C-reactive protein-to-albumin ratio and 8 ‐year incidence of type 2 diabetes: the Korean genome and epidemiology study
ConclusionsCAR, which is a ratio of commonly used biomarkers and reflects both oxidative stress and antioxidants, is suggested as a predictor of incident diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 15, 2021 Category: Endocrinology Source Type: research

Factors associated with stroke among patients with type 2 diabetes mellitus in China: a propensity score matched study
ConclusionsThe prevalence of stroke was high among T2DM in China. It is of great significance to strengthen comprehensive management of health-related behaviors including smoking cessation, moderate alcohol consumption, effective exercise, 6 –8 h of sleep duration, keeping normal weight and the prevention of hypertension and dyslipidemia to have sustained beneficial effects on improvements of stroke risk factors. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 14, 2021 Category: Endocrinology Source Type: research

Is diabetic retinopathy affected by diabetes type? A retrospective study using electronic medical record data from patients with latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
AbstractAimsTo determine whether the occurrence of diabetic retinopathy (DR) and its related factors are affected by diabetes type (latent autoimmune diabetes in adults [LADA], type 1 diabetes mellitus [T1DM], type 2 diabetes mellitus [T2DM]).MethodsLADA patients were matched for age ( ± 2 years) and sex to T1DM (1:1) and T2DM (1:2) patients. Retrieved variables included demographic characteristics, diabetes history, laboratory test findings, and history of DR screening, etc. Multiple logistic regression analysis was applied to identify influencing factors of DR. A decision tr ee was used to explore inte...
Source: Acta Diabetologica - June 13, 2021 Category: Endocrinology Source Type: research

Correction to: Screening of postpartum diabetes in women with gestational diabetes: high ‑risk subgroups and areas for improvements—the STRONG observational study
Authors would like to correct the error in their publication. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 11, 2021 Category: Endocrinology Source Type: research

Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p
ConclusionOur study showed that GAS5 promotes DCM progression by regulating miR-26a/b-5p, suggesting that GAS5 might be a potential therapeutic target for DCM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 6, 2021 Category: Endocrinology Source Type: research

Thiamine and diabetes: back to the future?
AbstractThe first reports of a link between thiamine and diabetes date back to the 1940s. Some years later, a role for thiamine deficiency in diabetic neuropathy became evident, and some pilot studies evaluated the putative effects of thiamine supplementation. However, the administration of thiamine and its lipophilic derivative benfotiamine for the treatment of this complication gained consensus only at the end of the ‘90 s. The first evidence of the beneficial effects of thiamine on microvascular cells involved in diabetic complications dates to 1996: from then on, several papers based onin vitro and animal mo...
Source: Acta Diabetologica - June 5, 2021 Category: Endocrinology Source Type: research

Dysglycemia after COVID-19 pneumonia: a six-month cohort study
AbstractAimThe aim of this study was to understand whether the dysglycemia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves.MethodsWe analyzed fasting blood glucose (FBG) after hospital discharge in a cohort of 621 adult cases with suspected COVID-19 pneumonia.ResultsAt admission, 18.8% of the patients in our cohort had pre-existing diabetes, 9.3% fasting glucose in the diabetes range without a prior diagnosis (DFG), 26% impaired fasting glucose (IFG), 44.9% normal fasting glucose (NFG), while 2% had no FBG available. FBG categories were similarly distributed in the 71 patients wit...
Source: Acta Diabetologica - June 4, 2021 Category: Endocrinology Source Type: research

Decision models in type 2 diabetes mellitus: A systematic review
ConclusionsThe existing decision models for T2DM are heterogeneous in terms of the level of detail in the classification of health states. Thus, more attention should be focused on balancing the desired level of complexity against the required level of transparency in the development of T2DM decision models. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 3, 2021 Category: Endocrinology Source Type: research

Effects of INSR genetic polymorphism on hippocampal volume and episodic memory in chinese type 2 diabetes
AbstractAimsWe aimed to investigate the effect of the type 2 diabetes-specific insulin/IGF signaling genetic variants on the hippocampal volume and their relationships with episodic memory in Chinese patients with type 2 diabetes.MethodsAnalysis of variance was used to evaluate the genotype-by-diagnosis interaction effect on hippocampal volume in Chinese participants (109 patients with type 2 diabetes, 116 healthy controls). Mediation analysis was performed to test whether the hippocampal volume would mediate the association between genotype and episodic memory in patients with type 2 diabetes.ResultsINSR (rs8101064) exhib...
Source: Acta Diabetologica - June 3, 2021 Category: Endocrinology Source Type: research

All-cause mortality prediction models in type 2 diabetes: applicability in the early stage of disease
ConclusionsIn conclusion, our data show that two well-established prediction models of all-cause mortality in type 2 diabetes can also be successfully applied in the early stage of the disease, thus becoming powerful tools for educated and timely prevention strategies for high-risk patients. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 29, 2021 Category: Endocrinology Source Type: research

Hemophilia and type 1 diabetes: not as black as it is painted —a case report
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 28, 2021 Category: Endocrinology Source Type: research

Playing around the anaerobic threshold during COVID-19 pandemic: advantages and disadvantages of adding bouts of anaerobic work to aerobic activity in physical treatment of individuals with obesity
We present a re-evaluation of the effects of physical activity on body mass and metabolism of individuals with obesity in light of potential benefits and pitfalls during COVID-19 pandemic. Comparison of a training program at moderate-intensity exercise (
Source: Acta Diabetologica - May 28, 2021 Category: Endocrinology Source Type: research

Klotho protects against diabetic kidney disease via AMPK- and ERK-mediated autophagy
ConclusionIn summary, our results proved that Klotho improved renal tubular cell autophagy via the AMPK and ERK pathways and played a role in renal protection. These findings provide new insight into the mechanism of Klotho and autophagy in DKD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 27, 2021 Category: Endocrinology Source Type: research

Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes
AbstractAimThe early identification of type 2 diabetic (T2D) patients at risk of developing coronary artery disease (CAD) remains a challenge. The coronary artery calcium score (CACs) is considered the most sensitive tool for assessing CAD risk in diabetic population, and the identification of a more targeted population in which the CACs would be more cost-efficient seems warranted. The accumulation of advanced glycation end products plays an important role in the pathogenesis of cardiovascular disease (CVD) in patients with diabetes. The aim of this study was to evaluate whether the assessment of skin autofluorescence (SA...
Source: Acta Diabetologica - May 25, 2021 Category: Endocrinology Source Type: research

Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies
ConclusionsThe prevalence and severity of periodontitis are greater in patients with diabetes than in non-diabetic populations. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 24, 2021 Category: Endocrinology Source Type: research

“Answer to: Diabetes distress and peripheral neuropathy are associated with medication non-adherence in individuals with type 2 diabetes in primary care”—authors’ reply
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 24, 2021 Category: Endocrinology Source Type: research

Felix dies natalis, insulin … ceterum autem censeo “beta is better”
AbstractOne hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success story thanks to the fact that insulin therapy has continuously integrated the knowledge developed over a century. In 1982, insulin becomes the first therapeutic protein to be produced using recombinant DNA technology. The first “mini” insulin pump and the first insulin pen become available in 1983 and 1985, respectively. In 1996, the first generation of insulin analogues were produced. In 1999, the first continuous glucose-monitoring device for reading inter...
Source: Acta Diabetologica - May 23, 2021 Category: Endocrinology Source Type: research

Correlation between retinal vascular parameters and cystatin C in patients with type 2 diabetes
ConclusionsMultiple retinal vascular geometrical and caliber measurements are associated with cystatin C in type 2 diabetic patients. Further studies are needed to explore whether these retinal vascular changes can predict the incidence and progress of diabetic nephropathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 21, 2021 Category: Endocrinology Source Type: research

Answer to: Diabetes distress and peripheral neuropathy are associated with medication non-adherence in individuals with type 2 diabetes in primary care
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 21, 2021 Category: Endocrinology Source Type: research

MicroRNAs modulation and clinical outcomes at 1 year of follow-up in obese patients with pre-diabetes treated with metformin vs. placebo
AbstractBackgroundsObese pre-diabetics over express cytokines that influence myocardial function via microRNAs (miRs) expression.ObjectivesTo evaluate inflammatory/oxidative stress, miRs ’ expression and cardiovascular function in obese pre-diabetics assigned to metformin therapy vs. placebo vs. normo-glycemics at 12 months of follow-up.Materials and methodsEighty-three obese patients after abdominoplastic surgery were divided in pre-diabetics (n 55), normo-glycemics (n 28), and assigned to hypocaloric diet. Pre-diabetics were assigned to metformin (n 23) or to placebo (n 22) plus hypocaloric diet.ResultsObese pre-di...
Source: Acta Diabetologica - May 19, 2021 Category: Endocrinology Source Type: research

Symptoms of depression are associated with reduced leisure-time physical activity in adult individuals with type 1 diabetes
AbstractAimsHere, we investigated the association between depressive symptoms and leisure-time physical activity (LTPA) in type 1 diabetes.MethodsData from adult individuals with type 1 diabetes without evidence of diabetic kidney disease or macrovascular complications, participating in the Finnish Diabetic Nephropathy Study, were included. Based on a questionnaire, weekly LTPA as metabolic equivalent of task hour was calculated. Activity levels (inactive, moderately active, active), weekly frequencies (  2), intensities (low, moderate, high), and single session durations (  60 min) were assessed. Depres...
Source: Acta Diabetologica - May 19, 2021 Category: Endocrinology Source Type: research

Metabolic surgery for type II diabetes: an update
AbstractBariatric operations have been documented in clinical trials to promote remission or dramatic improvement of Type II Diabetes Mellitus and related comorbidities. Herein we review randomized trials and meta-analyses published during the last 20  years on the results of bariatric/metabolic surgery in obese patients with type 2 diabetes with the aim of highlighting the scientific evidence available. Several studies and RCTs in the last 20 years have showed outstanding results of bariatric/metabolic surgery on Type II diabetes and comorbidi ties in patients with either BMI >  35 kg/m2 or BMI  
Source: Acta Diabetologica - May 18, 2021 Category: Endocrinology Source Type: research

Glucose variability and periodontal disease in type 1 diabetes: a cross-sectional study —The “PAROdontopatia e DIAbete” (PARODIA) project
AbstractAimsPeriodontal disease (PD) is a chronic inflammation of periodontal tissue associated with infection from specific anaerobic pathogens contained in dental plaque. Both type 1 and type 2 diabetes are associated with an increased prevalence of PDs. A two-way relationship between diabetes and periodontitis has been proposed, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. To date, the relationship between PD and glucose variability in type 1 diabetes has not been evaluated. To investigate the prevalence of PD in patients with type 1 diabetes a...
Source: Acta Diabetologica - May 17, 2021 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus and periodontitis: Are diabetic patients aware about this bidirectional association?
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 13, 2021 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence
AbstractDiabetes and sepsis are important causes of morbidity and mortality worldwide, and diabetic patients represent the largest population experiencing post-sepsis complications and rising mortality. Dysregulated immune pathways commonly found in both sepsis and diabetes contribute to worsen the host response in diabetic patients with sepsis. The impact of diabetes on mortality from sepsis is still controversial. Whereas a substantial proportion of severe infections can be attributed to poor glycemic control, treatment with insulin, metformin and thiazolidinediones may be associated with lower incidence and mortality fo...
Source: Acta Diabetologica - May 10, 2021 Category: Endocrinology Source Type: research

The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary fibre
AbstractGut microbiota and its metabolites have been shown to influence multiple physiological mechanisms related to human health. Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. Among dietary component, dietary fibre may play a pivotal role by virtue of its prebiotic effect on fibre-fermenting bacteria, that may increase SCFA production. The aim of this r...
Source: Acta Diabetologica - May 10, 2021 Category: Endocrinology Source Type: research

The combined impact of ankle –brachial index and transcutaneous oxygen pressure on mortality in patients with type 2 diabetes and foot ulcers
AbstractAimsA diabetic foot ulcer (DFU) is associated with increased cardiovascular risk and mortality, independently of ulcer etiology (ischemic, neuro-ischemic or neuropathic). Ankle –brachial index (ABI) is the most commonly used test when diagnosing peripheral macrovascular disease and is a well-known marker for increased cardiovascular risk. Transcutaneous oxygen pressure (TcPO2) is considered to better evaluate microvascular function and has in previous studies shown correlations with both wound healing and survival. The aim of this study was to evaluate the combined impact of a low TcPO2 (
Source: Acta Diabetologica - May 8, 2021 Category: Endocrinology Source Type: research

Glucagon-like peptide-1 receptor agonists (GLP1-RA) in the treatment of mitochondrial diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 5, 2021 Category: Endocrinology Source Type: research

Effectiveness of fast-track pathway for diabetic foot ulcerations
AbstractAimTo investigate the effectiveness of fast-track pathway (FTP) in the management of diabetic foot ulceration (DFU) after 2  years of implementation.MethodsThe study group was composed of patients who referred to a specialized DF centre due to DFUs. Those were divided in two groups: early referral (ER) and late referral (LR) patients. According to FTP, ER were considered patients who referred after 2  weeks in the case of uncomplicated non-healing ulcers (superficial, not infected, not ischemic), within 4 days in the case of complicated ulcers (ischemic, deep, mild infection) and within 24 h in ...
Source: Acta Diabetologica - May 3, 2021 Category: Endocrinology Source Type: research

The relationship between admission glucose and lactate with critical illness amongst adult patients presenting to the emergency department
ConclusionsHyperglycaemia and hyperlactataemia are part of the metabolic response to critical illness. Lactate and a diagnosis of diabetes modify the relationship between glycaemia and critical illness. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 2, 2021 Category: Endocrinology Source Type: research

Association of estimated glomerular filtration rate from serum creatinine and cystatin C with new-onset diabetes: a nationwide cohort study in China
AbstractAimsThe association between estimated glomerular filtration rate (eGFR) and the risk of diabetes remains uncertain. We aimed to examine the association between eGFR based on creatinine (eGFRcr), cystatin C (eGFRcys), or a combination of both (eGFRcr-cys) and new-onset diabetes, using data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative cohort study.MethodsA total of 4,775 participants with pertinent measurements and without diabetes at baseline from CHARLS were included in the final analysis. The eGFR was calculated by creatinine, cystatin C or a combination of both usi...
Source: Acta Diabetologica - April 28, 2021 Category: Endocrinology Source Type: research

Efficacy, safety, and user experience of DIY or open-source artificial pancreas systems: a systematic review
AbstractThe do-it-yourself artificial pancreas system (DIYAPS) is a patient-driven initiative with the potential to revolutionise diabetes management, automating insulin delivery with existing pumps and CGM combined with open-source algorithms. Given the considerable interest in this topic within the diabetes community, we have conducted a systematic review of DIYAPS efficacy, safety, and user experience. Following recognised procedures and reporting standards, we identified 10 eligible publications of 730 participants within the peer-reviewed literature. Overall, studies reported improvements in time in range, HbA1c (glyc...
Source: Acta Diabetologica - April 27, 2021 Category: Endocrinology Source Type: research

Long non-coding RNA KCNQ1OT1 increases the expression of PDCD4 by targeting miR-181a-5p, contributing to cardiomyocyte apoptosis in diabetic cardiomyopathy
ConclusionsOur findings suggest that KCNQ1OT1 and its target gene miR-181a-5p regulate myocardial inflammation and cardiomyocyte apoptosis by modulating PDCD4 in DCM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 27, 2021 Category: Endocrinology Source Type: research

Challenging steroid-induced worsening of hyperglycaemia in type 1 diabetes with advanced hybrid closed-loop systems
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 27, 2021 Category: Endocrinology Source Type: research

Off-label treatment with Pasireotide and use of continuous glucose monitoring in late familial hyperinsulinemic hypoglycemia: a case report
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 24, 2021 Category: Endocrinology Source Type: research

Decreased expression of programmed death-1 on CD8 + effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes
AbstractAimsChronic inflammation of autoimmune diseases, including type 1 diabetes (T1D), is mainly mediated by memory T(Tm) cells, predominantly effector memory T (Tem) cells. The roles of the programmed death-1 (PD-1) receptor on lymphocytes have been well studied in tumor and other infection models. However, little is known about the relationship between the expression of PD-1 on CD8+ Tem cells and the pathogenesis of T1D.MethodsA total of 52 patients diagnosed with T1D and 39 gender-, age-, and ethnically matched health control individuals were enrolled in this study. Peripheral blood mononuclear cells from these indiv...
Source: Acta Diabetologica - April 23, 2021 Category: Endocrinology Source Type: research

Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoSI Registry
AbstractAimsThe association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged  ≥ 65 years.MethodsData were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illnes...
Source: Acta Diabetologica - April 22, 2021 Category: Endocrinology Source Type: research

Serum metabolic signatures of subclinical atherosclerosis in patients with type 2 diabetes mellitus: a preliminary study
This study aimed to characterize serum metabolic signatures associated with carotid intima-media thickness (C-IMT), a proxy of subclinical atherosclerosis, in patients with type 2 diabetes mellitus (T2DM).MethodsAfter 1:1 matching by sex, age, body mass index, glycated haemoglobin A1c, and other clinical parameters, a total of 462 T2DM patients were enrolled, consisting of 231 patients with C-IMT of  ≥ 1 mm (abnormal C-IMT) and 231 patients with C-IMT of 
Source: Acta Diabetologica - April 19, 2021 Category: Endocrinology Source Type: research

Advanced hybrid closed-loop system: first successful clinical case after total pancreatectomy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 16, 2021 Category: Endocrinology Source Type: research

Mild periconceptional hyperglycemia: predictor of adverse fetomaternal outcomes in gestational diabetes?
AbstractAimTo clarify whether mild first trimester hyperglycaemia (characteristic of early-onset GDM) is associated with higher incidence of congenital malformations and other adverse fetomaternal outcomes compared to women with second trimester hyperglycaemia (later-onset GDM).Design and methodsWe analyzed the Portuguese National GDM database, containing data collected between 2011 and 2017. Two study groups were defined: Group 1 —Women with GDM diagnosed during the first trimester (with fasting glycemia ≥ 92 and 
Source: Acta Diabetologica - April 15, 2021 Category: Endocrinology Source Type: research

Supplemental light exposure improves sleep architecture in people with type 2 diabetes
ConclusionsIn this case series, we provide initial evidence that supplemental bright light improves daytime sleepiness in T2D with no DR, with the critical period of light exposure showing a beneficial effect after one week. We infer that supplemental light augments photoreceptor signalling in T2D and therefore optimises circadian photoentrainment leading to improved sleep. Our findings inform the development of tailored light therapy protocols in future clinical trials for improving sleep architecture in diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 14, 2021 Category: Endocrinology Source Type: research

Correction to: Higher HbA1c may reduce axial length elongation in myopic children: a comparison cohort study
A correction to this paper has been published: https://doi.org/10.1007/s00592-021-01695-w (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 13, 2021 Category: Endocrinology Source Type: research

Screening of postpartum diabetes in women with gestational diabetes: high-risk subgroups and areas for improvements —the STRONG observational study
ConclusionsIncreasing compliance to postpartum OGTT to prevent/delay PPD is a priority. Easily available characteristics identify subgroups of women more likely to benefit from preventive strategies. Fasting BG values during pregnancy lower than those usually considered deserve attention. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 12, 2021 Category: Endocrinology Source Type: research

Circadian rhythm and gestational diabetes: working conditions, sleeping habits and lifestyle influence insulin dependency during pregnancy
AbstractObjectiveManagement of gestational diabetes (GDM) is currently changing toward a more personalized approach. There  is a growing number of GDM patients requiring only a single dose of basal insulin at night to achieve glucose control. Well-known risk factors like obesity, parity and family history have been associated with GDM treatment requirements. Sleep quality and lifestyle factors interfering with the circ adian rhythm are known to affect glucose metabolism. The aim of this study was to investigate the impact of such lifestyle factors on insulin requirement in GDM patients, in particular on long-acting in...
Source: Acta Diabetologica - April 10, 2021 Category: Endocrinology Source Type: research

Pregnancy outcomes and maternal characteristics in women with pregestational and gestational diabetes: a retrospective study on 206,917 singleton live births
ConclusionsIn our population, pregestational T2D was more prevalent than T1D. Neonatal complications were mostly associated with pregestational T1D. Increased risk of previous spontaneous abortions was the hallmark of pregestational T2D. GDM, even if sharing adverse outcomes with pregestational T2D, was unrelated to rise in risk of neonatal macrosomia. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 9, 2021 Category: Endocrinology Source Type: research

The contribution of the English NHS Diabetic Eye Screening Programme to reductions in diabetes-related blindness, comparisons within Europe, and future challenges
AbstractThe aim of the English NHS Diabetic Eye Screening Programme (DESP) is to reduce the risk of sight loss amongst people with diabetes by the prompt identification and effective treatment if necessary of sight-threatening diabetic retinopathy, at the appropriate stage during the disease process, with a long-term aim of preventing blindness in people with diabetes.For the year 2009 –2010, diabetic retinopathy (DR) was no longer the leading cause of blindness in the working age group. There have been further reductions in DR certifications for WHO severe vision impairment and blindness from 1,334 (5.5% of all cert...
Source: Acta Diabetologica - April 8, 2021 Category: Endocrinology Source Type: research

Insulin and takotsubo syndrome: plausible pathophysiologic, diagnostic, prognostic, and therapeutic roles
AbstractThe pathophysiology of takotsubo syndrome (TTS) is elusive. Heightened adrenergic surge via the sympathetic nervous system (mainly by norepinephrine secretion) and/or elevated blood-borne catecholamines (mainly epinephrine, secreted by the adrenals) probably mediate TTS. Patients with TTS have a low prevalence of diabetes mellitus (DM), and it has been postulated that DM, via its associated neuropathy, prevents the emergence of TTS. Insulin, in animal experiments, has been shown to greatly attenuate the effects of NE on the cardiomyocytes; also, insulin in a limited clinical experience, has been found to improve he...
Source: Acta Diabetologica - April 2, 2021 Category: Endocrinology Source Type: research

Quantitative evaluation of hard exudates in diabetic macular edema by multicolor imaging and their associations with serum lipid levels
AbstractAimsTo quantify hard exudates (HEs) by multicolor imaging (MCI) and traditional color fundus photography (CFP) in diabetic macular edema (DME), and study their associations with serum lipid levels.MethodsObservational study. DME patients with HEs were recruited. The HE area and location both by MCI and CFP were measured by ImageJ software. Multivariate regression models were used to analyze the associations of serum lipid levels with the total HE area and HE location.ResultsSixty-two patients (74 eyes) were enrolled to quantify HEs in DME. The total HE area by MCI was larger than that by CFP (P = 0.00...
Source: Acta Diabetologica - April 2, 2021 Category: Endocrinology Source Type: research

Evidence for human diabetic cardiomyopathy
AbstractGrowing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia and insulin resistance, a lot of preclinical models were developed. However, the evidence of pathogenic and histological alterations of the so-called diabetic cardiomyopathy (DCM) is still poorly understood in humans. Here, we provide a stringent literature analysis to investigate unique data regarding human DCM. This appr...
Source: Acta Diabetologica - March 31, 2021 Category: Endocrinology Source Type: research

Alterations in Rev-ERB α/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study
AbstractObjectiveTo detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms.Design and methodsWe performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW,n = 111) and former (f-NSW,n = 98) rotating night shift workers with diurnal workers (controls,n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral ...
Source: Acta Diabetologica - March 31, 2021 Category: Endocrinology Source Type: research