Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis
Am J Physiol Endocrinol Metab. 2024 May 1. doi: 10.1152/ajpendo.00069.2024. Online ahead of print.ABSTRACTPancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate which controls hormone release and β-cell viability by acting on glutamate receptors expressed by endocrine cells. We here investigate whether alteration of the Excitatory Amino Acid Transporter 2 (EAAT2), the major glutamate clearance system in the islet, may occur in type 2 diabetes mellitus (T2DM) and contribute to β-cell dysfunction. Increased EAAT2 intracellular localiz...
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Alessandra Galli Stefania Moretti Nevia Dule Eliana Sara Di Cairano Michela Castagna Paola Marciani Cristina Battaglia Federico Bertuzzi Ida Pastore Paolo Fiorina Stefano La Rosa Alberto Davalli Franco Folli Carla Perego Source Type: research
Evidence-based screening, clinical care and health education recommendations for Alaska Native peoples with prediabetes living in southcentral Alaska: findings from the Alaska EARTH follow-up study
This study investigated how much of the recent increase in pre-DM identified among Alaska Native (AN) peoples living in urban southcentral Alaska may be due to changes in diagnostic methods. We used clinical and demographic data collected at baseline between 2004 and 2006 and at follow-up collected between 2015 and 2017 from the urban southcentral Alaska Education and Research Towards Health (EARTH) cohort. We used descriptive statistics and logistic regression to explore differences in demographic and clinical variables among the identified pre-DM groups. Of 388 participants in the follow-up study, 243 had A1c levels indi...
Source: International Journal of Circumpolar Health - May 1, 2024 Category: International Medicine & Public Health Authors: Kathryn R Koller Sarah H Nash Julie A Beans Gretchen M Day Vanessa Y Hiratsuka Ai-Ling Lin Meera Narayanan Christi A Patten Sherry A Hammock Barbara V Howard Jason G Umans Source Type: research
Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
< em > Klebsiella pneumoniae < /em > infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
CONCLUSION: KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.PMID:38689752 | PMC:PMC11056902 | DOI:10.4254/wjh.v16.i4.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Long Guo Peng Peng Wei-Ting Peng Jie Zhao Qi-Quan Wan Source Type: research
Home blood pressure measurement self-reporting in real-life practices using the Hy-Result app: self-monitoring and digital pathway
CONCLUSIONS: Our real-life study shows that 90% of the HBPM reports include the required minimum number of BP readings to allow the calculation of a reliable average among whom 40% have uncontrolled BP levels. The self-management Hy-Result web app demonstrates significant potential for inclusion in the patient care process and reinforces the patient's engagement to independently monitor and self-reported their BP. When the mean BP is not within the recommended range, the users were automatically prompted by text messages to seek medical advice by the software. Further research should determine the extent to which users adh...
Source: Primary Care - May 1, 2024 Category: Primary Care Authors: Nicolas Postel-Vinay Nicole Gebara Roland Asmar Dominique Stephan Aurelien Lorthioir Laurence Amar Source Type: research
Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice
ConclusionTaken together, these results suggest that SS-31 could improve CSD-induced mitochondrial biogenesis dysfunction, inflammatory response, synaptic dysfunction, and cognitive impairment by increasing SIRT1 expression levels. (Source: Brain and Behavior)
Source: Brain and Behavior - May 1, 2024 Category: Neurology Authors: Yue ‐Ming Zhang,
Ya‐Tao Wang,
Ru‐Meng Wei,
Xue‐Yan Li,
Bao‐Ling Luo,
Jing‐Ya Zhang,
Kai‐Xuan Zhang,
Shi‐Kun Fang,
Xue‐Chun Liu,
Gui‐Hai Chen Tags: ORIGINAL ARTICLE Source Type: research
Mean Blood Glucose Level During ICU Hospitalization is a Strong Predictor of the Mortality of COVID-19
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Formation Mechanisms, Interrelationships, and Effects of Cognitive Factors on Diet and Physical Activity During the Post-Bariatric Surgery Period: A Cross-Sectional Study Based on Compensatory Carry-Over Action Model
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1 α-Induced Angiogenesis
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - May 1, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Primary arthrodesis for diabetic ankle fractures using a modified retrograde femoral intramedullary locking nail combined with lateral plating, surgical technique, and early results of a pilot study
ConclusionUsing a modified femoral IMN combined with lateral plating is a promising technique to achieve ankle arthrodesis in diabetic patients with acute ankle fractures with acceptable outcomes; however, further studies with larger numbers are needed.Level of evidence: IV (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - May 1, 2024 Category: Orthopaedics Source Type: research
Robotic transversus abdominis release (TAR) for ventral hernia repairs is associated with low surgical site occurrence rates and length of stay despite increasing modifiable comorbidities
Conclusion2 + MCMs significantly increase the odds of SSO, specifically in patients who have a history of diabetes and obesity. However, the presence of any number of MCMs was not associated with increased odds of prolonged LOS. (Source: Hernia)
Source: Hernia - May 1, 2024 Category: Sports Medicine Source Type: research
Impact of age and anterior fibromuscular stroma preservation on post-enucleation voided volume
ConclusionsThe study concludes that intentional preservation of AFS during prostate enucleation positively impacts early postoperative VVs, with limited improvement in older patients. These findings highlight the potential of AFS preservation not only in enhancing urinary outcomes post-surgery but also in shaping future BPH surgical procedures and research directions. (Source: World Journal of Urology)
Source: World Journal of Urology - May 1, 2024 Category: Urology & Nephrology Source Type: research
A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes
We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in ... (Source: BMC Medicine)
Source: BMC Medicine - May 1, 2024 Category: Internal Medicine Authors: Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur and Jae Hyeon Kim Tags: Research article Source Type: research
