Serum levels of immunoglobulin G and complement 3 differentiate non-diabetic renal disease from diabetic nephropathy in patients with type 2 diabetes mellitus
ConclusionsAt different levels of proteinuria, reduced IgG and increased C3 levels were independent indicators of NDRD in T2DM. Insights into these factors will help to advance the clinical management of NDRD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 19, 2019 Category: Endocrinology Source Type: research

Effects of exenatide long-acting release on cardiovascular events and mortality in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
ConclusionsTreatment with ELAR does not increase the risk of cardiovascular events and may reduce all-cause mortality. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 16, 2019 Category: Endocrinology Source Type: research

High level of clinical inertia in insulin initiation in type 2 diabetes across Central and South-Eastern Europe: insights from SITIP study
ConclusionsDespite large regional variation, there is widespread delay of insulin initiation from specialist diabetes healthcare professionals in Central and South-Eastern Europe. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 16, 2019 Category: Endocrinology Source Type: research

Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery
ConclusionsA baseline low NLR is associated with long-term T2D remission in obese patients undergoing metabolic surgery, suggesting that circulating inflammatory cells (i.e., neutrophils) might negatively impact on T2D remission. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 16, 2019 Category: Endocrinology Source Type: research

Association between resting heart rate and incident diabetes risk: a Mendelian randomization study
ConclusionsThe present study supported a positive but not a causal association of RHR with incident diabetes risk. More studies are needed to verify our findings. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 15, 2019 Category: Endocrinology Source Type: research

Systematic review: associations of calcium intake, vitamin D intake, and physical activity with skeletal outcomes in people with Type 1 diabetes mellitus
ConclusionThere are insufficient data to determine if deficient calcium intake, vitamin D intake, or physical activity contributes to the skeletal complications of T1D. Future studies specifically designed to assess the impact of these interventions on the skeleton in T1D participants are needed. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 15, 2019 Category: Endocrinology Source Type: research

Lung function measurements in the prediabetes stage: data from the ILERVAS Project
AbstractAimsPatients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.MethodsPulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. A “restrictive spirometric pattern”, an “abnormal FEV1” and an “obstructive ventilatory defect” were assessed. Prediabetes was defined by glycosylated hemoglobin (HbA1c) between 5.7 and 6.4% according to the Ameri...
Source: Acta Diabetologica - April 15, 2019 Category: Endocrinology Source Type: research

Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer
ConclusionOur data demonstrate that carcinogenesis in KPC mice is not associated with paraneoplastic diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 15, 2019 Category: Endocrinology Source Type: research

Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes
ConclusionP2X7R blockade might be promising strategy for the treatment of microvascular changes observed in the early phases of diabetic retinopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 13, 2019 Category: Endocrinology Source Type: research

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes
AbstractAimThe impact of cholesteryl ester transfer protein (CETP) on atherosclerotic development in humans remains unclear. Plasma cholesteryl ester transfer was shown to be associated with carotid intima-media thickness in type 2 diabetic (T2D) patients with adequate metabolic control. Since glycation of CETP may influence cholesteryl ester transfer processes, it is important to determine if plasma cholesteryl ester transfer is still a determinant of carotid intima-media thickness (IMT) in patients with poorly controlled diabetes. The aim of the present study was to determine whether CETP activity influences carotid IMT ...
Source: Acta Diabetologica - April 12, 2019 Category: Endocrinology Source Type: research

Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 12, 2019 Category: Endocrinology Source Type: research

Functional characterization of p.Pro409His variant in HNF1A , a hypomorphic mutation involved in pancreatic β-cell dysfunction
ConclusionsTheHNF1A mutation p.Pro409His can be considered a mild variant that confers a moderate risk of type 2 diabetes mellitus in heterozygous carriers. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 9, 2019 Category: Endocrinology Source Type: research

Extreme hyperosmolarity and severe ketoacidosis in a child with type 1 diabetes mellitus at onset safely treated with current guidelines
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 9, 2019 Category: Endocrinology Source Type: research

Diabetes management and treatment approaches outside of North America and West Europe in 2006 and 2015
ConclusionsThere was no clear evidence that the use of new classes of GLMs was associated with improvements in glycaemic control or reduced the reliance on insulin. These findings were consistent across a range of economic and geographic settings. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 8, 2019 Category: Endocrinology Source Type: research

Analysis of S100A12 plasma levels in hyperlipidemic subjects with or without familial hypercholesterolemia
AbstractAimsInflammation is a key regulatory process that links hypercholesterolemia and immune mechanisms promoting atherosclerosis. Inflammatory biomarkers may be helpful to better define the atherosclerotic burden in patients with high cholesterol levels such as familial hypercholesterolemia (FH). Our aim was to evaluate the concentration of S100A12 protein in FH patients and its association with pulse wave velocity (PWV).MethodsWe measured glucose and lipid profile, S100A12, sRAGE, esRAGE and PWV in 39 patients with a genetically confirmed diagnosis of FH and 39 hypercholesterolemic subjects without a clinical diagnosi...
Source: Acta Diabetologica - April 8, 2019 Category: Endocrinology Source Type: research

Correction to: Agonistic autoantibodies against adrenergic receptors correlating with antihypertensive therapy in long-standing diabetes type 2
Unfortunately, the Conflict of interest statement was found incomplete in the original publication and now revised by the authors. The updated version is provided here. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 8, 2019 Category: Endocrinology Source Type: research

Accuracy of the 13 C-glucose breath test to identify insulin resistance in non-diabetic adults
ConclusionsThe13C-GBT is a valid and accurate method to detect IR in non-diabetic adults. Therefore, it is potentially useful in clinical and community settings. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 6, 2019 Category: Endocrinology Source Type: research

The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis
AbstractAimsDiabetic patients have multiple risk factors for colonisation with methicillin-resistantStaphylococcus aureus (MRSA), a nosocomial pathogen associated with significant morbidity and mortality. This meta-analysis was conducted to estimate the prevalence of MRSA among diabetic patients.MethodsThe MEDLINE, Embase, BIOSIS, and Web of Science databases were searched for studies published up to May 2018 that reported primary data on the prevalence of MRSA in 10 or more diabetic patients. Two authors independently assessed study eligibility and extracted the data. The main outcomes were the pooled prevalence rates of ...
Source: Acta Diabetologica - April 6, 2019 Category: Endocrinology Source Type: research

Maternal diabetes mellitus and risk of neonatal respiratory distress syndrome: a meta-analysis
ConclusionsThis meta-analysis suggests that maternal DM, including GDM and PGDM, is linked to an increased risk of neonatal RDS. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 6, 2019 Category: Endocrinology Source Type: research

Clinical practice of diabetic pregnancy screening in Asia-Pacific Countries: a survey review
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 6, 2019 Category: Endocrinology Source Type: research

Dementia complicating type 2 diabetes and the influence of premature mortality: the Fremantle Diabetes Study
AbstractAimsTo investigate risk factors for, and the influence of premature mortality on, dementia complicating type 2 diabetes.MethodsParticipants with type 2 diabetes in the community-based observational Fremantle Diabetes Study Phase 1 (n = 1291, mean age 64.0 years) were followed from 1993 to 1996 to end-June 2012. Incident dementia was identified from validated health databases. Dementia risk was assessed using Cox proportional hazards modelling supplemented by competing risk regression modelling in the total cohort and sub-g roups defined by age of diabetes onset as mid-life (
Source: Acta Diabetologica - April 3, 2019 Category: Endocrinology Source Type: research

Continuous subcutaneous insulin infusion vs modern multiple injection regimens in type 1 diabetes: an updated meta-analysis of randomized clinical trials
AbstractMeta-analyses of clinical trials comparing CSII with traditional insulin injections usually show a small, but significant advantage of CSII with respect to HbA1c and risk of severe hypoglycemia. On the other hand, CSII is associated with a small, but relevant risk of ketoacidosis, mainly due to malfunction of insulin pump and/or catheter occlusion. During last time, the technology of insulin pumps and infusion sets has improved as the profound evolution in type and schemes with traditional insulin injections. Aim of the present study is to update previous meta-analyses comparing CSII with traditional insulin inject...
Source: Acta Diabetologica - April 3, 2019 Category: Endocrinology Source Type: research

FreeStyle Libre flash glucose monitoring system in pregnant woman with type 1 diabetes: a focus on accuracy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 1, 2019 Category: Endocrinology Source Type: research

Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population
AbstractObjectiveTo determine the role of hypoglycemia, hyperglycemia or the combination of both as independent risk factors for falls in a hospital population. Secondary objectives included evaluation of other risk factors for falling and their relationships with glucose levels.Research design and methodsRetrospective cohort study over 2  years on hospitalized subjects (N = 57411) analyzing in-hospital-falls and capillary glucose values. Bivariate analysis (χ2 test) and multivariate analysis (logistic regression) were performed to test for correlation of glucose values, age, sex, Charlson index, ser...
Source: Acta Diabetologica - March 30, 2019 Category: Endocrinology Source Type: research

Dietary protein intake and subsequent risk of type 2 diabetes: a dose –response meta-analysis of prospective cohort studies
AbstractAimsDietary proteins, including those obtained from animal and plant sources, have inconsistently been correlated with type 2 diabetes mellitus (T2DM) risk. Therefore, a meta-analysis was conducted to evaluate the association between dietary proteins and the risk of T2DM.MethodsProspective cohort studies published until November 2018 were systematically searched in PubMed, Embase, and the Cochrane library. The pooled relative risks (RRs) were calculated with 95% confidence intervals (CIs) using the random-effects model.ResultsTen articles involving a total of 21 cohorts were included in the final meta-analysis. A t...
Source: Acta Diabetologica - March 30, 2019 Category: Endocrinology Source Type: research

Associations of BMI, waist circumference, body fat, and skeletal muscle with type 2 diabetes in adults
ConclusionsEstimated BF% associates strongly with T2D. Low SM% also has a significant association, suggesting a neglected aspect of aetiology within T2D. These two simple measures with biological relevance, available from data collected in most health surveys, may be more useful than the purely statistical terms BMI. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 29, 2019 Category: Endocrinology Source Type: research

Identification of clinical predictors of diabetic nephropathy and non-diabetic renal disease in Chinese patients with type 2 diabetes, with reference to disease course and outcome
AbstractAimsTo determine the prevalence of diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) in patients with type 2 diabetes mellitus (T2DM), and the important clinical predictors of renal outcome and clinical course.MethodsWe conducted a retrospective analysis of clinical, laboratory, and histopathologic data from T2DM patients with renal involvement confirmed by renal biopsy (n = 505). The outcome was defined as the progression to end-stage renal disease (ESRD).ResultsRenal biopsy revealed that 302 patients (59.8%) had DN, 174 (34.5%) had NDRD, and 29 (5.7%) had NDRD superimposed on DN. In mu...
Source: Acta Diabetologica - March 29, 2019 Category: Endocrinology Source Type: research

Therapeutic options in a patient with MELAS and diabetes mellitus: follow-up after 6  months of treatment
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 29, 2019 Category: Endocrinology Source Type: research

DPP-4 inhibitors: meeting the needs of the very old population
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 28, 2019 Category: Endocrinology Source Type: research

Comprehensive analysis of vitreous humor chemokines in type 2 diabetic patients with and without diabetic retinopathy
AbstractAimsTo compare the vitreous levels of chemokines in diabetic patients with and without retinopathy. To find the relationship between stages of diabetic retinopathy (DR) and levels of vitreous chemokines.MethodsThe study involved 20 non-diabetic and 20 diabetic patients without clinical signs of DR (NDR) and 40 diabetic patients with proliferative diabetic retinopathy (PDR). The vitreous humor was collected and the levels of 40 chemokines were measured using magnetic color-bead-based multiplex assay.ResultsThe control group, NDR group, PDR with vitreous hemorrhage (VH) group, and PDR with tractional retinal detachme...
Source: Acta Diabetologica - March 25, 2019 Category: Endocrinology Source Type: research

Our second genome and the impact on metabolic disorders: why gut microbiome is an important player in diabetes and associated abnormalities
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 25, 2019 Category: Endocrinology Source Type: research

Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study
AbstractAimsTo describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.MethodsA 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA)  ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) >  250 µm with intra- and/or subretinal fluid seen on optical coherence tomography.ResultsA total of 249 eyes were included, of which 155 were treated and 94 were non-trea...
Source: Acta Diabetologica - March 22, 2019 Category: Endocrinology Source Type: research

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles
AbstractThe human gut is a home for more than 100 trillion bacteria, far more than all other microbial populations resident on the body ’s surface. The human gut microbiome is considered as a microbial organ symbiotically operating within the host. It is a collection of different cell lineages that are capable of communicating with each other and the host and has an ability to undergo self-replication for its repair and maintenanc e. As the gut microbiota is involved in many host processes including growth and development, an imbalance in its ecological composition may lead to disease and dysfunction in the human. Gu...
Source: Acta Diabetologica - March 22, 2019 Category: Endocrinology Source Type: research

The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies
ConclusionOur findings demonstrated that almost one in four adults with T2DM experienced depression. Given the high prevalence of depressive disorders in diabetic patients, screening these patients for co-morbid depression and its relevant risk factors is highly recommended. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 22, 2019 Category: Endocrinology Source Type: research

Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis
ConclusionPA is associated with lower DR risk, and more studies should focus on the causality between them. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 21, 2019 Category: Endocrinology Source Type: research

Association of fasting glucose and glycated hemoglobin with the long-term risk of incident metabolic syndrome: Korean Genome and Epidemiology Study (KoGES)
This study was to investigate an association of incident MetS with levels of HbA1c and fasting glucose.MethodsIn a cohort of Korean Genome and Epidemiology Study, 5515 non-diabetic adults were grouped by the levels of baseline fasting glucose and HbA1c, and followed-up for 10  years. Using multivariate Cox proportional hazards assumption, hazards ratios (HRs) and 95% confidence interval (CI) for incident MetS (adjusted HRs [95% CI]) were calculated according to baseline fasting glucose and HbA1c. In individuals with normal fasting glucose, subgroup analysis was conducte d to evaluate an association of HbA1c levels wit...
Source: Acta Diabetologica - March 21, 2019 Category: Endocrinology Source Type: research

Normoglycaemic control with a selfmade fully closed-loop insulin delivery system during emergency surgery: an extemporaneous stress test
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 21, 2019 Category: Endocrinology Source Type: research

Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition
ConclusionsGut microbiota composition is associated with processing speed and mental flexibility in part through changes in fecal and plasma glutamate metabolism. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 19, 2019 Category: Endocrinology Source Type: research

Understanding the gut –kidney axis among biopsy-proven diabetic nephropathy, type 2 diabetes mellitus and healthy controls: an analysis of the gut microbiota composition
ConclusionGut microbiota composition was explored to be related to the occurrence of biopsy-proven DN from DM. DM could be distinguished from HC by detectingg_Prevotella_9 level in feces, while DN was different from DM by the variables ofg_Escherichia-Shigella andg_Prevotella_9, which potentially contributed to the physiopathological diagnosis of DN from DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 19, 2019 Category: Endocrinology Source Type: research

Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis
ConclusionsResults from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 19, 2019 Category: Endocrinology Source Type: research

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus
ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 16, 2019 Category: Endocrinology Source Type: research

Effect of night shift work on risk of diabetes in healthy nurses in Albania
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 15, 2019 Category: Endocrinology Source Type: research

Relationship between health care insurance status, social determinants and prevalence of diabetes-related microvascular complications in patients with type 1 diabetes: a nationwide survey in Brazil
ConclusionsBrazilian patients with type 1 diabetes had better clinical control and lower rates of DRCC, mainly retinopathy, when also having private health care insurance. These patients presented less frequently predictors of chronic complications such as high levels of HbA1c and blood pressure. BNHCS should change the approach for screening DRCC such as diabetic retinopathy, using methods such as telemedicine that would lead to earlier diagnosis, better outcomes and will be cost-effective sometime after its implementation. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 13, 2019 Category: Endocrinology Source Type: research

Oral glucose effectiveness and metabolic risk in obese children and adolescents
AbstractAimTo investigate whether GE is affected in children/adolescents with obesity and abnormalities of the metabolic syndrome (MetS).MethodsCross-sectional study of oral GE (oGE), insulin sensitivity and secretion (calculated on 5 time-points oral glucose tolerance test) and metabolic abnormalities in 1012 patients with overweight/obesity (aged 6.0 –17.9 years old). A MetS risk score was calculated on the basis of distribution of fasting glucose, triglycerides, HDL-cholesterol, total cholesterol, systolic and diastolic blood pressure. Non-alcoholic fatty liver disease (NAFLD) was suspected based on thresholds of ...
Source: Acta Diabetologica - March 13, 2019 Category: Endocrinology Source Type: research

Hyperinsulinemia impairs functions of circulating endothelial progenitor cells
ConclusionHyperinsulinemia impaired EPCs ’ tube formation ability by downregulation of PI-3K/Akt/eNOS pathway. Hyperinsulinemia induced apoptosis of EPCs via upregulation of p38 MAPK. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 11, 2019 Category: Endocrinology Source Type: research

A marker of type VI collagen formation (PRO-C6) is associated with higher arterial stiffness in type 1 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 9, 2019 Category: Endocrinology Source Type: research

The STOP DIABETES study: when prevention works
In conclusion, by an OGTT, a lot of individuals at risk for T2D may be detected when the central role for the 1-h plasma glucose concentration is al so considered. Consequently, these subjects would be treated early and with less drugs and delay T2D complications. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 2, 2019 Category: Endocrinology Source Type: research

Efficacy of vitrectomy combined with an intraoperative dexamethasone implant in refractory diabetic macular edema
AbstractAimsTo evaluate the safety and efficacy of vitrectomy combined with an intraoperative dexamethasone (Ozurdex®) implant in refractory diabetic macular edema (DME).MethodsPatients who were diagnosed at our institution as having DME refractory to more than 6  months of non-surgical treatment and underwent intravitreal dexamethasone implantation combined with vitrectomy. All patients were followed up for more than 12 months. Best-corrected visual acuity (BCVA, logMAR), central macular thickness (CMT), and intraocular pressure at the initial visit and 1 , 3, 4, 6, and 12 months after treatment were re...
Source: Acta Diabetologica - March 1, 2019 Category: Endocrinology Source Type: research

Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1 –RAGE and VIP–VPAC2 pathways in human gestational diabetes mellitus
ConclusionsThis study indicates that a fine tuned regulation exists between FMs and VAT throughout pregnancy to maintain immune metabolic homeostasis. In GDM a balance between inflammatory and anti-inflammatory mediators has been observed. Further studies are needed to establish their exact role on fetal and maternal outcomes in GDM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 28, 2019 Category: Endocrinology Source Type: research

Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects
AbstractAimsInflammation plays a role in the development and progression of type 2 diabetes macroangiopathy. Interleukin 33 (IL-33) drives production of Th2-associated cytokines. The soluble form of suppression of tumorigenicity 2 (sST2) acting as a decoy receptor blocks IL-33 and tones down Th2 inflammatory response. We investigated the role of sST2 as a predictor of CV and all-cause mortality in a cohort of patients affected by established atherosclerotic disease.Methods399 patients with atherosclerotic disease from the Tor Vergata Atherosclerosis Registry performed follow-up every year by phone interview. The primary en...
Source: Acta Diabetologica - February 24, 2019 Category: Endocrinology Source Type: research