Imaging-Based Risk Stratification for Recurrence Risk in Women with a History of Peripartum Cardiomyopathy
Conclusion Approximately one-third of women with PPCM developed recurrent PPCM in SSP. LVEF and GLS on prepregnancy echocardiography may predict the risk of recurrence. Additional studies evaluating risk for recurrence are required to better understand which women are the safest to consider SSP. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Ma'ayeh, Marwan Slivnick, Jeremy A. McKiever, Monique E. Garrett, Zachary D. Lim, Woobeen Cackovic, Michael Rood, Kara M. Bradley, Elisa A. Tags: SMFM Fellows Research Series Source Type: research

Glycemic Control and Aspirin Resistance in Patients Taking Low-Dose Aspirin for Pre-eclampsia Prevention
Am J Perinatol DOI: 10.1055/s-0041-1740250 Objectives To assess the association between aspirin and glycemic control in diabetic, pregnant patients, and the risk for aspirin resistance in those with poor glycemic control across gestation taking low-dose aspirin (LDA) for pre-eclampsia (PEC) prevention. Study Design We performed a secondary analysis of samples collected during the Maternal-Fetal Medicine Units trial of LDA for PEC prevention. A subset of insulin-controlled diabetic patient samples on placebo or 60 mg aspirin daily were evaluated. Glycosylated hemoglobin was measured at randomization, ...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Gee, Stephen E. Ma'ayeh, Marwan Kniss, Douglas Landon, Mark B. Gabbe, Steven G. Rood, Kara M. Tags: SMFM Fellows Research Series Source Type: research

Directly Measured Costs of Severe Maternal Morbidity Events during Delivery Admission Compared with Uncomplicated Deliveries
Conclusion SMM is associated with between 2.5- and 4-fold higher cost than uncomplicated deliveries. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Debbink, Michelle P. Metz, Torri D. Nelson, Richard E. Janes, Sophie E. Kroes, Alexandra Begaye, Lori J. Heuser, Cara C. Smid, Marcela C. Silver, Robert M. Varner, Michael W. Einerson, Brett D. Tags: SMFM Fellows Research Series Source Type: research

Incidence and Risk Factors for Postpartum Depression among Women with Preterm Prelabor Rupture of Membranes
Am J Perinatol DOI: 10.1055/s-0041-1740214 Objective Patients admitted for preterm prelabor rupture of membranes are more likely to have risk factors for postpartum depression, including preterm delivery, low-birthweight infants, and a stressful life event. However, there is a paucity of data characterizing the development of postpartum depression in this population. We aim to evaluate the incidence of and describe risk factors for postpartum depression among patients admitted with preterm prelabor rupture of membranes. Study Design This is a retrospective cohort study of patients admitted for preterm prela...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Zemtsov, Gregory Avram, Carmen M. Darling, Alice Dillon, Jacquelyn Wheeler, Sarahn Dotters-Katz, Sarah K. Tags: SMFM 2020 Source Type: research

Racial Disparities in the Rates of and Indications for Cesarean Delivery in California: Are They Changing Over Time?
Am J Perinatol DOI: 10.1055/s-0041-1740071 Objective: The aim of this study was to assess whether racial disparities in rates of and indications for cesarean delivery (CD) between non-Hispanic Black and non-Hispanic White birthing people in California changed from 2011 to 2017. Methods: This was a retrospective cohort study using a database of birth certificates linked to discharge records. Singleton term live births in nulliparous Black and White birthing people in California between 2011 and 2017 were included. Those with noncephalic presentation, placenta previa, and placenta accreta were excluded. CD ra...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Teal, E. Nicole Anudokem, Kelechi Baer, Rebecca J. Jelliffe-Pawlowski, Laura Mengesha, Biftu Tags: Review Article Source Type: research

Application of Electrocardiogram Localization during Peripherally Inserted Central Catheter Line Insertion into the Persistent Left Superior Vena Cava of Neonates
Conclusion The characteristic P wave changes on ECG during CI provide important clinical reference values for the application of the PICC technique under ECG localization in neonates with PLSVC. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Wu, Liyuan Wan, Lijia Peng, Min Cao, Tian Wang, Qin He, Xiaori Tags: Original Article Source Type: research

The Hassan Neonatal Morbidity Composite Scale and Neonatal Length of Stay —A Validation Study
The objective of this study was to validate the association between scores on the Hassan scale and neonatal intensive care unit (NICU) length of stay Study Design We conducted a cohort study of all infants born between 22 and 366/7 weeks' gestation and cared for within 419 neonatal units in the Pediatrix Medical Group between 1997 and 2018. Each infant was assigned a Hassan's score based on the number of neonatal morbidity events that occurred during the delivery hospitalization. The association between Hassan's scores and neonatal length of stay was evaluated using linear regression. Multivariable models were cons...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Patil, Avinash S. Grotegut, Chad A. Smith, P. Brian Clark, Reese H. Greenberg, Rachel G. Tags: Original Article Source Type: research

Changes in the Antenatal Utilization of High-Risk Obstetric Services and Stillbirth Rate during the COVID-19 Pandemic
Am J Perinatol DOI: 10.1055/s-0041-1740212 Objective The primary objective of this study was to evaluate coronavirus 2019 (COVID-19) pandemic–related changes in the antenatal utilization of high-risk obstetric services. Our secondary objective was to characterize change in stillbirth rate during the pandemic. Study Design This is a retrospective, observational study performed at a single, tertiary care center. Maternal-Fetal Medicine (MFM) visits, ultrasounds, and antenatal tests of fetal well-being during the pandemic epoch (2020), which spans the first 12 weeks of the year to include pandemic onset ...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Oakes, Megan C. Zhang, Fan Stevenson, Lori Porcelli, Bree Carter, Ebony B. Raghuraman, Nandini Kelly, Jeannie C. Tags: Original Article Source Type: research

Urinary N-terminal Pro-Brain Natriuretic Peptide in Newborn Infants with Cardiac and Pulmonary Diseases
Conclusion Urinary NT-proBNP is feasible to be a noninvasive screening tool to predict congenital heart diseases in full-term neonates. Further studies are needed to assess the correlation between plasma and urinary levels of NT-proBNP in congenital heart diseases in full-term and preterm infants. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Elgendy, Marwa M. Elzayat, Rania Salah Abdo, Mostafa Elsharkawy, Hamed M. Allam, Maha Midan, Dina Abdelrazek Tags: Original Article Source Type: research

The Influence of Diabetes on Labor Induction with Dinoprostone Vaginal Inserts
Conclusion Diabetes may represent an independent factor associated with prolonged induction among women undergoing induction of labor with dinoprostone. Dinoprostone is well tolerated in both diabetic and nondiabetic women. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Duffy, Jennifer Y. Chau, Cindy Raymond, Kyle Rugarn, Olof Wing, Deborah A. Tags: Original Article Source Type: research

Episiotomy: Evolution of a Common Obstetric Practice at a Public Hospital
This study aimed to evaluate the rate and impact of episiotomy on maternal and newborn outcomes before and after restricted use of episiotomy. Study Design This population-based observational study used an obstetric database of all deliveries since 1990 that has been maintained with quality checks. Inclusion criteria were vaginal deliveries at ≥37 weeks. Exclusion criteria included fetal malformations, multifetal gestations, or fetal deaths known on arrival to Labor and Delivery. The primary outcomes of interest were episiotomy, perineal lacerations, and newborn outcomes. To evaluate the impact of restrictive ep...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Dillon, Shena J. Nelson, David B. Spong, Catherine Y. McIntire, Donald D. Leveno, Kenneth J. Tags: Original Article Source Type: research

The Effect of “Off Hours” on Maternal and Perinatal Outcomes in a Diverse U.S. Cohort
This study aimed to evaluate the “off-hour effect” on maternal and neonatal adverse events in a large cohort representing U.S. population. Study Design A secondary analysis of the Consortium on Safe Labor (CSL) dataset with 208,695 women and 229,385 deliveries was performed. The study included the deliveries of ≥23 gestational weeks from 19 hospitals in the United States from 2002 to 2008. Babies with congenital anomalies were excluded from neonatal outcomes. We compared maternal and neonatal outcomes of patients delivered during weekdays versus off hours (nights and weekends). The primary outcomes o...
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Arslan, Erol Einerson, Brett D. Zhang, Jingwen Zhang, Jun Branch, D. Ware Tags: Original Article Source Type: research

A Scoping Review of Perinatal Palliative Care: Allowing Parents to Be Parents
Conclusions–PPC shares a similar risk profile to other options after life-limiting diagnosis, including satisfaction with choice of continuation of pregnancy. The present clinical opinion closes by noting common barriers to establishing PPC programs and offers a response to overcome each one. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 2, 2021 Category: Perinatology & Neonatology Authors: Buskmiller, Cara Calhoun, Byron C. Tags: Clinical Opinion Source Type: research

Duration of Exposure to General Endotracheal Anesthesia during Cesarean Deliveries at Term and Perinatal Complications
Conclusion When CD is performed at term using GETA without evidence of nonreassuring fetal status prior to delivery, I-D interval>4 minutes is associated with increased frequency of perinatal complications. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 29, 2021 Category: Perinatology & Neonatology Authors: Swanson, Kate Liang, Luzhou Grobman, William A. Higgins, Nicole Roy, Archana Son, Moeun Tags: SMFM Fellows Research Series Source Type: research

Value of HbA1c in Obese Women with Gestational Diabetes
Conclusion: A single HbA1c in women with GDM is not associated with a composite perinatal adverse outcome, but a HbA1c that increases or remains stable between 14 to 20 and 24 to 28 weeks is associated with an increase in preterm delivery. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Oben, Ayamo Jauk, Victoria Battarbee, Ashley Longo, Sherri Szychowski, Jeff Tita, Alan Harper, Lorie Tags: SMFM Fellows Research Series Source Type: research

Middle Cerebral Artery Dopplers and Abnormal Neonatal Outcomes among Pregnant Women with Zika Virus Infection
Conclusion In ZIKV-infected pregnancies, lower MCA PSV and PSV MoM measurements were seen with abnormal neonatal outcomes. This may represent a physiologic response to fetal ZIKV infection. Evaluation of MCA Dopplers may be of clinical utility in the surveillance of ZIKV-affected pregnancies. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Mok, Thalia Pereira, Jose Paulo Sobhani, Nasim C. Cardozo, Renan Fonseca Valle, Helena Abreu Dutra, Beatriz Ribeiro Torres Gama, Helder Dotta Moreira, Maria Elisabeth Vasconcelos, Zilton Pone, Marcos Gaw, Stephanie L. Tags: SMFM Fellows Research Series Source Type: research

Intravenous versus Oral iron for Iron-Deficiency Anemia in Pregnancy (IVIDA): A Randomized Controlled Trial
Am J Perinatol DOI: 10.1055/s-0041-1740003 Objective Iron-deficiency anemia (IDA) can have serious consequences for mothers and babies. Iron supplementation is recommended, but the administration route is controversial. We sought to conduct a randomized controlled trial (RCT) testing the effectiveness and safety of intravenous (IV) iron compared with oral iron on perinatal outcomes in pregnant women with IDA. Study Design This open-label RCT randomized patients with IDA (hemoglobin [hgb]
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Lewkowitz, Adam K. Stout, Molly J. Cooke, Emily Deoni, Seon C. D'Sa, Viren Rouse, Dwight J. Carter, Ebony B. Tuuli, Methodius G. Tags: SMFM Fellows Research Series Source Type: research

Comparing Two Testing Strategies: Universal versus Symptomatic SARS-CoV-2 Testing in Obstetric Patients
Conclusion Universal and symptomatic testing approaches demonstrated similar clinical performance within a single geographic region in obstetric patients. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Aderibigbe, Oluyemi A. Lappen, Justin R. Albertini, Megan Gibson, Kelly S. Tags: SMFM Fellows Research Series Source Type: research

Optimizing Post-Cesarean Opioid Prescription Practices at Mayo Clinic: A Quality Improvement Initiative
Am J Perinatol DOI: 10.1055/s-0041-1739491 Objective Optimal prescriptions practices of opioids in the post-cesarean period remain controversial. The primary aim of this initiative was to minimize unused prescription narcotic medication, with a goal of ≤4 leftover pills of 5-mg oxycodone at postoperative day (POD) 14 without affecting pain or satisfaction measures. Study Design This was a prospective longitudinal quality improvement (QI) initiative starting in 2017 utilizing the DMAIC methodology. The measurement phase consisted of validated surveys over 3 months, along with chart review to determine cur...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Kim, Sharon King, Amanda Parikh, Pavan Sangtani, Ajleeta Shazly, Sherif Brodrick, Ellen Thompson, Angela Tags: SMFM 2020 Source Type: research

Gestational Weight Gain and Adverse Maternal and Neonatal Outcomes for Pregnancies Complicated by Pregestational and Gestational Diabetes
This study aimed to investigate the association between excess and less than recommended gestational weight gain (GWG) and adverse maternal and neonatal outcomes in women with pregestational and gestational diabetes. Study Design We conducted a secondary analysis of the National Institute of Child Health and Human Development (NICHD) Consortium on Safe Labor (CSL) study. We included deliveries>23 weeks of nonanomalous singletons with either pregestational or gestational diabetes. The exposure was GWG greater than or less than compared with the U.S. Institute of Medicine recommendations for total pregnancy weight...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Kiefer, Miranda K. Adebayo, Adesomo Cleary, Erin Klebanoff, Mark Costantine, Maged M. Landon, Mark B. Gabbe, Steven Frey, Heather Venkatesh, Kartik K. Tags: SMFM 2020 Source Type: research

Risk Factors for Adverse Maternal Outcomes following Expectantly Managed Preterm Prelabor Rupture of Membranes
Am J Perinatol DOI: 10.1055/s-0041-1740011 Objective We sought to characterize the incidence and risk factors associated with developing maternal morbidity following preterm prelabor rupture of membranes. Study Design Retrospective case–control study of patients with preterm prelabor rupture of membranes at a single institution from 2013 to 2019 admitted at ≥23 weeks gestational age. The primary outcome was a composite of maternal morbidity which included: death, sepsis, intensive care unit (ICU) admission, acute kidney injury, postpartum dilation and curettage, postpartum hysterectomy, venous thro...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Darling, Alice J. Harris, Hailey M. Zemtsov, Gregory E. Small, Maria Grace, Matthew R. Wheeler, Sarahn Dotters-Katz, Sarah K. Tags: SMFM 2020 Source Type: research

Application of a Proposed Algorithm to Cesarean Deliveries for Nonreassuring Fetal Heart Rate Tracing
Am J Perinatol DOI: 10.1055/s-0041-1739412 Objectives The aim of the study is to evaluate how current management of Category II fetal heart rate tracings compares with that suggested by a published algorithm and whether these differences lead to disparate neonatal outcomes. Study Design This is a retrospective observational study from the resident service at an academic-community tertiary care center from 2013 to 2018. We reviewed archived fetal heart rate tracings from patients with cesarean delivery performed for nonreassuring fetal heart rate tracing and interpreted tracings against the algorithm. We ass...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Berger, Dana Senderoff Crosland, Adam Newman, Rachel Bosse, Bradley Makhoul, Joshua Chan, Kenneth Seet, Emily L. Tags: SMFM 2020 Source Type: research

Fetal Echocardiogram and Detailed First Trimester Obstetric Ultrasound: ICD-10 Indications
We present the corresponding International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes for those indications. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Bsat, Fadi Fisher, Barbra M. Malisch, Trisha Jain, Vanita Tags: Short Communication Source Type: research

Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study
Conclusion To the best of our knowledge, this is one of the few studies evaluating the clinical outcomes of premature infants born to SARS-CoV-2 infected mothers. There was no evidence of vertical transmission of SARS-CoV-2 from symptomatic SARS-CoV-2-infected women to the neonate in our cohort. The neonatal outcomes also seem to be favorable with no mortality in preterm infants. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American ...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Yasa, Beril Memur, Seyma Ozturk, Dilek Y. Bagci, Onur Uslu, Sait I. Cetinkaya, Merih Tags: Original Article Source Type: research

Breastfeeding Intention, Knowledge, and Attitude of Pregnant Women in Treatment for Opioid Use Disorder
Conclusion Prenatal programs for women in treatment for OUD should consider addressing patient-reported concerns and gaps in knowledge regarding the benefits of and recommendation for breastfeeding. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Short, Vanessa L. Abatemarco, Diane J. Gannon, Meghan Tags: Original Article Source Type: research

Association of Antenatal Corticosteroid Exposure and Infant Survival at 22 and 23 Weeks
Conclusion Exposure to ANCS was associated with higher survival rates to 1 YOL among resuscitated infants born at 22 and 23 weeks. National guidelines recommending against ANCS utilization at 22 weeks should be re-evaluated given emerging evidence of benefit. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Rossi, Robert M. DeFranco, Emily A. Hall, Eric S. Tags: Original Article Source Type: research

Adverse Perinatal Outcomes Associated with Stage 1 Hypertension in Pregnancy: A Retrospective Cohort Study
Am J Perinatol DOI: 10.1055/s-0041-1739470 Objective To determine if women who newly met criteria for stage 1 hypertension in early pregnancy were at increased risk for adverse perinatal outcomes compared with normotensive women. Study Design We conducted a retrospective cohort study of women who had prenatal care at a single institution and subsequently delivered a live infant between December 2017 and August 2019. Women with a singleton gestation who had at least two prenatal visits prior to 20 weeks of gestation were included. We excluded women with known chronic hypertension or other major maternal illn...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Norton, Elizabeth Shofer, Frances Schwartz, Hannah Dugoff, Lorraine Tags: Original Article Source Type: research

Effect of Using Silver Nylon Dressings on Postoperative Pain after Cesarean Delivery
Am J Perinatol DOI: 10.1055/s-0041-1739521 Objective Silver dressings have been associated with a decrease in postoperative pain in selected populations, but it is unknown if the benefit can be observed after cesarean deliveries. We sought to evaluate the impact of silver nylon dressings in reducing postoperative pain after cesarean delivery. Study Design A secondary analysis of data from a blinded randomized clinical trial of women undergoing cesarean delivery scheduled and unscheduled at a single site was conducted. Women were recruited for participation from a single site and randomized to a silver nylon...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Connery, Sheila Tanner, Jean Paul Odibo, Linda Raitano, Olivia Nikolic-Dorschel, Dusan Louis, Judette M. Tags: Original Article Source Type: research

Do Genetic Variants Modify the Effect of Smoking on Risk of Preeclampsia in Pregnancy?
We examined whether smoking-response genes modify the smoking-preeclampsia association to investigate potential biological explanations. Study Design We conducted a nested case–control study within the Norwegian Mother, Father and Child Birth Cohort (1999–2008) of 2,596 mother–child dyads. We used family-based log-linear Poisson regression to examine modification of the maternal smoking-preeclampsia relationship by maternal and fetal single nucleotide polymorphisms involved in cellular processes related to components of cigarette smoke (n = 1,915 with minor allele frequency ≥10%)....
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Bauer, Anna E. Avery, Christy L. Shi, Min Weinberg, Clarice R. Olshan, Andrew F. Harmon, Quaker E. Luo, Jingchun Yang, Jenny Manuck, Tracy Wu, Michael C. Klungs øyr, Kari Trogstad, Lill Magnus, Per Engel, Stephanie M. Tags: Original Article Source Type: research

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case –Control Study
Am J Perinatol DOI: 10.1055/s-0041-1740074 Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 2...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Abdelmaksoud, Shaimaa Reda Mostafa, Mostafa Abdel-Azim khashaba, Rana Atef Assar, Effat Tags: Original Article Source Type: research

Understanding Food Security as a Social Determinant of Diabetes-Related Health during Pregnancy
Am J Perinatol DOI: 10.1055/s-0041-1740194Gestational and pregestational diabetes during pregnancy are substantial and growing public health issues. Low-income individuals and individuals who identify as racial and ethnic minorities are disproportionately affected. Food security, which is defined as the degree to which individuals have capacity to access and obtain food, is at the center of nutritional resources and decisions for individuals with diabetes. While increasingly recognized as an important mediator of health disparities in the United States, food insecurity is understudied during pregnancy and specifically amon...
Source: American Journal of Perinatology - November 28, 2021 Category: Perinatology & Neonatology Authors: Gomez, Helen DiTosto, Julia D. Niznik, Charlotte M. Yee, Lynn M. Tags: Clinical Opinion Source Type: research

Screening Echocardiogram in High-Risk Women with Class III Obesity to Predict the Risk of Preeclampsia
This study evaluates whether screening echocardiogram can identify women with obesity at a higher risk of preeclampsia. Methods We conducted a retrospective cohort study of women with class III obesity (body mass index [BMI] ≥40 kg/m2) and one or more medical comorbidities associated with an increased risk of preeclampsia (such as diabetes, hypertension, and rheumatologic disease) undergoing screening echocardiogram. Abnormal findings were defined as the presence of one or more of the following: diastolic dysfunction, ejection fraction of ≤45%, or cardiac chamber enlargement or hypertrophy. Multivariab...
Source: American Journal of Perinatology - November 23, 2021 Category: Perinatology & Neonatology Authors: Hopkins, Maeve K. Levine, Lisa D. Koelper, Nathanael C. Durnwald, Celeste Tags: SMFM Fellows Research Series Source Type: research

Detection of Fetal Anomalies by Remotely Directed and Interpreted Ultrasound (Teleultrasound): A Randomized Noninferiority Trial
Conclusion Teleultrasound is not inferior to standard in-person ultrasound for the detection of fetal anomalies. Teleultrasound was uniformly well received by patients, regardless of demographics. These key findings support the continued expansion of telemedicine services. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 22, 2021 Category: Perinatology & Neonatology Authors: Whittington, Julie R. Hughes, Dawn S. Rabie, Nader Z. Ounpraseuth, Songthip T. Nembhard, Wendy N. Chauhan, Suneet P. Magann, Everett F. Tags: SMFM Fellows Research Series Source Type: research

Obstetric Inpatient and Ultrasound Clinical Personnel Absences during the COVID-19 Pandemic in New York City
Am J Perinatol DOI: 10.1055/s-0041-1740008 Objective To review obstetric personnel absences at a hospital during the initial peak of coronavirus disease 2019 (COVID-19) infection risk in New York City from March 25 to April 21, 2020. Study Design This retrospective study evaluated absences at Morgan Stanley Children's Hospital. Clinical absences for (1) Columbia University ultrasonographers, (2) inpatient nurses, (3) labor and delivery operating room (OR) technicians, (4) inpatient obstetric nurse assistants, and (5) attending physicians providing inpatient obstetric services were analyzed. Causes of absenc...
Source: American Journal of Perinatology - November 22, 2021 Category: Perinatology & Neonatology Authors: Spiegelman, Jessica Bertozzi-Villa, Clara D'Alton, Mary E. Aubey, Janice J. Fuchs, Karin Goffman, Dena Gyamfi-Bannerman, Cynthia Miller, Russell Robinson, Kenya E. Sheen, Jean-Ju Simpson, Lynn L. Valderrama, Natali E. Wen, Timothy Zork, Noelia Friedman, A Tags: Short Communication Source Type: research

Post-Thrombotic Syndrome and Chronic Pulmonary Embolism after Obstetric Venous Thromboembolism
The objective of this study was to determine risk of these two complications. Study Design A retrospective cohort study using the MarketScan databases was performed on deliveries from 2008 to 2014. We identified women aged 15 to 54 years diagnosed with acute VTE during pregnancy, the delivery hospitalization, or ≤60 days postpartum who received at least one prescription postpartum for anticoagulants. Risks of (1) chronic PE and (2) post-thrombotic syndrome were evaluated for women at 6, 12, 24, and 60 months after delivery hospitalization through 2017 via the International Classification of Diseases, Ninth/Tenth...
Source: American Journal of Perinatology - November 22, 2021 Category: Perinatology & Neonatology Authors: O'Shaugnessy, Fergal Govindappagari, Shravya Huang, Yongmei Syeda, Sbaa K. D'Alton, Mary E. Wright, Jason D. Friedman, Alexander M. Tags: Short Communication Source Type: research

Left-Handedness in Obstetrics and Gynecology: A Nationwide Survey of U.S. Trainees and Educators
This study aimed to evaluate the views and influence of left-handedness among obstetrics and gynecology (OBGYN) trainees and educators and to identify perceived obstacles in training by left-handed (LH) trainees. Study Design An online survey was sent to the U.S. Obstetrics and Gynecology training programs. All participants were asked questions on hand preference for various medical and nonmedical activities, as well as on demographics. Participant responses to handedness and their role as a learner or educator directed them toward further questions. Trainees were surveyed on their experience and outlook as a LH ph...
Source: American Journal of Perinatology - November 22, 2021 Category: Perinatology & Neonatology Authors: Moutos, Christopher P. Arena Goncharov, Daphne D. Saad, Antonio F. Richardson, Gwyn Jain, Sangeeta Tags: Original Article Source Type: research

Serum Lactate Level as a Predictor for Blood Transfusion in Postpartum Hemorrhage
Am J Perinatol DOI: 10.1055/s-0041-1740009 Objective Postpartum hemorrhage (PPH) is the leading cause of maternal morbidity and mortality. At present, there are no reliable clinical or laboratory indicators to identify which patients might require blood transfusions during a PPH. Serum lactate has long been used as an early biomarker of tissue hypoperfusion in trauma settings. The aim of this study is to understand serum lactate's role in the management of obstetric hemorrhage. Study Design A retrospective chart review was performed of women who delivered between 2016 and 2019 at our institution and experie...
Source: American Journal of Perinatology - November 22, 2021 Category: Perinatology & Neonatology Authors: Agrawal, Surbhi Smith, Maria Berg, Robert Hoskins, Iffath A. Tags: Original Article Source Type: research

Potentially Preventable Primary Cesarean Sections in Future Placenta Accreta Spectrum
Am J Perinatol DOI: 10.1055/s-0041-1739493 Background Prior cesarean delivery is a well-known risk factor for placenta accreta spectrum disorders. While primary cesarean section is unavoidable in some patients, in others it may not be clearly indicated. Objective The aim of the study is to determine the proportion of patients with placenta accreta spectrum who had a potentially preventable primary cesarean section and to identify factors associated with preventable placenta accreta spectrum. Study Design This was a single-center retrospective cohort study of women with pathology-confirmed placenta a...
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Matthews, Kathy C. Quinn, Andrew S. Chasen, Stephen T. Tags: SMFM 2020 Source Type: research

Postpartum Opioid Use among Military Health System Beneficiaries
Conclusion Our data indicates that women who received care in civilian facilities were more likely to fill an opioid prescription at discharge when compared with military facilities. Factors such as race and age were associated with opioid prescription at discharge. This study highlights areas for improvement for potential further studies. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Watters, Julie A. Banaag, Amanda Massengill, Jason C. Koehlmoos, Tracey P. Staat, Barton C. Tags: Original Article Source Type: research

Eligibility, Utilization, and Effectiveness of 17-Alpha Hydroxyprogesterone Caproate (17OHPC) in a Statewide Population-Based Cohort of Medicaid Enrollees
Conclusion The 17OHPC-eligible population represented 3.4% of singleton live births. Less than one-third of eligible mothers initiated treatment. Among initiators, 50% were treatment adherent. We found no difference in the risk of recurrent preterm birth or admission to NICU between treatment and comparison groups. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Wang, Xi Garcia, Stephanie M. Kellom, Katherine S. Boelig, Rupsa C. Matone, Meredith Tags: Original Article Source Type: research

Group B Streptococcus Rectovaginal Colonization and Resistance Patterns in HIV-Positive Compared to HIV-Negative Pregnant Patients
The objective of our study is to determine if human immunodeficiency virus (HIV)-positive pregnant patients have a higher rate of group B streptococcus (GBS) rectovaginal colonization compared with HIV-negative pregnant patients. Methods Our study is a multi-site retrospective study performed at Ochsner Louisiana State University-Health Shreveport and Monroe campuses including patients who delivered between December 2011and June 2019. Rates of GBS rectovaginal colonization between HIV-positive pregnant patients were compared with a control group of HIV-negative patients. The control group was age and race matched i...
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Morgan, John A. Hankins, Miriam E. Callais, Nicholas A. Albritton, Charles W. Vanchiere, John A. Betcher, Raymond E. Lewis, David F. Tags: Original Article Source Type: research

A Possible Mechanism of Action of 17 α-Hydroxyprogesterone Caproate: Enhanced IL-10 Production
Conclusion In women receiving 17-OHPC for PTB prevention, we demonstrate a relationship between plasma 17-OHPC and LPS-stimulated IL-10 production by circulating leukocytes. We also demonstrate that, in vitro, 17-OHPC treatment affects IL-10 production by LPS-stimulated macrophages. Collectively, these findings support an immunomodulatory mechanism of action of 17-OHPC in the prevention of recurrent PTB. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Ful...
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Megli, Christina J. Hauspurg, Alisse Venkataramanan, Raman Caritis, Steve N. Tags: Original Article Source Type: research

Standardized Cesarean Risk Counseling with Induction: Impact on Racial Disparities in Birth Satisfaction
Conclusion Implementation of standardized counseling with a validated calculator to predict cesarean risk after labor induction is associated with a decrease in racial disparities in birth satisfaction. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Hamm, Rebecca F. Srinivas, Sindhu K. Mccoy, Jennifer Morales, Knashawn H. Levine, Lisa D. Tags: Original Article Source Type: research

Perinatal Outcomes among Women Identified by a Community Health Needs Assessment
Am J Perinatol DOI: 10.1055/s-0041-1740014 Objective The aim of the study is to compare perinatal outcomes for women with greater social needs, as identified by the Community Health Needs Assessment, to those of women living in other areas of the county. Study Design This was a retrospective cohort study of pregnant women delivering at a large inner-city county hospital. Perinatal outcomes were analyzed for women living within a target area with substantial health disparities and social needs, and compared with those women living outside the target area. Statistical analysis included student's t-test, Chi s...
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Duryea, Elaine L. Martin, Robert McIntire, Donald Spong, Catherine Y. Nelson, David B. Tags: Original Article Source Type: research

Defining a Strategy for Laboratory Evaluation with Expectant Management of Preeclampsia
Conclusion Most laboratory abnormalities in PE occur earlier and more frequently in those with severe features. Individual phenotypes should undergo serial evaluation based on this risk stratification. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Cozzi, Gabriella D. Blanchard, Christina T. Sanjanwala, Aalok R. Page, Margaret R. Kim, Dhong-Jin Tita, Alan T. Szychowski, Jeff M. Subramaniam, Akila Tags: Original Article Source Type: research

Oral Glucose Tolerance Test in Pregnancy and Subsequent Maternal Hypertension
Conclusion Among persons with mild GDM or lesser degrees of glucose intolerance, the shape of the OGTT curve during pregnancy may help identify women who are at risk of HTN later in life, with biphasic shape to be associated with lower risk. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Costantine, Maged M. Rice, Madeline Murguia Landon, Mark B. Varner, Michael W. Casey, Brian M. Reddy, Uma M. Wapner, Ronald J. Rouse, Dwight J. Tita, Alan T.N. Thorp, John M. Chien, Edward K. Peaceman, Alan M. Blackwell, Sean C. Tags: Original Article Source Type: research

Basal Ganglia –Thalamic Pattern Injury and Subacute Gradual-Onset Intrapartum Hypoxia: A Response
Am J Perinatol DOI: 10.1055/s-0041-1739428 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 16, 2021 Category: Perinatology & Neonatology Authors: Buchmann, Eckhart Bhorat, Ismail Tags: Letter to the Editor Source Type: research

Prediction of Postoperative Day 1 Hemoglobin Level after Cesarean Delivery
Am J Perinatol DOI: 10.1055/s-0041-1739414 Objective To create a prediction model for postoperative hemoglobin levels after cesarean delivery, which could reduce routine use of postoperative laboratory test. Study Design This was a secondary analysis of a retrospective cohort study of all women who underwent cesarean delivery (primary or repeat) at or more than 23 weeks' gestation at a single academic center. The cohort was randomly divided into a training cohort to develop a prediction model and a validation cohort to test the model in a 2:1 ratio. Variables with p-value
Source: American Journal of Perinatology - November 14, 2021 Category: Perinatology & Neonatology Authors: Kawakita, Tetsuya Saeed, Haleema Amgalan, Ariunzaya Thomas, Alexandra Coviello, Elizabeth Tags: Original Manuscript Source Type: research

Characteristics of Patients Who Attend the 7- to 10-Day Postpartum Visit for Blood Pressure Evaluation
Conclusion Clinical factors such as nulliparity, severe HDP, and cesarean birth were associated with higher rates of postpartum blood pressure evaluation attendance, whereas sociodemographic factors such as maternal non-Hispanic black race and ethnicity and public insurance were associated with lower odds of postpartum blood pressure check attendance. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 14, 2021 Category: Perinatology & Neonatology Authors: Tallmadge, Maggie Livergood, Mary Christine Tvina, Alina Evans, Sarah McIntosh, Jennifer Palatnik, Anna Tags: Original Article Source Type: research

The Association Between Immediate Postpartum Depot Medroxyprogesterone Acetate Use and Postpartum Depressive Symptoms
Conclusion Receipt of postpartum DMPA is not associated with a positive postpartum PHQ-9 screen. Concerns about precipitating postpartum depression should not preclude the utilization of DMPA as a contraceptive agent. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 14, 2021 Category: Perinatology & Neonatology Authors: Ross, Carolyn M. Shim, Jessica Y. Stark, Elisabeth L. Wisner, Katherine L. Miller, Emily S. Tags: Original Article Source Type: research