Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
Differential effect by chronic disease risk: A secondary analysis of the ChooseWell 365 randomized controlled trial
CONCLUSIONS: Those with chronic diseases had greater reductions in calories purchased and gained less weight. Employers with limited resources for health promotion might consider tailoring programs to employees at highest risk.PMID:38699077 | PMC:PMC11063590 | DOI:10.1016/j.pmedr.2024.102736 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: J Cheng D E Levy J L McCurley E B Rimm E D Gelsomin A N Thorndike Source Type: research
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
Association of Blood Copper With the Subclinical Carotid Atherosclerosis: An Observational Study
CONCLUSIONS: Our findings identify copper as a novel risk factor of subclinical carotid atherosclerosis and show the potential synergistic proatherogenic effect of copper, cadmium, and lead mixture.PMID:38700020 | DOI:10.1161/JAHA.123.033474 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Denglu Zhou Qi Mao Yapei Sun Hao Cheng Jianhua Zhao Qingsong Liu Mengyang Deng Shangcheng Xu Xiaohui Zhao Source Type: research
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells
CONCLUSIONS: In summary, vaspin observably reduces HG-mediated inhibition of PDLSCs OD by modulating the TGF-β1/Smad signaling pathway. Vaspin may be a potential therapeutic for periodontal tissue regeneration in diabetic patients.PMID:38699861 | DOI:10.1111/jre.13254 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Zhihui Jing Xinran Feng Xin Li Xiaoyu Zhang Chunling Pan Source Type: research
Left ventricular systolic dysfunction predicts clinical prognosis in patients with acute ischemic stroke after intravenous thrombolysis
CONCLUSIONS: Our finding indicated that AIS patients with LVSD after IVT had poorer outcomes, suggesting the need to monitor and optimize LVEF in stroke management.PMID:38700495 | DOI:10.18632/aging.205786 (Source: Aging)
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chi Zhang Jun-Cang Wu Zheng Tan Xiao-Lu He Fei Li Long Wang Yu Wang Source Type: research
Analysis of chemoresistance characteristics and prognostic relevance of postoperative gemcitabine adjuvant chemotherapy in pancreatic cancer
ConclusionsPatients with pancreatic cancer receiving postoperative gemcitabine adjuvant therapy are more likely to develop chemoresistance when their tumor sizes are larger (diameter>3 cm). Development of chemoresistance exacerbates the prognosis of patients with pancreatic cancer, and larger tumor size is also a risk factor for poor prognosis in these patients. (Source: Cancer Medicine)
Source: Cancer Medicine - May 3, 2024 Category: Cancer & Oncology Authors: Jiaqiang Ren,
Shuai Wu,
Tong Su,
Jiachun Ding,
Fan Chen,
Jie Li,
Zheng Wang,
Liang Han,
Zheng Wu Tags: RESEARCH ARTICLE Source Type: research
GSE265976 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [first cohort, targeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE265980 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [first cohort, untargeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE265981 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [second cohort, untargeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats
In the present study, we investigated the effect of high-intensity interval training (HIIT) on cognitive behaviors in female rats with a high-fat diet + streptozotocin (STZ)-induced type 2 diabetes. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - May 3, 2024 Category: Neurology Authors: Kayvan Khoramipour, Maryam Hossein Rezaei, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Narjes Ebrahimnezhad and Hamideh Bashiri Tags: Research Source Type: research
Endoscopic Endonasal Approach for Residual and Recurrent Craniopharyngioma after Transcranial Approach: A Multi-institutional Experience
Conclusions EEA achieves reasonable GTR rates and is an effective, safe surgical option for recurrent CP postinitial TCA. This approach demonstrated stable or improved visual and endocrinologic outcomes in all patients within our two-institution series. Thus, EEA should be considered as an efficacious form of retreatment in cases of progressive and recurrent CP. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 3, 2024 Category: Neurosurgery Authors: Jani, Ronak H. Raju, Sudesh Kim, Miri Gardner, Paul Zenonos, Georgios A. Snyderman, Carl Wang, Eric W. Patel, Chirag Germanwala, Anand V. Tags: Original Article Source Type: research
Oral glucose tolerance test clearance in type 2 diabetes patients who underwent remission following intense lifestyle modification: A quasi-experimental study
by Pramod Tripathi, Nidhi Kadam, Diptika Tiwari, Anagha Vyawahare, Baby Sharma, Thejas Kathrikolly, Maheshkumar Kuppusamy, Venugopal Vijayakumar
Achieving diabetes remission (HbA1c (Source: PLoS One)
Source: PLoS One - May 3, 2024 Category: Biomedical Science Authors: Pramod Tripathi Source Type: research
Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial
This study has been registered with Chinese Clinical Trial Registry (ChiCTR2300070674). (Source: PLoS One)
Source: PLoS One - May 3, 2024 Category: Biomedical Science Authors: Yu-Hao Lin Source Type: research
Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review
Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD), pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds. Wound evolution partly depends on microbial co... (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - May 3, 2024 Category: Microbiology Authors: Madjid Morsli, Florian Salipante, Chlo é Magnan, Catherine Dunyach-Remy, Albert Sotto and Jean-Philippe Lavigne Tags: Review Source Type: research
