Retinal image measurements and their association with chronic kidney disease in Chinese patients with type 2 diabetes: the NCD study
AbstractAimsRetinal and renal microcirculations are known to share similar physiological changes during early diabetes because of abnormal glucose metabolism and other processes. The retinal vasculature therefore may serve as potential biomarker for the early identification of those at high risk of chronic kidney disease (CKD) in diabetes.MethodsData from 1925 patients (aged 49.0  ± 10.3) with type 2 diabetes were analyzed. Various retinal image measurements (RIMs) were collected using a validated fully automated computer program. Multiple logistic regressions were performed to investigate the correlat...
Source: Acta Diabetologica - October 24, 2020 Category: Endocrinology Source Type: research

Assessment of the effect of pregnancy planning in women with type 1 diabetes treated by insulin pump
AbstractBackgroundPregnant women with type 1 diabetes (T1D) have high risk of complications despite improved care based on technology advancements.ObjectiveTo assess the effects of pregnancy planning on fetal and maternal outcomes in T1D women treated with continuous subcutaneous insulin infusion (CSII).Study designWe retrospectively assessed maternal and neonatal outcomes in T1D women using CSII who had planned or unplanned pregnancies between 2002 and 2018. The study was done in two European countries with similar sustained programs for pregnancy planning over the study period.ResultsData from 107 pregnancies and newborn...
Source: Acta Diabetologica - October 24, 2020 Category: Endocrinology Source Type: research

Patterns of changes in fasting plasma glucose, hemoglobin A1c and the area under the curve during oral glucose tolerance tests in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients
ConclusionBased on a long-term evaluation of patterns of changes in glycemic indices, we classified prediabetic subjects into 2 groups (high or low risk to progress diabetes states in future). Also, the method used enabled us to estimate the transition probabilities from low- to high-risk states and vice versa. Our results reemphasized the values of all 3 glycemic measures in clinical settings for identifying prediabetic people with a high risk of progressing diabetes and the need for more effective prevention strategies, which should be conducted as urgently in prediabetic life as high-risk subjects. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 21, 2020 Category: Endocrinology Source Type: research

Association of 1-deoxy-sphingolipids with steatosis but not steatohepatitis nor fibrosis in non-alcoholic fatty liver disease
AbstractBackgroundNon-alcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver disease in the western world. Steatosis can be accompanied by inflammation and cell damage (non-alcoholic steatohepatitis, NASH), and even liver fibrosis. Sphingolipids are a heterogeneous class of lipids and essential components of the plasma membrane and plasma lipoproteins. The atypical class of deoxy-sphingolipids has been implicated in the metabolic syndrome and type 2 diabetes.AimTo determine if circulating (deoxy)sphingolipids are associated with NAFLD and its different entities, steatosis, inflammatory changes (...
Source: Acta Diabetologica - October 21, 2020 Category: Endocrinology Source Type: research

Health utility of type 2 diabetes patients using basal insulin in China: results from the BEYOND II study
ConclusionsThe derived health utility scores for diabetes complications could facilitate the assessment of the cost-effectiveness of health interventions for Chinese insulin-using T2D patients. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 17, 2020 Category: Endocrinology Source Type: research

Impact of COVID-19 lockdown on flash and real-time glucose sensor users with type 1 diabetes in England
AbstractAimsPeople with type 1 diabetes (T1D) face the daily task of implementing self-management strategies to achieve their glycaemic goals. The UK COVID-19 lockdown has had an impact on day-to-day behaviour, which may affect diabetes self-management and outcomes. We assessed whether sensor-based outcomes pre- and during lockdown periods were different in a cohort of glucose sensor users with T1D.MethodsData were collected from Freestyle Libre (FSL) or Dexcom G6 sensor users who remotely shared their data with the diabetes clinic web platform. Sensor metrics according to international consensus were analysed and compared...
Source: Acta Diabetologica - October 16, 2020 Category: Endocrinology Source Type: research

Correction to: Validation in the general population of a C-peptide estimate equation to measure beta cell function in recent-onset type 1 diabetes
Authors would like to correct the first name of author Joanne Wang from Joanne to Joanna. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 16, 2020 Category: Endocrinology Source Type: research

Elevated plasma trimethylamine- N -oxide levels are associated with diabetic retinopathy
AbstractAimsTo determine the relationship between plasma levels of trimethylamine-N-oxide (TMAO) and odds of diabetic retinopathy (DR).MethodsA cross-sectional study was conducted. Blood samples were obtained from 122 type 2 diabetes mellitus (T2DM) patients with or without DR. Multivariable logistic regression analyses were performed to identify the association between plasma TMAO and DR. The diagnostic value of plasma TMAO was assessed by the area under the receiver operating characteristic curve (AUROC) and integrated discrimination improvement (IDI).ResultsIn the T2DM patients, plasma levels of TMAO were significantly ...
Source: Acta Diabetologica - October 16, 2020 Category: Endocrinology Source Type: research

A case of a Rhizopus infection in a patient with diabetes and fear
(Source: Acta Diabetologica)
Source: Acta Diabetologica - October 15, 2020 Category: Endocrinology Source Type: research

Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial
AbstractAimsTo compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus.MethodsIn an a priori subgroup analysis of a randomized, double-blind, controlled trial, volunteers aged 30 –70 years, with stage I hypertension and diabetesmellitus, were randomized to 12.5/2.5  mg of chlorthalidone/amiloride (N = 47) or 50 mg of losartan (N = 50), and followed for 18 months in 21 clinical centers. If BP remained uncontrolled after...
Source: Acta Diabetologica - October 13, 2020 Category: Endocrinology Source Type: research

One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes
AbstractObjectiveTo evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI).MethodsThis was a 1-year observational study, as a continuation of the previous 3  months prospective study of pediatric patients with T1D conducted at Sidra Medicine in Qatar. The study enrolled individuals aged 7–18 years with T1D >  1 year, on MDI with self-monitoring of blood glucose or continuous glucose monitoring, with no prior pump experience, and with an HbA1c level 
Source: Acta Diabetologica - October 12, 2020 Category: Endocrinology Source Type: research

Microbiota, epidemiological and nutritional factors related to ketoacidosis at the onset of type 1 diabetes
AbstractAimsThe incidence of type 1 diabetes has increased over the last decades. The pathological pathway is not yet clear, even if genetic and environmental risk factors are known. An early diagnosis can avoid ketoacidosis and its complications. This work aims to discuss the determinants of both ketoacidosis at the onset and access by hospital emergency departments without a suspected diagnosis.MethodsAn observational bi-centric prospective study was conducted in Northern Italy, on a paediatric population including Italian and migrant patients at the diabetes onset. Seventy-four type 1 diabetes patients, both Italian and...
Source: Acta Diabetologica - October 11, 2020 Category: Endocrinology Source Type: research

Impact of sildenafil-containing ointment on wound healing in healthy and experimental diabetic rats
ConclusionOur results suggest that sildenafil-containing ointment can provide an advantage in wound healing by promoting wound contractions and resistance to wound breakage in healthy and diabetic conditions. Therefore, 5% sildenafil-containing ointment can be used as a support factor for wound healing in healthy and diabetic conditions; however, clinical trials are required to confirm the benefits of sildenafil in wound healing. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 11, 2020 Category: Endocrinology Source Type: research

Metformin use in prediabetes: is earlier intervention better?
ConclusionThe largest reductions in both incidence of diabetes and FPG occurred in prediabetic persons with a higher level of FPG at baseline. Metformin was able to stabilise insulin sensitivity and was more effective in persons with more pronounced IFG. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 11, 2020 Category: Endocrinology Source Type: research

Lessons learned from the continuous glucose monitoring metrics in pediatric patients with type 1 diabetes under COVID-19 lockdown
AbstractAimsBillions of people have been under lockdown in an attempt to prevent COVID-19 spread. Lifestyle changes during lockdown could lead to deterioration of glycemic control in type 1 diabetes (T1D). We aimed to assess the impact of COVID-19 lockdown on the glycemic control of pediatric patients with T1D.MethodsThis observational real-life study from the AWeSoMe Group assessed continuous glucose monitoring (CGM) metrics of 102 T1D patients (52.9% males, mean age 11.2  ± 3.8 years, mean diabetes duration 4.2 ± 3.8 years) who used  Dexcom G5. The data were access...
Source: Acta Diabetologica - October 6, 2020 Category: Endocrinology Source Type: research

Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
AbstractPurposeTo characterize the progression in retinopathy severity of different phenotypes of mild nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes.Design and methodsPatients with type 2 diabetes and mild NPDR (ETDRS 20 or 35) were followed in a 5-year longitudinal study. Examinations, including color fundus photography (CFP) and optical coherence tomography (OCT and OCTA), were performed at baseline, 6 months and then annually. Phenotype classification was performed based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Phenotype A is characterized by low MAT (
Source: Acta Diabetologica - October 5, 2020 Category: Endocrinology Source Type: research

Bacterial diversity and inflammatory response at first-time visit in younger and older individuals with diabetic foot infection (DFI)
ConclusionGram-positive species dominate bacterial spectrum in DFI. With increase in age,S. aureus,Streptococci andPseudomonas aeruginosa became more frequent. The inflammatory response did not differ significantly between different species, but gram-negative species were slightly but not significant more frequent in ischemic wounds. Climatic distinction like summer or winter half-year as well as foot ulcer localization seems to influence bacterial diversity in DFUs. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 16, 2020 Category: Endocrinology Source Type: research

Bacterial strains colonizing the sensor electrodes of a continuous glucose monitoring system in children with diabetes
ConclusionsIt seems that older children are more likely to have their sensor electrode colonized by bacterial strains. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 16, 2020 Category: Endocrinology Source Type: research

Validation in the general population of a C-peptide estimate equation to measure beta cell function in recent-onset type 1 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - September 16, 2020 Category: Endocrinology Source Type: research

Predictions of diabetes complications and mortality using hba1c variability: a 10-year observational cohort study
AbstractIntroductionEmerging evidence suggests that HbA1c variability, in addition to HbA1c itself, can be used as a predictor for mortality. The present study aims to examine the predictive power of mean HbA1c and HbA1c variability measures for diabetic complications as well as mortality.MethodsThe retrospective observational study analyzed diabetic patients who were prescribed insulin at outpatient clinics of the Prince of Wales Hospital and Shatin Hospital, Hong Kong, from 1 January to 31 December, 2009. Standard deviation (SD), root mean square (RMS), and coefficient of variation were used as measures of HbA1c variabil...
Source: Acta Diabetologica - September 15, 2020 Category: Endocrinology Source Type: research

Type 2 diabetes and metabolic surgery guidelines and recommendations should urgently be unified
AbstractMetabolic surgery has been studied in the last decades as an effective and safe treatment for type 2 diabetes (T2D), and randomized controlled trials generally found surgery superior when compared with medical treatment. In 2016, the DSS-II Joint Statement recognized the importance of metabolic surgery in the treatment of T2D and urged clinicians to discuss, recommend, or at least consider this procedure for their patients. Diabetes societies also cogitate metabolic surgery as an option for T2D patients in their guidelines. However, there are some differences in recommendations that could lead a careful reader to s...
Source: Acta Diabetologica - September 14, 2020 Category: Endocrinology Source Type: research

Maternal diabetes and risk of childhood malignancies in the offspring: a systematic review and meta-analysis of observational studies
AbstractAimsDiabetes mellitus (DM) is widely recognized as a risk factor for diverse cancers in adults. However, the association between maternal diabetes and risk of childhood cancer in the offspring has so far not been well studied. We thus conducted a meta-analysis to evaluate the role of maternal diabetes on the risk of childhood cancer.MethodsWe performed a comprehensive literature search to identify eligible studies published up to June 20, 2020, including the PubMed, Web of science and Embase databases. Summary odds ratios (OR) and 95% confidence intervals (CI) were computed using a random-effects model (I2 &...
Source: Acta Diabetologica - September 10, 2020 Category: Endocrinology Source Type: research

Type 1 diabetes outcomes of children born in Israel of Eritrean asylum seekers
AbstractAimsDisparities in health outcomes in pediatric type 1 diabetes (T1D) based on race/ethnicity and socioeconomic position (SEP) have been reported. We compared T1D characteristics between Eritrean status-less children living in Israel and native-born Israeli children.MethodsThis observational study compared 7 Eritrean and 28 Israeli children (  6 months from diagnosis, mean number of samples 10.6 ± 5.2) was good, with mean, best, and peak HbA1c levels of 7.4 ± 0.8% (57.4 mmol/mol), 6.7 ± 0.7% (49.7 mmol/mol), and 8.1 ±...
Source: Acta Diabetologica - September 10, 2020 Category: Endocrinology Source Type: research

Correction to: Diabetic retinopathy screening in urban primary care setting with a handheld smartphone-based retinal camera
Authors would like to correct the error in publication as follows. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 10, 2020 Category: Endocrinology Source Type: research

Functional capacity and left ventricular diastolic function in patients with type 2 diabetes
ConclusionsLVDD significantly impacted functional capacity in DM patients. Glycemic control, LV mass index and LVDD were independently related with peak oxygen consumption and ventilation/carbon dioxide slope in the study population. These results show that timely diagnosis of LVDD and more intensive antidiabetic treatment could prevent target organ damage in DM patients. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 3, 2020 Category: Endocrinology Source Type: research

Is diabetes mellitus a risk factor for COronaVIrus Disease 19 (COVID-19)?
AbstractThe COronaVirus DISease 19 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Older age and presence of comorbidities, including diabetes, were shown to be associated with a more severe course and a higher fatality rate. Studies from the most affected countries, including China, United States and Italy, seem to indicate that prevalence of diabetes among patients affected by COVID-19 is not higher than that observed in the general population, thus suggesting that diabetes is not a risk factor for SARS-CoV-2 infection. However, a l...
Source: Acta Diabetologica - August 30, 2020 Category: Endocrinology Source Type: research

Serum glycated albumin predicts all-cause mortality in dialysis patients with diabetes mellitus: meta-analysis and systematic review of a predictive biomarker
AbstractBackground and AimHbA1c, the traditional and current gold standard biomarker guiding diabetic management, has been scrutinized for low predictive value for patients with chronic kidney disease due to variables affecting erythrocyte number and turnover. Glycated albumin, the precursor to advanced glycation end products, reflects glycemic status over the preceding 2 –3 week period and already outperforms HbA1c for glycemic monitoring. Our aim was to establish whether serum GA can be further used to predict mortality risk in dialysis patients with diabetes mellitus (DM)MethodsWe did systematic review of the...
Source: Acta Diabetologica - August 29, 2020 Category: Endocrinology Source Type: research

Barriers and facilitators to accessing insulin pump therapy by adults with type 1 diabetes mellitus: a qualitative study
ConclusionsThis study identified factors that contribute to gaps in the delivery of diabetes care that policy-makers may use to improve access to CSII for adult PwD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 29, 2020 Category: Endocrinology Source Type: research

Insulin resistance may be misdiagnosed by HOMA-IR in adults with greater fat-free mass: the ELSA-Brasil Study
ConclusionsHigher odds of IR associated with greater FFMbsa contrasted with lower odds of IGT associated with greater FFMbsa. IR may be misdiagnosed by HOMA-IR in adults with greater fat-free mass. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 27, 2020 Category: Endocrinology Source Type: research

YAP mediates the interaction between the Hippo and PI3K/Akt pathways in mesangial cell proliferation in diabetic nephropathy
ConclusionsThe Hippo pathway is inhibited under diabetic conditions, leading to YAP activation and promoting MC proliferation. The PI3K/Akt pathway is activated through the inhibitory effect of YAP on its repressor, PTEN. Finally, activation of the PI3K/Akt pathway inhibits the Hippo pathway, resulting in nuclear YAP accumulation and accelerating MC proliferation and DN formation. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 19, 2020 Category: Endocrinology Source Type: research

microRNA-143-3p contributes to inflammatory reactions by targeting FOSL2 in PBMCs from patients with autoimmune diabetes mellitus
ConclusionThe expression of miR-143-3p in PBMCs from ADM patients is upregulated. miR-143-3p could function in the pathogenesis of ADM by modulating the inflammatory reaction throughFOSL2. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 19, 2020 Category: Endocrinology Source Type: research

Diabetes mellitus and SARS-CoV-2-related mortality: the impact of acute hyperglycemic crises and some further considerations
(Source: Acta Diabetologica)
Source: Acta Diabetologica - August 19, 2020 Category: Endocrinology Source Type: research

Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes
ConclusionsAdherence to and persistence with  DPP4 inhibitors is suboptimal but similar across all medications within the class. While in-class switching is uncommon, saxagliptin and alogliptin are the DPP4 inhibitors most commonly switched. Interventions to improve treatment adherence and persistence among patients with T2DM prescribed DPP 4 inhibitors may be warranted. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 17, 2020 Category: Endocrinology Source Type: research

The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis
ConclusionsOur study demonstrates that patients with COVID-19 and diabetes tend to have more severe disease and poorer clinical outcomes. African-American patients with diabetes did not differ in outcomes or disease severity when compared to non-African-American patients. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 16, 2020 Category: Endocrinology Source Type: research

Relative handgrip strength is inversely associated with the presence of type 2 diabetes in overweight elderly women with varying nutritional status
AbstractBackground and AimsTo describe cross-sectional associations of BMI-adjusted handgrip strength with the presence of diabetes and hypertension in a community setting.Methods and ResultsBetween 2016 and 2018, 601 consecutive elderly active women (70.7  ± 6.9 years) were enrolled. Nutritional status was evaluated by the Mini Nutritional Assessment (MNA) score. Muscle strength and level of fitness were assessed by standardized physical functional tests and handgrip strength (HGS). The majority of participants were overweight or obese (80% wit h BMI >  25). Prevalence of diabete...
Source: Acta Diabetologica - August 13, 2020 Category: Endocrinology Source Type: research

Effects of real-time continuous glucose monitoring in type 1 diabetes: a meta-analysis of randomized controlled trials
ConclusionGCM compared to SMBG has showed a reduction in HbA1c and severe hypoglycemia in patient with type 1 diabetes. The comparison between CGM  + CSII and SMBG + MDI showed a large reduction in HbA1c; it is conceivable that the effects of CSII + CGM on glycemic control additives. The only comparison available between FGM and SMBG was conducted in patients in good control. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 12, 2020 Category: Endocrinology Source Type: research

Up-regulation of MMP-2 by histone H3K9 β -hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat
ConclusionBHB treatments could up-regulate MMP-2 generation via causing elevated H3K9bhb in its promoter to antagonize glomerulosclerosis in the diabetic rats. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 8, 2020 Category: Endocrinology Source Type: research

National diabetes registries: do they make a difference?
ConclusionsNational diabetes registries confer clear insights into diagnostics, complications, and treatment. The extent to which registries influenced national healthcare policy was less clear. A globally implemented standard outcome set has the potential to improve concordance between national registries, enhance the comparison and exchange of diabetes outcomes, and allocate resources and interventions where most needed. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 7, 2020 Category: Endocrinology Source Type: research

Diabetic retinopathy screening in urban primary care setting with a handheld smartphone-based retinal camera
ConclusionsA low-cost DR screening strategy with a handheld device and telemedicine is feasible and has the potential to increase coverage of DR screening in underserved areas; the possibility of mobile units is relevant for DR screening in the context of COVID-19 pandemic.Graphic abstractDaily rate of patients whose examinations allowed clinical decision.X-axis: day of examination;Y-axis: rate (%) of patients whose examinations allowed a clinical decision (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 3, 2020 Category: Endocrinology Source Type: research

Knowledge levels among elderly people with Diabetes Mellitus concerning COVID-19: an educational intervention via a teleservice
ConclusionElderly participants did not have in-depth knowledge concerning COVID-19, which suggests that their knowledge sources may be deficient or that their capacity to retain information was inadequate. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 3, 2020 Category: Endocrinology Source Type: research

Toward targeted prevention: risk factors for prediabetes defined by impaired fasting glucose, impaired glucose tolerance and increased HbA1c in the population-based KORA study from Germany
ConclusionsThe overlap of people with IFG, IGT and elevated HbA1c is small, and some factors are associated with only one criterion. Knowledge on sociodemographic and socioeconomic risk factors can be used to effectively target interventions to people at high risk for type 2 diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 2, 2020 Category: Endocrinology Source Type: research

Adherence to a follow-up program after gestational diabetes
ConclusionDespite efforts to provide care for women with GDM, postpartum screening rates are still low among Italian women, and especially among immigrants. Hence, the need to improve these patients ’ awareness of the severe risk of developing diabetes after pregnancy, concentrating efforts especially on women belonging to the most at risk ethnic groups. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 31, 2020 Category: Endocrinology Source Type: research

Evaluation of the accuracy of FreeStyle ® Libre™ during gestational diabetes: Is this device acceptable for decision making?
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 31, 2020 Category: Endocrinology Source Type: research

Reply to the letter by professor Sert
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 31, 2020 Category: Endocrinology Source Type: research

Nonalcoholic fatty liver disease and cardiovascular risk in severely obese adolescents
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 31, 2020 Category: Endocrinology Source Type: research

No effect of gestational diabetes or pre-gestational obesity on 6-year offspring left ventricular function —RADIEL study follow-up
ConclusionsNo evidence of foetal cardiac programming related to GDM or maternal pre-pregnancy obesity was observed in early childhood. Maternal pre-pregnancy obesity is associated with early weight gain. Child adiposity in early childhood is independently associated with increased left atrial volume, but its implications for long-term left ventricle diastolic function and cardiovascular health remain unknown. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 27, 2020 Category: Endocrinology Source Type: research

Reply letter to the editor by Dr. Kawada
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 27, 2020 Category: Endocrinology Source Type: research

Food addiction and psycho-physiological condition in patients with type 2 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 27, 2020 Category: Endocrinology Source Type: research

Frequency of flash glucose monitoring readings, hemoglobin A1c and time in range: a real life study in adults with type 1 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 26, 2020 Category: Endocrinology Source Type: research

The crucial role of early-life gut microbiota in the development of type 1 diabetes
AbstractEarly-life healthy gut microbiota has a profound implication on shaping the mucosal immune system as well as maintaining healthy status later in life, especially at the prenatal or neonatal stages, while intestinal dysbiosis in early life is associated with several autoimmune diseases, including type 1 diabetes (T1D). Since the gut microbiome is potentially modifiable, optimizing the intestinal bacterial composition in early life may be a novel option for T1D prevention. In this review, we will review current data depicting the crucial role of early-life intestinal microbiome in the development of T1D and discuss t...
Source: Acta Diabetologica - July 24, 2020 Category: Endocrinology Source Type: research