Diagnostic performance of HbA1c for detecting prediabetes and diabetes in Turkish adults
ConclusionHbA1c showed poor performance in diagnosis of diabetes and prediabetes. Instead, using HbA1c as a screening test with well-defined cutoff may offer practical and economical advantages greatly reducing the number of OGTTs required. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 17, 2020 Category: Endocrinology Source Type: research

Effect of liraglutide on epicardial adipose tissue thickness with echocardiography in patients with obese type 2 diabetes mellitus
AbstractBackgroundLiraglutide, an analogue of glucagon-like peptide 1 (GLP-1), indicated for the treatment of type 2 diabetes mellitus (T2DM), has shown the effect on loss of weight and adipose deposits. The study was to evaluate the effect of liraglutide on epicardial adipose tissue (EAT) with echocardiography in patients with obese T2DM controlled on liraglutide monotherapy.MethodsA single-arm follow-up research was performed in our study. Thirty-six subjects with obese T2DM were enrolled in the study, who were administered with liraglutide monotheraphy daily. The study period was 3  months. EAT thickness was measur...
Source: International Journal of Diabetes in Developing Countries - May 17, 2020 Category: Endocrinology Source Type: research

Prolonged diabetic ketoacidosis and glycemic fluctuations associated with dapagliflozin: a case report
ConclusionProlonged DKA may be a result of SGLT-2 inhibition and individualized treatment and follow-up should be performed instead of standard DKA treatment. Also, we suggest that we need to evaluate endogenous insulin reserves of the patients before starting a SGLT-2I treatment. We believe that in order to raise awareness, these cases should be reported. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 17, 2020 Category: Endocrinology Source Type: research

Sensorimotor impairments, postural instability, and risk of falling in older adults with diabetic peripheral neuropathy
AbstractBackgroundOlder adults with type 2 diabetes mellitus (DM) have high incidence of falls. The aim of this study was to compare sensorimotor functions, balance, mobility, fear of falling, and fall history in older people with DM (with and without neuropathy) and non-diabetic healthy controls.MethodsWe enrolled 153 participants aged 50 –70 years: 51 people with diabetic peripheral neuropathy (D-PN), 52 with diabetes without neuropathy (D-noPN), and 50 healthy controls (HC). Participants completed a fear of falling assessment and detailed test battery comprising sensorimotor functions, lower limb strength, co...
Source: International Journal of Diabetes in Developing Countries - May 12, 2020 Category: Endocrinology Source Type: research

Lockdown —the only solution to defeat COVID-19
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 5, 2020 Category: Endocrinology Source Type: research

The impact of limited and strategic blood glucose monitoring on metabolic control in a type 1 diabetes clinic in Central India
This study assessed whether the use of two SMBG tests per day improves glycemic control, measured by a change in HbA1c, in youth with T1D followed at the DREAM Trust (DT) in Nagpur, India.MethodsSingle-site prospective cohort study of youth ≤ 23 years of age with T1D ≥ 1 year followed by DT, who were provided with SMBG meters and two test strips per day. Patients received education regarding SMBG and how to respond to blood glucose values and trends. They were followed every 3 months with HbA1c and questionnaires for a total of 21 months.ResultsHbA1c declined significantly from 10.2 ...
Source: International Journal of Diabetes in Developing Countries - May 3, 2020 Category: Endocrinology Source Type: research

Optimal reference values for insulin sensitivity indices in Iranian healthy females: a population-based study
ConclusionThis study determined reference values for various insulin sensitivity indices in healthy Iranian women. These values can be used to define insulin sensitivity in women in epidemiological and clinical studies. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 20, 2020 Category: Endocrinology Source Type: research

Hypoglycemic, hypolipidemic, and hepatoprotective effects of Polyscias fulva (Hiern) Harms ethanolic bark extract in streptozotocin-induced diabetic Wistar rats
This study sought to examine the antidiabetic effects of ethanolic stem bark extract ofP. fulva in streptozotocin (STZ) –induced diabetic Wistar albino rats.MethodsDiabetes in rats was induced by intraperitoneal injection of STZ (50  mg/kg bwt) in experimental groups. Rats were divided into five groups (n = 5 per group): group 1, control; group 2, diabetic untreated rats; groups 3 and 4, diabetic rats on 200 and 400 mg/kg bwt/day of extract, respectively; and group 5, diabetic rats on metformin (100 mg/kg bwt/day). The rats received oral treatments daily for 21 days, and fasting blood ...
Source: International Journal of Diabetes in Developing Countries - April 13, 2020 Category: Endocrinology Source Type: research

Influence of yoga on status of lipid indices in type 2 diabetes mellitus subjects
AbstractBackgroundAtherogenic index of plasma (AIP) is a strong marker to predict the risk of atherosclerosis and cardiovascular disease (CVD). Diabetes alters the utilization of lipids and lipoproteins which cause diabetes-induced atherogenic dyslipidemia leading to CVD.ObjectivesThe study aims to determine whether yoga intervention influences lipid indices in type 2 diabetes mellitus subjects.MethodsA total of 104 persons with type 2 diabetes were included in this hospital-based prospective randomized trial. These were further randomized into non-yoga (n = 52) and yoga (n = 52) groups. Interve...
Source: International Journal of Diabetes in Developing Countries - March 29, 2020 Category: Endocrinology Source Type: research

Candidate gene association study of UCP3 variant rs1800849 with T2D in Mizo population of Northeast India
ConclusionThus, it is concluded that the present study could not replicate the association of variant rs1800849 with genetic susceptibility to T2D in the Mizo population group. This absence of association highlights the genetic heterogeneity prevalent in Indian population groups and warrants screening of other T2D candidate genes in Mizo population group. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 29, 2020 Category: Endocrinology Source Type: research

Correction to: The role of osteocalcin in mechanism of steroid induced diabetes mellitus
The manuscript used in the original version of this article was outdated. In this connection, the following errors were encountered. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 22, 2020 Category: Endocrinology Source Type: research

Diabetes education and basic insulin related knowledge assessment in nursing staff in a tertiary care hospital in India
ConclusionThis study shows a significant deficit in basic insulin-related knowledge in nursing staff. There is a need for continuous medical education of nursing staff to stay updated on Diabetes management. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 16, 2020 Category: Endocrinology Source Type: research

Association between hemoglobin A1c and acute ischemic stroke among patients with type-2 diabetes: a case-control study
AbstractBackgroundAt present, stroke is a major health burden and the leading cause of death and long-term disability in the elderly. Ischemic stroke is the most common stroke type in the Thai population. Causes of ischemic stroke are likely to be multifactorial.ObjectiveThe purpose of this study was to determine the association between hemoglobin A1c (HbA1c) and acute ischemic stroke (AIS) among Thai patients with type-2 diabetes (PTDs).MethodsA hospital-based case-control study was conducted among PTDs attending the Bhuddasothorn hospital with 100 cases and 300 controls from 2013 to 2016. Cases were defined as PTDs who h...
Source: International Journal of Diabetes in Developing Countries - March 2, 2020 Category: Endocrinology Source Type: research

Study on the expression of CD14  + CD16 + monocytes and VEGF in peripheral blood of patients with type 2 diabetes mellitus and diabetic macroangiopathy
AbstractObjectivesTo study the expression of CD14  + CD16 + monocytes and VEGF and the levels of serum adiponectin and MCP-1 in peripheral blood of patients with type 2 diabetes mellitus (T2DM) and diabetic macroangiopathy to understand the possible mechanism of inflammatory immune response in T2DM and diabetic macroangiopathy.MethodsPeripheral blood CD14  + CD16 + monocytes were detected by flow cytometry in 50 T2DM patients, 50 patients with diabetic macroangiopathy, and 20 healthy controls or normal controls who participated in outpatient physical examination, and used the Ficoll-Hypaq...
Source: International Journal of Diabetes in Developing Countries - March 2, 2020 Category: Endocrinology Source Type: research

Liver iron concentration is an independent risk factor for the prediabetic state in β-thalassemia patients
ConclusionBased on the findings, HOMA-IR and QUICKI can be applied as useful glycemic metabolism indices for predicting prediabetic and normoglycemic states among β-TM patients. Also, LIC was an independent risk factor for the prediabetic state. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 27, 2020 Category: Endocrinology Source Type: research

Diagnostic efficiency of diabetes in pregnancy study group of India versus World Health Organization 2013 criteria
This study aims to see the diagnostic efficiency of Diabetes in Pregnancy Study Group of India (DIPSI) criterion in context to World Health Organization (WHO) 2013 criterion for detection of AGT in pregnancy.MethodsPregnant mothers (n = 231; age, 26.07 ± 5.21 years; body mass index (BMI), 25.00 ± 4.09 kg/m2; mean  ± SD) were screened for AGT including gestational diabetes mellitus (GDM) and diabetes in pregnancy (DIP) from July 2016 to July 2017 in the “GDM Clinic” of BSMMU following WHO 2013 and DIPSI protocol with an interv...
Source: International Journal of Diabetes in Developing Countries - February 27, 2020 Category: Endocrinology Source Type: research

Vitamin B 12 and diabetes risk —myth or reality
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 26, 2020 Category: Endocrinology Source Type: research

Association of gestational diabetes mellitus with adverse pregnancy outcomes: our experience and meta-analysis
ConclusionsWomen with GDM still have an increased incidence of adverse pregnancy outcomes, which indicated that early prevention and clinical treatment of disease should be enhanced. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 20, 2020 Category: Endocrinology Source Type: research

Beliefs of Caribbean type 2 diabetes patients towards insulin therapy and prescription
ConclusionContrary to several reports, this study shows that insulin-na ïve Caribbean type 2 diabetes patients do not have a significant negative perception towards insulin therapy. This finding might be related to the socio-cultural background of the patients studied. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 18, 2020 Category: Endocrinology Source Type: research

Secular trends and rural-urban differences in endocrine and metabolic disease mortality in China: an age-period-cohort modeling of National Data
ConclusionIncreases in EMD mortality in China since 1991 can be explained primarily by the period effect, reflecting unhealthy lifestyles adapted along with rapid economic growth. The 100-year declines in cohort effect and the rural-urban differences could be largely attributed to the overall progress and rural-urban inequity in medical and healthcare. Future public health planning and decision-making must emphasize these two factors. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 18, 2020 Category: Endocrinology Source Type: research

Health-related quality of life of Pakistani adolescents with type 1 diabetes and their parents
ConclusionIt is imperative for health care professionals to be aware of the effect of diabetes on QOL as timely screening is important for better health care outcomes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 14, 2020 Category: Endocrinology Source Type: research

Gestational diabetes mellitus, its associated factors, and the pregnancy outcomes among pregnant women attending tertiary care hospitals of Bhubaneswar, India
ConclusionEarly diagnosis and appropriate management of gestational diabetes among pregnant women may have far-reaching repercussions for maternal and child health. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 13, 2020 Category: Endocrinology Source Type: research

Changes in SFRP5, WNT5A, HbA1c, BMI, PBF, and insulin resistance in men with type 2 diabetes after 12  weeks of combined exercise (HIIT and resistance)
ConclusionThe improvement of type 2 diabetic men ’s health can be a result of increased anti-inflammatory factor SFRP5 and decreased inflammatory factor WNT5A through reduction of BMI and PBF.Trial registrationIRCT20151026024717N3 (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 10, 2020 Category: Endocrinology Source Type: research

ABCD score of & gt;  6 predicts diabetes remission following bariatric surgery
ConclusionBariatric surgery leads to substantial weight loss and amelioration of type 2 diabetes. An ABCD score of>  6 predicts diabetes remission following bariatric surgery, and is recommended as an aid for patient selection and counseling. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2020 Category: Endocrinology Source Type: research

Care burden and quality of life in mothers of children with type 1 diabetes mellitus
AbstractPurposeThis was a descriptive study to determine the care burden and quality of life of mothers of children with type 1 diabetes mellitus (T1DM) and the correlation between these two variables.MethodsThe sample consisted of 106 mothers of children with T1DM. Data were collected using a descriptive questionnaire, the Zarit Caregiver Burden Interview and WHOQOL-BREF quality of life scale, and were evaluated with the Mann-WhitneyU test, Student ’st test, ANOVA, Kruskal-Wallis test and Spearman ’s correlations.ResultsMothers had a moderate burden level (34.95  ± 12.48) with a statistica...
Source: International Journal of Diabetes in Developing Countries - February 7, 2020 Category: Endocrinology Source Type: research

The role of osteocalcin in mechanism of Steroid induced diabetes mellitus
ConclusionDecrease in serum osteocalcin level with increase in glycemic parameters in steroid induced diabetes group, point to have a new role in mechanism of steroid induced diabetes. This may be a novel target to discover drugs that can maintain the OC levels so that the effect of steroids on blood sugar level can be minimised. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 4, 2020 Category: Endocrinology Source Type: research

The novel mechanism of steroid-induced diabetes mellitus
ConclusionDecrease in serum osteocalcin level with increase in glycemic parameters in steroid-induced diabetic group points to the novel mechanism of steroid-induced diabetes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 4, 2020 Category: Endocrinology Source Type: research

BDNF is obverse to oxidative stress (adenosine deaminase and nitric oxide) in type II diabetes mellitus
AbstractAimThe relational analysis of adenosine deaminase (ADA), nitric oxide (NO), BDNF (brain-derived neurotrophic factor), and TP (total protein) is accomplished by comparing these parameters with glucose levels of healthy and type II diabetes mellitus people. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF. ADA is an important enzyme that plays a relevant role in purine and DNA metabolism, immune responses, and peptidase activity and for modulating the bioactivity of insulin. Nitric oxide is associated with loss of normal cellular function an...
Source: International Journal of Diabetes in Developing Countries - January 30, 2020 Category: Endocrinology Source Type: research

Gender-specific siblings and women with maternal history of diabetes are at high risk of developing type2 diabetes-a family study from South India
AbstractBackgroundRisk factors associated with diabetes (DM) are to be well studied, and this study was aimed to investigate the family transmission pattern of type 2 DM in South Indian population.MethodsA total of 3093 subjects were selected between June 2017 and May 2018. Details on family history of diabetes, treatment, and age at onset of DM were recorded. The subjects are divided into three groups based on family history risk categories maintained as registries. Group 1 (NPDR) (n = 1414) was with no parent diabetes, group 2 (OPDR) (n = 1216) with one parent diabetes, and group 3 (CPDR) (n&t...
Source: International Journal of Diabetes in Developing Countries - January 29, 2020 Category: Endocrinology Source Type: research

Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic status and insulin resistance
AbstractIntroductionType 2 diabetes mellitus (T2DM) is associated with long-term complications in different organs, and this is attributable to macrovascular and microvascular changes as reported by Fowler. Pulmonary complications, however, have been poorly characterised.Materials and methodsThe present study was a case –control study done at SRN Hospital, Prayagraj to correlate the pulmonary functions with glycemic status and insulin resistance in 100 patients with diabetes (cases) and compare these parameters in patients without diabetes (controls). Baseline values of fasting plasma glucose (FPG), prandial plas ma ...
Source: International Journal of Diabetes in Developing Countries - January 29, 2020 Category: Endocrinology Source Type: research

Frameshift variance in SLC19A2 gene causing thiamine responsive megaloblastic anemia (TRMA): a case report from Pakistan
ConclusionThe diagnosis of TRMA should be kept in mind in differential diagnosis of DM with anemia and or sensorineural hearing loss. Particularly in the populations where the consanguinity is frequent as diagnosis has great impact on management. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 29, 2020 Category: Endocrinology Source Type: research

Prevalence and predictors of osteopenia and osteoporosis in patients with type 2 diabetes mellitus: a cross-sectional study from a tertiary care institute in North India
ConclusionThe prevalence of osteoporosis and osteopenia in patients with T2DM is high. Female gender, increasing age, normal BMI, low serum 25-hydroxyvitamin D, and pioglitazone use further increase the risk of osteoporosis. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 15, 2020 Category: Endocrinology Source Type: research

MACF1 gene variant rs2296172 is associated with T2D susceptibility in Mizo population from Northeast India
ConclusionThis study is the first replication report from Northeast India, showing variant rs2296172 of MACF1 gene associated with T2D in Mizo population. This independent study highlightsMACF1 as a candidate gene for T2D in Asian Indian populations, suggesting it is critical to evaluate the variant rs2296172 in other distinct endogamous Indian population cohorts. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 15, 2020 Category: Endocrinology Source Type: research

Irisin in elderly people with hypertension, diabetes mellitus type 2, and overweight and obesity
This study aimed to investigate the irisin levels in elderly patients with hypertension, diabetes mellitus type 2, and overweight and obesity, to investigate the possible association between irisin levels and anthropometric and biochemical parameters, and also to assess the irisin levels associated with a risk of hypertension, diabetes mellitus type 2, and overweight and obesity.MethodsA nested case-control study was conducted, with hypertension, diabetes mellitus type 2, and overweight and obesity being set as the case group; 71 elderly patients from the cohort were enrolled in each case group, and 71 healthy elderly from...
Source: International Journal of Diabetes in Developing Countries - January 15, 2020 Category: Endocrinology Source Type: research

Hematocrit levels and arterial stiffness: the Cardiometabolic Risk in Chinese (CRC) Study
ConclusionsIn adults in China, HCT level was associated with elevated central arterial stiffness, independent of conventional cardiovascular risk factors. As a serological marker, HCT can predict the degree of central arterial stiffness. HCT combined with other traditional cardiovascular risk factors can better assess vascular heart disease. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 14, 2020 Category: Endocrinology Source Type: research

The relationship between insulin resistance, obesity, and endotrophin
In this study, we aimed to reveal the relationship between human adipose tissue, inflammation, and insulin resistance (IR).MethodsThe study included 51 IR patients and 37 healthy controls. The presence of IR was based on Homeostatic model of assessment-insulin resistance (HOMA-IR) level of 2, 7, or higher. Fasting plasma samples were obtained from the patients and the control group.ResultsThe IR patients had a higher HOMA-IR, waist circumference, fasting plasma glucose (FPG), fasting insulin (FI), and triglyceride levels than the control subjects (p 
Source: International Journal of Diabetes in Developing Countries - January 8, 2020 Category: Endocrinology Source Type: research

Association of adiponectin gene polymorphisms and their haplotypes with type 2 diabetes and related metabolic traits in an Iranian population
AbstractIntroductionAdiponectin is an adipocyte-secreted protein that contributes to glucose homeostasis. Contradictory reports are available on single nucleotide polymorphisms (SNPs) in the adiponectin gene and the risk of type 2 diabetes (T2D). We investigate the association of adiponectin gene SNPs (+45T/G and +276G/T) with serum adiponectin, insulin resistance, lipid profile, and T2D risk in an Iranian population.Method The +45T/G and +276G/T SNPs were genotyped in 211 non-familial T2D patients and 202 non-diabetic subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and TaqMan prob...
Source: International Journal of Diabetes in Developing Countries - January 8, 2020 Category: Endocrinology Source Type: research

A systematic review of the effect of sleep apnea syndrome and its therapy on HbA1c in type 2 diabetes
ConclusionCurrent findings suggest an effect of hypoxemia during apnea/hypopnea episodes on glycemic control and do not support any effect of CPAP on glycemic control in type 2 diabetes.PROSPERO register numberCRD42019123097 (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 7, 2020 Category: Endocrinology Source Type: research

Association of SRB1 and PON1 gene polymorphisms with type 2 diabetes mellitus: a case control study
AbstractObjectiveSingle-nucleotide polymorphism (SNP) in Paraoxonase 1 (PON1) and scavenger receptor class b member 1 (SRB1) gene has been associated with impairing high-density lipoprotein (HDL) functionality as an antioxidant and shown to diminish ability of PON1 in cholesterol homeostasis. Several studies found that SRB1 and PON1 polymorphism increases T2DM risk. Our study aimed to investigate the association and susceptibility of polymorphic variants in SRB1 rs9919713 and PON1 rs662 with type 2 diabetes mellitus.MethodsIn the present case-control study, 250 type 2 diabetes mellitus patients (T2DM) and 250 healthy volun...
Source: International Journal of Diabetes in Developing Countries - January 1, 2020 Category: Endocrinology Source Type: research

The status of frailty in poor older adults with type 2 diabetes mellitus or hypertension: the case of Mexico
ConclusionsBy sexes we observed significant frequencies of frailty and pre-frailty in males with DM ” and in women with HTN. In the Katz scale, women with DM2 have high percentages of disability in basic activities of daily living. Associating DM2 and HTN with frailty, dysfunction and depression reveals a lack of prevention. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - December 12, 2019 Category: Endocrinology Source Type: research

Phenotypic characterization of patients with type 2 diabetes mellitus
This study describes the phenotypic subgroups based on anthropometric and biochemical characteristics.MethodsThis was a cross-sectional study involving 96 patients with early type 2 diabetes conducted from July 2017 to December 2018. Clinical history was recorded and anthropometric measurements were done. Beta cell function was estimated using oral disposition index (DIo). Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated using the fasting plasma glucose and fasting insulin levels. The cut off to define insulin resistance was 1.93.ResultsThe median age was 53.5  years. Fifty-five (57.3%) pat...
Source: International Journal of Diabetes in Developing Countries - December 4, 2019 Category: Endocrinology Source Type: research

Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients
ConclusionAdvanced age, metabolic control, and hypokalemia are the main determinants of both prevalence and extent of musculoskeletal disorders in diabetics. Along with the strict glycemic control, an additional effort should be taken to avoid potassium depletion associated with diabetic ketoacidosis and to maintain optimal potassium homeostasis in diabetic patients receiving insulin, diuretics, or suffer gastrointestinal motility disorders. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 26, 2019 Category: Endocrinology Source Type: research

Combination of negative pressure wound therapy using vacuum-assisted closure and ozone water flushing for treatment of diabetic foot ulcers
ConclusionThe combination use could enhance the recovery of DFUs, shorten the treatment duration, and reduce the pain during treatment. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 24, 2019 Category: Endocrinology Source Type: research

Blockade of receptor for advanced glycation end products improved essential response of inflammation in diabetic wound healing
ConclusionsIn summary, these findings suggest that rather than a hyper-inflammatory state, diabetic wounds are lack of an essential inflammatory response in the early phase, thus may induce a paradoxical and persistent inflammation state, and AGEs-RAGE play a vital role in these pathogenic progresses. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - November 24, 2019 Category: Endocrinology Source Type: research

Genetic polymorphism of eNOS (G894T) gene in insulin resistance in type 2 diabetes patients of Pakistani population
AbstractBackgroundInsulin resistance associated with type 2 diabetes (T2DM) consequences in the development of metabolc syndrome. Due to the complex mechanism, various pathogenic factors like enviromental and genetic predispositon contribute to the disease pathogenicity.  The reduced availability of eNOS has been determined as a mark of insulin resistance pathogenesis.ObjectiveThe objctive  of this study was to investigate genetic polymorphism ofeNOS (rs1799983; G894T) with susceptibility of insulin resistance in type 2 diabetes (T2DM) patients from Pakistani population.MethodsTotal of 322 (161 T2DM cases an...
Source: International Journal of Diabetes in Developing Countries - November 5, 2019 Category: Endocrinology Source Type: research

RSSDI consensus recommendations on insulin therapy in the management of diabetes
AbstractThe Research Society for the Study of Diabetes in India (RSSDI) has regularly updated its Clinical Practice Guidelines on various aspects of diabetes. The pharmacotherapeutic management of diabetes involves a plethora of agents targeting different aetiopathogenic mechanisms administered orally or via injections as well as insulin. While most people with type 1 diabetes need complete insulin replacement therapy with multiple-daily subcutaneous injections of insulin or a continuous subcutaneous insulin infusion pump, patients with type 2 diabetes may also need insulin as and when needed, especially owing to the decli...
Source: International Journal of Diabetes in Developing Countries - November 4, 2019 Category: Endocrinology Source Type: research

Abstracts of The 47th Annual Conference of Research Society for the Study of Diabetes in India
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - October 31, 2019 Category: Endocrinology Source Type: research

Type 2 diabetes: epidemiological changes at Instituto Mexicano del Seguro Social —associated with complications in Mexico
AbstractBackgroundMexico is a country with a high frequency of type 2 diabetes mellitus (DM2). DM-related complications can increase the number of medical appointments and hospitalizations, impact patient quality of life, and exacerbate hospital care costs. The goals of this study were to analyze epidemiological data of DM2 over the last 10  years and to compare its comorbidities and mortality in individuals listed at the Instituto Mexicano del Seguro Social (IMSS) in 2013 and 2015. The database was compiled for doctors, validated by engineers in computer systems, and analyzed by statisticians. E-10-E-14 registered pa...
Source: International Journal of Diabetes in Developing Countries - October 24, 2019 Category: Endocrinology Source Type: research

Mild hyperamylasemia in type 1 diabetic children without diabetic ketoacidosis is associated with C-peptide
AbstractBackgroundThe aim of this study is to investigate the relationship between plasma amylase concentration and C-peptide level in type 1 diabetic and healthy children.MethodsThe cross-sectional study involved 31 Chinese type 1 diabetic children without complications and 107 healthy control subjects. Clinical examination and laboratory examinations were assessed for all participants.ResultsSignificantly higher amylase concentrations were measured in type 1 diabetic children than in controls (102.8  U/l vs. 70.2 U/l, respectively;p 
Source: International Journal of Diabetes in Developing Countries - October 23, 2019 Category: Endocrinology Source Type: research

Long-term remission of type 2 diabetes —two roads to the elusive goal
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - October 23, 2019 Category: Endocrinology Source Type: research