Usual dietary treatment of gestational diabetes mellitus assessed after control diet in randomized controlled trials: subanalysis of a systematic review and meta-analysis
(Source: Acta Diabetologica)
Source: Acta Diabetologica - October 17, 2018 Category: Endocrinology Source Type: research

Measurement of corneal thickness, optic nerve sheath diameter and retinal nerve fiber layer as potential new non-invasive methods in assessing a risk of cerebral edema in type 1 diabetes in children
AbstractAimsSome patients with diabetic ketoacidosis develop cerebral edema (CE) in the course of type 1 diabetes mellitus (T1D), which may result in central nervous system disorders and high mortality. The imperfection of existing neuroimaging techniques for early recognition of CE forces us to search for the new and non-invasive methods. The aim of the study was to assess the usefulness of new methods (pachymetry, transorbital ultrasonography —USG, optical coherence tomography—OCT study) in the assessment of the risk of CE occurrence in children with newly diagnosed T1D.MethodsThe study group included 50 chil...
Source: Acta Diabetologica - October 16, 2018 Category: Endocrinology Source Type: research

Prevalence of vitamin B 12 deficiency in South Indians with different grades of glucose tolerance
AbstractAimsTo determine the prevalence of vitamin B12 deficiency in an urban south Indian population in individuals with different grades of glucose tolerance.MethodsA total of 1500 individuals [900 normal glucose tolerance (NGT), 300 prediabetes and 300 type 2 diabetes (T2DM)] who were not on vitamin B12 supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study (CURES) follow-up study. Anthropometric, clinical and biochemical investigations, which included vitamin B12, insulin, homocysteine, HbA1c and serum lipids, were measured. Vitamin B12 ≤ 191 pg/ml was defined as...
Source: Acta Diabetologica - October 13, 2018 Category: Endocrinology Source Type: research

Transient neonatal diabetes mellitus and hypomethylation at additional imprinted loci: novel ZFP57 mutation and review on the literature
ConclusionWe provide additional support to the role ofZFP57 as a genetic determinant cause of MLID in patients with TNMD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 13, 2018 Category: Endocrinology Source Type: research

High prevalence of humoral autoimmunity in first-degree relatives of Mexican type 1 diabetes patients
ConclusionsFDR of Mexican T1D patients have high prevalence of islet Aab, comparable to countries with the highest incidence of T1D. However, Aab positivity does not seem to be associated with HLA risk genotypes, which may have an impact on the low incidence of T1D in Mexico. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 10, 2018 Category: Endocrinology Source Type: research

Patient preferences for treatment in type 2 diabetes: the Italian discrete-choice experiment analysis
AbstractAimsSeveral drug classes are now available to achieve a satisfactory metabolic control in patients with type 2 diabetes (T2DM), but patients ’ preferences may differ.MethodsIn a discrete-choice experiment, we tested T2DM patients ’ preferences for recent antidiabetic drugs, in the event that their treatment might require intensification. The following attributes were considered: (a) route of administration; (b) type of delivery; (c) timing; (d) risk of adverse events; (e) effects on body weight. Twenty-two possible scenari os were built, transferred into 192 paired choices and proposed to 491 cases na&i...
Source: Acta Diabetologica - October 10, 2018 Category: Endocrinology Source Type: research

Regulation of MMP 2 and MMP 9 expressions modulated by AP-1 (c-jun) in wound healing: improving role of Lucilia sericata in diabetic rats
AbstractAimsLucilia sericata larvae have been successfully used on healing of wounds in the diabetics. However, the involvement of the extraction/secretion (ES) products of larvae in the treatment of diabetic wounds is still unknown. Activator protein-1 (AP-1) transcription, composed of c-jun and c-Fos proteins, has been shown to be the principal regulator of multiple MMP transcriptions under a variety of conditions, also in diabetic wounds. Specifically, MMP-2 and MMP-9 ’s transcriptions are known to be modulated by AP-1. c-jun has been demonstrated to be a repressor of p53 in immortalized fibroblasts. The aim of th...
Source: Acta Diabetologica - October 9, 2018 Category: Endocrinology Source Type: research

Screening of HNF1A and HNF4A mutation and clinical phenotype analysis in a large cohort of Chinese patients with maturity-onset diabetes of the young
ConclusionsThe prevalence ofHNF1A mutation was relatively lower in Mainland China andHNF4A mutation was rare. Serum hsCRP concentrations performed well in discriminating MODY3 from T2DM. Molecular diagnosis of MODY3/1 did transform management in clinical practice and facilitated the glycemic control. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 6, 2018 Category: Endocrinology Source Type: research

Early and localized retinal dysfunction in patients with type 1 diabetes mellitus studied by multifocal electroretinogram
ConclusionsIn DM1 patients, localized retinal dysfunction, described by reduced mfERG RAD, can be observed also in the absence of clinical signs of DR and it is related to aging. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 5, 2018 Category: Endocrinology Source Type: research

Diabetes mellitus induced by PD-1 and PD-L1 inhibitors: description of pancreatic endocrine and exocrine phenotype
ConclusionsIn the patients presented herein, immunotherapy-induced diabetes was not associated with T1D-related autoantibodies. The hormonal and morphological analysis of the pancreatic glands of these six cases contributes to the understanding of the underlying and probably heterogeneous mechanisms. There is a need to find biomarkers to identify patients at risk to develop these new forms of diabetes at early stages of the process to prevent ketoacidosis and to evaluate preventive strategies. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 4, 2018 Category: Endocrinology Source Type: research

Malnutrition in type 2 diabetic patients does not affect healing of foot ulcers
ConclusionWe demonstrated that wound healing was not affected by the initial presence of malnutrition. In our study, there is no evidence to support nutritional intervention to improve wound healing in diabetic patients. Nevertheless, malnutrition is responsible for an increase in morbidity and mortality and it is essential to identify malnutrition systematically for all patients with DFU, initially and during follow-up to treat it quickly and efficiently. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 3, 2018 Category: Endocrinology Source Type: research

Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study
AbstractAimsTo assess whether disturbances in glucose regulation are associated with impairment in physical performance during a 10-year follow-up.Methods 475 Men and 603 women from the Helsinki Birth Cohort Study were studied. Glucose regulation was evaluated with a 2-h 75-g oral glucose tolerance test (OGTT) in 2001 –2004. Subjects were categorised as having either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), newly diagnosed diabetes or previously known diabetes. Physical performance was assessed approximately 10 years later using the validated senior fitness test (SFT). The relationship b...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Assessment of glucose effectiveness from short IVGTT in individuals with different degrees of glucose tolerance
AbstractAimsMinimal model analysis of intravenous glucose tolerance test (IVGTT) data represents the reference method to assess insulin sensitivity (SI) and glucose effectiveness (SG) that quantify the insulin-dependent and insulin-independent processes of glucose disappearance, respectively. However, test duration (3  h) and need for modeling expertise limit the applicability of this method. Aim of this study was providing a simple predictor ofSG applicable to short test (1  h), as previously done withSI.MethodsThree groups of subjects reflecting different glucose tolerance degrees underwent a 3  h IVGTT: s...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

The effects of probiotics and synbiotic supplementation on glucose and insulin metabolism in adults with prediabetes: a double-blind randomized clinical trial
ConclusionGlycemic improvement by probiotics and particularly synbiotic supplements in prediabetic individuals has been supported by current study. However, further studies are required for optimal recommendations in this important area of patient treatment.Trial registrationIranian Registry of Clinical Trials: IRCT201511032321N2, Date registered February 27, 2016. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Novel insights into the regulation of miRNA transcriptional control: implications for T2D and related complications
AbstractIn recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Along with DNA methylation (DNA-me), histone modifications and RNA-based mechanisms as the major epigenetic controllers, small non-coding RNA...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Real-world use of self-monitoring of blood glucose in people with type 2 diabetes: an urgent need for improvement
ConclusionsSMBG is underutilized in patients with T2DM treated or not with insulin. In all treatment groups, PPG is seldom investigated. Poor metabolic control and rates of hyper- and hypoglycemia deserve consideration in all treatment groups. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Diabetes, myometrium, and mitochondria in pregnant women at term
ConclusionNo indication of decreased mitochondrial function, content, morphology, or localization in the myometrium at term in women with diabetes compared with controls was observed. The increase in citrate syntase activity in the myometrium could be explained by the lower protein content in the myometrium, which we suggest is due to alterations in tissue or cellular composition. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

FRAX tool in type 2 diabetic subjects: the use of HbA 1c in estimating fracture risk
ConclusionsWe propose a correction factor derived from HbA1c that could enhance the predictive ability of fracture risk estimated by the FRAX algorithm in subjects with T2DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Optical coherence tomography angiography findings of neurovascular changes in type 2 diabetes mellitus patients without clinical diabetic retinopathy
AbstractAimsTo evaluate the effect of early screening with OCTA in type 2 diabetes mellitus (T2DM) patients without clinical DR (NDR).MethodsThis was a cross-sectional case –control clinical study. Eighty-four eyes of 84 patients (44 T2DM and 40 control subjects) were included. Images were obtained using AngioVue software 2.0 of the OCTA device. Foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), choriocapillary flow area (CCF), acircularity index (AI), foveal v essel density in a 300-µm-wide region around FAZ (FD), macular-associated vessel density (VD) and optic disc-associated capillary density (CD) wer...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Optimal glycaemic control during caesarean section provided by sensor-augmented pump therapy with predictive low-glucose suspend function
(Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Fasting plasma glucose is a stronger predictor of diabetes than triglyceride –glucose index, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance: Tehran Lipid and Glucose Study
AbstractAimsTo compare the impact of triglyceride –glucose index (TyG-index), the product of fasting plasma glucose (FPG) and triglycerides (TG) with FPG, 2 h post-challenge plasma glucose (2 h-PCPG), TG/high-density lipoprotein cholesterol (TG/HDL-C), and homeostasis model assessment of insulin resistance (HOMA-IR) indices for prediction of ty pe 2 diabetes (T2D) in Iranian adults during a median follow-up of 12 years.MethodsStudy population included 4419 (1858 men) subjects with mean age of 40.6  ± 13.2 years. Multivariable Cox proportional hazard models were used to calculate th...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Maternal gestational diabetes mellitus and the risk of subsequent pediatric cardiovascular diseases of the offspring: a population-based cohort study with up to 18 years of follow up
AbstractAimsThe prevalence of gestational diabetes mellitus (GDM) has been increasing worldwide. We aimed to study the effect of GDM on the risk for childhood cardiovascular morbidity of the offspring.MethodsA population-based cohort analysis was performed comparing total and different subtypes of cardiovascular related pediatric diagnoses among offspring of mothers with GDM vs. offspring of mothers with no diabetes. The analysis included all singletons born between the years 1991 –2014. Cardiovascular related morbidities included hospitalizations involving a pre-defined set of ICD-9 codes. Mothers with pregestationa...
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia
ConclusionsGAM has potential as a biomarker for susceptibility to hypoglycemic episodes.Trail registrationClinicaltrials.gov ID: NCT02690168. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Correction to: The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
Oxidative stress plays a pivotal role in the pathogenesis of type 2 diabetes (T2D). In vitro and animal studies have shown that resveratrol exerts an antioxidant effect, but clinical trials addressing this effect in patients with T2D are limited. The aim of this study was to determine whether resveratrol supplementation affects oxidative stress markers in a randomized, placebo-controlled, double-blind clinical trial. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Correction to: Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus
The title “Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus” should be replaced by “Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus”. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 1, 2018 Category: Endocrinology Source Type: research

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus
ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 27, 2018 Category: Endocrinology Source Type: research

Alternative treatment or alternative to treatment? A systematic review of randomized trials on homeopathic preparations for diabetes and obesity
(Source: Acta Diabetologica)
Source: Acta Diabetologica - September 27, 2018 Category: Endocrinology Source Type: research

Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects
AbstractAimsInflammation plays a role in the development and progression of type 2 diabetes macroangiopathy. Interleukin 33 (IL-33) drives production of Th2-associated cytokines. The soluble form of suppression of tumorigenicity 2 (sST2) acting as a decoy receptor blocks IL-33 and tones down Th2 inflammatory response. We investigated the role of sST2 as a predictor of CV and all-cause mortality in a cohort of patients affected by established atherosclerotic disease.Methods399 patients with atherosclerotic disease from the Tor Vergata Atherosclerosis Registry performed follow-up every year by phone interview. The primary en...
Source: Acta Diabetologica - September 26, 2018 Category: Endocrinology Source Type: research

The efficacy and safety of dipeptidyl peptidase-4 inhibitors for type 2 diabetes: a Bayesian network meta-analysis of 58 randomized controlled trials
ConclusionOur network meta-analysis presents the associations of DPP4-I versus placebos on HbA1c, FPG, 2  h postprandial blood glucose (2HPPG), BMI, body weight and adverse events. DPP4-I have a lowering effect on the glycemic level (HbA1c, FPG), especially vildaglipti50BID and linagliptin10QD, respectively. Besides, linagliptin5QD has the greatest probabilities of reducing BMI. In addition, DPP4-I we re associated with not increasing the incidence of adverse events. Among them, vildagliptin100QD and sitagliptin100QD have the lowest probability in reducing the incidence of hypoglycemia and URTI, respectively. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 21, 2018 Category: Endocrinology Source Type: research

Comment on “Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - September 18, 2018 Category: Endocrinology Source Type: research

The risk stratification of adverse neonatal outcomes in women with gestational diabetes (STRONG) study
ConclusionsA deep investigation on the factors associated with adverse neonatal outcomes requires a risk stratification. In particular, great attention must be paid to the prevention and treatment of obesity. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 17, 2018 Category: Endocrinology Source Type: research

Heterogeneity of gestational diabetes (GDM) and challenges in developing a GDM risk score
ConclusionsOur findings suggest that the marked heterogeneity of GDM challenges the development of risk scores for detection of GDM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 17, 2018 Category: Endocrinology Source Type: research

Negative pressure wound therapy in the treatment of diabetic foot ulcers may be mediated through differential gene expression
ConclusionsWe found initial evidence that the NPWT effect on DFUs may be mediated through differential gene expression. A discovery of the specific molecular mechanisms of NPWT is potentially valuable for its clinical application and development of new therapies. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 17, 2018 Category: Endocrinology Source Type: research

Authors ’ response to the commentary by Bonaventura and Montecucco on: ‘Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis’
(Source: Acta Diabetologica)
Source: Acta Diabetologica - September 15, 2018 Category: Endocrinology Source Type: research

Issue focusing: a new topical collection on diabetic nephropathy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - September 12, 2018 Category: Endocrinology Source Type: research

Correction to: Use of flash glucose-sensing technology (FreeStyle Libre) in youth with type 1 diabetes: AWeSoMe study group real-life observational experience
Unfortunately, the co-author name was misspelled as “Avivit Brenner” instead of “Avivit Brener” in the original publication and the correct author name is updated here (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 12, 2018 Category: Endocrinology Source Type: research

Dexmedetomidine restores autophagy and cardiac dysfunction in rats with streptozotocin-induced diabetes mellitus
ConclusionsDEX reduces cardiac dysfunction and impaired autophagy in DM rats. This study reinforces our understanding of the potential anti-autophagic effect of DEX in patients with diabetic cardiomyopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 11, 2018 Category: Endocrinology Source Type: research

Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats
AbstractAimsCompound 21 (C21), selective AT2 receptor agonist, has cardioprotective effects in experimental models of hypertension and myocardial infarction. The aims of the study was to evaluate the effect of C21, losartan, or both in Zucker diabetic fatty (ZDF) rats (type 2 diabetes) on (1) the prevention of myocardial hypertrophy; (2) myocardial expression of phosphatase and tensin homolog (PTEN), a target gene of miR-30a-3p, involved in myocardial remodelling.MethodsExperiments were performed in ZDF (n = 33) and in control Lean (8) rats. From the 6th to the 20th week of age, we administered C21 (0.3 ...
Source: Acta Diabetologica - September 5, 2018 Category: Endocrinology Source Type: research

Optimization of kidney dysfunction prediction in diabetic kidney disease using targeted metabolomics
ConclusionsTargeted metabolomics using blotted samples in filter paper is a simple, low-cost approach to identify outcomes associated with DKD; the inclusion of metabolomics improves predictive capacity of clinical models to identify kidney dysfunction and DKD-related outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 1, 2018 Category: Endocrinology Source Type: research

Use of flash glucose-sensing technology (FreeStyle Libre) in youth with type 1 diabetes: AWeSoMe study group real-life observational experience
ConclusionsReal-life observational data in a self-selected young T1D population demonstrated a significant and sustained reduction in HbA1c with FSL-CGM in one-third of the participants. Surveillance of glucose monitoring should be individualized, especially for patients with hypoglycemia unawareness. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 31, 2018 Category: Endocrinology Source Type: research

Ethnicity-specific association of BMI levels at diagnosis of type 2 diabetes with cardiovascular disease and all-cause mortality risk
ConclusionsThis study suggests a paradoxical association of BMI with cardiovascular and mortality risks in different ethnic groups, which may partially be driven by different cardiovascular and glycaemic risk profiles at diagnosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 30, 2018 Category: Endocrinology Source Type: research

Circulating miRNAs in diabetic kidney disease: case –control study and in silico analyses
ConclusionsOur study found four miRNAs differentially expressed in patients with severe DKD, providing significant information about the biological pathways in which they are involved. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 30, 2018 Category: Endocrinology Source Type: research

Age at menarche and the future risk of gestational diabetes: a systematic review and dose response meta-analysis
AbstractPublished studies show an inconsistent association between age at menarche and the subsequent risk of developing gestational diabetes mellitus when pregnant. This systematic review and meta-analysis was performed to clarify any trends in this association in published observational population studies. We searched online databases for relevant studies, entered into them up until June 21st 2017. Five eligible studies were found and a pooled random effects dose response meta-analysis of results from these was conducted. This included coverage of 58,133 pregnancies, from which 3,035 women developed gestational diabetes....
Source: Acta Diabetologica - August 29, 2018 Category: Endocrinology Source Type: research

Efficacy of urinary glucose for diabetes screening: a reconsideration
This study was designed to have a re-evaluation of its efficacy, taking into consideration the collection method of urine and the measurement approach for UG among Chinese adults.MethodsThis cross-sectional study enrolled a total of 7689 participants without known diabetes, who were fasted and asked to empty bladders before a 75  g glucose loading. Urine was collected 2 h post glucose loading, and UG was measured using quantitative and qualitative approaches. The efficacy of UG in detecting diabetes was assessed by the receiver operating characteristic (ROC) curve.ResultsThe area under the ROC curve was 0.89 for quant...
Source: Acta Diabetologica - August 29, 2018 Category: Endocrinology Source Type: research

Expectations and fear of diabetes-related long-term complications in people with type 2 diabetes at primary care level
ConclusionPrevalence of diabetes-related long-term complications was overestimated in people with diabetes type 2. Approximately one third of the participants showed even great fear. Patient expectation and fear about diabetes-associated complications did not correspondent with data on clinical reality. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 29, 2018 Category: Endocrinology Source Type: research

Autonomic testing: which value for each cardiovascular test? An observational study
ConclusionsVM could be useful when screening for possible or early autonomic neuropathy, VM  + LS is useful as a diagnostic tool for probable or advanced autonomic neuropathy, and VM + LS + PH is useful for certain diagnosis of definite or late stage autonomic neuropathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 29, 2018 Category: Endocrinology Source Type: research

Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy
AbstractIt usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy. This long, complication-free, period represents the best possible moment to start a successful preventive strategy (primary prevention) aimed to avoid or at least to postpone the increase of albumin excretion rate. Prevention is based on understanding and counteracting the initial mechanisms leading to the development of the disease and unfortunately, in case of diabetic nephropathy, most of them remain...
Source: Acta Diabetologica - August 29, 2018 Category: Endocrinology Source Type: research