From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research
Diabulimia and Type 1 Diabetes: An Unknown and Emerging Problem
CONCLUSION: T1DM patients need to pay great attention to food quality and quantity; hence, an eating disorder diagnosis may be challenging. Additionally, there are currently no standard screening methods for this purpose. In our experience, an integrated approach is fundamental and may be a valid strategy to face this emerging problem.PMID:38693738 | DOI:10.2174/0118715303314948240419060714 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Benedetta Rivolta Benedetta Masserini Irene Bernardi Antonella Camera Federico Libo à Sebastiano Bruno Solerte Chiara Cerabolini Nadia Cerutti Source Type: research
Beneficial Effects of PIN1 Inhibition on Diabetes Mellitus: A Concise Review
Endocr Metab Immune Disord Drug Targets. 2024 Apr 30. doi: 10.2174/0118715303297663240307060019. Online ahead of print.ABSTRACTType 2 diabetes mellitus is a long-term medical illness in which the body either becomes resistant to insulin or fails to produce it sufficiently. Mostly, combinatorial therapy is required to control blood glucose levels. However, combinatorial therapy has detrimental side effects. The prevalence of the cases and subsequent increases in medical costs of the same intimidate human health globally. While there have been a lot of studies focused on developing diabetic regimens that work to lower blood ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Meeramol C Chellappan V Soumya Shriraam Mahadevan M K Kathiravan J Saravanan Soniya Naik Source Type: research
Teucrium polium: new toxic effects added to the literature: a case report
CONCLUSION: For this reason, herbal treatment should be used with caution to avoid catastrophic side effects.PMID:38694375 | PMC:PMC11060313 | DOI:10.1097/MS9.0000000000001760 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ali Ghassa Mousa Ismail Leen Alabd Alrazak Alani Source Type: research
Genetic and inflammatory factors underlying gestational diabetes mellitus: a review
Front Endocrinol (Lausanne). 2024 Apr 17;15:1399694. doi: 10.3389/fendo.2024.1399694. eCollection 2024.ABSTRACTGestational diabetes mellitus (GDM) poses a significant global health concern, impacting both maternal and fetal well-being. Early detection and treatment are imperative to mitigate adverse outcomes during pregnancy. This review delves into the pivotal role of insulin function and the influence of genetic variants, including SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK, in GDM development. These genetic variations affect beta-cell function and insulin activity in crucial tissues, such as muscle, disrupting glucose regul...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Gyan Watson Ray Qiaoli Zeng Phidelia Kusi Hengli Zhang Taotao Shao Taili Yang Yue Wei Mianqin Li Xiaoqun Che Runmin Guo Source Type: research
Needs-based considerations for the role of low-dose aspirin along the CV risk continuum
Am J Prev Cardiol. 2024 Apr 15;18:100675. doi: 10.1016/j.ajpc.2024.100675. eCollection 2024 Jun.ABSTRACTCardiovascular disease (CVD) remains the leading cause of death worldwide. The risk of a cardiovascular (CV) event is not static and increases along a continuum, making identification and management complex. Aspirin has been the cornerstone of antiplatelet therapy in CV risk reduction and remains the only antiplatelet agent with current guideline recommendations throughout the CV risk continuum. In light of recent trials, the role of aspirin in CVD prevention in asymptomatic patients has been downgraded in clinical guide...
Source: Atherosclerosis - May 2, 2024 Category: Cardiology Authors: Francesca Santilli Gerhard Albrecht Michael Blaha Angel Lanas Li Li Dirk Sibbing Source Type: research
Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states
CONCLUSION: Although the K isotope results should be considered exploratory and hypothesis-generating and future studies should focus on larger sample size and δ41K analysis of other K-disrupting diseases (e.g., chronic kidney disease), our data hold great promise for K isotopes as disease marker.PMID:38694937 | PMC:PMC11062322 | DOI:10.3389/fendo.2024.1332895 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: Kathrin Schilling Heng Chen Ronald A Glabonjat Silvana Debernardi Oleg Blyuss Ana Navas-Acien Alex N Halliday Tatjana Crnogorac-Jurcevic Source Type: research
Characterizing the treatment patterns, medication burden, and patient demographics of older adults with major depressive disorder treated with antidepressants with or without selected comorbidities
Conclusion: This study highlights the medication burden and ADT patterns in older adults with MDD, assessing these outcomes among patients with and without comorbidities. Numerically higher medication burdens among those with selected comorbidities suggests future studies could investigate the impact of comorbidities on MDD-related care.PMID:38693906 | DOI:10.1080/03007995.2024.2348603 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 2, 2024 Category: Research Authors: Laxmi Gann Francesca Devine Lyuba Popadic Sagar Lal Michael Witte Marci Potter Steve Hass Source Type: research
Self-initiated lifestyle changes during a fasting-mimicking diet programme in patients with type 2 diabetes: a mixed-methods study
Lifestyle changes, especially regarding diet quality and physical activity, are important in the management of type 2 diabetes (T2D). This mixed-methods study explores self-initiated lifestyle changes in patie... (Source: BMC Family Practice)
Source: BMC Family Practice - May 2, 2024 Category: Primary Care Authors: Elske L. van den Burg, Marjolein P. Schoonakker, Bregje Korpershoek, Lara E. Sommeling, Carlijn A. Sturm, Hildo J. Lamb, Hanno Pijl, Mattijs E. Numans, Marieke A. Adriaanse and Petra G. van Peet Tags: Research Source Type: research
Prematurity and congenital malformations differ according to the type of pregestational diabetes
Diabetes mellitus (DM) is the most common metabolic disorder in pregnancy. Women with Type 2 DM seems to have no better perinatal outcomes than those with Type 1 DM. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - May 2, 2024 Category: OBGYN Authors: Monica Ballesteros, A Guarque, M Ingles, N Vilanova, M Lopez, L Martin, M Jane, L Puerto, M Martinez, M De la Flor, J Vendrell and A Megia Tags: Research Source Type: research
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure... (Source: Biological Research)
Source: Biological Research - May 2, 2024 Category: Biomedical Science Authors: Omar I. Badr, Mohamed M. Kamal, Shohda A. El-Maraghy and Heba R. Ghaiad Tags: Research article Source Type: research
Correction: Community-based integrated care for patients with diabetes and depression (CIC-PDD): study protocol for a cluster randomized controlled trial
(Source: Trials)
Source: Trials - May 2, 2024 Category: General Medicine Authors: Yanshang Wang, Dan Guo, Ming Wang, Mingzheng Hu, Dawei Zhu, Qianqian Yu, Zhansheng Li, Xiaoyi Zhang, Ruoxi Ding, Miaomiao Zhao and Ping He Tags: Correction Source Type: research
The Impact on Birth Outcomes of Sonographic Fetal Weight Estimation in Neonatal Macrosomia
Conclusion Larger EFW increased CD risk among pregnancies with actual neonatal macrosomia. Antenatally suspected macrosomia might alter labor management due to concerns for potential complications, especially when associated with primiparity, diabetes mellitus, or maternal obesity. The increase in the CD rate did not show an association with improved maternal and neonatal outcomes.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 2, 2024 Category: Perinatology & Neonatology Authors: Sgayer, Inshirah Nskovica, Karina Murkhovskyi, Iuliia Shqara, Raneen Abu Bilyk, Artyom Lowenstein, Lior Wolf, Maya Frank Tags: Original Article Source Type: research
Albumin Oxidation and Albumin Glycation Discordance During Type 2 Diabetes Therapy: Biological and Clinical Implications
Metabolic Syndrome and Related Disorders, Ahead of Print. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - May 2, 2024 Category: Endocrinology Authors: Madhumati S. Vaishnav Namita Kumari Sathyanarayana Srikanta Vinaya Simha Patnam R. Krishnaswamy Padmanabhan Balaram Navakanta Bhat Source Type: research
Comparison of bacterial species and clinical outcomes in patients with diabetic hand infection in tropical and nontropical regions
AbstractHand infection is a rare complication in patients with diabetes. Its clinical outcomes depend on the severity of hand infection caused by bacteria, but the difference in bacterial species in the regional disparity is unknown. The purpose of this study was to explore the influence of tropical and nontropical regions on bacterial species and clinical outcomes for diabetic hand. A systematic literature review was conducted using PubMed, EMBASE, Web of Science, and Google Scholar. Moreover, the bacterial species and clinical outcomes were analyzed with respect to multicenter wound care in China (nontropical regions). B...
Source: Archives of Dermatological Research - May 2, 2024 Category: Dermatology Source Type: research
