Simulation in Neonatal-Perinatal Medicine Fellowship Programs
Conclusion While the majority of fellowship programs use simulation, the time and scope of fellow exposure to simulation experiences are limited. The creation of a standardized simulation curriculum may address identified barriers to simulation. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - July 15, 2019 Category: Perinatology & Neonatology Authors: Sawyer, Taylor Stavroudis, Theodora A. Ades, Anne Dadiz, Rita Dammann, Christiane E. L. Halamek, Louis P. Moussa, Ahmed Soghier, Lamia Gupta, Arika Aliaga, Sofia Umoren, Rachel French, Heather Tags: Original Article Source Type: research

Antibiotic Treatments and Patient Outcomes in Necrotizing Enterocolitis
Amer J Perinatol DOI: 10.1055/s-0039-1693429 Objective To examine the impact of different antibiotic treatments on necrotizing enterocolitis (NEC) outcomes. Study Design Patient outcomes, including total parenteral nutrition and hospitalization durations, abdominal surgeries, intestinal strictures, and mortality data, were analyzed and compared by various antibiotic groups and treatment durations for 160 NEC patients managed at the Women and Children's Hospital of Buffalo between 2008 and 2016. Results Fourteen different antibiotics were used for NEC, most commonly ampicillin, gentamicin, and metron...
Source: American Journal of Perinatology - July 15, 2019 Category: Perinatology & Neonatology Authors: Murphy, Catherine Nair, Jayasree Wrotniak, Brian Polischuk, Emily Islam, Shamim Tags: Original Article Source Type: research

Factors Associated with Timeliness of Surgical Repair among Infants with Myelomeningocele: California Perinatal Quality Care Collaborative, 2006 to 2011
Conclusion There was a significant disparity in myelomenigocele repair based on medical care payer. Families and hospitals should work together for timely repair in hospitals having specialized multidisciplinary teams. Findings from the study can be used to follow best clinical practices for myelomeningocele repair. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - July 15, 2019 Category: Perinatology & Neonatology Authors: Kancherla, Vijaya Ma, Chen Grant, Gerald Lee, Henry C. Shaw, Gary M. Hintz, Susan R. Carmichael, Suzan L. Tags: Original Article Source Type: research

Placental Findings in Postpartum Preeclampsia: A Comparative Retrospective Study
The objective was to describe placental findings in postpartum preeclampsia. Study Design This is a case–control study, comparing the placental histologic findings in four groups of 30 patients with postpartum preeclampsia, early-onset preeclampsia, late-onset preeclampsia, and normotensive controls. Results Placentas of postpartum preeclampsia had a mean placental weight not different from that of late-onset preeclampsia at a similar gestational age (479.0 ± 152.7 vs. 521.3 ± 144.1 g, p = 0.07); they showed a higher rate of acute deciduit...
Source: American Journal of Perinatology - July 2, 2019 Category: Perinatology & Neonatology Authors: Ditisheim, Agn ès Sibai, Baha Tatevian, Nina Tags: Original Article Source Type: research

Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization
Conclusion Probiotics do not affect STB levels in the first 24 hours of life or duration of phototherapy in neonates with jaundice caused by blood group incompatibility. The effect of probiotic supplementation by reducing enterohepatic circulation occurs at 36 hours of life in newborns with isoimmunization. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 26, 2019 Category: Perinatology & Neonatology Authors: Mutlu, Mehmet Aslan, Yakup Kader, Şebnem Akt ürk Acar, Filiz Tags: Original Article Source Type: research

Exploration of the Vaginal and Gut Microbiome in African American Women by Body Mass Index, Class of Obesity, and Gestational Weight Gain: A Pilot Study
Conclusion These results contribute new evidence showing that GWG in combination with obesity and obesity class is associated with an altered distal gut and vaginal composition early in pregnancy among AA women. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 26, 2019 Category: Perinatology & Neonatology Authors: Faucher, Mary Ann Greathouse, Kristen Leigh Hastings-Tolsma, Marie Padgett, Robert Noah Sakovich, Kimberly Choudhury, Ankan Sheikh, Aadil Ajami, Nadim J. Petrosino, Joseph F. Tags: Original Article Source Type: research

Chorioamnionitis and Infectious Complications after Vaginal Delivery
Amer J Perinatol DOI: 10.1055/s-0039-1692718 Objective To estimate the incidence of and define risk factors for postpartum infectious complications after vaginal birth after cesarean (VBAC) complicated by chorioamnionitis. Study Design A secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Cesarean Registry was performed. The primary outcome was a composite of postpartum infection: endometritis, sepsis, pelvic abscess, urinary tract infection, necrotizing fasciitis, and septic pelvic thrombophlebitis. Peripartum predictors wer...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: DeNoble, Anna E. Heine, R. Phillips Dotters-Katz, Sarah K. Tags: SMFM Fellowship Series Article Source Type: research

Association of Caloric Intake, Protein Intake, and Enteral Feeding Initiation with Weight Gain in Infants Born 32 to 34 Weeks' Gestation
Conclusion Enteral feeds ≤12 hours after delivery is associated with lower %WL at 7 days among preterm infants 32 to 34 weeks' GA. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Talbo, Meryem Khadija Besner, Marie-Eve Plourde, Hugues Claveau, Martine Beltempo, Marc Tags: Original Article Source Type: research

Self-Reported Alcohol, Tobacco, and Marijuana Use in Pregnant Women with Depressive Symptomatology
Conclusion Depressive symptomatology was associated with an increase in self-reported the use of alcohol, tobacco, and marijuana during pregnancy. These data reveal the importance of targeted screening of pregnant women with depressive symptomatology for substance use. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Hyer, Jennifer Ulrickson, Claire Yerelian, Elise Metz, Torri D. Allshouse, Amanda A. Hoffman, M. Camille Tags: Original Article Source Type: research

Resident Education in Complex Obstetric Procedures: Are We Adequately Preparing Tomorrow's Obstetricians?
Conclusion Despite ACGME recommendations, data suggest that many graduating residents may not be comfortable with these complex procedures. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Dotters-Katz, Sarah K. Gray, Beverly Heine, Robert Phillips Propst, Katie Tags: Original Article Source Type: research

Effects of Partially Hydrolyzed Formula on Severity and Outcomes of Neonatal Abstinence Syndrome
Conclusion Use of PHF failed to impact short-term outcomes in infants treated for NAS including maximum MSO4 dose, duration of MSO4 treatment, and length of hospital stay. A prospective randomized controlled trial may be indicated to confirm this finding. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Alsaleem, Mahdi Berkelhamer, Sara K. Wilding, Gregory E. Miller, Lorin M. Reynolds, Anne Marie Tags: Original Article Source Type: research

Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia
Conclusion Our case shows how a single low dose of zoledronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional treatment while minimizing the risk of hypocalcemic rebounds. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Militello, Maria Angela Re, Maria Paola Vitaliti, Giuliana Finazzo, Francesca Manzoni, Paolo Vitaliti, Salvino Marcello Tags: Original Article Source Type: research

Fungal Ecology in a Tertiary Neonatal Intensive Care Unit after 16 Years of Routine Fluconazole Prophylaxis: No Emergence of Native Fluconazole-Resistant Strains
Amer J Perinatol 2019; 36: S126-S133 DOI: 10.1055/s-0039-1691808 Objective We analyzed the fungal ecology of a neonatal intensive care unit (NICU) over a period of 20 consecutive years following the introduction of routine fluconazole prophylaxis for all very low birth weight (VLBW;
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Luparia, Martina Landi, Francesca Mesini, Alessio Militello, Maria Angela Galletto, Paolo Farina, Daniele Castagnola, Elio Manzoni, Paolo Tags: Original Article Source Type: research

Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials
Amer J Perinatol 2019; 36: S120-S125 DOI: 10.1055/s-0039-1691807 Background Lactoferrin is the major antimicrobial protein in human milk. In our randomized controlled trial (RCT) of bovine lactoferrin (BLF) supplementation in preterm neonates, BLF reduced late-onset sepsis (LOS). Mother's own milk (MM) contains higher concentrations of lactoferrin than donor milk or formula, but whether BLF is more effective in infants who receive formula or donor milk is uncertain. Aim To evaluate the incidence of LOS in preterm infants fed MM and in those fed formula and/or donor milk. Study Design This is a (A) p...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Manzoni, Paolo Militello, Maria Angela Rizzollo, Stefano Tavella, Elena Messina, Alessandro Pieretto, Marta Boano, Elena Carlino, Martina Tognato, Eleonora Spola, Roberta Perona, Anna Maule, Milena Maria Garc ía Sánchez, Ruben Meyer, Mike Stolfi, Ilaria Tags: Original Article Source Type: research

Pulmonary Recruitment Strategy in Preterm Neonates   <  29 Weeks of Gestational Age to Reduce the Need for Intubation in the Delivery Room
Amer J Perinatol 2019; 36: S115-S119 DOI: 10.1055/s-0039-1692134 Background The application of noninvasive ventilation (NIV) modalities from birth in the delivery room (DR) during fetal–neonatal transition reduces the need for invasive mechanical ventilation, mortality, and bronchopulmonary dysplasia (BPD). The use of a RAM nasal cannula (RAM NC) in the DR for resuscitation results in less need for intubation, chest compressions, and epinephrine administration when compared with using a face mask for PPV in the DR. Objective To evaluate the need for endotracheal intubation in the DR among extremely lo...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Petrillo, Flavia Valenzano, Luigia Franco, Caterina Cal ò, Giovanna Dentico, Domenico Manzoni, Paolo D'Amato, Gabriele Del Vecchio, Antonio Tags: Original Article Source Type: research

Effects of Sustained Inflation or Positive Pressure Ventilation on the Release of Adrenomedullin in Preterm Infants with Respiratory Failure at Birth
Conclusion The present data, showing the absence of any differences in AM blood and urine levels, suggest that PPV and SI are both feasible and equally effective DR maneuvers. The findings open the way to further studies evaluating the effects of PPV and SI on short-/long-term respiratory outcome through biomarkers assessment. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: La Verde, Azzurra Franchini, Simone Lapergola, Giuseppe Lista, Gianluca Barbagallo, Ignazio Livolti, Giovanni Gazzolo, Diego Tags: Original Article Source Type: research

Neonatal Encephalopathy and SIADH during RSV Infection
Conclusion In presence of neurological involvement during RSV-infection must be taken in consideration to performing instrumental test to detect cerebral edema. In addiction could be useful to dose inflammatory cytokines, and to consider the immune-modulatory therapy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Picone, Simonetta Mond ì, Vito Di Palma, Federico Martini, Ludovica Paolillo, Piermichele Tags: Original Article Source Type: research

Lung Ultrasound: A New Tool in the Management of Congenital Lung Malformation
Conclusion We described the first case series of neonates affected by complex pulmonary malformations, assessed by LUS. In our experience, LUS was safe and effective for the diagnosis with high degree of consistency with CT scan findings. We suggest that LUS might be an important diagnostic method for lung malformations in newborns and a useful technique for their follow-up and late management, avoiding multiple exposures to radiations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Quercia, Michele Panza, Raffaella Calderoni, Grazia Di Mauro, Antonio Laforgia, Nicola Tags: Original Article Source Type: research

Pregnancy after Endometriosis: Maternal and Neonatal Outcomes according to the Location of the Disease
Amer J Perinatol 2019; 36: S91-S98 DOI: 10.1055/s-0039-1692130 Objective To systematically evaluate pregnancy and labor course, obstetrical complications, and maternal and neonatal outcomes in women with endometriosis, stratifying according to the specific location of the disease. Study Design We retrospectively analyzed our prospectively maintained obstetrical database from January 2011 to August 2014 to identify all women with a previous histological diagnosis of endometriosis who delivered at our institution (cases). We divided the cases according to the specific location of the disease (deep infiltratin...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Uccella, Stefano Manzoni, Paolo Cromi, Antonella Marconi, Nicola Gisone, Baldo Miraglia, Andrea Biasoli, Sara Zorzato, Pier Carlo Ferrari, Stefania Lanzo, Gabriele Bertoli, Francesca Capozzi, Vito Andrea Gallina, Davide Agosti, Massimo Ghezzi, Fabio Tags: Original Article Source Type: research

Impact of Sport Activity and Physical Exercise on Obstetrical and Perineal Outcomes at Delivery: A Prospective Study
Conclusion Perineal outcomes are not influenced by the intensity of sport activity performed before/during pregnancy. Continuous sports during pregnancy that specifically train the perineal muscles are associated with a lower rate of episiotomy and perineal lacerations ≥ 2nd degree. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Uccella, Stefano Manzoni, Paolo Marconi, Nicola Toscani, Carlotta Biasoli, Sara Cianci, Stefano Franchi, Massimo Sorice, Paola Bertoli, Francesca Zorzato, Pier Carlo Gallina, Davide Ghezzi, Fabio Serati, Maurizio Tags: Original Article Source Type: research

Restricted Palivizumab Recommendations and the Impact on RSV Hospitalizations among Infants Born at   >  29 Weeks of Gestational Age: An Italian Multicenter Study
Conclusion Restricting eligibility for palivizumab reimbursement led to a significant increase in RSVH but had no impact on hospitalizations for other respiratory viruses. Future decisions on palivizumab prescription and coverage rules should be driven by a careful assessment of the cost-benefit ratio. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Priante, Elena Tavella, Elena Girardi, Elisa Militello, Maria Angela Mardegan, Veronica Maule, Milena M. Dall'Agnola, Alberto Baraldi, Eugenio Manzoni, Paolo Tags: Original Article Source Type: research

Neonatal Marfan Syndrome
Conclusion Early diagnosis of this rare condition is critical for adequate treatment and specific follow-up, and impacts significantly on prognosis. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Tognato, Eleonora Perona, Anna Aronica, Angela Bertola, Antonella Cimminelli, Lina De Vecchi, Simona Eshraghy, Mohammad Reza Loperfido, Bruna Vivenza, Claudia Manzoni, Paolo Tags: Original Article Source Type: research

Stem Cells for Extreme Prematurity
Amer J Perinatol 2019; 36: S68-S73 DOI: 10.1055/s-0039-1691774Regenerative medicine is a bourgeoning field promising to repair damaged organs and thus has created high hopes in neonatology to curb some of the complications due to extreme preterm birth. Extensive laboratory investigations over the past 15 years have tried to harness the regenerative potential of a variety of (stem) cell-based therapies. Most preclinical studies have focused on experimental neonatal lung and brain injury. These promising results lead to the initiation of phase I clinical trials for chronic lung disease of prematurity and severe intraventricu...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Th ébaud, Bernard Tags: Review Article Source Type: research

Recent Trends in RSV Immunoprophylaxis: Clinical Implications for the Infant
Amer J Perinatol 2019; 36: S63-S67 DOI: 10.1055/s-0039-1691803Respiratory syncytial virus (RSV) remains the leading cause for hospitalizations in infants worldwide, resulting in significant health and financial burden. Since 1998, the humanized monoclonal antibody palivizumab remains the only available option licensed for the prevention of severe RSV disease in high-risk children, namely premature infants and those with chronic lung disease and congenital heart disease. In 2014, the American Academy of Pediatrics modified the recommendations on the use of RSV prophylaxis in these high-risk children, and limited its use to ...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Acero-Bedoya, Santiago Wozniak, Phillip S. S ánchez, Pablo J. Ramilo, Octavio Mejias, Asuncion Tags: Review Article Source Type: research

Update on Postnatal Corticosteroids to Prevent or Treat Bronchopulmonary Dysplasia
Amer J Perinatol 2019; 36: S58-S62 DOI: 10.1055/s-0039-1691802Bronchopulmonary dysplasia (BPD) is a major complication of premature birth that significantly affects mortality and long-term morbidity in numerous immature infants. Corticosteroids are particularly suitable for treating BPD, as lung inflammation is central to its pathogenesis. Corticosteroids have considerable, fast beneficial effects on lung function in premature infants with lung disease, but they are also associated with several serious adverse effects, which may have a detrimental impact on long-term outcome. Dexamethasone is the most often used corticoste...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Filippone, Marco Nardo, Daniel Bonadies, Luca Salvadori, Sabrina Baraldi, Eugenio Tags: Review Article Source Type: research

Community-Acquired Pneumonia in Children: Myths and Facts
Amer J Perinatol 2019; 36: S54-S57 DOI: 10.1055/s-0039-1691801Community-acquired pneumonia (CAP) is the leading cause of death in children 
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Yun, Ki Wook Wallihan, Rebecca Juergensen, Alexis Mejias, Asuncion Ramilo, Octavio Tags: Review Article Source Type: research

The ReSVinet Score for Bronchiolitis: A Scale for All Seasons
Amer J Perinatol 2019; 36: S48-S53 DOI: 10.1055/s-0039-1691800The ReSVinet Scale is a clinical score for the assessment of respiratory difficulty in infancy. Our aim was to provide an update on the characteristics that make this tool different to any other. We descriptively compared the characteristics of the ReSVinet Scale with other options that can be found in the current literature or mobile apps stores. The ReSVinet Scale has been devised for its use regardless of the age of the child, entity causing respiratory symptoms, and setting. To this date, it is the only pediatric respiratory scale for acute respiratory distr...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Justicia-Grande, Antonio Jos é Martin ón-Torres, Federico Tags: Review Article Source Type: research

Post-trial Access in Maternal Vaccine Trials
Amer J Perinatol 2019; 36: S41-S47 DOI: 10.1055/s-0039-1691799Provisions for post-trial access (PTA) of the experimental intervention are required before the start of a clinical trial. Although there has been ample attention for PTA in the context of preventive vaccine research, discussions on PTA barely include maternal vaccine trials in which mother–infant pairs are exposed to the intervention. In maternal vaccination trials, specific PTA arrangements are required because pregnancy is transient and PTA may apply to the next pregnancy or the child. In this article, we examine the application and adherence to PTA in ...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Van Roessel, I. M. A. A. Mazur, N. I. Shah, S. K. Bont, L. Van Der Graaf, R. Tags: Review Article Source Type: research

Updates in Red Blood Cell and Platelet Transfusions in Preterm Neonates
Amer J Perinatol 2019; 36: S37-S40 DOI: 10.1055/s-0039-1691775Anemia and thrombocytopenia occur frequently in preterm neonates and the majority of them require at least one blood transfusion during the first few weeks of life. However, there is no international consensus on optimal transfusion management neither for red blood cell nor for platelet transfusions, resulting in large worldwide variations in transfusion practices between neonatal intensive care units. In the past decade, several studies performed in adults, infants as well as neonates showed that restrictive transfusion guidelines are just as safe as liberal gu...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Lopriore, Enrico Tags: Review Article Source Type: research

State of the Art on Kidney Development: How Nephron Endowment at Birth Can Shape Our Susceptibility to Renal Dysfunction Later in Life
Amer J Perinatol 2019; 36: S33-S36 DOI: 10.1055/s-0039-1691798In the present article, we discuss the following topics: (1) the fetal programming of adult kidney diseases and (2) the role of neonatologists in the regenerative renal medicine, based on the activation of resident renal SC. Here, we report the most important steps of our collaboration between neonatologists, nephrologists, and pathologists. Nephrologists should be more interested in clinical data regarding the first month of life in the womb of their adult patients, being particularly focused on birth weight and on the weeks of gestation at birth, without forge...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Fanos, Vassilios Gerosa, Clara Loddo, Cristina Faa, Gavino Tags: Review Article Source Type: research

Neonatal Resuscitation: State of the Art
The objective of this study is to revise novel evidence and forthcoming clinical trials that focused on the gap of knowledge raised during the 2015 guidelines for neonatal resuscitation. Literature search on main topics on neonatal resuscitation published after 2015 edition of the consensus on science and guidelines was performed. Only relevant articles (mainly randomized controlled trials [RCTs] and meta-analyses) were included and presented as descriptive review. In the past years, new RCTs and/or meta-analyses have become available on umbilical cord clamping and umbilical cord milking, oxygen concentrations to start res...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Trevisanuto, Daniele Galderisi, Alfonso Tags: Review Article Source Type: research

Updates in Congenital Heart Disease: Can Outcomes Improve?
This article will discuss the recent impact of pulse oximetry screening for critical CHD, describe the contributions of advanced cardiac imaging in the neonate with CHD, and highlight the growing importance of quality improvement and safety programs in the cardiac intensive care unit. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Martin, Gerard R. Cross, Russell R. Hom, Lisa A. Klugman, Darren Tags: Review Article Source Type: research

Neonatal Therapeutics: Considerations for Dosing
Amer J Perinatol 2019; 36: S18-S21 DOI: 10.1055/s-0039-1691772Neonates are a uniquely vulnerable population, compromised by immature physiology and critical illness if born premature. Furthermore, neonates have frequent exposures to drugs that lack adequate data on safety, efficacy, and appropriate dosing in this population. Key physiologic differences between neonates and older children and adults affect drug absorption, distribution, metabolism, and elimination. Adequate understanding and consideration of these differences is essential to ensure optimal dosing of therapeutic agents in this vulnerable population. Moreover...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Zimmerman, Kanecia O. Benjamin, Daniel K. Becker, Mara L. Tags: Review Article Source Type: research

New Developments in Respiratory Support for Preterm Infants
Amer J Perinatol 2019; 36: S13-S17 DOI: 10.1055/s-0039-1691817The evolution of neonatal respiratory support has been one of the cornerstones for the advancements in neonatal–perinatal medicine, allowing survival of infants previously considered not viable. There is an increasing focus on developing strategies which are not only lifesaving but also minimize lung and other organ systems injury, thereby reducing long-term morbidities. Respiratory support immediately after birth is an area that had lagged behind in terms of evidence base and technological advancements until recently. Some of these advancements include us...
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Jain, Deepak Bancalari, Eduardo Tags: Review Article Source Type: research

Advocacy in Neonatology
Amer J Perinatol 2019; 36: S9-S12 DOI: 10.1055/s-0039-1691776 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Fanaroff, Avroy A. Fanaroff, Jonathan M. Tags: Editorial Source Type: research

The Zika Virus Epidemic Four Years After: Where are We?
Amer J Perinatol 2019; 36: S4-S8 DOI: 10.1055/s-0039-1691769 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: S áfadi, Marco Aurélio Palazzi Almeida, Flavia J. Tags: Editorial Source Type: research

The Amazing Premature Lung
Amer J Perinatol 2019; 36: S1-S3 DOI: 10.1055/s-0039-1691768 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Authors: Jobe, Alan H. Tags: Editorial Source Type: research

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American Journal of Perinatology 2019; S 02 Article in Thieme eJournals: Table of contents  |  Congress (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 25, 2019 Category: Perinatology & Neonatology Source Type: research

The Impact of Fetal Anomalies on Contemporary Labor Patterns
Amer J Perinatol DOI: 10.1055/s-0039-1691765 Objective To compare labor patterns in pregnancies affected by fetal anomalies to low-risk singletons. Study Design Labor data from the Consortium on Safe Labor, a multicenter retrospective study from 19 U.S. hospitals, including 98,674 low-risk singletons compared with 6,343 pregnancies with fetal anomalies were analyzed. Repeated-measures analysis constructed mean labor curves by parity, gestational age, and presence of fetal anomaly in women who reached full dilation. Interval-censored regression analysis adjusted for covariables was used to determine the medi...
Source: American Journal of Perinatology - June 14, 2019 Category: Perinatology & Neonatology Authors: McCormick, Anna C. McIntosh, Jennifer J. Gao, Weihua Hibbard, Judith U. Cruz, Meredith O. Tags: SMFM Fellowship Series Article Source Type: research

The Association between Travel Time and Prenatal Care Attendance
Amer J Perinatol DOI: 10.1055/s-0039-1692455 Objective To evaluate the association between a patient's travel time to clinic and her prenatal care attendance. Study Design We conducted a retrospective cohort study of women (≥18 years) who received prenatal care and delivered at North Carolina Women's Hospital between July 1, 2014, and June 30, 2016 (n = 2,808 women, 24,021 appointments). We queried demographic data from the electronic medical record and calculated travel time with ArcGIS. Multinomial logistic regression models estimated the association between travel time and attendance, ad...
Source: American Journal of Perinatology - June 12, 2019 Category: Perinatology & Neonatology Authors: Maldonado, Lauren Y. Fryer, Kimberly E. Tucker, Christine M. Stuebe, Alison M. Tags: Original Article Source Type: research

Therapeutic Plasma Exchange in Neonatal Septic Shock: A Retrospective Cohort Study
Amer J Perinatol DOI: 10.1055/s-0039-1692184 Objective To examine the use of therapeutic plasma exchange (TPE) as adjunctive therapy in neonatal septic shock. Study Design This retrospective cohort study was performed on a convenience sample of neonates in a quaternary children's hospital between January 2018 and February 2019. Results We identified three neonates with septic shock who received TPE. Two neonates had adenovirus sepsis, and one had group B streptococcal sepsis. All neonates were on extracorporeal life support (ECLS) when TPE was started. The median duration of TPE was 6 days (interqua...
Source: American Journal of Perinatology - June 8, 2019 Category: Perinatology & Neonatology Authors: Sawyer, Taylor Billimoria, Zeenia Handley, Sarah Smith, Kendra Yalon, Larissa Brogan, Thomas V. DiGeronimo, Robert Tags: Original Article Source Type: research

Outcome and Feasibility after Seven Years of Therapeutic Hypothermia in Southern Brazil
Conclusion Mortality and adverse events were similar to those described in large randomized controlled trials. TH is a safe and an effective method of neurologic protection in asphyxiated newborns in a developing country when performed adequately. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 6, 2019 Category: Perinatology & Neonatology Authors: Procianoy, Renato S. Corso, Andrea L. Schoenardie, Bruna O. de Oliveira, Georgia P. F. Longo, Maria G. Silveira, Rita C. Tags: Original Article Source Type: research

Anal Sphincter Injury Associated with Vaginal Twin Delivery
Conclusion Sphincter injury occurs at a lower rate in vaginal twin pregnancies than in singletons. No twin-specific risk factors were identified. Discussion of the risk of sphincter injury should form part of patient counseling with regard to the mode of delivery. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 6, 2019 Category: Perinatology & Neonatology Authors: O'Leary, Bobby D. Bholah, Tariq Kalisse, Tamara Hehir, Mark P. Geary, Michael P. Tags: Original Article Source Type: research

Physician Burnout among Members of the Society for Maternal-Fetal Medicine
Conclusion Physician burnout among the SMFM members is higher than has been reported in other specialties. While some of these factors are modifiable, further study into why women have higher rates of burnout needs to be performed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 6, 2019 Category: Perinatology & Neonatology Authors: Hughes, Francine Francis, Antonia P. Sciscione, Anthony C. Tags: Original Article Source Type: research

Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia
Conclusion VF distribution may contribute to the variation in PE phenotype. Adiponectin specifically may be a promising marker representing VFA. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 6, 2019 Category: Perinatology & Neonatology Authors: Chandrasekaran, Suchitra Barry, Darcy Melhorn, Susan Easterling, Thomas Gammill, Hilary Schur, Ellen Tags: Original Article Source Type: research

Management of Breech Presentation: A Comparison of Four National Evidence-Based Guidelines
Conclusion The differences among national guidelines point out the need for the adoption of an international consensus on the management of breech presentation. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 5, 2019 Category: Perinatology & Neonatology Authors: Tsakiridis, Ioannis Mamopoulos, Apostolos Athanasiadis, Apostolos Dagklis, Themistoklis Tags: Review Article Source Type: research

Length of Resuscitation for Severely Depressed Newborns
Conclusion Prolonged resuscitation of newborns is rare. In this cohort, 92% died or had severe neurodevelopmental disability. Infants with ROSC received 20 minutes of resuscitation. Infants with ROSC typically did not survive beyond 24 hours unless they survived to discharge. To increase the number of infants with ROSC, continuing resuscitation beyond 10 minutes may be reasonable. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 5, 2019 Category: Perinatology & Neonatology Authors: Zhang, Stephanie Q. Friedman, Hayley Strand, Marya L. Tags: Original Article Source Type: research

Association between Cervical Dysplasia and Adverse Pregnancy Outcomes
Conclusion Biopsy and/or colposcopy determined cervical dysplasia during pregnancy was not associated with pregnancy complications. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 5, 2019 Category: Perinatology & Neonatology Authors: Lantsman, Taliya Seagle, Brandon-Luke Yang, Junhua Margul, Daniel J. Thorne-Spencer, Jeanmarie Miller, Emily S. Kocherginsky, Masha Shahabi, Shohreh Tags: Original Article Source Type: research

Effects and Tolerability of Treprostinil in Neonates with Persistent Pulmonary Hypertension
Conclusion Treprostinil was well tolerated with satisfactory clinical response. Further studies are required to identify early responder subgroups. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - June 5, 2019 Category: Perinatology & Neonatology Authors: Jozefkowicz, Mariela Haag, Dora Fabiana Mazzucchelli, Mar ía Teresa Salgado, Gladys Fari ña, Diana Tags: Original Article Source Type: research

Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?
Amer J Perinatol DOI: 10.1055/s-0039-1692389 Objective We investigated the relationship of serum potassium (K+) and ionized calcium (iCa2+) levels with the persistence of ductus arteriosus. Study Design This retrospective cohort study included infants with birth weight 
Source: American Journal of Perinatology - June 5, 2019 Category: Perinatology & Neonatology Authors: Cakir, Ufuk Tayman, Cuneyt Buyuktiryaki, Mehmet Unsal, Handan Ozer Bekmez, Buse Tags: Original Article Source Type: research