A Retrospective Analysis of the Effects of an Exclusively Human Milk Protein Diet on Neonatal Feeding Tolerance
Conclusion Using HMPF to provide an exclusively HMD allowed VLBW infants to achieve full feeds sooner, but did not affect rate of NEC compared with using a BMPF with an HMD. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 29, 2020 Category: Perinatology & Neonatology Authors: Wickland, Jessica Wade, Christine Micetic, Becky Meredith, Keith Martin, Gregory Tags: Original Article Source Type: research

Proficiency of Laryngeal Mask Airway Insertion Skill in NRP Certified Providers
Am J Perinatol DOI: 10.1055/s-0040-1721379 Objective In 2015, Neonatal Resuscitation Program (NRP) recommended laryngeal mask airway (LMA) as an alternative to the endotracheal tube (ETT) in situations where the provider is “unable to intubate and unable to ventilate.” LMA insertion is being taught in the NRP routinely. However, endotracheal intubation is the primary method considered as the standard of care in neonatal resuscitation. LMA insertion is a relatively simple procedure with an average insertion time of
Source: American Journal of Perinatology - November 29, 2020 Category: Perinatology & Neonatology Authors: Mani, Srinivasan Rawat, Munmun Tags: Original Article Source Type: research

Nebulization of High-Dose Poractant Alfa in Newborn Piglets on Nasal Continuous Positive Airway Pressure Yields Therapeutic Lung Doses of Phospholipids
Conclusion Nebulization was well tolerated, and the mean lung dose of phospholipids was above 100 mg/kg, that is, not different from the instillation group. These experimental findings suggest that it may be feasible to reach therapeutic lung doses of phospholipids by surfactant nebulization during nCPAP. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 26, 2020 Category: Perinatology & Neonatology Authors: Nord, Anders Bianco, Federico Salomone, Fabrizio Ricci, Francesca Schlun, Martin Linner, Rikard Cunha-Goncalves, Doris Tags: Original Article Source Type: research

Accuracy and Reliability of Lung Ultrasound to Diagnose Transient Tachypnoea of the Newborn: Evidence from a Meta-analysis and Systematic Review
Conclusion The performance of ultrasound for the detection of TTN was excellent. Considering the various advantages of LUS compared with chest radiographs in diagnosing TTN, this study supports the routine use of LUS for the detection of TTN. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 26, 2020 Category: Perinatology & Neonatology Authors: Ma, Hai-Ran Liu, Jing Yan, Wen-Kang Tags: Original Article Source Type: research

Gestational Age Dependency of Umbilical Cord Serum IL-6 Levels for Detecting Fetal Inflammation
Conclusion UC-s-IL-6 levels were inversely correlated with GA especially in newborns with funisitis. Such GA dependency of UC-s-IL-6 should be considered for detecting fetal inflammation. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 26, 2020 Category: Perinatology & Neonatology Authors: Iwatani, Sota Kobayashi, Takao Matsui, Sachiko Hirata, Akihiro Yamamoto, Miwa Yoshida, Makiko Yoshimoto, Seiji Nakao, Hideto Tags: Original Article Source Type: research

Birth Weight Standard Deviation Score is a Significant Determinant of Serum Urotensin-II Levels at Term-Equivalent Age in Preterm Infants
Conclusion Our results indicate that birth weight SD score might be associated with serum U-II levels in preterm LBW infants at term-equivalent age. Further studies are required to determine whether U-II levels at an early stage of life might influence the risk of atherosclerosis and hypertension. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 26, 2020 Category: Perinatology & Neonatology Authors: Ebata, Akio Nakano, Yuya Ujiie, Gakuto Ishii, Yoko Shimizu, Takeshi Fujii, Takanari Mizuno, Katsumi Tags: Original Article Source Type: research

The Golden Hour: Early Interventions for Medical Emergencies during Pregnancy
Am J Perinatol DOI: 10.1055/s-0040-1721393Maternal mortality has increased in the last decades in the United States as a result of increased prevalence of coexisting medical diseases such as hypertension, diabetes, and both acquired and congenital heart diseases. Obstetricians and maternal–fetal medicine physicians should have the basic medical knowledge to initiate appropriate diagnostic and early therapeutic interventions since they may be the only provider available at the time of presentation. The goal of this article is not to extensively discuss the management of complex medical diseases during pregnancy, rathe...
Source: American Journal of Perinatology - November 26, 2020 Category: Perinatology & Neonatology Authors: Pacheco, Luis D. Lozada, M. J. Saade, George R. Tags: Clinical Opinion Source Type: research

Leukopenia and Neutropenia at Birth and Sepsis in Preterm Neonates of < 32 Weeks' Gestation
This study aimed to evaluate associations between leukopenia or neutropenia at birth and risk of sepsis in very preterm neonates. Study Design We conducted a retrospective unmatched cohort study of neonates of
Source: American Journal of Perinatology - November 23, 2020 Category: Perinatology & Neonatology Authors: Shah, Jyotsna Balasubramaniam, Tharshini Yang, Jie Shah, Prakesh S. Tags: Original Article Source Type: research

Risk Factors and Predictors of Rebound Hyperbilirubinemia in a Term and Late-Preterm Infant with Hemolysis
This study aimed to assess the incidence and predictors of rebound in term and late-preterm infants with hemolytic hyperbilirubinemia postphototherapy. Study Design A 4-year retrospective data analysis of neonates with hemolytic indirect hyperbilirubinemia admitted to the neonatal intensive care unit (NICU) of Medina Maternity and Children's Hospital was conducted. Bilirubin rebound was defined as the return of total serum bilirubin (TSB) to phototherapy threshold within 72 hours of postphototherapy. Results Of 386 identified neonates; 44 (11%) experienced rebound. Neonates in the rebound group demon...
Source: American Journal of Perinatology - November 23, 2020 Category: Perinatology & Neonatology Authors: Almohammadi, Hanaa Nasef, Nehad Al-Harbi, Aziza Saidy, Khalid Nour, Islam Tags: Original Article Source Type: research

Rooming-in for Infants at Risk for Neonatal Abstinence Syndrome: Outcomes 5 Years following Its Introduction as the Standard of Care at One Hospital
Conclusion Early observations of the benefits of rooming-in on neonatal outcomes were sustained. Infants allowed to room-in were significantly less likely to require initiation of pharmacotherapy and a prolonged hospital stay than similar infants prior to the implementation of rooming-in as standard care. A large proportion of the infants who might have benefited from rooming-in required admission to the NICU for reasons other than neonatal abstinence syndrome (NAS). Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of conte...
Source: American Journal of Perinatology - November 17, 2020 Category: Perinatology & Neonatology Authors: Newman, Adam Isaiah Mauer-Vakil, Dane Coo, Helen Newton, Lynn Wilkerson, Emily McKnight, Sarah Brogly, Susan B. Tags: Original Article Source Type: research

Pathogenesis of Congenital Malformations: Possible Role of Oxidative Stress
Conclusion Because OS plays a significant role in pathogenesis of congenital malformations, studies should be developed in order to better define their OS mechanisms and the beneficial effects of supplemental therapeutic strategies. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 9, 2020 Category: Perinatology & Neonatology Authors: Impellizzeri, Pietro Nascimben, Francesca Di Fabrizio, Donatella Antonuccio, Pietro Antonelli, Enrica Peri, Flora Maria Calabrese, Ugo Arena, Salvatore Romeo, Carmelo Tags: Review Article Source Type: research

Birth Tourism Is Associated with Fewer Neonatal Intensive Care Unit Admissions: A Healthy Migrant Effect?
Am J Perinatol DOI: 10.1055/s-0040-1719117 Objective This work aimed to study perinatal, maternal, and neonatal characteristics of birth tourism (BT) mother–baby dyads and the rate of neonatal intensive care unit (NICU) admissions of BT infants. Study Design Retrospective study at a regional perinatal center comparing BT mother–baby dyads to all dyads. BT infants admitted to the NICU were compared with a randomly selected group of infants admitted to the NICU during the same time period. Results A total of 1,755 BT dyads were identified over 4 years. BT mothers were older (32 vs. 28 years, p 
Source: American Journal of Perinatology - November 9, 2020 Category: Perinatology & Neonatology Authors: Lim, Jina Sun, Wang-Dar Zhang, Lishi Mikhael, Michel Tags: Original Article Source Type: research

Neonatal Preterm Respiratory Care in Ukraine: An Observational Study of Outcomes in Relation to Timing and Methods of Surfactant Treatment
The objective of this study was to evaluate the impact of the changes in clinical practice of surfactant administration on clinical outcomes and the incidence of continuous positive airway pressure (CPAP) failure defined as the need for mechanical ventilation (MV) during the first 5 days of life in preterm infants
Source: American Journal of Perinatology - November 5, 2020 Category: Perinatology & Neonatology Authors: Dobryanskyy, Dmytro O. Menshykova, Anna O. Salabay, Zoriana V. Detsyk, Olga Y. Tags: Original Article Source Type: research

Charge Nurses Taking Charge, Challenging the Culture of Culture-Negative Sepsis, and Preventing Central-Line Infections to Reduce NICU Antibiotic Usage
Conclusion Our sequential quality improvement (QI) efforts led to a reduction in AUR. We implemented processes to establish a robust antibiotic stewardship program that included antibiotic time-outs led by NICU charge nurses and a focus on preventing CLABSI that were sustained beyond the QI period. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 3, 2020 Category: Perinatology & Neonatology Authors: Shukla, Samarth Cortez, Josef Renfro, Bill Makker, Kartikeya Timmons, Colleen Nandula, P. Sireesha Hazboun, Rita Dababneh, Rima Hoopes, Cristina VanRavestein, Jenny McCarter, Yvette Middlebrooks, Marilyn Ingyinn, Ma Alvarez, Ana Hudak, Mark L. Tags: Original Article Source Type: research

Perinatal Outcomes of Subjects Enrolled in a Multicenter Trial with a Waiver of Antenatal Consent
This study aimed to determine whether outcomes differed between infants enrolled in the PREMOD2 trial and those otherwise eligible but not enrolled, and whether the use of waiver effected these differences. Study Design The multicenter PREMOD2 (PREmature infants receiving Milking Or Delayed cord clamping) trial was approved for waiver of antenatal consent by six of the nine sites institutional review boards, while three sites exclusively used antenatal consent. Every randomized subject delivered at a site with a waiver of consent was approached for postnatal consent to allow for data collection. Four of those six s...
Source: American Journal of Perinatology - November 3, 2020 Category: Perinatology & Neonatology Authors: Katheria, Anup C. Allman, Phillip Szychowski, Jeff M. Essers, Jochen Carlo, Waldemar A. Schm ölzer, Georg M. Dempsey, Eugene Yanowitz, Toby Kaempf, Joseph Vora, Farha Bhat, Shazia Arnell, Kathy Rich, Wade Varner, Michael Tags: Original Article Source Type: research

Code Blue Events in the Neonatal and Pediatric Intensive Care Units at a Tertiary Care Children's Hospital
Conclusion Our study suggests that NICU code events as compared with PICU code events are more likely to be driven by airway problems, involve patients
Source: American Journal of Perinatology - November 3, 2020 Category: Perinatology & Neonatology Authors: Groden, Catherine M. Cabacungan, Erwin T. Gupta, Ruby Tags: Original Article Source Type: research

Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy
Am J Perinatol DOI: 10.1055/s-0040-1719151Hypoxic-ischemic encephalopathy (HIE) is the main cause of long-term neurodevelopmental morbidity in term born infants worldwide. Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia. Probably, the synergistic use of hypothermia associated with melatonin treatment may improve the neurological outcome in infants with HIE. In the past 20 years, the efficacy of melatonin in reducing oxidative stress has been demonstrated in animals; however, clinical trials with sufficient sample size of newborn...
Source: American Journal of Perinatology - October 31, 2020 Category: Perinatology & Neonatology Authors: D'angelo, Gabriella Cannav ò, Laura Reiter, Russel J. Gitto, Eloisa Tags: Review Article Source Type: research

Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic –Ischemic Encephalopathy
Conclusion H19 improved the brain tissue and alleviated nerve damage of neonatal HIE rats by upregulating the Akt3/mTOR pathway as a miR-29b sponge. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 27, 2020 Category: Perinatology & Neonatology Authors: Zhu, Hongwei Wang, Lei Chen, Juanjuan Shen, Huaiyun Chen, Zhenxiang Tags: Original Article Source Type: research

What Are the Factors Affecting Total Sleep Time During Video Polysomnography in Infants?
Am J Perinatol DOI: 10.1055/s-0040-1718948 Objective The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if
Source: American Journal of Perinatology - October 27, 2020 Category: Perinatology & Neonatology Authors: Paul, Grace R. Hayes, Don Tumin, Dmitry Gulati, Ish Jadcherla, Sudarshan Splaingard, Mark L. Tags: Original Article Source Type: research

Shifting Provider Attitudes and Institutional Resources Surrounding Resuscitation at the Limit of Gestational Viability
Conclusion There appears to be discordance in provider attitudes surrounding preferred actions at 23 and 22 weeks. Provider attitudes regarding decision-making at the limit of viability and identified resource limitations are nonuniform. Between-hospital variations in outcomes for periviable infants may be partly attributable to lack of provider consensus and nonuniform resource availability across institutions. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (S...
Source: American Journal of Perinatology - October 27, 2020 Category: Perinatology & Neonatology Authors: Arbour, Kaitlyn Lindsay, Elizabeth Laventhal, Naomi Myers, Patrick Andrews, Bree Klar, Angelle Dunbar, Alston E. Tags: Original Article Source Type: research

Improving Utilization of Aspirin for Prevention of Preeclampsia in a High-Risk Urban Cohort: A Prospective Cohort Study
This study aimed to evaluate the utilization of aspirin for preeclampsia prevention before and after implementation of a screening tool during nuchal translucency (NT) ultrasound. Study Design One-year prospective cohort study of patients at high risk for preeclampsia after the implementation of a screening tool (postscreen) administered to all patients at check in for NT (11–13 weeks) ultrasound. Prospective cohort was compared with one-year retrospective cohort (prescreen) the year prior (2017). All patients who presented for NT ultrasound in both cohorts were evaluated for the presence of one or more risk ...
Source: American Journal of Perinatology - October 24, 2020 Category: Perinatology & Neonatology Authors: Boelig, Rupsa C. Wanees, Mariam Zhan, Tingting Berghella, Vincenzo Roman, Amanda Tags: SMFM Fellowship Series Article Source Type: research

Ampicillin Dose for Early and Late-Onset Group B Streptococcal Disease in Neonates
Am J Perinatol DOI: 10.1055/s-0040-1718880Ampicillin is frequently used in neonates for early- and late-onset group B streptococcal (GBS) disease. In 2019, the American Academy of Pediatrics (AAP) published guidelines for GBS which included updated dosing recommendations for ampicillin for bacteremia and provided specific dosing recommendations for meningitis. The dosing recommendations in the guidelines were based off the 2018 Report of the Committee on Infectious Diseases (i.e., Red Book), which differed from the 2015 Red Book. For bacteremia, no dosing changes were recommended for ampicillin dosing in neonates ≤&thin...
Source: American Journal of Perinatology - October 22, 2020 Category: Perinatology & Neonatology Authors: Lim, Sin Yin Miller, Jamie L. Tags: Review Article Source Type: research

Antibiotic Timing in Previable Prelabor Rupture of Membranes Less Than 24 Weeks of Gestation
Conclusion Our data suggest that there is no maternal or neonatal benefit to immediate administration of latency antibiotics compared with delayed administration. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 22, 2020 Category: Perinatology & Neonatology Authors: Knupp, Rubymel J. Pederson, Sarah Blanchard, Christina Szychowski, Jeff Etikala, Deepa Sinkey, Rachel Wetta, Luisa Harper, Lorie M. Tags: Original Article Source Type: research

The Relationship between Serum Total Bilirubin and Severity of Hypoxic Injury in Neonatal Hypoxic –Ischemic Encephalopathy
Conclusion These results are consistent with the hypothesis that bilirubin functions as an antioxidant in vivo, and is consumed by scavenging free radicals in proportion to the severity of hypoxic injury. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 22, 2020 Category: Perinatology & Neonatology Authors: Haga, Mitsuhiro Kawabata, Ken Sumiya, Wakako Kurita, Saori Imanishi, Toshiyuki Kanno, Chika Kanno, Masayuki Kanno, Masami Shimizu, Masaki Tags: Original Article Source Type: research

Maternal Hypothyroidism Increases the Risk of Attention-Deficit Hyperactivity Disorder in the Offspring
Conclusion Exposure to maternal hypothyroidism during the periconceptual period significantly increases the risk of ADHD and that the association varies with gestational age at delivery, child sex, and race-ethnicity. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 21, 2020 Category: Perinatology & Neonatology Authors: Peltier, Morgan R. Fassett, Michael J. Chiu, Vicki Y. Getahun, Darios Tags: Original Article Source Type: research

Pilot Study of Sham Feeding in Postoperative Neonates
Am J Perinatol DOI: 10.1055/s-0040-1718881 Objective Sham feeding may enhance development of oral skills in neonates after bowel surgery and decrease stress levels in mothers. In this pilot study, we test the feasibility of sham feeding, identify safety hazards, and assess maternal satisfaction. Study Design A convenience sample of 15 postoperative neonates was enrolled. Sham feeding with unfortified human milk was offered following a strict advancement protocol beginning with 5 mL once daily and increasing up to 30 mL, three times daily. Continuous gastric suction was used during sham feeding...
Source: American Journal of Perinatology - October 20, 2020 Category: Perinatology & Neonatology Authors: Tucker, Alyssa Huang, Eunice Y. Peredo, Julia Weems, Mark F. Tags: Original Article Source Type: research

Prolonged Second Stage of Labor and Anal Sphincter Injury in a Contemporary Cohort of Term Nulliparas
This study aimed to assess whether a prolonged second stage of labor is an independent predictor of obstetric anal sphincter injury (OASI) in a contemporary cohort of nulliparous and term parturients, and to evaluate whether predelivery factors can accurately predict OASI. Study Design This was a nested case-control study within a cohort of consecutive nulliparous term parturients with a singleton gestation who underwent a vaginal delivery at a single institution between January 2014 and January 2015. Cases were defined as women with a third- or fourth-degree laceration at the time of delivery, and controls were wo...
Source: American Journal of Perinatology - October 20, 2020 Category: Perinatology & Neonatology Authors: Naqvi, Mariam Jaffe, Elana F. Goldfarb, Ilona T. Bryant, Allison S. Wylie, Blair J. Kaimal, Anjali J. Tags: Original Article Source Type: research

Longitudinal Survey of COVID-19 Burden and Related Policies in U.S. Neonatal Intensive Care Units
Conclusion Among a large cohort of NICU infants, the prevalence of infants under investigation or with confirmed neonatal COVID-19 disease was low. Policies regarding universal maternal screening for SARS-CoV-2, infant isolation from positive mothers, and direct maternal breastfeeding for infants born to positive mothers are rapidly evolving. As universal maternal screening for SARS-CoV-2 becomes more common, the impact of these policies requires further investigation. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  ...
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Ahmad, Kaashif A. Darcy-Mahoney, Ashley Kelleher, Amy S. Ellsbury, Dan L. Tolia, Veeral N. Clark, Reese H. Tags: Short Communication Source Type: research

Longitudinal Analysis of Continuous Pulse Oximetry as Prognostic Factor in Neonatal Respiratory Distress
Am J Perinatol DOI: 10.1055/s-0040-1718877 Objective Analysis of longitudinal data can provide neonatologists with tools that can help predict clinical deterioration and improve outcomes. The aim of this study is to analyze continuous monitoring data in newborns, using vital signs to develop predictive models for intensive care admission and time to discharge. Study Design We conducted a retrospective cohort study, including term and preterm newborns with respiratory distress patients admitted to the neonatal ward. Clinical and epidemiological data, as well as mean heart rate and saturation, at every minute...
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Sol ís-García, Gonzalo Maderuelo-Rodr íguez, Elena Perez-P érez, Teresa Torres-Soblechero, Laura Guti érrez-Vélez, Ana Ramos-Navarro, Cristina L ópez-Martínez, Raúl S ánchez-Luna, Manuel Tags: Original Article Source Type: research

The Safety of Low-Dose Aspirin on the Mode of Delivery: Secondary Analysis of the Effect of Aspirin in Gestation and Reproduction Randomized Controlled Trial
Conclusion Preconception-initiated daily LDA was not associated with mode of delivery among women with one to two prior losses. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Eubanks, Allison A. Nobles, Carrie J. Mumford, Sunni L. Kim, Keewan Hill, Micah J. Decherney, Alan H. Sjaarda, Lindsey A. Ye, Aijun Radoc, Jeannie G. Perkins, Neil J. Silver, Robert M. Schisterman, Enrique F. Tags: Original Article Source Type: research

Association of Delivery Room and Neonatal Intensive Care Unit Intubation, and Number of Tracheal Intubation Attempts with Death or Severe Neurological Injury among Preterm Infants
Conclusion The DR TI is associated with higher odds of death and/or SNI compared with NICU TI, and may help identify higher risk infants. There was no association between the number of TI attempts and death and/or SNI. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Debay, Anthony Patel, Sharina Wintermark, Pia Claveau, Martine Olivier, Fran çois Beltempo, Marc Tags: Original Article Source Type: research

A Model to Predict Vaginal Delivery and Maternal and Neonatal Morbidity in Low-Risk Nulliparous Patients at Term
This study aimed to develop and validate a model to predict the probability of vaginal delivery (VD) in low-risk term nulliparous patients, and to determine whether it can predict the risk of severe maternal and neonatal morbidity. Methods Secondary analysis of an obstetric cohort of patients and their neonates born in 25 hospitals across the United States (n = 115,502). Trained and certified research personnel abstracted the maternal and neonatal records. Nulliparous patients with singleton, nonanomalous vertex fetuses, admitted with an intent for VD ≥ 37 weeks were included in this ...
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Costantine, Maged M. Sandoval, Grecio Grobman, William A. Bailit, Jennifer L. Reddy, Uma M. Wapner, Ronald J. Varner, Michael W. Thorp, John M. Caritis, Steve N. Prasad, Mona Tita, Alan T.N. Sorokin, Yoram Rouse, Dwight J. Blackwell, Sean C. Tolosa, Jorge Tags: Original Article Source Type: research

The Changing Landscape in Pediatric Hospitals: A Multicenter Study of How Pediatric Chronic Critical Illness Impacts NICU Throughput
Am J Perinatol DOI: 10.1055/s-0040-1718572 Objective Pediatric inpatient bed availability is increasingly constrained by the prolonged hospitalizations of children with medical complexity. The sickest of these patients are chronic critically ill and often have protracted intensive care unit (ICU) stays. Numbers and characteristics of infants with chronic critical illness are unclear, which undermines resource planning in ICU's and general pediatric wards. The goal of this study was to describe infants with chronic critical illness at six academic institutions in the United States. Study Design Infants admit...
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Boss, Renee D. Henderson, Carrie M. Weiss, Elliott M. Falck, Alison Madrigal, Vanessa Shapiro, Miriam C. Williams, Erin P. Donohue, Pamela K. Tags: Original Article Source Type: research

Noninvasive High-Frequency Oscillatory Ventilation: A Retrospective Chart Review
This study aimed to review the feasibility of nasal high-frequency oscillatory ventilation (NHFOV) in preventing reintubation in preterm infants Study Design This is a retrospective cohort study of all premature newborn infants placed on NHFOV in a single-center neonatal intensive care unit. Results Twenty-seven patients (birth weight: 765 ± 186 g, gestational age: 28 ± 2 weeks) were commenced on NHFOV on 32 occasions. NHFOV was used immediately postextubation as the primary mode of noninvasive ventilation (NIV; prophylaxis) in 10 of 32 occasions and as &ldqu...
Source: American Journal of Perinatology - October 19, 2020 Category: Perinatology & Neonatology Authors: Ali, Yaser A.H. Seshia, Mary M. Ali, Ebtihal Alvaro, Ruben Tags: Original Article Source Type: research

Maternal-Neonatal Dyad Outcomes of Maternal COVID-19 Requiring Extracorporeal Membrane Support: A Case Series
Conclusion This case series highlights that ECMO is a feasible treatment in the pregnant woman with severe COVID-19 and that delivery can be performed safely on ECMO with no additional risk to the fetus. While ECMO carries its natural risks, it should be considered a viable option during pregnancy and the postpartum period. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 17, 2020 Category: Perinatology & Neonatology Authors: Douglass, K. Marie Strobel, Katie M. Richley, Michael Mok, Thalia de St Maurice, Annabelle Fajardo, Viviana Young, Andrew T. Rao, Rashmi Lee, Lydia Benharash, Peyman Chu, Alison Afshar, Yalda Tags: Original Article Source Type: research

Insulin Dosing, Glycemic Control, and Perinatal Outcomes in Pregnancies Complicated by Type-2 Diabetes
This study aimed to evaluate the prevalence of severe insulin resistance (insulin requirements ≥2 units/kg) at delivery and the relationship between severe insulin resistance, glycemic control, and adverse perinatal outcomes in pregnant women with type-2 diabetes mellitus. Study Design This is a retrospective cohort study of women with type-2 diabetes mellitus who delivered between January 2015 and December 2017 at a tertiary academic medical center. Maternal demographic information, self-monitored blood sugars, and insulin doses were abstracted from the medical record. Multivariable logistic regression was used...
Source: American Journal of Perinatology - October 16, 2020 Category: Perinatology & Neonatology Authors: Nadeau, Hugh C.G. Maxted, Marta E. Madhavan, Devika Pierce, Stephanie L. Feghali, Maisa Scifres, Christina Tags: SMFM Fellowship Series Article Source Type: research

Timing of Repeat Cesarean Delivery for Women with a Prior Classical Incision
Conclusion Delivery at 37 weeks for women with a history of prior CCD is associated with a decrease in adverse neonatal outcomes, compared with delivery at 36 weeks. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Ma'ayeh, Marwan Haight, Paulina Oliver, Emily A. Landon, Mark B. Rood, Kara M. Tags: SMFM Fellowship Series Article Source Type: research

A Growing Dilemma: Antenatal Corticosteroids and Long-Term Consequences
Conclusion Continued research is needed to identify sufficient safety data, both short term and long term. Caution in the use of antenatal corticosteroids should be exercised while additional work is undertaken to optimize dosing strategies and better identify women at risk of preterm birth prior to administration of antenatal corticosteroids. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Asztalos, Elizabeth V. Murphy, Kellie E. Matthews, Stephen G. Tags: Review Article Source Type: research

The Impact of Obesity on the Management and Outcomes of Postpartum Hemorrhage
Am J Perinatol DOI: 10.1055/s-0040-1718574 Objective The study aimed to evaluate the impact of obesity on the management and outcomes of postpartum hemorrhage. Study Design We conducted a retrospective cohort study of women who delivered at a tertiary care center between February 1, 2013 and January 31, 2014 and experienced a postpartum hemorrhage. Charts were reviewed for clinical and sociodemographic data, and women were excluded if the medical record was incomplete. Hemorrhage-related severe morbidity indicators included blood transfusion, shock, renal failure, transfusion-related lung injury, cardiac ar...
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Polic, Aleksandra Curry, Tierra L. Louis, Judette M. Tags: Original Article Source Type: research

Therapeutic Hypothermia in Transport Permits Earlier Treatment Regardless of Transfer Distance
In this study, we sought to determine if the initiation of servo-controlled TH in transport allowed neonates to reach target temperature earlier, without a significant delay in the transfer process, for both local and long-distance transport. Study Design In this single-center cohort study of neonates referred to a level IV neonatal intensive care unit for TH, we determined the chronologic age at which target temperature was reached for those cooled in transport. Short-term outcome measures were assessed, including survival, incidence of electrographic seizures, discharge feeding method, and length of hospitalizati...
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Leon, Rachel L. Krause, Katherine E. Sides, Rebecca S. Koch, Mary Beth Trautman, Michael S. Mietzsch, Ulrike Tags: Original Article Source Type: research

Comparison of Three Nursing Workload Assessment Tools in the Neonatal Intensive Care Unit and Their Association with Outcomes of Very Preterm Infants
Am J Perinatol DOI: 10.1055/s-0040-1718571 Objective Nursing workload assessment tools are widely used to determine nurse staffing requirements in the neonatal intensive care unit (NICU). We aimed to compare three existing workload assessment tools and assess their association with mortality or morbidity among very preterm infants. Study Design Single-center retrospective cohort study of infants born
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Lemieux-Bourque, Charlotte Piedboeuf, Bruno Gignac, Simon Taylor-Ducharme, Sharon Julien, Anne-Sophie Beltempo, Marc Tags: Original Article Source Type: research

Inflammatory Proteins in the Amniotic Fluid, Plasma, and Cervicovaginal Fluid for the Prediction of Intra-amniotic Infection/Inflammation and Imminent Preterm Birth in Preterm Labor
Conclusion Noninvasive models based on CVF cytokine/chemokine levels and widely used noninvasive parameters (especially CRP) act as good indicators for predicting the risk of IAI and imminent SPTD in women with PTL. Evaluation of cytokine/chemokine levels in plasma samples did not add valuable information regarding the two outcome measures in the PTL setting. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 14, 2020 Category: Perinatology & Neonatology Authors: Kim, Su A. Park, Kyo H. Lee, Seung M. Kim, Yu M. Hong, Subeen Tags: Original Article Source Type: research

Blood Biomarkers and 6- to 7-Year Childhood Outcomes Following Neonatal Encephalopathy
This study aimed to profile the cytokine/chemokine response from day 0 to 7 in infants (≥36 weeks of gestational age) with neonatal encephalopathy (NE) and to explore the association with long-term outcomes. Study Design This was a secondary study of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network randomized controlled trial of whole body hypothermia for NE. Eligible infants with moderate–severe NE were randomized to cooling or normothermia. Blood spots were collected on days 0 to 1, 2 to 4, and 6 to 7. Twenty-four cytokines/chemokines w...
Source: American Journal of Perinatology - October 10, 2020 Category: Perinatology & Neonatology Authors: Pappas, Athina Shankaran, Seetha McDonald, Scott A. Carlo, Waldemar A. Laptook, Abbot R. Tyson, Jon E. Das, Abhik Skogstrand, Kristin Hougaard, David M. Higgins, Rosemary D. Tags: Original Article Source Type: research

Addressing Disparities in Prenatal Care via Telehealth During COVID-19: Prenatal Satisfaction Survey in East Harlem
Conclusion While there were lower scores in patient satisfaction for televisits in every category, there were no clinically significant differences since all medians were in the “satisfied” range. By lowering patient exposure to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), especially for those at risk for reduced access to care and higher COVID-19 cases by zip code, telehealth allowed for appropriate continuation of satisfactory prenatal care with no impact on patient perceived satisfaction of care. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, US...
Source: American Journal of Perinatology - October 10, 2020 Category: Perinatology & Neonatology Authors: Futterman, Itamar Rosenfeld, Emily Toaff, Miriam Boucher, Taryn Golden-Espinal, Samantha Evans, Kamilah Clare, Camille A. Tags: Original Article Source Type: research

The Use of Sequential Integrated Screening to Stratify Risk in Monochorionic-Diamniotic Twin Pregnancies
This study aimed to identify differences in sequential integrated screening and early ultrasound markers in monochorionic/diamniotic (MC/DA) pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and unequal placental sharing (UPS). Study Design Retrospective cohort study of MC/DA pregnancies evaluated between January 2012 and July 2017 at the University of California San Francisco. MC/DA pregnancies with ultrasound surveillance up to 26 weeks who participated in the California Prenatal Screening Program (CPSP) were included. Pregnancies with structural or genetic anomalies were excluded. UPS was defin...
Source: American Journal of Perinatology - October 8, 2020 Category: Perinatology & Neonatology Authors: Miller, Edward Blat, Cinthia Gosnell, Kristen Gonzalez, Juan Ghaffari, Neda Tags: SMFM Fellowship Series Article Source Type: research

Effect of a Nonoptimal Cervicovaginal Microbiota and Psychosocial Stress on Recurrent Spontaneous Preterm Birth
Conclusion Among a predominantly non-Hispanic Black cohort of women with a prior spontaneous preterm birth, a nonoptimal cervicovaginal microbiota is associated with increased odds of recurrent spontaneous preterm birth. Adjustment for perceived stress may amplify associations between CST IV and recurrent spontaneous preterm birth. Identification of modifiable social or behavioral factors may unveil novel nonpharmacologic interventions to decrease recurrent spontaneous preterm birth among women with underlying biologic risk. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.A...
Source: American Journal of Perinatology - October 8, 2020 Category: Perinatology & Neonatology Authors: Gerson, Kristin D. Mccarthy, Clare Ravel, Jacques Elovitz, Michal A. Burris, Heather H. Tags: SMFM Fellowship Series Article Source Type: research

Racial/Ethnic Differences in Prenatal Supplement and Medication Use in Low-Risk Pregnant Women
This study aimed to describe the overall quantity and type of supplements and medications used during pregnancy in a low-risk cohort and to examine any racial/ethnic differences in intake. Study Design We used data from 2,164 racially/ethnically diverse, nonobese, and low-risk pregnant women participating without pre-pregnancy chronic conditions in a prospective cohort study at 12 sites across the United States. Medication data were self-reported as free text in enrollment, follow-up visit questionnaires, and abstracted from medical records at delivery. Supplements and medications data were mapped to their active i...
Source: American Journal of Perinatology - October 8, 2020 Category: Perinatology & Neonatology Authors: Vafai, Yassaman Yeung, Edwina H. Sundaram, Rajeshwari Smarr, Melissa M. Gerlanc, Nicole Grobman, William A. Skupski, Daniel Chien, Edward K. Hinkle, Stefanie N. Newman, Roger B. Wing, Deborah A. Ranzini, Angela C. Sciscione, Anthony Grewal, Jagteshwar Zha Tags: Original Article Source Type: research

Suspected or Proven Early-Onset Sepsis and NLR, PLR, and MPV Parameters in Neonates with Born through MSAF
Conclusion MSAF might be a risk factor for early-onset sepsis in neonates. However, MPV, NLR, PLR, and MLR values cannot be helpful for the detection of suspected or proven early-onset neonatal sepsis in born MSAF neonates. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - October 8, 2020 Category: Perinatology & Neonatology Authors: Ta şkın, Ahmet Can, Emrah Hamil çıkan, Şahin Tags: Original Article Source Type: research

Rates of Cesarean Conversion and Associated Predictors and Outcomes in Planned Vaginal Twin Deliveries
Am J Perinatol DOI: 10.1055/s-0040-1718368 Objective Twin vaginal deliveries (VDs) are often performed in the operating room (OR) given the risk of conversion to cesarean delivery (CD) for the aftercoming twin. We aim to investigate the rates of conversion to CD for planned twin VDs and identify predictors and outcomes of conversion. Study Design A retrospective cohort study of all women who underwent a planned twin VD at two large academic medical centers over 4 years. Demographic and outcome data were chart abstracted. Various statistical tests were used to evaluate the influence of perinatal variables on...
Source: American Journal of Perinatology - October 8, 2020 Category: Perinatology & Neonatology Authors: Mei, Jenny Y. Mu ñoz, Hector E. Kim, Jessica S. Szlachta-McGinn, Alec Blat, Cinthia Rao, Rashmi Han, Christina S. Irani, Roxanna A. Afshar, Yalda Tags: Original Article Source Type: research

The Association of Cesarean Skin Incision Length and Postoperative Wound Complications
Conclusion Increasing skin incision length is not independently associated with an increased risk of postoperative wound complications. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - September 30, 2020 Category: Perinatology & Neonatology Authors: Subramaniam, Akila Jauk, Victoria Saade, George Boggess, Kim Longo, Sheri Clark, Erin A.S. Esplin, Sean Cleary, Kirsten Wapner, Ron Letson, Kellett Owens, Michelle Y. Blackwell, Sean Szychowski, Jeff M. Andrews, William W. Tita, Alan T. Tags: Original Article Source Type: research