Factors influencing optimal diabetes care and clinical outcomes in Thai patients with type 2 diabetes mellitus: a multilevel modelling analysis
Conclusion
This highlights the necessity for targeted interventions to bridge urban–suburban care gaps, optimise drug prescriptions and implement comprehensive care strategies for improved glycaemic control, DR prevention and CKD progression mitigation among in Thai patients with T2DM. The value of the clinical target aggregate (ABC) and the process of care aggregate (FAACE) was also conclusively demonstrated. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Surawit, A., Pongkunakorn, T., Manosan, T., Mongkolsucharitkul, P., Chamnan, P., Suvarnabhumi, K., Puangpet, T., Suta, S., Pumeiam, S., Pinsawas, B., Ophakas, S., Pisitpornsuk, S., Utchin, C., Mayurasakorn, K. Tags: Open access, Diabetes and Endocrinology Source Type: research
Utilisation of the health belief model to study the behavioural intentions relating to obesity management among university students: a cross-sectional study
Conclusion
This study underscores the need for tailored health promotion strategies that consider the perceptions and beliefs of people about the management of obesity. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Albasheer, O., Hakami, N., Abdelwahab, S. I., Alqassim, A. Y., Alharbi, A., Abdelmola, A. O., Altraifi, A. A. A., Medani, I. E., Hakami, A. M. S., Moafa, M. H., Abuhadi, R. I., Hobani, A. H. Tags: Open access, Public health Source Type: research
Financial protection and equity in the healthcare financing system in Iran: a cross-sectional study among slum dwellers with type 2 diabetes
Conclusions
As a result of insufficient use of insurance, cost-coping strategies used by slum dwellers vis-à-vis T2D expenditures do not protect them from financial risks. Expanding universal health coverage and providing supplemental insurance for those with T2D living in slums are recommended. Iran Health Insurance should adequately cover the costs of T2D care for slum dwellers so that they do not need to use alternative strategies. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Ghammari, F., Heidari, K., Jalilian, H. Tags: Open access, Health services research Source Type: research
Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model
British Journal of Cancer, Published online: 03 May 2024; doi:10.1038/s41416-024-02693-9Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Ash Kieran Clift Pui San Tan Martina Patone Weiqi Liao Carol Coupland Rachael Bashford-Rogers Shivan Sivakumar Julia Hippisley-Cox Source Type: research
Deciphering M üller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis
AbstractDiabetic retinopathy (DR), a leading cause of visual impairment, demands a profound comprehension of its cellular mechanisms to formulate effective therapeutic strategies. Our study presentes a comprehensive single-cell analysis elucidating the intricate landscape of M üller cells within DR, emphasizing their nuanced involvement. Utilizing scRNA-seq data from both Sprague–Dawley rat models and human patients, we delineated distinct Müller cell clusters and their corresponding gene expression profiles. These findings were further validated through differential gene expression analysis utilizing human transcripto...
Source: European Journal of Medical Research - May 3, 2024 Category: Research Source Type: research
Optimal Glycated Hemoglobin Cutoff for Diagnosis of Diabetes and Prediabetes in Chinese Breast Cancer Women
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 2, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
The Efficacy of Diabetic Foot Treatment in a “TOSF” Pattern: A Five-Year Retrospective Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 2, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Don't hold the metformin: Enhancing inpatient diabetes education to encourage best practices in a public hospital
(Source: Journal of Hospital Medicine)
Source: Journal of Hospital Medicine - May 2, 2024 Category: Hospital Management Authors: Samantha F. Sanders,
Michael S. Shen,
Daniel Alaiev,
Brianna Knoll,
Hyung J. Cho,
Surafel Tsega,
Mona Krouss,
Ian Fagan,
Amanda Klinger Tags: INNOVATIONS CORNER Source Type: research
Syndecans and diabetic complications: a narrative review
Am J Med Sci. 2024 Apr 30:S0002-9629(24)01210-2. doi: 10.1016/j.amjms.2024.04.017. Online ahead of print.ABSTRACTSyndecan (SDC) is a member of the heparan sulfate proteoglycan (HSPG) family. It appears to play a role in the aetiology of diabetic complications, with decreased levels of SDCs being reported in the kidney, retina, and cardiac muscle in models of diabetes mellitus (DM). The reduced levels of SDCs may play an important role in the development of albuminuria in DM. Some studies have provided the evidence supporting the mechanisms underlying the role of SDCs in DM. However, SDCs and the molecular mechanisms involv...
Source: The American Journal of the Medical Sciences - May 2, 2024 Category: General Medicine Authors: Yasamin Rajabloo Maryam Saberi-Karimian Sara Saffar Soflaei Gordon A Ferns Majid Ghayour-Mobarhan Source Type: research
Cellular and Molecular Mechanisms of Neuronal Degeneration in Early-Stage Diabetic Retinopathy
CONCLUSION: Current DR treatments primarily address vascular symptoms but fall short of preventing or halting the disease. Insights into the mechanisms of retinal neurodegeneration in the setting of diabetes mellitus not only enhance our understanding of DR but also pave the way for future therapeutic interventions aimed at preventing disease progression and preserving vision.PMID:38693745 | DOI:10.2174/0115701611272737240426050930 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Authors: Andrew Callan Sonal Jha Laura Valdez Andrew Tsin Source Type: research
Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF- κB/p38MAPK signaling pathway modulation
CONCLUSION: This study utilized network pharmacology, molecular docking, and animal experiments to identify the potential mechanism of the WenYang FuYuan recipe, which may be associated with the regulation of the AGE-RAGE signaling pathway and the inhibition of target proteins and mRNAs in the downstream NF-kB/p38MAPK pathway.PMID:38697555 | DOI:10.1016/j.exger.2024.112448 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 2, 2024 Category: Geriatrics Authors: Ding Zhang Hongling Qin Wei Chen Junjun Xiang Minghe Jiang Ling Zhang Keqing Zhou Yueqiang Hu Source Type: research
Disentangling fetal insulin hypersecretion and insulin resistance
Trends Endocrinol Metab. 2024 May 1:S1043-2760(24)00091-2. doi: 10.1016/j.tem.2024.04.008. Online ahead of print.ABSTRACTDisentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.PMID:38697899 | DOI:10.1016/j.tem.2024.04.008 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 2, 2024 Category: Endocrinology Authors: Christopher J Nolan Gernot Desoye Source Type: research
Pancreatic islet adaptation in pregnancy and postpartum
Trends Endocrinol Metab. 2024 May 1:S1043-2760(24)00090-0. doi: 10.1016/j.tem.2024.04.007. Online ahead of print.ABSTRACTPancreatic islets, particularly insulin-producing β-cells, are central regulators of glucose homeostasis capable of responding to a variety of metabolic stressors. Pregnancy is a unique physiological stressor, necessitating the islets to adapt to the complex interplay of maternal and fetal-placental factors influencing the metabolic milieu. In this review we highlight studies defining gestational adaptation mechanisms within maternal islets and emerging studies revealing islet adaptations during the ear...
Source: Trends in Endocrinology and Metabolism: TEM - May 2, 2024 Category: Endocrinology Authors: Nelmari Ruiz-Otero Jeffery S Tessem Ronadip R Banerjee Source Type: research
Beneficial Effects of PIN1 Inhibition on Diabetes Mellitus: A Concise Review
Endocr Metab Immune Disord Drug Targets. 2024 Apr 30. doi: 10.2174/0118715303297663240307060019. Online ahead of print.ABSTRACTType 2 diabetes mellitus is a long-term medical illness in which the body either becomes resistant to insulin or fails to produce it sufficiently. Mostly, combinatorial therapy is required to control blood glucose levels. However, combinatorial therapy has detrimental side effects. The prevalence of the cases and subsequent increases in medical costs of the same intimidate human health globally. While there have been a lot of studies focused on developing diabetic regimens that work to lower blood ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Meeramol C Chellappan V Soumya Shriraam Mahadevan M K Kathiravan J Saravanan Soniya Naik Source Type: research
Diabulimia and Type 1 Diabetes: An Unknown and Emerging Problem
CONCLUSION: T1DM patients need to pay great attention to food quality and quantity; hence, an eating disorder diagnosis may be challenging. Additionally, there are currently no standard screening methods for this purpose. In our experience, an integrated approach is fundamental and may be a valid strategy to face this emerging problem.PMID:38693738 | DOI:10.2174/0118715303314948240419060714 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Benedetta Rivolta Benedetta Masserini Irene Bernardi Antonella Camera Federico Libo à Sebastiano Bruno Solerte Chiara Cerabolini Nadia Cerutti Source Type: research
