Effect of rosuvastatin on sortilin and fetuin-A in type 2 diabetic patients: a randomized controlled trial
ConclusionRosuvastatin co-treatment in T2DM patients improves glycemic control and aids in decreasing the atherogenic biomarkers sortilin and fetuin-A levels, so it can be considered tolerable and efficient in improving lipid profile and  atherogenic index.Trial registrationClinicalTrials.gov identifier (NCT number):  NCT03907423, (The registration date: April 9, 2019).https://clinicaltrials.gov/ct2/show/NCT03907423. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 2, 2024 Category: Endocrinology Source Type: research

Correction to: Factors affecting the prolongation of glycemic time in range among children with type 1 diabetes using continuous glucose monitoring systems: A case control study
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 28, 2024 Category: Endocrinology Source Type: research

Decoding the mystery of non-nutritive sweeteners
ConclusionWhile the article underscores the complexities and debates surrounding non-nutritive sweeteners (NNS), it also sheds light on the positive aspects. In the Indian context, where the intake of sweeteners is relatively low and mainly limited to beverages (tea or coffee), NNS appear to be safe, but prudent use is advocated. The article emphasizes the value of public education on NNS usage and concludes that, overall, NNS are reasonably safe when consumed in moderation. Continued research is needed to elucidate their intricate effects on health and impact on global health outcomes.ImplicationsThe article concludes wit...
Source: International Journal of Diabetes in Developing Countries - February 24, 2024 Category: Endocrinology Source Type: research

Examining risk factors for diabetic foot: assessing diabetes self-management in type 2 diabetes patients
ConclusionEffective diabetes self-management plays a crucial role in improving diabetes complications. Care should be taken regarding diabetic foot in patients who have difficulties in effective diabetes self-management, as well as those with high systolic blood pressure, high HbA1c levels, shorter total education duration, and longer duration of diabetes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 22, 2024 Category: Endocrinology Source Type: research

A randomized, double-blind, active-controlled trial assessing the efficacy and safety of a fixed-dose combination (FDC) of MEtformin hydrochloride 1000  mg ER, SItagliptin phosphate 100 mg, and DApagliflozin propanediol 10 mg in Indian adults with type 2 diabetes: The MESIDA trial
ConclusionFDC of DSM was superior to SM in reducing HbA1c, FPG, and PPG in Indian adults with T2D. Both triple and dual FDCs had optimal safety profiles. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2024 Category: Endocrinology Source Type: research

Corneal endothelial morphology changes in patients with proliferative diabetic retinopathy
ConclusionsPDR had deleterious effects on the corneal endothelium. PDR patients should undergo a rigorous corneal assessment to analyze the status of endothelial health, to identify the optimal treatment. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2024 Category: Endocrinology Source Type: research

Effectiveness and safety of insulin glargine U-300 as compared to insulin glargine U-100 in oral antidiabetic (OAD) failure cases —record-based observational study
ConclusionThe results suggest that insulin glargine U-300 is an effective and safer treatment option than insulin glargine U-100 for Indian patients with OAD failure. These findings have the potential to improve the management of type 2 diabetes patients with OAD failure globally. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2024 Category: Endocrinology Source Type: research

The HNF1B mutations and deletion associated with diabetes and their resulting diabetic phenotypes: a systematic review
ConclusionsHNF1B-DM patients were with younger onset age, normal or low BMI, renal cyst, pancreatic  dysplasia, and hypomagnesemia. The patients should be recommended for genetic testing to differentiateHNF1BDM from other young-onset diabetes earlier. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2024 Category: Endocrinology Source Type: research

Impacts of a 12-week aerobic, resistance, and combined exercise training on serum FAM19A5, glucose homeostasis, and novel cardiovascular risk factors among adults with obesity
ConclusionThis is the first report to assess the influence of exercise interventions on circulating FAM19A5 levels in obese adults. Although FAM19A5 levels remained unchanged in all three interventions, our work provides information to support that aerobic, resistance, and combined regimens can be effective in improving HOMA-IR, triglyceride, systolic blood pressure, BMI, and aerobic performance in obese men. Additional studies with large sample size should be conducted to further clarify the underlying mechanisms. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2024 Category: Endocrinology Source Type: research

Advancing the understanding and management of diabetic peripheral neuropathy
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 6, 2024 Category: Endocrinology Source Type: research

24-h Glucose profile of patients with gestational diabetes mellitus and comparison with pregnant women with normoglycemia
ConclusionGDM patients, who have mild hyperglycemia but not overt diabetes, also have an abnormal 24 h glucose profile as compared to normal pregnancy. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 29, 2024 Category: Endocrinology Source Type: research

Predictive value of Lp-PLA2 for coronary artery disease in type 2 diabetes mellitus patients: an observational study
ConclusionsIn T2DM patients with or without  CAD, serum Lp-PLA2 concentrations may serve as a diagnostic marker. The cutoff value of> 115 ng/mL exhibited  excellent sensitivity and specificity, especially in T2DM patients without CAD. This finding suggests the clinical utility of Lp-PLA2 as a diagnostic tool for identifying those at risk for CAD in the context of T2DM. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 24, 2024 Category: Endocrinology Source Type: research

Biomarkers of endothelial dysfunction (vWF), hypofibrinolysis (PAI-1) and metabolic syndrome components in hypertensive patients with and without thrombotic complications
ConclusionsWe found higher levels of vWF and PAI-1 in hypertensive patients, with highest concentration of vWF in patients with hypertension and thrombotic disease and the highest of PAI-1 in hypertensive patients without atherothrombotic disease. The lowest level of vWF was determined in patients with angiotensin II receptor blocker, and for the PAI-1 level in patients with calcium channel blocker medication. The lowest concentration of both biomarkers was present in patients who were treated with 3 or more drugs. Hypertension, older age, disorders in glucose and lipid metabolism were the main determinants of vWF and PAI-...
Source: International Journal of Diabetes in Developing Countries - January 22, 2024 Category: Endocrinology Source Type: research

Diabetic retinopathy screening guidelines for Physicians in India: position statement by the Research Society for the Study of Diabetes in India (RSSDI) and the Vitreoretinal Society of India (VRSI)-2023
AbstractDiabetic retinopathy (DR) is a leading cause of blindness among working-age adults worldwide. India is the diabetes capital of the world and one in five adults is said to have diabetes in India. With the increase in diabetes, there is an increasing burden of diabetic retinopathy (DR). All patients with diabetes have a risk of losing vision due to DR. The prevalence of diabetic retinopathy is 12.5%; out of which, 4% are said to have vision-threatening diabetic retinopathy (VTDR) The early stages of DR are symptomless, necessitating a proactive screening for an early detection of DR in all people with diabetes before...
Source: International Journal of Diabetes in Developing Countries - January 20, 2024 Category: Endocrinology Source Type: research

Factors affecting the prolongation of glycemic time in range among children with type 1 diabetes using continuous glucose monitoring systems: A case control study
ConclusionsHyperglycemia and high glycemic variability prevent patients from achieving the target TIR. Advanced features in the CGM systems, premeal insulin bolus, and patients ’ involvement in diabetes treatment are the main factors contributing to TIR prolongation. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - January 19, 2024 Category: Endocrinology Source Type: research