diabetes mellitus are at a higher risk of longer disease duration and enhanced risk for chronic complications. We have studied the difference between early- and late-onset type 2 diabetes mellitus with respect to various glycemic and non-glycemic parameters.Material and methodsThis is an observational cross-sectional study conducted from November 2018 to October 2019. A total of 5142 patients were included in the st...
Source: International Journal of Diabetes in Developing Countries - January 12, 2021 Category: Endocrinology Source Type: research

De novo mutation in HNF-1 β gene as a cause for Maturity-onset Diabetes of the Young type 5 with sustained hypomagnesemia
ConclusionOur findings indicted that MODY is highly heterogeneous and patients with additional extrapancreatic clinical features and hypomagnesemia should be screened for MODY5. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 12, 2021 Category: Endocrinology Source Type: research

Efficacy and safety of a new insulin infusion protocol adapted for the target glycemic range of 140 –180 mg/dl in adult critical care units: a tertiary care centre experience
In this study, we have studied the efficacy of our insulin infusion protocol (IIP) in terms of bringing and maintaining blood glucose to target range, and its safety in terms of preventing hypoglycemia.Research design and methodsIt is a retrospective review of all patients who received insulin infusion from the 1st of July 2017 to the 30th of June 2018. A total of 231 were included and data pertaining to demographic details and related to insulin infusion was documented in a predefined questionnaire.ResultsInsulin infusion was continued for a mean duration of 26.3± 13.7  h taking 5.7± 3.1  h to reac...
Source: International Journal of Diabetes in Developing Countries - January 8, 2021 Category: Endocrinology Source Type: research

Prevalence and associated factors of metabolic syndrome among a national population-based sample of 18 –108-year-olds in Iraq: results of the 2015 STEPS survey
ConclusionTwo in five participants had MetS and several associated indicators were found which could be supportive in designing intervention activities. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 8, 2021 Category: Endocrinology Source Type: research

Detection of early diabetic retinopathy using visual electrophysiological tests
ConclusionWith a limited sample, we found that 56% of newly diagnosed diabetic patients with normal fundoscopy had defective RPE-photoreceptor interaction. Further studies are needed to obtain more precise point estimates of these EOG abnormalities, and to determine the conversion rates into more advanced stages of diabetic retinopathy. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Use of the online Framingham platform for the evaluation of the cardiovascular risk in diabetes mellitus and systemic arterial hypertension patients in primary health care
ConclusionIn conclusion, the online Framingham platform tool was able to identify the CVR. Additionally, SAH seems to be a more powerful factor to increase CVR, and the coexistence of DM and SAH increases this risk even more. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Ethanol extract of Tephrosia bracteolata leaves and its fractions ameliorates alloxan-induced diabetes and its associated complications in Wistar rat model
This study investigated the biochemical and histopathological effects of the ethanol extract ofT.bracteolata leaves (EETB) and its fractions on alloxan-induced diabetic rats.MethodsEETB was fractionated successively with n-hexane, chloroform, ethyl acetate, methanol, and water to yield the respective fractions (nHF, CF, EAF, MF, and AF). The antidiabetic activities of EETB and its fractions at 250 and 500  mg/kg body weight (groups 4–15) were investigated in comparison to the normal control (group 1), the diabetic control (group 2), and the standard (150 mg/kg b.w. metformin, group 3) on alloxan-induced dia...
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research