Nurse-managed basal-bolus versus sliding-scale insulin regimen in subjects with hyperglycemia at admission for orthopedic surgery: a propensity score approach
AbstractAimsA sliding-scale (SS) regimen is discouraged to correct hyperglycemia in hospital patients, but there is resistance to adoption of basal –bolus (BB) treatment in surgical units. We tested the feasibility and the effects of a nurse-based BB regimen in orthopedic surgery.MethodsFollowing an intense training to implement a protocol amenable by nurses, a group of patients admitted with hyperglycemia in an orthopedic institute were prospectively followed according to a basal –bolus insulin regimen (BB,n = 80). They were compared with a hyperglycemic group eventually treated by sliding-scale ...
Source: Acta Diabetologica - February 25, 2020 Category: Endocrinology Source Type: research

Differential unfolded protein response in skeletal muscle from non-diabetic glucose tolerant or intolerant patients with obesity before and after bariatric surgery
AbstractAimsNot all people with obesity become glucose intolerant, suggesting differential activation of cellular pathways. The unfolded protein response (UPR) may contribute to the development of insulin resistance in several organs, but its role in skeletal muscle remains debated. Therefore, we explored the UPR activation in muscle from non-diabetic glucose tolerant or intolerant patients with obesity and the impact of bariatric procedures.MethodsMuscle biopsies from 22 normoglycemic (NG, blood glucose measured 120  min after an oral glucose tolerance test, G120 
Source: Acta Diabetologica - February 21, 2020 Category: Endocrinology Source Type: research

Analysis via Markov decision process to evaluate glycemic control strategies of a large retrospective cohort with type 2 diabetes: the ameliorate study
ConclusionsUse of data-driven prescriptive analytics would help clinicians make evidence-based treatment decisions for HbA1c control for patients with type 2 diabetes, in particular for those at high risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 21, 2020 Category: Endocrinology Source Type: research

Fulminant type 1 diabetes in Caucasians: a new Spanish case and the first related to thiazides
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 21, 2020 Category: Endocrinology Source Type: research

Insulin allergy brought out 8  years after starting insulin therapy in a subject with type 1 diabetes mellitus
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 20, 2020 Category: Endocrinology Source Type: research

Intranasal versus injectable glucagon for hypoglycemia in type 1 diabetes: systematic review and meta-analysis
ConclusionsThis meta-analysis indicates that in conscious T1DM patients IN glucagon and IM/SC glucagon are equally effective in resolution of hypoglycemia. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

Abrogation of postprandial triglyceridemia with dual PPAR α/γ agonist in type 2 diabetes mellitus: a randomized, placebo-controlled study
This study was aimed to investigate whether saroglitazar suppresses postprandial lipemia in patients with diabetes and dyslipidemia.MethodsThis was a 12-week, prospective, multicenter, randomized, double-blinded, placebo-controlled study of saroglitazar in patients with diabetes and dyslipidemia. Thirty patients were randomized (1:1) to receive saroglitazar 4  mg or placebo orally once daily with metformin for 12 weeks. The primary endpoint was change in plasma triglyceride (TG) area under the curve (AUC) on a standardized 8-h fat tolerance test.ResultsThirty participants were randomized for interventions and eve...
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects
ConclusionsHere, we report for the first time a novel population-specific rare variant in theMFGE8 gene linked with the increased Mfge8 concentrations and the risk for developing T2DM and cardiovascular risk factors in a population of Punjabi Sikhs from India. In view of a strong evidence from animal studies supporting the role of Mfge8 in obesity, insulin resistance, and the development of atherosclerosis in T2DM, our findings are important and timely. If validated in a large independent dataset, early screening of Mfge8 in blood levels may especially benefit those patients with genetically elevated Mfge8 levels to preven...
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

Altered circulatory levels of miR-128, BDNF, cortisol and shortened telomeres in patients with type 2 diabetes and depression
AbstractAimsSeveral studies have reported the role of biomarkers either in diabetes or depression. The present study is aimed at profiling the circulating levels of miR-128, brain-derived neurotrophic factor (BDNF), cortisol and telomere length in patients with type 2 diabetes with and without depression compared to individuals with normal glucose tolerance.MethodsStudy subjects (n = 160) were recruited from an ongoing epidemiological study in southern India. Non-diabetic and diabetic individuals were diagnosed as per the World Health Organization criteria. Depression score was derived using PHQ-12 questionna...
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

Reply to Tomoyuki Kawada: “Physical activity and risk of diabetic retinopathy: a risk assessment”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

Physical activity and risk of diabetic retinopathy: a risk assessment
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 6, 2020 Category: Endocrinology Source Type: research

Physical activity recommendations for patients with type 2 diabetes: a cross-sectional survey
ConclusionsThe quality of the guidelines concerning physical activity for T2DM was found to be moderate to low and varied substantially. Recommendations regarding physical activity for T2DM are not very specific or clear and remain incompletely consistent, while the level of evidence and the strength of the recommendations were seldom reported. Our findings suggest a need for guidelines for diabetes based on high levels of evidence. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 5, 2020 Category: Endocrinology Source Type: research

Sex difference in the incidence of microvascular complications in patients with type 2 diabetes mellitus: a prospective cohort study
AbstractAimsType 2 diabetes mellitus is a major cause of death and disability due to its long-term macro- and microvascular diseases. Although women with type 2 diabetes have more macrovascular diseases, it is unclear whether there are sex differences in the occurrence of microvascular disease. The aim of our study was to investigate sex differences in the incidence of microvascular complications in type 2 diabetes.MethodsAnalyses were performed in the DiaGene study, a prospective cohort study for complications of type 2 diabetes, collected in the city of Eindhoven, the Netherlands (n = 1886, mean follow-up t...
Source: Acta Diabetologica - February 5, 2020 Category: Endocrinology Source Type: research

Exercise improves metformin 72-h glucose control by reducing the frequency of hyperglycemic peaks
AbstractPurposeTo determine the separated and combined effects of metformin and exercise on insulin sensitivity and free-living glycemic control in overweight individuals with prediabetes/type 2 diabetes (T2DM).MethodsWe recruited 16 adults with BMI of 32.7  ± 4.3 kg m−2 and insulin resistance (HOMA-IR 3.2  ± 0.4) under chronic metformin treatment (1234 ± 465 g day−1) enrolled in a high-intensity interval training (HIIT) program. Participants underwent four 72-h experimental trials in a random-counterbalanced order: (1) maintaini...
Source: Acta Diabetologica - February 4, 2020 Category: Endocrinology Source Type: research

Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders
ConclusionsOxidative stress due to deficiency of GPx-1 and Cat may improve obesity-related metabolic disorders through attenuation of inflammation and fat browning. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 1, 2020 Category: Endocrinology Source Type: research

A potent risk model for predicting new-onset acute coronary syndrome in patients with type 2 diabetes mellitus in Northwest China
ConclusionsA potent risk predictive model was established, which is of great value for the secondary prevention of diabetes. Weight loss, lowering of SBP and blood uric acid levels and appropriate control for DBP may significantly reduce the risk of new-onset ACS in T2DM patients in Northwest China. (Source: Acta Diabetologica)
Source: Acta Diabetologica - February 1, 2020 Category: Endocrinology Source Type: research

Diminished heart rate variability in type 2 diabetes is exacerbated during exercise-heat stress
(Source: Acta Diabetologica)
Source: Acta Diabetologica - February 1, 2020 Category: Endocrinology Source Type: research

First-trimester fasting glycemia as a predictor of gestational diabetes (GDM) and adverse pregnancy outcomes
AbstractAimsStudies to prevent gestational diabetes (GDM) have shown the best results when lifestyle measures have been applied early in pregnancy. We aimed to investigate whether first-trimester fasting plasma glucose (FPG) could predict GDM risk and adverse pregnancy outcomes.MethodsA retrospective analysis of prospectively collected data from singleton pregnancies who were attended at our hospital between 2008 and 2018 (n = 27,198) was performed. We included patients with a recorded first-trimester FPG and complete pregnancy data (n = 6845). Patients under 18, with pregestational diabetes or ...
Source: Acta Diabetologica - January 27, 2020 Category: Endocrinology Source Type: research

Pericardial fat in type 2 diabetes: not just a biomarker, but a promising treatment target?
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 27, 2020 Category: Endocrinology Source Type: research

Self-care activities adherence in Tunisian patients with type 2 diabetes: role of diabetes-related distress and self-efficacy
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 21, 2020 Category: Endocrinology Source Type: research

GCK-MODY and obesity: symptom overlap makes diagnosis difficult
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 21, 2020 Category: Endocrinology Source Type: research

Risk of cancer in patients treated with dipeptidyl peptidase-4 inhibitors: an extensive meta-analysis of randomized controlled trials
ConclusionsAvailable data do not support the hypothesis of an association of DPP4i treatment with malignancies, with a possible beneficial effect for colon-rectal cancer. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 18, 2020 Category: Endocrinology Source Type: research

10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
AbstractAimThe aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control.MethodsAn open-label single-arm, single-center, clinical investigation in children aged 7 –18 years on MDI following a structured protocol: 2 days, HCL system assessment; 5 days, HCL system training (2-h sessions on 5 consecutive days with groups of 3–5 participants and families); 3 days, Manual Mode use of HCL system; 84 days, Auto Mode use of the HCL system, cumulating ...
Source: Acta Diabetologica - January 17, 2020 Category: Endocrinology Source Type: research

Circulating mitochondrial DNA is decreased in children and adolescents with obesity and/or insulin resistance
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 17, 2020 Category: Endocrinology Source Type: research

Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model
AbstractAimsTo investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI).MethodsFifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis.ResultsEight T2DM monkeys...
Source: Acta Diabetologica - January 14, 2020 Category: Endocrinology Source Type: research

Estimating the risk of gestational diabetes mellitus based on the 2013 WHO criteria: a prediction model based on clinical and biochemical variables in early pregnancy
ConclusionsA model based on easy to use variables in early pregnancy has a moderate accuracy to predict GDM based on the 2013 WHO criteria. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 8, 2020 Category: Endocrinology Source Type: research

Diabetes and diabetic retinopathy in patients undergoing cataract surgery: a prevalence study —DiCat study report #2
DiscussionDiabetic retinopathy and DME worsen after cataract extraction thus complicating long-term prognosis and requiring expensive injective therapy. Since unknown diabetics represent 2 –4% of the many million cataract candidates and even known diabetics show poor metabolic control and high rates of DME, preoperative medical testing and accurate retinopathy screening may prove both ethically necessary and cost-effective. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 7, 2020 Category: Endocrinology Source Type: research

A comparison of diabetes self-care behavior in people with type 2 diabetes with and without insomnia symptoms
AbstractAimsIndividuals with type 2 diabetes (T2DM) are advised to undertake diabetes self-care behavior (DSCB) in order to avoid complications of T2DM. However, comorbidities, such as insomnia symptoms which are commonly reported in people with T2DM, may limit the ability to engage in DSCB. Insomnia and the common sequelae accompanying insomnia such as pain, depression, and anxiety may negatively influence the performance of DSCB. Therefore, this study aimed to compare the DSCB of people with T2DM with and without insomnia symptoms.MethodsSixty participants with T2DM were divided into two groups based on the presence of i...
Source: Acta Diabetologica - January 7, 2020 Category: Endocrinology Source Type: research

Tamoxifen treatment causes early hepatic insulin resistance
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 6, 2020 Category: Endocrinology Source Type: research

Clinical utility of noninvasive scores in assessing advanced hepatic fibrosis in patients with type 2 diabetes mellitus: a study in biopsy-proven non-alcoholic fatty liver disease
ConclusionBoth FIB-4 and NFS scores have an acceptable clinical utility in the exclusion of advanced fibrosis in patients with NAFLD, regardless of the presence of type 2 diabetes. However, their usefulness in identifying advanced fibrosis is limited —especially in the absence of diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 2, 2020 Category: Endocrinology Source Type: research

Metabolite profiling paradoxically reveals favorable levels of lipids, markers of oxidative stress and unsaturated fatty acids in a diabetes susceptible group of Middle Eastern immigrants
AbstractAimsThe population of immigrants from the Middle East in Sweden show a higher prevalence of type 2 diabetes (T2D) compared to native Swedes. The exact reason for this is unknown. Here, we have performed metabolite profiling to investigate these differences.MethodsMetabolite profiling was conducted in Iraqi immigrants (n = 93) and native Swedes (n = 77) using two complementary mass spectrometry-based platforms. Differences in metabolite levels were compared after adjustment for confounding anthropometric, diet and clinical variables.ResultsThe Iraqi immigrant population were more obese (4...
Source: Acta Diabetologica - December 20, 2019 Category: Endocrinology Source Type: research

Pericardial fat versus BMI in the assessment of coronary atherosclerotic burden in patients with diabetes mellitus
ConclusionsPFV was independently associated with CAC in diabetic patients. PFV, rather than obesity measured by BMI, could be used as an imaging biomarker for assessing coronary atherosclerotic burden in patients with DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 20, 2019 Category: Endocrinology Source Type: research

The novel loss of function Ile354Val mutation in PPARG causes familial partial lipodystrophy
ConclusionsOur present data extend the spectrum ofPPARG mutations responsible for FPLD3 and reinforce the notion that even loss of function mutations affecting transcriptional activity to an extent lower than that observed in the case of haploinsufficiency are able to cause a severe FPLD3 phenotype. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 20, 2019 Category: Endocrinology Source Type: research

The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance
ConclusionsThere is a weak relationship between oral glucose-induced GIP and GLP-1 secretions in non-diabetic subjects. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 17, 2019 Category: Endocrinology Source Type: research

Metagenomic analysis reveals gestational diabetes mellitus-related microbial regulators of glucose tolerance
AbstractAimsRecent studies have suggested a possible association between microbiota and gestational diabetes (GDM). However, the results are inconsistent. Our objective was to investigate further the relationship between GDM and microbiota and verify the potential microbial marker.MethodsTwo complementary approaches were used for the demonstration. First, we compared the gut microbial composition of 23 GDM patients and 26 non-GDM ethnically Chinese Han pregnant women, by using whole-metagenome shotgun sequencing of their stool samples collected at the third trimester. Second, we used Q-PCR (quantitative polymerase chain re...
Source: Acta Diabetologica - December 9, 2019 Category: Endocrinology Source Type: research

Physical activity, sedentary behavior and development of preeclampsia in women with preexisting diabetes
AbstractAimsTo explore the association between physical activity in early pregnancy and development of preeclampsia in women with preexisting diabetes.MethodsIn a prospective cohort study of 189 women with preexisting diabetes (110 type 1 and 79 type 2 diabetes), physical activity during pregnancy including sedentary behavior was evaluated with the Pregnancy Physical Activity Questionnaire. Primary outcome was preeclampsia. Secondary outcomes were preterm delivery, large and small for gestational age infants.ResultsWomen developing preeclampsia (n = 23) had higher diastolic blood pressure in early pregnancy (...
Source: Acta Diabetologica - November 28, 2019 Category: Endocrinology Source Type: research

The association of plasma levels of liver enzymes and risk of gestational diabetes mellitus: a systematic review and dose –response meta-analysis of observational studies
AbstractAimsRelationship between liver enzymes such as gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline phosphatase and risk of gestational diabetes mellitus (GDM) is a controversial issue. The aim of this systematic review and dose –response meta-analysis was to investigate the association between liver enzymes and risk of GDM in observational studies.MethodsA comprehensive systematic literature search was conducted in MEDLINE/PubMed, SCOPUS and Web of Science databases up to September 2019. Combined odds ratios (ORs) with 95% confidence intervals (CIs) were...
Source: Acta Diabetologica - November 28, 2019 Category: Endocrinology Source Type: research

Sustained hypoglycemia with therapeutic use of repaglinide
(Source: Acta Diabetologica)
Source: Acta Diabetologica - November 27, 2019 Category: Endocrinology Source Type: research

Successful allogeneic islet transplantation after total pancreatectomy with islet autotransplantation to restore normoglycemia: a case report
(Source: Acta Diabetologica)
Source: Acta Diabetologica - November 26, 2019 Category: Endocrinology Source Type: research

Association of severe hypoglycemia with mortality for people with diabetes mellitus during a 20-year follow-up in Denmark: a cohort study
ConclusionIn this study, severe hypoglycemic episodes increased the mortality risk for people with type 1 and type 2 diabetes. The risk was higher among people with type 2 diabetes. Whether severe hypoglycemia is a symptom of other underlying illnesses increasing mortality risk or a risk factor itself needs further investigation. (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 21, 2019 Category: Endocrinology Source Type: research

One-year follow-up of ischemic index changes after intravitreal dexamethasone implant for diabetic macular edema: an ultra-widefield fluorescein angiography study
AbstractAimTo investigate late changes in peripheral ischemia in patients affected by diabetic macular edema (DME) and treated with repeated dexamethasone (DEX) intravitreal implants over a 1-year period.MethodsIn this retrospective cohort study, patients older than 18  years of age and with type 2 non-proliferative treatment-naïve diabetic retinopathy (DR) and DME at baseline were included. All patients were treated with two intravitreal DEX implants within 1 year of follow-up. A minimum of two annual ultra-widefield fluorescein angiography (UWF FA) were requi red to ensure that all cases had a baseline UWF FA (
Source: Acta Diabetologica - November 21, 2019 Category: Endocrinology Source Type: research

Comparison of pain experience and time required for pre-planned navigated peripheral laser versus conventional multispot laser in the treatment of diabetic retinopathy
AbstractPurposeTo compare the pain and the duration of a panretinal photocoagulation (PRP) session using a conventional multispot laser (Quantel Medical) versus the Navilas® laser.MethodsTreatment-na ïve patients requiring bilateral PRP for diabetic retinopathy were included. For each patient, PRP was carried out using a conventional multispot laser (Quantel Medical, 577 nm) in one eye and the other eye was treated with the Navilas laser (OD-OS, 577 nm). For both PRP treatments, similar param eters (same power, exposure time, number, size and spacing of the spots) were used. For each eye, the duration of...
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients
ConclusionsThe changed profiling of circRNAs in the vitreous humour was reliable and may become a promising biomarker of DR and the circRNA –miRNA–mRNA network. It may also play an important role in the progression of DR. (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Modulation of gut microbiota contributes to effects of intensive insulin therapy on intestinal morphological alteration in high-fat-diet-treated mice
ConclusionsFor the first time, our data indicate that intensive insulin therapy recovers diabetes-associated gut structural abnormalities and restores the microbiome landscape. Moreover, specific altered ‘functionally relevant phylotypes’ correlates with improvement in diabetes-associated gut structural alterations. (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Frequent physical activity is associated with reduced risk of severe diabetic retinopathy in type 1 diabetes
ConclusionsFrequent LTPA is associated with a lower incidence of severe diabetic retinopathy during the follow-up. The total amount or the other components of LTPA (intensity or duration of a single session) were not associated with severe diabetic retinopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Diabetic retinopathy, diabetic macular edema, and cardiovascular risk: the importance of a long-term perspective and a multidisciplinary approach to optimal intravitreal therapy
AbstractDiabetic retinopathy (DR), diabetic macular edema (DME), and cardiovascular disease (CVD) resulting from vascular damage from persistently elevated blood glucose levels are among the serious secondary pathologies associated with long-standing diabetes mellitus. The established link between DR and CVD suggests the need for appropriate and early management of patients with diabetes to minimize CV risk. This is of particular importance in patients with recent, or a history of, major CV events. Early management of DR is a complex task that requires comprehensive evaluation and a multidisciplinary approach to manage com...
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Outcomes in diabetic macular edema switched directly or after a dexamethasone implant to a fluocinolone acetonide intravitreal implant following anti-VEGF treatment
This study compared outcomes of patients with DME switched directly to an FAc implant, versus indirectly via dexamethasone, after anti-VEGF therapy failure.MethodsThis is a retrospective, single-center chart review. Patients were assigned to Group A (switched to FAc after anti-VEGF) or Group B (switched to dexamethasone and then to FAc after>  4 months). Charts were reviewed for best-corrected visual acuity (BCVA), central macular thickness (CMT), intraocular pressure (IOP) and cataract development.ResultsForty-nine eyes were included. BCVA increased and CMT decreased with anti-VEGF (both groups), and dexame...
Source: Acta Diabetologica - November 20, 2019 Category: Endocrinology Source Type: research

Selecting the optimal risk threshold of diabetes risk scores to identify high-risk individuals for diabetes prevention: a cost-effectiveness analysis
AbstractAimsAlthough risk scores to predict type 2 diabetes exist, cost-effectiveness of risk thresholds to target prevention interventions are unknown. We applied cost-effectiveness analysis to identify optimal thresholds of predicted risk to target a low-cost community-based intervention in the USA.MethodsWe used a validated Markov-based type 2 diabetes simulation model to evaluate the lifetime cost-effectiveness of alternative thresholds of diabetes risk. Population characteristics for the model were obtained from NHANES 2001 –2004 and incidence rates and performance of two noninvasive diabetes risk scores (German...
Source: Acta Diabetologica - November 19, 2019 Category: Endocrinology Source Type: research

1,5-Anhydroglucitol  × glycated hemoglobin A 1c /100 as a potential biomarker for islet β-cell function among patients with type 2 diabetes
This study aimed to explore the level of and changes in the 1,5-anhydroglucitol  × glycated hemoglobin A1c/100 (AH index, AHI) associated with different glucose metabolism statuses and to evaluate the islet function and insulin sensitivity of patients with type 2 diabetes (T2DM) with different AHI levels.MethodsOf the 3562 subjects enrolled in this study, 1697 had T2DM. The disposition index (DI) was the product of islet secretion function and insulin sensitivity-related indexes.ResultsThe mean AHI level was 1.0 (0.7 –1.3) in the general population, while the mean AHI level in the T2DM group was 0...
Source: Acta Diabetologica - November 14, 2019 Category: Endocrinology Source Type: research

Improved metabolic control using glucose monitoring systems leads to improvement in vibration perception thresholds in type 1 diabetes patients
ConclusionsLower HbA1c and lower VPTs in T1DM patients were associated with improved VPT, suggesting a reversible effect on nerve function by improved metabolic control. (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 8, 2019 Category: Endocrinology Source Type: research