Increased of fasting active glucagon-like peptide-1 is associated with insulin resistance in patients with hypertriglyceridemia
AbstractBackgroundGlucagon-like peptide-1 (GLP-1) is an incretin hormone that facilitates insulin secretion and preserves β cell function. hypertriglyceridemia plays an important role in the pathogenesis of insulin resistance and T2DM. The purpose of this study was to measure fasting active GLP-1 levels in hypertriglyceridemia subjects and analyse the relationship between GLP-1 and insulin resistance.MethodsWe recruited 146 subjects including 38 diabetes patients with hypertriglyceridemia, 33 diabetes patients without hypertriglyceridemia, 35 hypertriglyceridemia subjects, and 40 healthy subjects as the normal control...
Source: International Journal of Diabetes in Developing Countries - July 21, 2021 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus and the risk of hip and vertebral fractures: a systematic review and meta-analysis of cohort studies
ConclusionT2DM was positively associated with an increased risk of hip fracture but not with vertebral fracture. Bone health in patients with T2DM requires more attention, and further research is warranted. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 13, 2021 Category: Endocrinology Source Type: research

Resveratrol exerts antiproliferative effects on high-glucose-cultured vascular smooth muscle cells via inhibition of STAT3 and upregulation of mitochondrial gene GRIM-19 which is responsible for STAT3 activation
ConclusionThe results of the study suggest that Resv has an antiproliferative effect in high-glucose-cultured VSMCs partly through inhibiting STAT3 function and upregulating mitochondrial biogenesis. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - July 10, 2021 Category: Endocrinology Source Type: research

Glycemic control among children and adolescents with type 1 diabetes during COVID-19 pandemic in Egypt: a pilot study
AbstractBackgroundThe COVID-19 pandemic and the consequences of lockdown significantly impacted glycemic control.AimTo evaluate the impact of the pandemic and lockdown on glycemic control among Egyptian children and adolescents with type 1 diabetes.MethodsCross-sectional study conducted through an online questionnaire. The participants were patients with type 1 diabetes and/or their caregiversResultsA total of 115 valid responses to the questionnaire were received. During the lockdown, almost 64% of patients showed worsening of their HbA1C with significant increment of HbA1c after the lockdown (p  
Source: International Journal of Diabetes in Developing Countries - July 9, 2021 Category: Endocrinology Source Type: research

Association between neutrophil –lymphocyte ratio on arterial stiffness in type-2 diabetes mellitus patients: a part of DiORS Study
This study is part of the Diabetic Ocular Renal Surabaya Study (DiORS Study). Participants were measured for their NLR count by dividing absolute neutrophil count with absolute lymphocyte count in peripheral blood and measuring of arterial stiffness with baPWV. The statistical analysis in use included independent t-test, Mann –Whitney test, Pearson correlation test, or Spearman correlation test. The results of the statistical analysis were significant ifp   1.65). The mean of baPWV was 15.19 ± 2.72 m/s with a range of 10.20–23.30 m/s, and 75.0% of them saw an increas...
Source: International Journal of Diabetes in Developing Countries - July 9, 2021 Category: Endocrinology Source Type: research

Effect of constructing doctor-pharmacist joint pharmacy clinic for outpatients on the comprehensive management of type 2 diabetes mellitus: a pilot RCT
This study was designed to investigate the effectiveness of pharmacists participating in the comprehensive management of T2DM patients in the form of building doctor-pharmacist joint pharmacy clinic in the National Metabolic Management Center (MMC).MethodsA total of 204 patients with type 2 diabetes mellitus were enrolled and randomly divided into control group and intervention group. During the 3-month study period, both groups received standardized MMC diagnosis and treatment, and clinical pharmacists provided pharmaceutical care for the intervention group. Observation indicators include drug compliance, fasting blood gl...
Source: International Journal of Diabetes in Developing Countries - July 2, 2021 Category: Endocrinology Source Type: research

To study the awareness of gestational diabetes mellitus in antenatal women, and medical and paramedical trainees in teaching hospital in North India
AbstractIntroductionGestational diabetes mellitus (GDM) increases pregnancy complications and future development of diabetes. Success of initiatives to increase GDM awareness depends upon the knowledge level of healthcare providers and antenatal women.Materials and methodIt is a descriptive, cross-sectional study done in a teaching hospital in North India. Two pre-tested, semi-structured questionnaires assessing the basic and advanced knowledge on GDM were used. Participants included antenatal women, undergraduate trainees who filled the level 1 questionnaire, and postgraduate residents, MBBS 3rd professional students, who...
Source: International Journal of Diabetes in Developing Countries - June 25, 2021 Category: Endocrinology Source Type: research

In-hospital fasting hyperglycemia and increased risk of mortality after acute coronary syndrome: a systematic overview and meta-analysis
AbstractBackgroundSeveral studies noted that increased fasting blood glucose in hospital is associated with increasing mortality of acute coronary syndrome (ACS). We conducted a meta-analysis to assess the risk of mortality after ACS in patients who had fasting hyperglycemia (FH) in hospital.MethodsWe conducted searches on PubMed, Cochrane Library, Web of Science, and Embase for relevant studies published before August 31, 2019. We pooled odds ratios (OR) from individual studies using a random effects model. Data abstraction was conducted by two independent reviewers, and the meta-analysis was performed using Review Manage...
Source: International Journal of Diabetes in Developing Countries - June 23, 2021 Category: Endocrinology Source Type: research

Obesity and dyslipidemia among Bhil tribal population: A cross-sectional study from India
ConclusionThe observed high prevalence of obesity and dyslipidemia, particularly low HDL-C and hypertriglyceridemia, warrants a public health concern. This study emphasizes the need for population-specific disease documentation to highlight underlying mechanisms of risk factors and to set forth a targeted approach to disease treatment and management. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 23, 2021 Category: Endocrinology Source Type: research

Two nested syndromes: fibromyalgia and neuropathic pain in prediabetes —a pilot study
This study aimed to determine the prevalence of neuropathic pain (NeP) and fibromyalgia syndrome (FMS) in prediabetics and to compare them with normoglycemic controls, to disclose the impact of NeP and FMS in disease burden.MethodsPeople, 18 –65 years old, who were admitted to a tertiary hospital’s internal medicine outpatient clinic for routine health check-ups and then those who were newly diagnosed with prediabetes were recruited as a prediabetic group and those who were normoglycemic were recruited as a control group. Participa nts’ demographics and clinical data were recorded. The ShortForm-36 a...
Source: International Journal of Diabetes in Developing Countries - June 16, 2021 Category: Endocrinology Source Type: research

Effect of vitamin D on arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease
AbstractPurposeTo evaluate the association between serum 25-hydroxy vitamin D level and arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease (CKD).MethodsThe serum 25-hydroxy vitamin D level and various parameters of vascular functions were assessed in type 2 diabetes patients with intermediate CKD (stages 3a and 3b). The carotid-femoral pulse wave velocity (cfPWV) among vitamin D-deficient, -insufficient, and normal patients was compared.ResultsOne hundred and twenty-one patients were included. The cfPWV in the vitamin D-deficient group (1190.32  ± 256.95 cm/s) ...
Source: International Journal of Diabetes in Developing Countries - June 15, 2021 Category: Endocrinology Source Type: research

Effects of comprehensive nursing intervention on maternal and infant outcomes for gestational diabetes mellitus patients
This study aimed to investigate the effects of comprehensive nursing intervention on maternal and infant outcomes for GDM patients.MethodsNinety-three GDM patients were randomly divided into intervention group (45 cases) and control group (48 cases). During the perinatal period, the control group received the routine nursing (one-off health education and nutrition and exercise guidance, regular pregnancy monitoring, regular postpartum care, etc.). The intervention group received the comprehensive nursing intervention including psychological intervention, health education, diet control, exercise intervention, pregnancy moni...
Source: International Journal of Diabetes in Developing Countries - June 8, 2021 Category: Endocrinology Source Type: research

Diabetes Mellitus and Heart Failure: A Consensus Statement
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 4, 2021 Category: Endocrinology Source Type: research

Predictive low-glucose suspend system and glycemic variability
ConclusionWith PLGS therapy, TIR was> 70% and the time spent in hypoglycemia was very low. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 3, 2021 Category: Endocrinology Source Type: research

Diabetic nephropathy with and without retinopathy: comparison between urine and serum vascular endothelial growth factor
ConclusionThe occurrence of DR in patients with DN is associated with higher mean serum than urine VEGF levels, as compared to lower serum to urine ratio of VEGF levels in DN patients without DR. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 2, 2021 Category: Endocrinology Source Type: research

Genetic association of vascular endothelial growth factor (VEGF) gene variants with the risk for diabetic retinopathy: a meta-analysis
ConclusionThe meta-analysis suggested the substantial role ofVEGF polymorphism rs3025039 as a possible biomarker for the assessment of DR risk. However, genome-wide association study (GWAS) is required in future to elucidate the multi-SNP effect of these polymorphisms inVEGF gene. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - June 1, 2021 Category: Endocrinology Source Type: research

Post-liver transplantation diabetes mellitus — a clinical challenge for diabetologists?
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 26, 2021 Category: Endocrinology Source Type: research

Add-on therapy with dapagliflozin in routine outpatient care of type 2 diabetes patients from Turkey: a retrospective cohort study on HbA1c, body weight, and blood pressure outcomes
This study aimed to evaluate HbA1c, blood pressure (BP), and weight outcomes in dapagliflozin-treated patients with type 2 diabetes (T2D) treated in a real-world setting.MethodsA total of 1683 T2D patients (mean (SD) age: 54.6 years (9.1), 56.6% were females) initiating dapagliflozin were included in this multicenter retrospective observational cohort study. Data on patient demographics, comorbidities, duration of diabetes, and concomitant antidiabetic treatment were recorded. Change in glycated hemoglobin (HbA1c), body weight, body mass index (BMI), and BP levels with dapagliflozin treatment and dapagliflozin discontinuat...
Source: International Journal of Diabetes in Developing Countries - May 4, 2021 Category: Endocrinology Source Type: research

Association between rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 with type 2 diabetes susceptibility among the Isfahan population in Iran
AbstractBackground and aimType 2 diabetes mellitus (T2DM) is a global human disease that affects millions of people. Long non-coding RNAs (LncRNAs) are transcripts with more than two-hundred nucleotides that play essential roles in the management of mRNAs. In the present study, we examined whether the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 is associated with the susceptibility to T2DM among the Isfahan population, Iran.MethodsTo this end, a case-control study was conducted on 200 healthy persons and 200 patients with T2DM. The genomic DNA was extracted from blood samples to strengthen the intended f...
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research

Dietary supplementation of mustard oil reduces blood glucose levels by triggering insulin receptor signaling pathway
ConclusionsMustard oil inclusion in the diet reduces blood glucose levels by increased insulin receptor signaling, thereby partially reversing diabetic state in experimentally induced diabetic rats. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 26, 2021 Category: Endocrinology Source Type: research

The impact of different modes of exercise training on GLP-1: a systematic review and meta-analysis research
ConclusionIn this meta-analysis, it was found that the levels of GLP-1 could be affected by short-term and long-term training with different modes and intensity. As a result, current evidence shows that it may be a good choice for patients with type 2 diabetes to control their blood glucose. The mechanism of this GLP-1 increase has not yet been fully discovered. Further longitudinal studies and exploration into mechanisms of action are required in order to determine the precise role of GLP-1 in insulin responses to an exercise intervention. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 22, 2021 Category: Endocrinology Source Type: research

High expression of lncRNA MALAT1 is associated with decreased insulin secretion under hyperglycemic stress in patients with type 2 diabetes mellitus
This study aimed to explore the expression of lncRNA MALAT1 in patients with T2DM and its clinical significance. A total of 25 normal controls and 69 patients with T2DM were selected.MethodsReal-time polymerase chain reaction was used to determine the expression level of lncRNA MALAT1 in blood leukocytes of the two groups.ResultsThe expression level of lncRNA MALAT1 in patients with T2DM was significantly higher than that in the control group (p
Source: International Journal of Diabetes in Developing Countries - April 21, 2021 Category: Endocrinology Source Type: research

Investigation of extracellular matrix genes associated with Alzheimer ’s disease in the hippocampus of experimental diabetic model rats
ConclusionThese genes encoding proteases that regulate neuronal activity have decreased levels in the T2D model. There may be potential in the adoption of new treatment approaches for Alzheimer ’s and T2D. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 17, 2021 Category: Endocrinology Source Type: research

Predicted HbA1c and fructosaminated HbA1c: evaluating their role as an indicator of glycemic status in diabetes mellitus: a hospital based cross-sectional study
AbstractBackgroundGlycated hemoglobin has been a popular investigation to access the glycemic status. It is a marker for intracellular glycation, and hence, an investigation which can comply with both intracellular and extracellular glycation statuses is preferred.MethodologyIn this regard, fructosaminated HbA1c (FHbA1c), predicted HbA1c (PHbA1c) and glycation gap (GG) were evaluated in 57 cases of diabetes mellitus (DM) without complication and having a normal serum protein and albumin levels. Fifty controls were also evaluated. FHbA1c, PHbA1c and post-prandial predicted HbA1c (PPHbA1c) were plotted using population linea...
Source: International Journal of Diabetes in Developing Countries - April 16, 2021 Category: Endocrinology Source Type: research

Risk factors for diabetes mellitus in patients with gastroesophageal reflux disease
ConclusionWe conclude that DM in patients with GERD should have regular physical examinations that include a thorough patient history, appropriate laboratory tests, and possible endoscopy. We also suggest that patients with either DM or GERD should be evaluated and treated immediately if they have symptoms, including regular physical examinations and lifestyle interventions, to improve health-related quality of life. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 16, 2021 Category: Endocrinology Source Type: research

The effects of in-water and on-land aerobic training on postural sway and balance in patients with type 2 diabetes
AbstractBackgroundBalance and maintaining posture are essential requirements for the daily activities of diabetic patients. The purpose of this study was to investigate the effect of in-water and on-land aerobic training on balance of type 2 diabetic patients.Research questionIs there a difference in the balance of patients between aerobic training environments in water and on land?MethodsFor this, 24 participants were assigned randomly in three eight-person groups of control, aerobics on land, and aerobics in water. Patients performed aerobic protocol in 12 weeks (2 sessions per week) and total of twenty-four 60-min train...
Source: International Journal of Diabetes in Developing Countries - April 14, 2021 Category: Endocrinology Source Type: research

Albuminuria increased the risk of left ventricular hypertrophy in type 2 diabetes patients with early renal insufficiency
ConclusionsAlbuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal insufficiency. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 8, 2021 Category: Endocrinology Source Type: research

Risk factors associated with gestational diabetes mellitus: a retrospective case-control study
This study aims to identify the prevalence of GDM, the risk factors, and the effect on pregnancy outcome based on a retrospective case-control study.MethodsTwo hundred ninety-three parturients with GDM who delivered in a general hospital in Fujian province and met the inclusion criteria were selected as the case group from January to June 2018. Two hundred ninety-three parturients without GDM who delivered in the same period served as the control group. Risk factors for GDM were determined by univariate and binary logistic regression analysis. The prevalence of pregnancy outcomes was determined by a chi-square test.Results...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

High prevalence of prolonged QTc interval among individuals in ambulatory diabetic care in southwestern Uganda
AbstractBackgroundHeart rate-corrected QT (QTc) interval is associated with increased risk for cardiovascular events and mortality among individuals with diabetes mellitus (DM). Little is known about the epidemiology of prolonged QTc among people with DM in resource-limited settings.MethodsWe conducted a cross-sectional study among adults with diabetes in ambulatory care at the Mbarara Regional Referral Hospital, from November 2018 to April 2019. Twelve-lead ECG recordings were performed on all participants. We collected clinical and laboratory data related to diabetes disease status and treatment control. We estimated QTc...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

Knowledge, attitude, and practice towards diabetes mellitus among outpatient diabetic elderly persons: a descriptive study
AbstractObjectiveTo investigate the knowledge, attitude, and practice (KAP) towards diabetes mellitus (DM) among outpatient diabetic elderly persons attending tertiary healthcare facilities in Nigeria and also to verify the null hypotheses of no significant differences within demographic variables.MethodsThe study was based on descriptive research design and was carried out in 36 public tertiary healthcare facilities in Nigeria, from August to December 2019. Using the purposive sampling technique, a total of 360 diabetic elderly persons aged 60 years and above were studied. An adapted KAP questionnaire with 0.86 reliabilit...
Source: International Journal of Diabetes in Developing Countries - April 7, 2021 Category: Endocrinology Source Type: research

An ultra-rare case of 47,XXY/48,XXXY/49,XXXXY mosaic Klinefelter syndrome associated with diabetic ketosis and foot ulcer
ConclusionsThis case provides information on KS patients with the extremely rare karyotype 47,XXY/48,XXXY/49,XXXXY, and also emphasizes the importance of considering KS in the differential diagnosis of a sterile male with diabetes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 6, 2021 Category: Endocrinology Source Type: research

Elevated levels of fasting serum GIP may be protective factors for diabetic retinopathy in type 2 diabetes mellitus
ConclusionsPrevalence of DR was independently and negatively correlated with fasting serum GIP in T2DM, indicating that elevated levels of fasting serum GIP may act as protective factors for DR. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 17, 2021 Category: Endocrinology Source Type: research

A study on diabetes-related distress among type 2 diabetes mellitus patients using the diabetes distress scale in a tertiary care center in Telangana
ConclusionsDiabetes distress and glycemic control have a strong correlation with each other, and both need to be addressed during management of type 2 DM. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 15, 2021 Category: Endocrinology Source Type: research

Influence of a 12-week physical activity program on leptin resistance in metabolic syndrome: a preliminary study
ConclusionFrom present study, it is concluded that a 12-week physical activity promotion program brought marginal changes in leptin levels and has potential to modify metabolic syndrome parameters and improve physical activity. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 9, 2021 Category: Endocrinology Source Type: research

Stewart (physicochemical) approach versus conventional anion gap approach for resolution of metabolic acidosis in diabetic ketoacidosis
AbstractBackgroundDiabetic ketoacidosis (DKA) frequently requires emergency admission. The anion gap approach is conventionally used for the diagnosis and documenting the resolution of acidosis during treatment. However, it fails to detect hyperchloremic acidosis during the resolution and may result in the prolongation of treatment.ObjectivesTo determine the role of the Stewart approach of acid-base disorder during DKA management for the prediction of an earlier resolution.MethodsA prospective comparative study was conducted between January 2017 and December 2017 at a single academic hospital in north India. Patients aged ...
Source: International Journal of Diabetes in Developing Countries - March 9, 2021 Category: Endocrinology Source Type: research

Doege-Potter syndrome: a case report
ConclusionThis case stresses upon thorough evaluation of patients presenting with non-diabetic hypoglycemia to rule out underlying malignancy. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 8, 2021 Category: Endocrinology Source Type: research

Mauriac syndrome: a rare cause of massive hepatomegaly
We report a 10-year-old boy with poorly controlled type I diabetes mellitus (on pre-mix insulin), hepatomegaly, and extremely high levels of liver transaminases. He underwent a liver biopsy elsewhere which showed glycogen deposits. He was referred to our institution for confirmation of diagnosis of glycogen storage disorder. Clinical examination revealed short stature, moon facies, and protuberant abdomen with hepatomegaly of 8 cm below the right costal margin. After exclusion of other causes of hepatitis, we controlled his sugars using basal bolus insulin regimen. Clinical exome sequencing revealed no abnormal mutations i...
Source: International Journal of Diabetes in Developing Countries - March 6, 2021 Category: Endocrinology Source Type: research

The efficacy of negative pressure wound therapy compared with conventional dressing in treating infected diabetic foot ulcers: a randomized controlled trial
ConclusionNPWT seems to be more efficacious than conventional dressing in treating infected DFUs. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 4, 2021 Category: Endocrinology Source Type: research

Is there a need to reconsider the use of metformin in COVID-19 patients with type 2 diabetes mellitus?
ConclusionsOur findings indicated that metformin may be safely continued in COVID-19 patients. The benefit of metformin therapy with simultaneous continuous monitoring of COVID-19 severity and kidney function may outweigh the risks of lactic acidosis, of which incidence is relatively rare. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - March 2, 2021 Category: Endocrinology Source Type: research

RSSDI clinical practice recommendations for screening, diagnosis, and treatment in type 2 diabetes mellitus with obstructive sleep apnea
AbstractPurpose of the study Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are closely associated diseases with a significant impact on public health. Both diseases are highly prevalent and the common overlapping risk factors include obesity, old age, and a generally high preponderance in men. A growing body of evidence suggests a bidirectional association between OSA and T2DM; both, in turn, constitute as strong risk factors for cardiovascular diseases, the leading cause of premature deaths and morbidity in India. Several studies have reported a higher prevalence of OSA in Indian patients with T2DM, de...
Source: International Journal of Diabetes in Developing Countries - February 25, 2021 Category: Endocrinology Source Type: research

Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
AbstractBackgroundSeveral studies have been performed to assess the relationship between hyperhomocysteinemia and type 2 diabetes mellitus (T2DM). However, inconsistent results have been obtained. Therefore, we performed this meta-analysis to address this knowledge gap.MethodsWe searched PubMed, Cochrane library, and EMBASE database for studies that evaluated the relationship between blood homocysteine (HCY) level and T2DM from inception to Jun 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). RevMan5.3 and Stata12.0 were used f...
Source: International Journal of Diabetes in Developing Countries - February 23, 2021 Category: Endocrinology Source Type: research

MiRNA expression analysis emphasized the role of miR-424 in diabetic cardiovascular complications
ConclusionCardiovascular risk assessment, supported by emerging circulating biomarkers, such as miRNAs, is important for stratifying high-risk individuals, optimizing treatment strategies, and enhancing our understanding of basic biology. Our study showed the highest increase in expression levels of miR-424-5p in target group and emphasized its role as a biomarker for cardiovascular damage in patients with type 2 diabetes mellitus. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 20, 2021 Category: Endocrinology Source Type: research

Secondary diabetes mellitus in Prader-Willi syndrome
ConclusionsThis case emphasizes the importance of considering PWS in the differential diagnosis of an adolescent with diabetes. Antenatal history of neonatal hypotonia and childhood history of feeding disorder are the keys to the diagnosis of PWS. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients
Conclusions/interpretationIn conclusion, Lys inhibited protein glycation, improved glycemic control, and increased antioxidant markers in type 2 diabetic patients; thus, it could be suggested for combinatorial therapy of diabetes with oral hypoglycemic agents to protect against vascular risk factors and other diabetic complications. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 17, 2021 Category: Endocrinology Source Type: research

Evaluation of ultrasound examination combined with intensive injection technique education on insulin-induced lipohypertrophy (LH) management: a prospective cohort study in China
This study was aimed to assess the impact of ultrasound examination combined with intensive injection technique education for LH management.MethodA total of 120 patients with diabetes who were identified as existing clinical LH were enrolled into the study. All patients underwent ultrasound examination and received intensive injection technique education based on ultrasound detection results and Chinese guideline for diabetic injection technology in a prospective single study in China with a follow-up of 3 months. Injection Technique Questionnaire (ITQ) and assessment of glycemic control were used to assess the impact of u...
Source: International Journal of Diabetes in Developing Countries - February 16, 2021 Category: Endocrinology Source Type: research

Sleep: an emerging therapeutic target in diabetes care
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 13, 2021 Category: Endocrinology Source Type: research

Circulating microRNAs associated with prediabetes and geographic location in Latinos
Conclusions/interpretationThis study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. Future studies should consider other microRNAs related to different biological pathways as possible biomarkers for type 2 diabetes in Latinos. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

Correction to: Prevalence of peripheral neuropathy among type 2 diabetes mellitus patients in a rural health centre in South India
A Correction to this paper has been published:https://doi.org/10.1007/s13410-020-00885-6 (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 11, 2021 Category: Endocrinology Source Type: research

The self-efficacy improvement in adolescent girls with type 1 diabetes mellitus with self-care education through mobile-based social networking
This study aimed to assess the effectiveness of a self-care educational program provided by mobile-based social networking (MBSN) on the self-efficacy of diabetic adolescent girls.MethodsA quasi-experimental study with 76 Iranian 14- to 18-year-old girls with T1DM was conducted in 2018 –2019. The subjects were selected with aconvenient sampling method and randomly assigned to the experimental and control groups. The MBSN was applied to implement a self-care educational program in the experimental group for 12 weeks. The Diabetes Management Self-Efficacy Scale (DMSES) questionnai re with the main domains of blood suga...
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research

Genetic characterization of suspected MODY patients in Pakistan by next generation sequencing —a pilot study
ConclusionThis study was the first in Pakistan to investigate the MODY using next-generation sequencing for clinical applications. There is huge public health burden of diabetes in the country. The study identified mutation in one known MODY gene. More extensive studies involving large sample size are required in future. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 10, 2021 Category: Endocrinology Source Type: research