Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
AbstractBackgroundSeveral studies have been performed to assess the relationship between hyperhomocysteinemia and type 2 diabetes mellitus (T2DM). However, inconsistent results have been obtained. Therefore, we performed this meta-analysis to address this knowledge gap.MethodsWe searched PubMed, Cochrane library, and EMBASE database for studies that evaluated the relationship between blood homocysteine (HCY) level and T2DM from inception to Jun 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). RevMan5.3 and Stata12.0 were used f...
Source: International Journal of Diabetes in Developing Countries - February 23, 2021 Category: Endocrinology Source Type: research

MiRNA expression analysis emphasized the role of miR-424 in diabetic cardiovascular complications
ConclusionCardiovascular risk assessment, supported by emerging circulating biomarkers, such as miRNAs, is important for stratifying high-risk individuals, optimizing treatment strategies, and enhancing our understanding of basic biology. Our study showed the highest increase in expression levels of miR-424-5p in target group and emphasized its role as a biomarker for cardiovascular damage in patients with type 2 diabetes mellitus. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 20, 2021 Category: Endocrinology Source Type: research

Secondary diabetes mellitus in Prader-Willi syndrome
ConclusionsThis case emphasizes the importance of considering PWS in the differential diagnosis of an adolescent with diabetes. Antenatal history of neonatal hypotonia and childhood history of feeding disorder are the keys to the diagnosis of PWS. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients
Conclusions/interpretationIn conclusion, Lys inhibited protein glycation, improved glycemic control, and increased antioxidant markers in type 2 diabetic patients; thus, it could be suggested for combinatorial therapy of diabetes with oral hypoglycemic agents to protect against vascular risk factors and other diabetic complications. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

Evaluation of ultrasound examination combined with intensive injection technique education on insulin-induced lipohypertrophy (LH) management: a prospective cohort study in China
This study was aimed to assess the impact of ultrasound examination combined with intensive injection technique education for LH management.MethodA total of 120 patients with diabetes who were identified as existing clinical LH were enrolled into the study. All patients underwent ultrasound examination and received intensive injection technique education based on ultrasound detection results and Chinese guideline for diabetic injection technology in a prospective single study in China with a follow-up of 3 months. Injection Technique Questionnaire (ITQ) and assessment of glycemic control were used to assess the impact of u...
Source: International Journal of Diabetes in Developing Countries - February 16, 2021 Category: Endocrinology Source Type: research

Sleep: an emerging therapeutic target in diabetes care
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 13, 2021 Category: Endocrinology Source Type: research

Circulating microRNAs associated with prediabetes and geographic location in Latinos
Conclusions/interpretationThis study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. Future studies should consider other microRNAs related to different biological pathways as possible biomarkers for type 2 diabetes in Latinos. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

Correction to: Prevalence of peripheral neuropathy among type 2 diabetes mellitus patients in a rural health centre in South India
A Correction to this paper has been published:https://doi.org/10.1007/s13410-020-00885-6 (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

The self-efficacy improvement in adolescent girls with type 1 diabetes mellitus with self-care education through mobile-based social networking
This study aimed to assess the effectiveness of a self-care educational program provided by mobile-based social networking (MBSN) on the self-efficacy of diabetic adolescent girls.MethodsA quasi-experimental study with 76 Iranian 14- to 18-year-old girls with T1DM was conducted in 2018 –2019. The subjects were selected with aconvenient sampling method and randomly assigned to the experimental and control groups. The MBSN was applied to implement a self-care educational program in the experimental group for 12 weeks. The Diabetes Management Self-Efficacy Scale (DMSES) questionnai re with the main domains of blood suga...
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research

Genetic characterization of suspected MODY patients in Pakistan by next generation sequencing —a pilot study
ConclusionThis study was the first in Pakistan to investigate the MODY using next-generation sequencing for clinical applications. There is huge public health burden of diabetes in the country. The study identified mutation in one known MODY gene. More extensive studies involving large sample size are required in future. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research

Epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic patients
ConclusionDiabetes is associated with increased mortality rate in patients with COVID-19 and is considered as a major risk factor for COVID-19 infection, posing a major public health challenge for health policymakers in managing and controlling the disease. Therefore, development of prevention and treatment strategies aimed at reducing COVID-19 morbidity and mortality in diabetes patients is of significant importance. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 9, 2021 Category: Endocrinology Source Type: research

Arbutin alleviates diabetic symptoms by attenuating oxidative stress in a mouse model of type 1 diabetes
ConclusionsThis investigation demonstrated that arbutin possesses antioxidant activities and can alleviate symptoms of type-1 diabetes mellitus (T1DM) in mice. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 8, 2021 Category: Endocrinology Source Type: research

Effects of anti-CD20 monoclonal antibody and IL-10 on pancreatic β cell regeneration in nonobese diabetic mice
AbstractObjectiveTo investigate the effects of anti-CD20 monoclonal antibody (mAb) combined with IL-10 mediated by adenovirus on the regeneration of pancreatic β cells in nonobese diabetic (NOD) mice.MethodsSerum IL-10, TGF- β, TNF-α, IFN-γ, C-peptide, and insulin were determined using commercial ELISA. Western blot assay and real-time PCR were performed to determine the expression of mRNA and protein expression, respectively. Besides, immunohistochemistry and immunofluorescence were performed.ResultsImmunohistochemisty assay indicated Ngn3 expression showed decrease in the anti-CD20+IL-10 group compa...
Source: International Journal of Diabetes in Developing Countries - January 27, 2021 Category: Endocrinology Source Type: research

Transcription factor 7-like 2 ( TCF7L2 ) rs12255372 variant and the risk of type 2 diabetes mellitus among the Kurdish population in Erbil, Iraq
ConclusionOur results suggest rs12255372 T allele as a putative risk factor that increases the susceptibility of T2D among the Iraqi Kurdish population. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 26, 2021 Category: Endocrinology Source Type: research

The association between dairy products consumption with risk of type 1 diabetes mellitus in children: a meta-analysis of observational studies
AbstractAimThe cornerstone of diabetes management is the diagnosis of its risk factors and then applying appropriate therapy. The aim of the study was to find if dairy consumption increases the risk of T1DM in children.MethodA systematic search of PubMed and Scopus was done up to 22 February 2020. The overall estimates and their 95% confidence intervals were calculated using a random effects model.ResultOur meta-analysis was performed on 7 studies. We extracted 14 effect sizes for T1DM risk. The analysis indicated that dairy consumption increased the risk of T1DM (RR: 1.04, 95% CI: 1.01, 1.08), with high heterogeneity (I2&...
Source: International Journal of Diabetes in Developing Countries - January 26, 2021 Category: Endocrinology Source Type: research

Type 1 diabetes in children: a scientometric assessment of Indian research output from 1990 to 2019
ConclusionsIndian contribution to global scientific output on pediatric T1D is lagging in quantity and quality compared to developed countries but has shown improvement in recent years. There is a need for Indian researchers to focus on collaborative research in pediatric T1D. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 25, 2021 Category: Endocrinology Source Type: research

What makes poor diabetic control worse? A cross-sectional survey of biopsychosocial factors among patients with poorly controlled diabetes mellitus in Malaysia
This study explored what biopsychosocial factors are associated with poor vs. very poor glycemic control among Malaysian patients with sub-optimal glycated hemoglobin (HbA1c) levels.MethodsThis cross-sectional study recruited diabetic patients with poor glycemic control (HbA1c ≥ 7.0%) from the Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia. The Generalized Anxiety Disorder (GAD)-7, Beck Depression Inventory (BDI) and Big Five Inventory (BFI) questionnaires assessed for anxiety, depression and personality traits, respectively. Multivariate logistic regre ssion analysis was performed to evaluate associati...
Source: International Journal of Diabetes in Developing Countries - January 23, 2021 Category: Endocrinology Source Type: research

New-onset diabetes mellitus after liver transplantation in the patients with acute liver failure
ConclusionWe showed that pretransplant hyperglycemia increased NODAT risk by 4 times, but hypoglycemia did not affect. So, pretransplant hyperglycemia should be controlled also in the patients with acute liver failure as in the patients with chronic liver failure. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 22, 2021 Category: Endocrinology Source Type: research

Molecular basis of non-alcoholic fatty liver disease and metabolic syndrome in a subset of South Asians
AbstractBackgroundMetabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) are emerging threats in Pakistan. The prevalence of MetS is reported to be 18 –46% in general population. Adipokines and their genetic polymorphisms are now considered as risk factors for these conditions. Chemerin modulates glucose and lipid homeostasis, nesfatin-1 acts as an anorexigenic peptide, desnutrin regulates adipose tissue fatty acid oxidation, adipocyte fat conte nt, and size. Therefore, this study was designed to identify the molecular and genetic differences in the above-mentioned biomarkers in metabolic syndrome po...
Source: International Journal of Diabetes in Developing Countries - January 14, 2021 Category: Endocrinology Source Type: research

Prevalence and risk factors associated with diabetes in Meru County, Kenya: a cross-sectional study
ConclusionPreventive intervention strategies should aim to address the modifiable correlates so as to reduce the burden of diabetes in rural communities in Kenya. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 14, 2021 Category: Endocrinology Source Type: research

Extremely low HDL and residual cardiovascular risk —a case report
ConclusionSuch cases are infrequent and pose a diagnostic challenge. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 13, 2021 Category: Endocrinology Source Type: research

Comparison of clinical features, complication profile, and achievement of guideline targets in early- and late-onset type 2 diabetes patients from North India
AbstractIntroductionThe prevalence of diabetes in young people is rising in India. The risk factors are high body mass index, lack of physical activity, and a positive family history. Young patients with type 2 diabetes mellitus are at a higher risk of longer disease duration and enhanced risk for chronic complications. We have studied the difference between early- and late-onset type 2 diabetes mellitus with respect to various glycemic and non-glycemic parameters.Material and methodsThis is an observational cross-sectional study conducted from November 2018 to October 2019. A total of 5142 patients were included in the st...
Source: International Journal of Diabetes in Developing Countries - January 12, 2021 Category: Endocrinology Source Type: research

De novo mutation in HNF-1 β gene as a cause for Maturity-onset Diabetes of the Young type 5 with sustained hypomagnesemia
ConclusionOur findings indicted that MODY is highly heterogeneous and patients with additional extrapancreatic clinical features and hypomagnesemia should be screened for MODY5. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 12, 2021 Category: Endocrinology Source Type: research

Efficacy and safety of a new insulin infusion protocol adapted for the target glycemic range of 140 –180 mg/dl in adult critical care units: a tertiary care centre experience
In this study, we have studied the efficacy of our insulin infusion protocol (IIP) in terms of bringing and maintaining blood glucose to target range, and its safety in terms of preventing hypoglycemia.Research design and methodsIt is a retrospective review of all patients who received insulin infusion from the 1st of July 2017 to the 30th of June 2018. A total of 231 were included and data pertaining to demographic details and related to insulin infusion was documented in a predefined questionnaire.ResultsInsulin infusion was continued for a mean duration of 26.3± 13.7  h taking 5.7± 3.1  h to reac...
Source: International Journal of Diabetes in Developing Countries - January 8, 2021 Category: Endocrinology Source Type: research

Prevalence and associated factors of metabolic syndrome among a national population-based sample of 18 –108-year-olds in Iraq: results of the 2015 STEPS survey
ConclusionTwo in five participants had MetS and several associated indicators were found which could be supportive in designing intervention activities. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 8, 2021 Category: Endocrinology Source Type: research

Detection of early diabetic retinopathy using visual electrophysiological tests
ConclusionWith a limited sample, we found that 56% of newly diagnosed diabetic patients with normal fundoscopy had defective RPE-photoreceptor interaction. Further studies are needed to obtain more precise point estimates of these EOG abnormalities, and to determine the conversion rates into more advanced stages of diabetic retinopathy. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Use of the online Framingham platform for the evaluation of the cardiovascular risk in diabetes mellitus and systemic arterial hypertension patients in primary health care
ConclusionIn conclusion, the online Framingham platform tool was able to identify the CVR. Additionally, SAH seems to be a more powerful factor to increase CVR, and the coexistence of DM and SAH increases this risk even more. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Ethanol extract of Tephrosia bracteolata leaves and its fractions ameliorates alloxan-induced diabetes and its associated complications in Wistar rat model
This study investigated the biochemical and histopathological effects of the ethanol extract ofT.bracteolata leaves (EETB) and its fractions on alloxan-induced diabetic rats.MethodsEETB was fractionated successively with n-hexane, chloroform, ethyl acetate, methanol, and water to yield the respective fractions (nHF, CF, EAF, MF, and AF). The antidiabetic activities of EETB and its fractions at 250 and 500  mg/kg body weight (groups 4–15) were investigated in comparison to the normal control (group 1), the diabetic control (group 2), and the standard (150 mg/kg b.w. metformin, group 3) on alloxan-induced dia...
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and computational analysis
AbstractIntroductionGenetic background is an important risk factor for type 2 diabetes mellitus (T2DM). We designed this study to examine the role of rs12778366 and rs3758391, two functionalSIRT1 gene polymorphisms, on the risk of T2DM in an Iranian population.Material and methodsIn this case-control study, a total of 813 subjects were enrolled. SNPs were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Multiple computational analyses were also performed to examine the potential effects of the studied variants.Results and conclusionWe found a significant association betwee...
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Rare neurological complications associated with critically ill pediatric diabetic ketoacidosis —a report of two cases
ConclusionThe severity of DKA at presentation with altered sensorium and/or hemodynamic compromise with renal involvement and dyselectrolytemia and a coexistent infection may have more propensity for such complications. Strict implementation of DKA management guidelines and a multidisciplinary approach to deal with the critically ill child is needed to optimize the outcome in such situations. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2021 Category: Endocrinology Source Type: research

Expanding the collation of urinary biomarkers in improving the diagnosis of diabetic nephropathy
ConclusionAs tubular damage occurs prior to glomerular damage in DN, we conclude that measurement of urinary NGAL predicts DN better than microalbumin alone. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 6, 2021 Category: Endocrinology Source Type: research

Development and testing of Diabetes Complications Risk Educational Tool (DiREcT) for improving risk perception among patients with diabetes mellitus: a mixed method study
ConclusionThe DiREcT tool was effective in changing perception of developing complications among patients with diabetes mellitus. It can be used by the healthcare provider at the primary healthcare level for both educating and monitoring of patients with high risk. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 6, 2021 Category: Endocrinology Source Type: research

A global view on prevalence of diabetes and the Human Development Index
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 6, 2021 Category: Endocrinology Source Type: research

The impact of high-fat and high-protein meal of adolescents with type 1 diabetes mellitus receiving intensive insulin therapy on postprandial blood glucose level: a randomized, crossover, breakfast study
AbstractBackgroundIn addition to carbohydrate count, this study aims to investigate the impact of the determination of bolus insulin doses by fat and protein counts on postprandial blood glucose level for adolescents having type 1 diabetes mellitus.MethodsThe study was crossover and randomized; and all of participants were given standard breakfast (insulin dose according to carbohydrate/insulin ratio) for 1  day, and high-fat and high-protein breakfast for 2 days. The insulin dose for one of test meal was determined based on carbohydrate/insulin ratio. In the second application, in addition to carbohydrate/insuli...
Source: International Journal of Diabetes in Developing Countries - January 5, 2021 Category: Endocrinology Source Type: research

Prevalence and correlates of pre-diabetes and diabetes among a national population-based sample of adults in Zambia: results of the first national STEPS survey in 2017
This study aimed to estimate for the first time the national prevalence and its correlates of pre-diabetes and diabetes among individuals aged 18 –69 years in Zambia.MethodsNationally representative cross-sectional data were analyzed from 3608 persons aged 18 –69 years (median age: 31 years) that participated in the “2017 Zambia STEPS survey,” with complete blood glucose measurements.ResultsResults indicate that 8.8% of 18 –69 year-olds had pre-diabetes and 7.2% diabetes.In adjusted multinomial logistic regression analysis, rural residence (adjusted relative risk ratio &thi...
Source: International Journal of Diabetes in Developing Countries - January 5, 2021 Category: Endocrinology Source Type: research

Prevalence and risk factors in metabolic syndrome among Temiar in Kelantan
ConclusionThe prevalence of MetS was higher than reported figures for other OA and ethnic groups in Malaysia with an apparent younger onset. Associated (risk) factors are discussed. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 4, 2021 Category: Endocrinology Source Type: research

Risk of LGA in pregnant women with different GDM status and risk profiles
ConclusionWomen with different GDM status had different characteristics and outcomes. Second trimester weight gain>  7 kg was the common independent risk of LGA and suboptimal glycemic control increased LGA risk in GDM women. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 2, 2021 Category: Endocrinology Source Type: research

Management of periodontal disease in patients with diabetes good clinical practice guidelines: A joint statement by Indian Society of Periodontology and Research Society for the Study of Diabetes in India
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - December 2, 2020 Category: Endocrinology Source Type: research

The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-analysis
ConclusionsOur review shows a definite association of metabolic syndrome with gallstone disease, and the more the components of metabolic syndrome, the higher the prevalence of gallstone disease. Although not as obvious as women, men also support this conclusion. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 28, 2020 Category: Endocrinology Source Type: research

Function of family of origin and current quality of life: exploring the mediator role of resilience in Chinese patients with type 2 diabetes
AbstractObjectivesEarly physical and mental experiences from family of origin and parents might influence individuals ’ later adulthood quality of life (QOL). The present study was undertaken to examine the inter-relationships among function of family of origin, resilience, and current quality of life in a T2DM sample from China.MethodsThree hundred T2DM participants were included in this investigation. A Chinese version of Connor-Davidson Resilience Scale 25, an APGAR family functioning scale, and a Diabetes Specificity Quality of Life Scale were used to assess the levels of mental resilience, function of family of ...
Source: International Journal of Diabetes in Developing Countries - November 26, 2020 Category: Endocrinology Source Type: research

Knowledge, attitude, and practice towards self-management among diabetic patients at Debre Tabor General Hospital chronic diseases follow-up clinic, Northwest Ethiopia
ConclusionMore than half of the participants had poor knowledge and attitude towards self-management and nearly two-thirds of them had poor practice. It is better to emphasize the importance of the patient as the key person in diabetic management. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 25, 2020 Category: Endocrinology Source Type: research

Lipohypertrophy in insulin injecting patients with diabetes mellitus: an under-recognized barrier for glycemic control
AbstractBackgroundLipohypertrophy is the one of the commonest local complications that significantly affects glycemic control in patients of diabetes mellitus on treatment with insulin. Our study aimed at assessing the clinical and ultrasonographic characteristics and risk factors for lipohypertrophy on the abdomen in a cohort of insulin-injecting Indian diabetes patients.MaterialsEighty-eight consecutive patients with type 1 (15/88) or type 2 diabetes mellitus (73/88) were included in this cross-sectional study conducted over a period of 6 months. The prevalence of lipohypertrophy and associated risk factors was assessed ...
Source: International Journal of Diabetes in Developing Countries - November 23, 2020 Category: Endocrinology Source Type: research

Glycemic control rate of type 2 diabetes mellitus in Chinese adults: a multi-centered, retrospective, cross-sectional study
This study aims to clarify the current status of glycemic control in type 2 diabetes mellitus (T2DM) patients in China.MethodsThis study was a multi-centered, retrospective, cross-sectional study based on electronic medical records. Individuals with T2DM who were admitted to a hospital between January 1, 2018, and December 31, 2018, and had either a fasting blood glucose or HbA1c tests results were included to assess the glycemic control. T2DM patients with fasting blood glucose
Source: International Journal of Diabetes in Developing Countries - November 18, 2020 Category: Endocrinology Source Type: research

Missing the wood for the trees: cardiocentricity in current diabetes guidelines
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 17, 2020 Category: Endocrinology Source Type: research

Prevalence of peripheral neuropathy among type 2 diabetes mellitus patients in a rural health centre in South India
This study aimed to assess the prevalence of DPN and its risk factors among the type 2 DM patients attending a rural health centre.MethodologyA cross-sectional study was conducted among 390 type 2 DM patients attending the Rural Health and Training Centre of Sri Ramachandra Medical College& Research Institute. Data was collected using a standardized questionnaire followed by general inspection and physical examination of the feet. Blood sample was taken to estimate HbA1c and urine sample was collected to detect presence of albumin.ResultsAmong the 390 participants, 175 (44.9%) had neuropathy of which 87 (51.5%) were sy...
Source: International Journal of Diabetes in Developing Countries - November 16, 2020 Category: Endocrinology Source Type: research

Human gut microbiota and its possible relationship with obesity and diabetes
AbstractBackgroundObesity and diabetes are public health problems that are leading causes of death in the world. Recent surveys suggest that there is a relationship between diabetes and bacterial residents of the gastrointestinal tract.ObjectiveThis case-control study was designed to evaluate the composition of the gut microbiota in patients with type 2 diabetes (T2DM) and obesity compared to the healthy people.MethodsA total of 91 adult subjects (25 patients diagnosed with T2DM, 48 obese patients, and 18 healthy individuals) were included in the study. The gut microbiota composition was investigated by quantitative real-t...
Source: International Journal of Diabetes in Developing Countries - November 16, 2020 Category: Endocrinology Source Type: research

Prevalence of IA-2 antibody in patients suffering from diabetes and their first-degree relatives
AbstractBackgroundType 1 diabetes mellitus (T1DM) is an autoimmune disorder accompanied by activation of auto-reactive B cells, autoantibody production, and consequently insulin-producing beta cell destruction. Some evidences support the value of autoantibodies such as anti-islet cell antigen (IA-2) auto-antibody in T1DM diagnosis and prognosis. The present study investigated the presence of IA-2 antibody in T1DM patients and their first-degree relatives as well as T2DM patients and healthy people to evaluate the diagnostic and prognostic value of anti-IA-2 in T1DM.MethodsIn total 264 cases including 38 T1DM patients, 36 f...
Source: International Journal of Diabetes in Developing Countries - November 11, 2020 Category: Endocrinology Source Type: research

Could the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?
AbstractBackgroundA good glycemic regulation should be provided to reduce mortality and morbidity in patients with end-stage renal failure due to diabetes mellitus. However, the use of insulin therapies in patients with renal failure is troublesome due to the increased rate of side effects. In our study, we investigated the frequency of hypoglycemia and its symptoms in patient groups receiving intensive and mixed insulin therapies.Materials and methodsThis prospective study included 89 hemodialysis patients with DM-related stage 5 chronic kidney disease who were followed up in a nephrology clinic of a university hospital b...
Source: International Journal of Diabetes in Developing Countries - November 10, 2020 Category: Endocrinology Source Type: research

Real-world outcomes of insulin pump compared to multiple daily injection therapy in adult type 1 diabetes mellitus patients in a Mediterranean scenario
AbstractAimTo analyze the real-life outcomes of insulin pump therapy, as compared to multiple daily injection (MDI) treatment, in adult type 1 diabetes mellitus (T1DM) patients from a tertiary diabetes care hospital in a Mediterranean scenario.Materials and methodsObservational cross-sectional study regarding all T1DM patients on insulin pump therapy compared (1:1) with MDI-treated patients selected through simple random sampling from our database. Primary efficacy outcome was to describe glycated hemoglobin A1c (HbA1c) differences.ResultsNinety patients were analyzed (male 53%). Mean age was 40.0 ± 14.4 years, and ...
Source: International Journal of Diabetes in Developing Countries - November 10, 2020 Category: Endocrinology Source Type: research

Relationship of HbA1c with plasma atherogenic index and non-HDL cholesterol in patients with type 2 diabetes mellitus
AbstractPurposeType 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present study is conducted to investigate the relationship between glycated hemoglobin (HbA1c), non-HDL (high-density lipoprotein) cholesterol, and atherogenic index within patients with T2DM.Materials and methodsA total of 4252 patients with T2DM were screened retrospectively and parameters including glucose, HbA1c, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholester...
Source: International Journal of Diabetes in Developing Countries - November 10, 2020 Category: Endocrinology Source Type: research