Impact of Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus on Offspring Cardiovascular Health in Early Adolescence
Adverse pregnancy outcomes, including hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), influence maternal cardiovascular heath (CVH) long after pregnancy, but their relationship to offspring CVH following in utero exposure remains uncertain. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 1, 2024 Category: OBGYN Authors: Kartik K. Venkatesh, Amanda M. Perak, Jiqiang Wu, Patrick Catalano, Jami L. Josefson, Maged M. Costantine, Mark B. Landon, Nicola Lancki, Denise Scholtens, William Lowe, Sadiya S. Khan, William A. Grobman Tags: Original Research: Obstetrics Source Type: research
Protective effect of phospholipids in lipoproteins against diabetic kidney disease: A Mendelian randomization analysis
ConclusionsThis study found that a higher proportion of phospholipids in intermediate-density lipoprotein and the various subfractions of low-density lipoprotein, including large LDL, medium LDL, and small LDL, is associated with a lower risk of developing diabetic kidney disease. (Source: PLoS One)
Source: PLoS One - May 1, 2024 Category: Biomedical Science Authors: Tongyi Li Source Type: research
Identification of potential key lipid metabolism-related genes involved in tubular injury in diabetic kidney disease by bioinformatics analysis
ConclusionOur study identified several key lipid metabolism-related genes (LPL, AHR, ME1 and ALOX5) that might be involved in tubular injury in DKD, which provide new insights and perspectives for exploring the pathogenesis and potential therapeutic targets of DKD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 1, 2024 Category: Endocrinology Source Type: research
Reply to letter to editor “Knowledge gaps in diabetic striatopathy and other movement disorders in diabetes”
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Knowledge gaps in diabetic striatopathy and other movement disorders in diabetes
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Choroidal vascularity index as a predictor for the development of retinopathy in diabetic patients
ConclusionsCVI tends to be lower in diabetic patients with or without DR compared to healthy controls. Moreover, patients with DR have a lower CVI than those without DR. CVI can be considered an early and sensitive biomarker for the onset of DR. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study
ConclusionWomen with a prior history of GDM face an elevated risk of future CAD. This increased risk of CAD cannot be solely attributed to the subsequent onset of diabetes. Regular CAD risk assessment and primary prevention strategies are of paramount importance for women with a history of GDM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Artificial intelligence in endocrinology: a comprehensive review
ConclusionsBy embracing AI in endocrinology, a future can be envisioned where medical professionals and AI systems synergistically collaborate, ultimately enhancing the lives of individuals affected by endocrine disorders. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity
ConclusionsOur data suggests that specific NAEs such as OEA and AEA are promising biomarkers of GLP-1RA metabolic efficacy in humans with obesity during weight loss maintenance. Plasma profiling of EC-related molecules may be a promising strategy to tailor GLP-1R-based therapies to individual needs in obesity and diabetes management. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Nature Reviews Endocrinology, Published online: 01 May 2024; doi:10.1038/s41574-024-00985-xCentral diabetes insipidus has been renamed as arginine vasopressin deficiency. This Review discusses advances in diagnosis and management of arginine vasopressin deficiency. In addition, the possibility of oxytocin deficiency in these patients is considered, as well as oxytocin provocation testing and the future therapeutic potential of oxytocin replacement. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 1, 2024 Category: Endocrinology Authors: Cihan Atila Julie Refardt Mirjam Christ-Crain Source Type: research
Cost analysis for initiating an integrated package of essential non-communicable disease interventions (PEN-Plus) in Kondoa District Hospital, Tanzania: a time-driven activity-based costing (TDABC) study protocol
This study aims to estimate the cost of initiating PEN-Plus for rheumatic heart disease, sickle cell disease and type 1 diabetes at Kondoa district hospital in Tanzania.
Methods and analysis
We will employ time-driven activity-based costing (TDABC) to quantify the capacity cost rates (CCR), and capital and recurrent costs associated with the implementation of PEN-Plus. Data on resource consumption will be collected through direct observations and interviews with nurses, the medical officer in charge and the heads of laboratory and pharmacy units/departments. Data on contact times for targeted NCDs will be collected by obs...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Ndumwa, H. P., Mori, A. T., Ruhago, G. M., Willilo, R., McBain, R., Boudreaux, C., Wroe, E., Adler, A. J., Bukhman, G., Mayige, M. T., Kaarboe, O. Tags: Open access, Health economics Source Type: research
Sensorineural hearing loss among type 2 diabetic patients and its association with peripheral neuropathy: a cross-sectional study from a lower middle-income country
Conclusions
The study highlights the substantial prevalence of SNHL among patients with T2DM and emphasises the importance of targeted audiological care as part of a holistic approach to diabetes management. Addressing HL early may significantly improve communication and overall quality of life. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Asghar, S., Ali, Z., Abdullah, A., Naveed, S., Ahmad, M. S., Rafi, T. S. M. Tags: Open access, Diabetes and Endocrinology Source Type: research
The effect of adjuvant Mitomycin C during vitrectomy on functional and anatomical outcomes in patients with severe diabetic tractional retinal detachment
ConclusionIntraoperative adjuvant MMC application for severe dTRD significantly reduces re-surgery rates with good anatomical and functional outcomes safely. (Source: International Ophthalmology)
Source: International Ophthalmology - May 1, 2024 Category: Opthalmology Source Type: research
Predictive values of relative fat mass and body mass index on cardiovascular health in community-dwelling older adults: Results from the Longevity Check-up (Lookup) 7+
Cardiovascular disease (CVD) is the leading cause of death and non-communicable diseases worldwide [1,2]. Cardiovascular risk factors (CRFs) such as excess body weight, high blood pressure (BP), diabetes, high low-density lipoprotein cholesterol, and active smoking are responsible for more than half of new CVD diagnoses and one fifth of 10-year mortality [3]. Assessing and managing cardiovascular risk is particularly relevant in older adults, as advancing age itself is a predisposing factor for CVD [4]. (Source: Maturitas)
Source: Maturitas - May 1, 2024 Category: Primary Care Authors: Stefano Cacciatore, Riccardo Calvani, Emanuele Marzetti, Helio Jos é Coelho-Júnior, Anna Picca, Alberto Emanuele Fratta, Ilaria Esposito, Matteo Tosato, Francesco Landi Tags: Original article Source Type: research
