Ramadan fasting and type 1 diabetes: on a case successfully managed with an integrated system based on predictive low-glucose suspend algorithm
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 8, 2021 Category: Endocrinology Source Type: research

Sodium –glucose cotransporter 2 inhibitors as an add-on therapy to insulin for type 1 diabetes mellitus: Meta-analysis of randomized controlled trials
ConclusionSGLT2i as an add-on therapy to insulin improved glycemic control and body weight and decreased the required dose of insulin without increasing the risk of hypoglycemia. However, after 6  months the benefits of SGLT2is on glycemic control may weaken and the risks of GTIs and DKA increased. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 2, 2021 Category: Endocrinology Source Type: research

Correction to: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial
A correction to this paper has been published: https://doi.org/10.1007/s00592-021-01689-8. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 1, 2021 Category: Endocrinology Source Type: research

Labetalol and hypoglycaemia unawareness: two case reports and considerations about its use as an antihypertensive drug for women with diabetes and pregnancy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 27, 2021 Category: Endocrinology Source Type: research

The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study
ConclusionThis 2-sample MR analysis found no evidence of a causal association between plasma Hcy levels and CAD risk in individuals with diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 26, 2021 Category: Endocrinology Source Type: research

Management of glucose profile throughout strict COVID-19 lockdown by patients with type 1 diabetes prone to hypoglycaemia using sensor-augmented pump
AbstractAimsSpain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycaemia using sensor-augmented pump (SAP).MethodsPatients with T1D prone to hypoglycaemia using SAP (640G Medtronic-Minimed®) for at least 6  months under the funding of a National Health Service were included in an observational, retrospective study. Data were collected in two periods: pre-lockdown (PL), February 2...
Source: Acta Diabetologica - February 26, 2021 Category: Endocrinology Source Type: research

Exercise-heat tolerance in middle-aged-to-older men with type 2 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 25, 2021 Category: Endocrinology Source Type: research

Vascular complications of diabetes: natural history and corresponding risks of dementia in a national cohort of adults with diabetes
ConclusionsPatients with diabetes-related complications, particularly stroke and neuropathy, and those with rapidly developed vascular diseases appeared to have a high risk of dementia. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 23, 2021 Category: Endocrinology Source Type: research

The triumvirate: why hypertension, obesity, and diabetes are risk factors for adverse effects in patients with COVID-19
AbstractThe outbreak of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic. The cellular receptor for SARS-CoV-2 entry is the angiotensin-converting enzyme 2, a membrane-bound homolog of angiotensin-converting enzyme. Henceforth, this has brought the attention of the scientific community to study the interaction between COVID-19 and the renin –angiotensin system (RAS), as well as RAS inhibitors. However, these inhibitors are commonly used to treat hypertension, chronic kidney disorder, and diabetes. Obesity is a known ...
Source: Acta Diabetologica - February 15, 2021 Category: Endocrinology Source Type: research

Risk of cause-specific death, its sex and age differences, and life expectancy in post-pancreatitis diabetes mellitus
ConclusionsPeople with PPDM have a higher risk of cancer mortality compared with those with T2DM or T1DM. This is especially pronounced in women. Young and middle-aged adults with PPDM have a lower life expectancy compared with their counterparts with T2DM or T1DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 15, 2021 Category: Endocrinology Source Type: research

Higher HbA1c may reduce axial length elongation in myopic children: a comparison cohort study
AbstractAimsTo compare the annual axial length (AL) changes in myopic children with type 1 diabetes mellitus (T1DM) and those without diabetes.MethodsThere are two groups of myopic children in this retrospective cohort study. Group 1 consisted of myopic children with T1DM (44 eyes of 22 patients). Group 2 comprised age-matched myopic children without diabetes (44 eyes of 22 children). These two groups were compared with regard to their baseline clinical characteristics. A generalized estimating equations (GEE) model was also used to determine the most likely factor that contributed to the results.ResultsThe average ages of...
Source: Acta Diabetologica - February 15, 2021 Category: Endocrinology Source Type: research

Similar glycaemic control and risk of hypoglycaemia with patient- versus physician-managed titration of insulin glargine 300 U/mL across subgroups of patients with T2DM: a post hoc analysis of ITAS
AbstractAimsThe Italian Titration Approach Study (ITAS) demonstrated comparable HbA1c reductions and similarly low hypoglycaemia risk at 6  months in poorly controlled, insulin-naïve adults with T2DM who initiated self- or physician-titrated insulin glargine 300 U/mL (Gla-300) in the absence of sulphonylurea/glinide. The association of patient characteristics with glycaemic and hypoglycaemic outcomes was assessed.MethodsThis post hoc analysis investigated whether baseline patient characteristics and previous antihyperglycaemic drugs were associated with HbA1c change and hypoglycaemia risk in patient- versus physi...
Source: Acta Diabetologica - February 14, 2021 Category: Endocrinology Source Type: research

Metformin use and risk of COVID-19 among patients with type II diabetes mellitus: an NHIS-COVID-19 database cohort study
AbstractAimsThe relationship between metformin therapy and the risk of coronavirus disease (COVID-19) has not been reported among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether metformin therapy was associated with the incidence of COVID-19 among type 2 DM patients in South Korea.MethodsThe National Health Insurance Service-COVID-19 cohort database, comprising COVID-19 patients from 1 January 2020 to 4 June 2020, was used for this study. Among them, adult patients with type 2 DM were included in this study. Metformin users were defined as those who had been prescribed continuous oral metformin...
Source: Acta Diabetologica - February 13, 2021 Category: Endocrinology Source Type: research

1-Hour postprandial glucose target of   & lt;  120 mg/dL is superior to  & lt;  140 mg/dL in the treatment for gestational diabetes mellitus in relation to pregnancy outcomes: A retrospective study
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 12, 2021 Category: Endocrinology Source Type: research

TPTEP1 suppresses high glucose-induced dysfunction in retinal vascular endothelial cells by interacting with STAT3 and targeting VEGFA
ConclusionsTPTEP1 alleviated HG-induced dysfunction in HRVECs via interacting with STAT3 and targeting VEGFA. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 12, 2021 Category: Endocrinology Source Type: research

Association between fasting blood glucose and intracranial cerebral artery stenosis: a secondary analysis based on a retrospective cross-sectional study in Korean adults
AbstractAimsDiabetes mellitus (DM) is one of the main risk factors for intracranial cerebral artery stenosis (ICAS), and fasting blood glucose (FBG) might be an effective predictor of ICAS. However, there are a few studies revealing the relationship between FBG and ICAS. We aim to identify the association between FBG and ICAS in Koreans.MethodsThis was a secondary study based on a cross-sectional study. A total of 1011 Korean individuals who were asymptomatic but with high cerebrovascular risk underwent an examination in a Korean medical centre from March 2008 to December 2014. The main measure was FBG, while the main outc...
Source: Acta Diabetologica - February 8, 2021 Category: Endocrinology Source Type: research

Health service organisation impact on lower extremity amputations in people with type 2 diabetes with foot ulcers: systematic review and meta-analysis
ConclusionsSpecific organizational arrangements including multidisciplinary teams and care pathways can prevent half of the amputations in people with diabetes and foot ulcers. Further studies using standardized criteria are needed to investigate the cost-effectiveness to facilitate wider implementation of improved organizational arrangements. Similarly, research should identify specific roadblocks to translating evidence into action. These may be structures and processes at the health system level, e.g. availability of professionals with the right skillset, reimbursement mechanisms, and clear organizational intervention i...
Source: Acta Diabetologica - February 6, 2021 Category: Endocrinology Source Type: research

Current landscape of type 1 diabetes mellitus-related interventional clinical trials registered on ClinicalTrials.gov: a cross-sectional study
AbstractAimsA better understanding of the current features of type 1 diabetes mellitus (T1DM)-related interventional clinical trials is important for improving clinical trial designs and identifying neglected research areas. Therefore, this study aimed to comprehensively assess T1DM-related interventional clinical trials registered in the ClinicalTrials.gov database.MethodsIn this cross-sectional study, T1DM-related clinical trials registered in the ClinicalTrials.gov database were searched on July 1, 2020. The characteristics of the relevant trials were assessed. PubMed and Google Scholar were used to search for publicati...
Source: Acta Diabetologica - February 5, 2021 Category: Endocrinology Source Type: research

Diabetic neuropathy: a risk factor for severe COVID-19?
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 3, 2021 Category: Endocrinology Source Type: research

Novel biomarkers of diabetic kidney disease: current status and potential clinical application
AbstractDiabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Although both albuminuria and glomerular filtration rate (GFR) are well-established diagnostic/prognostic biomarkers of DKD, they have important limitations. There is, thus, increasing quest to find novel biomarkers to identify the disease in an early stage and to improve risk stratification. In this review, we will outline the major pitfalls of currently available markers, describe promising novel biomarkers, and discuss their potential clinical relevance. In particular, we will focus on the importance of recent advancements in mul...
Source: Acta Diabetologica - February 2, 2021 Category: Endocrinology Source Type: research

Glycemic control of children and adolescents with type 1 diabetes improved after COVID-19 lockdown in Italy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 2, 2021 Category: Endocrinology Source Type: research

Correction to: Maternal diabetes and risk of childhood malignancies in the offspring: a systematic review and meta ‑analysis of observational studies
Authors would like to correct the error in in their original publication of the article. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 2, 2021 Category: Endocrinology Source Type: research

Targeting of the diabetes prevention program leads to substantial benefits when capacity is constrained
ConclusionsTargeting active diabetes prevention to patients at highest risk could improve health outcomes and reduce costs compared to providing the same intervention to a similar number of patients with pre-diabetes without targeted selection. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 30, 2021 Category: Endocrinology Source Type: research

A four-week prehabilitation program in candidates for bariatric surgery improves hemodynamic load, metabolism and cardiac autonomic regulation
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 30, 2021 Category: Endocrinology Source Type: research

Glycaemic control in the paediatric and young adult population with type 1 diabetes following a single telehealth visit - what have we learned from the COVID-19 lockdown?
AbstractAimsChildren with chronic diseases were unable to receive their usual care during COVID-19 lockdown. We assessed the feasibility and impact of telehealth visits on the time-in-range (TIR) of paediatric individuals with type 1 diabetes (T1D).MethodsAn observational multicentre real-life study. Patients scheduled for an in-clinic visit during the lockdown were offered to participate in a telehealth visit. Sociodemographic, clinical, continuous glucose monitor and pump data were recorded 2 weeks prior and 2 weeks after telehealth visit. The primary endpoint was change in relative-TIR, i.e. change in TIR divided by the...
Source: Acta Diabetologica - January 28, 2021 Category: Endocrinology Source Type: research

Lack of awareness of liver organ damage in patients with type 2 diabetes
ConclusionsDespite increasing evidence of a frequent hepatic involvement associated with poor prognosis, awareness of suffering of advanced liver disease in patients with T2D is remarkably low, likely reflecting little recognition also among the team of health care professionals. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 26, 2021 Category: Endocrinology Source Type: research

Unexpected adverse event of insulin therapy in diabetes mellitus
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 25, 2021 Category: Endocrinology Source Type: research

The effects of saxagliptin on cardiac structure and function using cardiac MRI (SCARF)
ConclusionsIn this cohort of stable ambulatory patients with T2DM without heart failure, saxagliptin treatment was not associated with adverse ventricular remodeling over 6  months as assessed using CMR and biomarkers. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 23, 2021 Category: Endocrinology Source Type: research

Factors associated with non-attendance in the Irish national diabetic retinopathy screening programme (INDEAR study report no. 2)
ConclusionsThis study is the first to outline factors that are associated with non-attendance within the Irish national diabetic retinopathy screening service. In particular, when corrected for age and other factors, patients with type 2 diabetes had higher rates of non-attendance. Additionally, this is the first study of any diabetic screening programme to demonstrate that weather may influence attendance. This research provides unique insight to guide the implementation of an optimal and cost-effective intervention strategy to improve attendance. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 23, 2021 Category: Endocrinology Source Type: research

Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry
AbstractAimsTo analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D).MethodsWe included 79,067 T1D patients aged 6 –20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n  =  73,699), T1 + CD (n  =  3379), T1D + depression (n  =  1877), or T1D + CD + depression (n  = &thin...
Source: Acta Diabetologica - January 23, 2021 Category: Endocrinology Source Type: research

Effects of catheter-based renal denervation on glycemic control and lipid levels: a systematic review and meta-analysis
ConclusionsCatheter-based RDN appeared to have no impact on glucose metabolism. There was a statistically significant but clinically negligible improvement in HDL-C and TG levels based on the current evidence. Future research with more rigorous designs is warranted to draw definitive conclusions.Registration detailsThe protocol of this meta-analysis was registered on PROSPERO (CRD42020192805). (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=192805) (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 18, 2021 Category: Endocrinology Source Type: research

Metformin combined with insulin in women with gestational diabetes mellitus: a propensity score-matched study
ConclusionsWomen with GDM treated with insulin plus metformin had similar obstetric and neonatal complications, weight gained and insulin dose compared to those only treated with insulin. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 18, 2021 Category: Endocrinology Source Type: research

High baseline FGF21 levels are associated with poor glucose-lowering efficacy of exenatide in patients with type 2 diabetes
AbstractAimsTo investigate the association between fibroblast growth factor 21 (FGF21) levels and glycemic response to exenatide in patients with type 2 diabetes.MethodsThe exploratory analysis of a multi-center trial included 190 patients with type 2 diabetes inadequately controlled by monotherapy or combination therapy of metformin and insulin secretagogues. All participants received exenatide twice daily as an add-on therapy for 16  weeks. Serum FGF21 and other information at the baseline and end of follow-ups were obtained. Linear regression analysis was used to determine the correlations between baseline FGF21 le...
Source: Acta Diabetologica - January 15, 2021 Category: Endocrinology Source Type: research

Efficacy of medical treatment for Charcot neuroarthropathy: a systematic review and meta-analysis of randomized controlled trials
Abstract No pharmacotherapeutic agents are yet recommended for active CN though many anti-resorptive agents have been studied. We conducted a systematic review and meta-analysis of the randomized placebo-controlled trials (RCTs) evaluating the time to remission of active CN with anti-resorptive or antiinflammatory drugs. RCTs published in PubMed, EMBASE, SCOPUS and Cochrane Library from January 1994 to December 2019 were accessed. We reviewed studies and extracted information on study design, participants ’ characteristics, time to remission, bone turnover markers, bone mineral content (BMC) and temperature differe...
Source: Acta Diabetologica - January 13, 2021 Category: Endocrinology Source Type: research

I fear COVID but diabetic foot (DF) is worse: a survey on patients ’ perception of a telemedicine service for DF during lockdown
AbstractAimsTo evaluate the patients ’ perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF).MethodsIn May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, with a structured interview, focusing on their perceptions about telemedicine service for DF and on the anxiety toward COVID and DF.ResultsWe analyzed 257 remote monitoring visits in 211 patients. Two hundred and six patients answered the follow-up interview; 177 patients (85.9%) remembered the monito...
Source: Acta Diabetologica - January 13, 2021 Category: Endocrinology Source Type: research

The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis
ConclusionOur results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 8, 2021 Category: Endocrinology Source Type: research

Glycemic status affects the severity of coronavirus disease 2019 in patients with diabetes mellitus: an observational study of CT radiological manifestations using an artificial intelligence algorithm
This study aimed to explore the impact of diabetes mellitus (DM) and glycemic control on chest CT manifestations, acquired using an artificial intelligence (AI)-based quantitative evaluation system, and COVID-19 disease severity and to investigate the association between CT lesions and clinical outcome.MethodsA total of 126 patients with COVID-19 were enrolled in this retrospective study. According to their clinical history of DM and glycosylated hemoglobin (HbA1c) level, the patients were divided into 3 groups: the non-DM group (Group 1); the well-controlled blood glucose (BG) group, with HbA1c  
Source: Acta Diabetologica - January 8, 2021 Category: Endocrinology Source Type: research

Educational attainment protects against type 2 diabetes independently of cognitive performance: a Mendelian randomization study
ConclusionsWe provided evidence to suggest that educational attainment protects against T2D independently of cognitive performance, but does not support a negative causal association between cognitive performance and T2D independently of educational attainment. Education might represent a potential target for intervention to battle type 2 diabetes risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 6, 2021 Category: Endocrinology Source Type: research

Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model
ConclusionsThe FXR agonist improves insulin resistance, renal lipid metabolism, and functional and structural changes in the kidney and other organs. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 5, 2021 Category: Endocrinology Source Type: research

Efficacy of liraglutide on glycemic endpoints in people of Western European and South Asian descent with T2DM using multiple daily insulin injections: results of the MAGNA VICTORIA studies
ConclusionsLiraglutide treatment resulted in increased chance of reaching target HbA1c as compared to placebo. Liraglutide efficacy was sustained in participants using MDI regimens and those of SA descent. Liraglutide should be considered for T2DM people with inadequate glycemic control despite MDI. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 5, 2021 Category: Endocrinology Source Type: research

Association between Osteoprotegerin and Charcot Neuroarthropathy: a systematic review
ConclusionsHere, we determined a potential correlation between the CN and serum OPG concentrations and that only the CC genotype of the 245A  >  C polymorphism showed an increased risk of developing CN. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 4, 2021 Category: Endocrinology Source Type: research

Genomic risk score provides predictive performance for type 2 diabetes in the UK biobank
AbstractAimsType 2 diabetes (T2D) is affected by a combination of genetic and environmental factors. However, the comprehensive genomic risk scores (GRSs) for T2D prediction have not been evaluated.MethodsUsing a meta-scoring approach, we developed a metaGRS for T2D; T2D-related traits consist of 1,692 genetic variants in the UK Biobank training set (n  = 40,423 + 7,558 events) and evaluate this score in the validation set (n = 303,053).ResultsThe hazard ratio (HR) for T2D was 1.32 (95% confidence interval [CI]: 1.29 –1.35) per standard deviation of metaGRS and was larger tha...
Source: Acta Diabetologica - January 3, 2021 Category: Endocrinology Source Type: research

Diabetic ketoacidosis and sinus arrest conditions in a patient with an inserted cardiac pacemaker
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 3, 2021 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus and risk of head and neck cancer subtypes: a systematic review and meta-analysis of observational studies
ConclusionsThis meta-analysis indicates that T2DM is associated with an increased risk of HNC in East Asia. As for site-specific cancer types, the risk of oral cancer was significantly increased in T2DM patients, which appear to be mediated or confounded by smoking, alcohol use, or BMI/obesity. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 3, 2021 Category: Endocrinology Source Type: research

A novel AGPAT2 mutation associated with a case of late-diagnosed congenital generalized lipodystrophy type 1
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 2, 2021 Category: Endocrinology Source Type: research

Association between maternal triglycerides and disturbed glucose metabolism in pregnancy
ConclusionsHypertriglyceridemia at the start of pregnancy is closely related to impaired insulin action andβ-cell function. Women with hypertriglyceridemia have higher mean glucose levels in early- and mid-gestation. Pregnant women with elevated triglycerides in early pregnancy are at increased risk of developing gestational diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 2, 2021 Category: Endocrinology Source Type: research

Associations of dairy intake with risk of incident metabolic syndrome in children and adolescents: Tehran Lipid and Glucose Study
ConclusionsHigher consumption of dairy products, particularly low-fat milk and yogurt, was associated with reduced risk of incident MetS, suggesting the capability of low-fat dairy products in the primary prevention of MetS in children and adolescents. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 2, 2021 Category: Endocrinology Source Type: research

Prenatal diagnosis of HNF1b mutation allows recognition of neonatal dysglycemia
(Source: Acta Diabetologica)
Source: Acta Diabetologica - December 1, 2020 Category: Endocrinology Source Type: research

The association of the level of self-care on adherence to treatment in patients diagnosed with type 2 diabetes
AbstractAimsThe study aimed to assess the impact of self-care on adherence to treatment in patients diagnosed with type 2 diabetes and effect of complex interaction of social, lifestyle, economic, environmental and behavioural.MethodsThe study was carried out between June 2018 and May 2019 on 324 patients (162 females, 162 males) with type 2 diabetes. To measure the levels of self-care, the Self-Care of Diabetes Index (SCODI) questionnaire was used. Adherence to treatment was assessed with the Adherence in Chronic Diseases Scale (ACDS).ResultsThe highest scores of health behaviour were on the subscale of adherence with the...
Source: Acta Diabetologica - November 29, 2020 Category: Endocrinology Source Type: research

Resilience in pregnant women with pre-gestational diabetes during COVID-19 pandemic: the experience of the Papa Giovanni XXIII Hospital in Bergamo, Italy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - November 25, 2020 Category: Endocrinology Source Type: research