Complicated Monochorionic –Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester
Conclusion This case of SARS-CoV-2 argues against transplacental transmission after a second-trimester infection but brings attention to the possible downstream complications that may arise following early infection. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Mok, Thalia Contreras, Deisy Chmait, Ramen H. Goldstein, Jeffrey Pluym, Ilina D. Tabsh, Khalil Aldrovandi, Grace Afshar, Yalda Tags: Short Communication Source Type: research

Preventing Brain Damage from Hypoxic –Ischemic Encephalopathy in Neonates: Update on Mesenchymal Stromal Cells and Umbilical Cord Blood Cells
Conclusion The authors suggest that the next step will include reaching a consensus on cell therapies for HIE and establishment of effective protocols for cell therapy for HIE. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Nabetani, Makoto Mukai, Takeo Shintaku, Haruo Tags: Review Article Source Type: research

Factors Associated with Umbilical Venous Catheter Malposition in Newborns: A Tertiary Center Experience
Conclusion Noncentral UVC position as well as migration were common after initial placement in this cohort. The use of larger size UV catheters and increasingly invasive respiratory support were risk factors associated with higher incidence of UVC malposition. Ongoing surveillance of UVC position is thus recommended. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Soonsawad, Sasivimon Kieran, Emily A. Ting, Joseph Y. AlonsoPrieto, Esther Panczuk, Julia K. Tags: Original Article Source Type: research

Mother –Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes
Conclusion At our urban, safety-net hospital among pregnant women with positive SARS-CoV-2 tests, 41% had a cesarean delivery and 19% had a preterm birth. Seven percent of infants had one or more positive SARS-CoV-2 tests and all infants had clinical courses expected for gestational age. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Sabharwal, Vishakha Bartolome, Ruby Hassan, Sacha Al Levesque, Bernadette M. Camelo, Ingrid Y. Wachman, Elisha M. Figueira, Marisol Yarrington, Christina D. Cooper, Ellen R. Barnett, Elizabeth D. Parker, Margaret G. Tags: Original Article Source Type: research

Astaxanthin Reduces the Severity of Intestinal Damage in a Neonatal Rat Model of Necrotizing Enterocolitis
This study aimed to ascertain the effects of astaxanthin (ASX) in an experimental necrotizing enterocolitis (NEC) model using rat pups. Study Design Forty-two pups born from five Wistar albino rats were randomly divided into three groups as the control group, NEC + placebo (saline), and NEC + ASX. Pups in the NEC + ASX group were given 100 mg/kg/day oral ASX from day 1 to day 4 of the study. Saline of 2 mL/kg was given to the NEC + placebo group. Histopathological, immunohistochemical (caspase-3), and biochemical evaluations including the total a...
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Akduman, Hasan Tayman, Cuneyt Korkmaz, Veli Akduman, Filiz Fettah, Nurdan D. G ürsoy, Başak K. Turkmenoglu, Tugba T. Çağlayan, Murat Tags: Original Article Source Type: research

Comparison of High CPAP versus NIPPV in Preterm Neonates: A Retrospective Cohort Study
Conclusion Based on this cohort, there was no difference in incidence of failure between high CPAP and NIPPV, although infants receiving high CPAP were more likely to require an alternate mode of noninvasive support. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 14, 2021 Category: Perinatology & Neonatology Authors: Ahmad, Hussain Alsaid Deekonda, Veena Patel, Waseemoddin Thabane, Lehana Shah, Prakesh S Mukerji, Amit Tags: Original Article Source Type: research

A Survey of Neonatal Nurses on Mydriatic Regimens Used in Neonatal Retinopathy of Prematurity Eye Examinations
Conclusion Low-concentration single-microdrop regimens are currently in use and resulting in successful ROPEE, yet doses exceeding adult doses are in use throughout Aotearoa NZ and Australian units. We know from this dataset that neonates are experiencing unwanted and potentially preventable, adverse effects associated with mydriatics, and every effort should be made to minimize this risk. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source:...
Source: American Journal of Perinatology - March 30, 2021 Category: Perinatology & Neonatology Authors: Kremer, Lisa Reith, David Medlicott, Natalie J. Sime, Mary J. Edmonds, Liza Broadbent, Roland Tags: Original Article Source Type: research

Presumptive Neonatal Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019
Conclusion COVID-19 associated MIS-C like disease has not been well described in neonates. As typical features may be conspicuously absent, a high index of suspicion is warranted in critically ill neonates born to mothers with COVID-19. Echocardiography may provide critical diagnostic information and narrow the differential diagnosis. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Divekar, Abhay A. Patamasucon, Pisespong Benjamin, Joshua S. Tags: Short Communication Source Type: research

Integrated MicroRNA –mRNA Analyses of Distinct Expression Profiles in Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice
Conclusion Our findings revealed the integrated miRNA–mRNA data of distinct expression profiles in hyperoxia-induced BPD mice, and may provide some clues of the potential biomarkers for BPD, and provide novel insights into the development of new promising biomarkers for the treatment of BPD. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Wang, Chengqiang Zhang, Sheng Zhu, Lina Duan, Jun Huang, Bo Zhang, Xiaoying Tags: Original Article Source Type: research

Effect of Early Parent Participation Program on Physiological Stability in Preterm Infants: A Randomized Controlled Trial
Conclusion Very early parent participation was feasible in the NICU and led to decrease in physiological instability in preterm infants. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Pillai, Anish Pournami, Femitha Prabhakar, Jyothi Nair, PMC Jain, Naveen Tags: Original Article Source Type: research

Nucleated Red Blood Cells as Markers of Perinatal Adaptation in Preterm Neonates Receiving Minimally Invasive Surfactant Therapy
Am J Perinatol DOI: 10.1055/s-0041-1726317 Objective The study aimed to assess the association of nucleated red blood cells (NRBC), a surrogate of intrauterine hypoxia, and elevated pulmonic vascular resistance (E-PVR) and oxygen requirement after minimally invasive surfactant therapy (MIST). Study Design Retrospective study of a cohort of preterm neonates that received MIST in a single unit. Results NRBC were measured in 65 of 75 (87%) neonates administered MIST during the period. In total, 22 of 65 (34%) infants had pre-MIST echocardiography (ECHO).Neonates with elevated NRBC (predefined as>5&t...
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Nitzan, Itamar Roberts, Calum T. Bhatia, Risha Mimouni, Francis B. Sehgal, Arvind Tags: Original Article Source Type: research

Comparison of Point-of-Care versus Central Laboratory Testing of Electrolytes, Hemoglobin, and Bilirubin in Neonates
Am J Perinatol DOI: 10.1055/s-0041-1726125 Objective Electrolyte, hemoglobin, and bilirubin values are routinely reported with point-of-care (POC) testing for blood gases. Results are rapidly available and require a small blood volume. Yet, these results are underutilized due to noted discrepancies between central laboratory (CL) and POC testing. The study aimed to determine the correlation between POC and CL measurement of electrolytes, hemoglobin, and bilirubin in neonates. Study Design Electrolyte, hemoglobin, and bilirubin results obtained from capillary blood over a 4-month period were analyzed. Each C...
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Choi, Ha-young Corder, William Tefera, Eshetu Abubakar, Kabir M. Tags: Original Article Source Type: research

Efficacy and Safety of Two Different Flow Rates of Nasal High-Flow Therapy in Preterm Neonates ≥28 Weeks of Gestation: A Randomized Controlled Trial
Conclusion Higher nasal flow rate (8–10 L/min) when compared with lower nasal flow rate of 5 to 7 L/min did not reduce the need for higher respiratory support (CPAP/mechanical ventilation) or surfactant therapy in moderately and late preterm neonates. However, initial flow rates of 5 L/min were not optimal for most preterm infants receiving primary nasal flow therapy. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 23, 2021 Category: Perinatology & Neonatology Authors: Balasubramanian, Haribalakrishna Sakharkar, Sachin Majarikar, Swati Srinivasan, Lakshmi Kabra, Nandkishor S. Garg, Bhawandeep Ahmed, Javed Tags: Original Article Source Type: research

Neonatal Septic Shock and Hemodynamic Monitoring in Preterm Neonates in a NICU: Added Value of Electrical Cardiometry in Real-Time Tailoring of Management and Therapeutic Strategies
Conclusion This case report suggests that electrical cardiometry could be a useful tool in assessing, monitoring, and guiding care of neonates who develop severe septic shock. We suggest that electrical cardiometry is a promising approach in the management strategies of such patients that warrants informative clinical trials. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 15, 2021 Category: Perinatology & Neonatology Authors: Gatelli, Italo F. Vitelli, Ottavio Fossati, Marco De Rienzo, Francesca Chiesa, Gaia Martinelli, Stefano Tags: Short Communication Source Type: research

Management and Early Outcomes of Neonates Born to Women with SARS-CoV-2 in 16 U.S. Hospitals
Conclusion In this multisite case series of 70 neonates born to women with SARS-CoV-2 infection, clinical outcomes were overall good, and there were no documented neonatal SARS-CoV-2 infections. Clinical management was largely inconsistent with contemporaneous U.S. COVID-19 guidelines for nursery care, suggesting concerns about the acceptability and feasibility of those recommendations. Longitudinal studies are urgently needed to assess the benefits and harms of current practices to inform evidence-based clinical care and aid shared decision-making. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Av...
Source: American Journal of Perinatology - March 15, 2021 Category: Perinatology & Neonatology Authors: Congdon, Jayme L. Kair, Laura R. Flaherman, Valerie J. Wood, Kelly E. LoFrumento, Mary Ann Nwaobasi-Iwuh, Eberechi Phillipi, Carrie A. Tags: Original Article Source Type: research

Effects of Placental Transfusion on Late Preterm Infants Admitted to a Mother Baby Unit
Am J Perinatol DOI: 10.1055/s-0041-1726387 Objective Well-appearing late preterm infants admitted to a mother baby unit may benefit from either delayed cord clamping (DCC) or umbilical cord milking (UCM). However, there are concerns of adverse effects of increased blood volume such as polycythemia and hyperbilirubinemia. The purpose of this study is to examine the short-term effects of placental transfusion on late preterm infants born between 350/7 and 366/7 weeks of gestation. Study Design In this pre- and postimplementation retrospective cohort study, we compared late preterm infants who received placent...
Source: American Journal of Perinatology - March 15, 2021 Category: Perinatology & Neonatology Authors: Chiruvolu, Arpitha George, Reshma Stanzo, Karen C. Kindla, Cassandra M. Desai, Sujata Tags: Original Article Source Type: research

Procedural Analgesia in the Neonatal Intensive Care Unit: A Quality Improvement Initiative
Conclusion Procedural analgesia can improve and be sustained by using simple interventions. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 11, 2021 Category: Perinatology & Neonatology Authors: Reddy, Sushma Nesargi, Saudamini V. Stevens, Sofia Jose, Jiya Babu, Hindumati Tags: Original Article Source Type: research

Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates
Am J Perinatol DOI: 10.1055/s-0041-1726035 Introduction The average time for umbilical cord separation in term neonates is 7 to 10 days. Prematurity, phototherapy, prolonged duration of antibiotic treatment, and parenteral nutrition are other factors which were demonstrated to delay cord separation. In the previous studies including greater premature infants, the time of separation of the umbilical cord was shown to vary 2 to 3 weeks. We aimed to determine the cord separation time and associated factors in very-low-birth-weight (VLBW) infants. Study Design In this retrospective study, VLBW infants (birth weight [BW]
Source: American Journal of Perinatology - March 3, 2021 Category: Perinatology & Neonatology Authors: Unal, Sezin Demirel, Nihal Arslan, Zehra Tokgoz-Cuni, Bet ül Ulubas-Isik, Dilek Bas, Ahmet Yagmur Tags: Original Article Source Type: research

Electroencephalogram Background Predicts Time to Full Oral Feedings in Hypoxic-Ischemic Encephalopathy
Conclusion These findings may help clinicians counsel families on what to expect in neonates with HIE and make decisions on the need for and timing to pursue gastrostomy tube in this population. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - March 3, 2021 Category: Perinatology & Neonatology Authors: Takle, Mrinmayee Conaway, Mark Burnsed, Jennifer Tags: Original Article Source Type: research

Respiratory Syncytial Virus Immunoprophylaxis with Palivizumab: 12-Year Observational Study of Usage and Outcomes in Canada
This study aimed to evaluate palivizumab (PVZ) use, trends in indications, and outcomes of respiratory illness hospitalizations (RIH) and respiratory syncytial virus hospitalizations (RSVH). Study Design It involves a large, Canadian prospective (2005–2017) observational multicenter study of children at high risk for RSV infection. Results A total of 25,003 infants (56.3% male) were enrolled at 32 sites; 109,579 PVZ injections were administered. Indications included: prematurity (63.3%); “miscellaneous” (17.8%); hemodynamically significant congenital heart disease (10.5%); bronchopulmonary...
Source: American Journal of Perinatology - March 3, 2021 Category: Perinatology & Neonatology Authors: Mitchell, Ian Li, Abby Bjornson, Candice L. Lanctot, Krista L. Paes, Bosco A. Tags: Original Article Source Type: research

Genetic Implications in High-Risk Pregnancy and Its Outcome: A 2-year Study
Conclusion Parental consanguinity and endogamy were increased among high-risk pregnancies. Public awareness about potential adverse effects of consanguineous marriages and the importance of genetic testing are imperative. A structured multidisciplinary team of specialists in fetal medicine, clinical genetics, and neonatology provides good genetic services. Expansion and financial support of these services are urgently required. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract&nbs...
Source: American Journal of Perinatology - February 26, 2021 Category: Perinatology & Neonatology Authors: Afifi, Hanan H. Gaber, Khaled R. Thomas, Manal M. Taher, Mohamed B. Tosson, Angie M.S. Tags: Original Article Source Type: research

Gestational and Age-Specific Cystatin C Reference Intervals for Newborns
In this study, the mean GA was 35.8 ± 2.9 weeks and the birth weight (BW) was 2,614 ± 697 g. Reference ranges of serum CysC were determined, and a general decreasing trend of CysC levels was observed as the GA increased. CysC levels differed significantly among the PA and GA categories (p 
Source: American Journal of Perinatology - February 23, 2021 Category: Perinatology & Neonatology Authors: Tong, Chao Liu, Yalan Wu, Yanqiu Li, Qiong Wu, Yipin Wang, Lin Chen, Yan Tags: Original Article Source Type: research

Postextubation Noninvasive Ventilation in Respiratory Distress Syndrome: A Randomized Controlled Trial
Am J Perinatol DOI: 10.1055/s-0041-1723999 Objective Successful extubation and prevention of reintubation remain primary goals in neonatal ventilation. Our aim was to compare three modalities of postextubation respiratory support—noninvasive positive pressure ventilation (NIPPV), nasal bilevel positive airway pressure (N-BiPAP), and nasal continuous positive airway pressure (NCPAP)—using the RAM cannula in preterm neonates with respiratory distress syndrome (RDS). Our secondary aim was to define the predictors of successful extubation. Study Design A total of 120 preterm neonates (gestational ag...
Source: American Journal of Perinatology - February 23, 2021 Category: Perinatology & Neonatology Authors: El-Farrash, Rania A. DiBlasi, Robert M. AbdEL-Aziz, Eman A. El-Tahry, Adham M. Eladawy, Mohammed S. Tadros, Mourad A. Koriesh, Mohamed A. Farid, John V. AbdElwahab, Riham S. Elsayed, Medhat A. Barakat, Noha M. Tags: Original Article Source Type: research

Influence of Alveolar Fluid on Aquaporins and Na+/K+-ATPase and Its Possible Theoretical or Clinical Significance
Conclusion The results of this study suggest that increased alveolar fluid may induce the downregulation of the mRNA and protein expression of AQPs and Na+/K+-ATPase, which appear to affect alveolar fluid clearance in rabbit lungs. Early intervention is required to avoid excessive alveolar fluid accumulation. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 21, 2021 Category: Perinatology & Neonatology Authors: Zong, Hai-Feng Guo, Guo Liu, Jing Yang, Chuan-Zhong Bao, Lin-Lin Tags: Original Article Source Type: research

SARS-CoV-2 Infection during Pregnancy in a Rural Midwest All-delivery Cohort and Associated Maternal and Neonatal Outcomes
This study aimed to estimate the prevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) among pregnant patients at the time of delivery in a rural Midwest tertiary care hospital and to examine demographics, clinical factors, and maternal and neonatal outcomes associated with SARS-CoV-2 infection during pregnancy. Study Design This prospective cohort study included all delivering patients between May 1 and September 22, 2020 at the University of Iowa Hospitals and Clinics. Plasma SARS-CoV-2 antibody testing was performed. SARS-CoV-2 viral reverse-transcription polymerase chain reaction (RT-PCR) r...
Source: American Journal of Perinatology - February 21, 2021 Category: Perinatology & Neonatology Authors: Steffen, Haley A. Swartz, Samantha R. Jackson, J. Brooks Kenne, Kimberly A. Ten Eyck, Patrick P. Merryman, Abbey S. Castaneda, Claire N. Marsden, Katharine Maxwell, Timothy Merrill, Anna E. Krasowski, Matthew D. Rysavy, Mary B. Tags: Original Article Source Type: research

Early Growth and Cognitive Development in Children Born Preterm: Relevance of Maternal Body Mass Index
Conclusion Increasing maternal pre-pregnancy BMI may reflect risk of altered growth and cognitive development in children born preterm. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 16, 2021 Category: Perinatology & Neonatology Authors: Robinson, Daniel T. Josefson, Jami Balmert, Lauren C. Van Horn, Linda Silton, Rebecca L. Tags: Original Article Source Type: research

The Effect of a Short Course of Tocolytic Indomethacin on Urinary Biomarkers in Premature Infants
Conclusion Our findings suggest that a short course of tocolytic indomethacin does not result in neonatal acute kidney injury. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 16, 2021 Category: Perinatology & Neonatology Authors: El Samra, Ahmad Mian, Ayesa Lande, Marc Wang, Hongyue Guillet, Ronnie Tags: Original Article Source Type: research

The US National Trend for Retinopathy of Prematurity
Am J Perinatol DOI: 10.1055/s-0041-1723830 Objective The use of supplemental oxygen in premature infants is essential for survival. However, its use has been associated with unintended complications. The restricted use of oxygen is associated with increased mortality and necrotizing enterocolitis (NEC), whereas its liberal use is associated with increased risk for retinopathy of prematurity (ROP). Although there is no clear consensus on the acceptable oxygen saturation range, clinicians have recently become more liberal with the use of oxygen. We aim to assess (1) the national trends for ROP in very low birth weigh...
Source: American Journal of Perinatology - February 16, 2021 Category: Perinatology & Neonatology Authors: Aly, Hany Othman, Hasan F. Munster, Chelsea Das, Anirudha Sears, Jonathan Tags: Original Article Source Type: research

Cord-Blood High-Sensitivity Troponin-I Reference Interval and Association with Early Neonatal Outcomes
This study was aimed to establish a reference interval for high-sensitivity cardiac troponin I (hs-cTnI) in umbilical cord blood of infants and to assess its association with the risk of predetermined early neonatal outcomes in a high-acuity tertiary care hospital. Study Design Umbilical cord-blood samples were collected and hs-cTnI was measured in all infants born between August 2015 and September 2015 at McMaster Children's Hospital (n = 256). Gestational age, birth weight, Apgar's scores, age in days at which feeding was established, neonatal intensive care unit (NICU) admission, and discharge in d...
Source: American Journal of Perinatology - February 6, 2021 Category: Perinatology & Neonatology Authors: Mondal, Tapas Ryan, Paul M. Gupta, Kaaran Radovanovic, George Pugh, Edward Chan, Anthony K.C. Hill, Stephen Tags: Original Article Source Type: research

Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience
Am J Perinatol DOI: 10.1055/s-0041-1723761 Objective The aim of this study was to describe baseline characteristics of a cohort of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and determine if these correlate with disease severity and perinatal outcomes. Study Design This was a retrospective cohort trial conducted at the University of Texas Medical Branch Galveston, Texas. All pregnant women presented to our medical center, who were screened and tested positive for SARS-CoV-2 virus, were included. We stratified our study population in three groups: asymptomatic, ...
Source: American Journal of Perinatology - February 6, 2021 Category: Perinatology & Neonatology Authors: Berry, Marissa Wang, Amanda Clark, Shannon M. Harirah, Hassan M. Jain, Sangeeta Olson, Gayle L. Pacheco, Luis D. Saade, George R. Saad, Antonio F. Tags: Original Article Source Type: research

A Retrospective Cohort Study on Mortality and Neurodevelopmental Outcomes of Preterm Very Low Birth Weight Infants Born to Mothers with Hypertensive Disorders of Pregnancy
We examined the effects of maternal hypertensive disorders of pregnancy (HDP) on the mortality and neurodevelopmental outcomes in preterm very low birth weight (VLBW) infants (BW ≤1,500 g) based on their intrauterine growth status and gestational age (GA). Study Design We included singleton VLBW infants born at
Source: American Journal of Perinatology - February 3, 2021 Category: Perinatology & Neonatology Authors: Kono, Yumi Yonemoto, Naohiro Nakanishi, Hidehiko Hosono, Shigeharu Hirano, Shinya Kusuda, Satoshi Fujimura, Masanori Tags: Original Article Source Type: research

Central Line Utilization and Complications in Infants with Congenital Diaphragmatic Hernia
Conclusion Central lines are an important component of intensive care for infants with CDH. Careful selection of line type and location and understanding of common complications may attenuate the need for early removal and reduce risk of infection, obstruction, and malposition in this high-risk group of patients. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 3, 2021 Category: Perinatology & Neonatology Authors: Grover, Theresa R. Weems, Mark F. Brozanski, Beverly Daniel, John Haberman, Beth Rintoul, Natalie Walden, Alyssa Hedrick, Holly Mahmood, Burhan Seabrook, Ruth Murthy, Karna Zaniletti, Isabella Keene, Sarah Tags: Original Article Source Type: research

High Prevalence of Abnormal General Movements in Hospitalized Very Low Birth Weight Infants
Am J Perinatol DOI: 10.1055/s-0041-1722943 Objective Abnormal general movements (GMs) are predictive of later risk of motor impairments in preterm infants. The goals of this study are to (1) describe the implementation of the GM assessment (GMA) in a neonatal intensive care unit (NICU) and (2) investigate the prevalence and evolution of abnormal GMs in very low birth weight (VLBW) infants. Study Design Observational study of GMs in VLBW infants (gestational age [GA]
Source: American Journal of Perinatology - February 3, 2021 Category: Perinatology & Neonatology Authors: Alonzo, Corrie J. Letzkus, Lisa C. Connaughton, Elizabeth A. Kelly, Nancy L. Michel, Joseph A. Zanelli, Santina A. Tags: Original Article Source Type: research

Evaluation of Morbidities and Complications of Neonatal İntensive Care Unit Patients with Respiratory Disorders at Different Gestational Ages
Conclusion This study offers an epidemiological perspective for respiratory disorders from a single-center level-III neonatal intensive care unit. Although number of births, premature newborns, extremely low birth weight/very low birth weight infants, and complicated pregnancies increase in years, decreasing rates of mortality and complications are very promising. As perinatal and neonatal cares are getting better in every day, we think that more promising results can be achieved over the coming years. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle...
Source: American Journal of Perinatology - January 31, 2021 Category: Perinatology & Neonatology Authors: Yarci, Erbu Canpolat, Fuat E. Tags: Original Article Source Type: research

Laryngeal Mask Airway for Surfactant Administration Versus Standard Treatment Methods in Preterm Neonates with Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
Conclusion LMA might be an effective alternative method of surfactant delivery; however, further high-quality RCTs with larger sample size and including extreme preterm infants are needed to establish LMA as an alternative technique for surfactant delivery. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 31, 2021 Category: Perinatology & Neonatology Authors: Al Ali, Roqaia Ayesh Gautam, Bishal Miller, Michael R. Coulson, Sherry Yuen, Doris Tags: Original Article Source Type: research

Mortality and Morbidity in Premature Infants: An East and West Comparative Study
Am J Perinatol DOI: 10.1055/s-0040-1722654 Objective Survival of preterm infants differs dramatically depending on birthplace. No previous studies have compared outcomes of preterm infants between low middle-income and high-income countries such as India and the United States. The purpose of this study is to evaluate differences in care practices, resources, mortality, and morbidities in preterm infants with birth weight 700 to 1,500 g between two major neonatal centers in these countries. Study Design This is a retrospective cohort study with de-identified data from Fernandez Hospital (FH) in Hydera...
Source: American Journal of Perinatology - January 24, 2021 Category: Perinatology & Neonatology Authors: Patil, Monika Vardhelli, Venkateshwarlu Hagan, Joseph L. Deshabhotla, Saikiran Murki, Srinivas Tags: Original Article Source Type: research

Fresh Frozen Plasma Transfusion: An Independent Risk Factor for Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants
Conclusion FFP transfusion is a significant risk factor for the subsequent development of hsPDA in our study population. FFP transfusion may complicate the fluid management of premature infants and increase the risk of hsPDA. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 24, 2021 Category: Perinatology & Neonatology Authors: Huang, Chun-Pin Hung, Yi-Li Hsieh, Wu-Shiun Shen, Chung-Min Tags: Original Article Source Type: research

Erratum: Neurodevelopmental Outcome in Very Low Birth Weight Infants Exposed to Donor Milk
Am J Perinatol DOI: 10.1055/s-0041-1722896 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 22, 2021 Category: Perinatology & Neonatology Authors: Patra, Kousiki Greene, Michelle M. Tobin, Grace Casini, Gina Esquerra-Zwiers, Anita L. Meier, Paula P. Patel, Aloka L. Tags: Erratum Source Type: research

Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn
Am J Perinatol DOI: 10.1055/s-0040-1722653 Objective The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in neonates with persistent pulmonary hypertension of the newborn (PPHN). Study Design We conducted a retrospective chart review of 30 patients with PPHN from January 2014 to November 2018, who did not respond to inhaled nitric oxide (iNO) alone and received inhaled iloprost. Twenty-two patients met the inclusion criteria and eight patients were excluded from the study (complex cardiac disease and extreme prematurity). Patients were categorized as responders or nonresponder...
Source: American Journal of Perinatology - January 21, 2021 Category: Perinatology & Neonatology Authors: Verma, Sourabh Lumba, Rishi Kazmi, Sadaf H. Vaz, Michelle J. Prakash, Shrawani Soorneela Bailey, Sean M. Mally, Pradeep V. Randis, Tara M. Tags: Original Article Source Type: research

Mother-to-Child HIV Transmission among Pregnant Women in a City with the Highest Rates of HIV in Brazil
Conclusion MTCT rate was 2.18%. With the institution of two-drug prophylaxis for high-risk newborns, persistent cases HIV MTCT were predominantly found among women with absence of antenatal care, late HIV diagnosis, syphilis coinfection, high viral load, and inadequate ARV therapy during pregnancy. Although zidovudine and nevirapine were administered postnatally to high-risk newborns, this regimen could not prevent transplacental transmission. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  | &n...
Source: American Journal of Perinatology - January 21, 2021 Category: Perinatology & Neonatology Authors: Menegotto, Mariana Magdaleno, Amanda M. da Silva, Carmem L.O. Friedrich, Luciana da Silva, Cl écio H. Tags: Original Article Source Type: research

Umbilical Cord Management in Late Preterm and Term Infants: A Randomized Controlled Trial
Conclusion These findings suggest that I-UCM is more beneficial choice. Further trials are needed to assess the various long- and short-term effects of different cord milking methods. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 20, 2021 Category: Perinatology & Neonatology Authors: Kilicdag, Hasan Karagun, Barbaros Sahin Antmen, Ali Bulent Candan, Erdal Erbas, Hale Tags: Original Article Source Type: research

Antimicrobial Prophylaxis Use in the Neonatal Intensive Care Unit: An Antimicrobial Stewardship Target That Deserves Attention!
Conclusion Surgical prophylaxis is a common reason for antimicrobial misuse in outborn NICU. NICU-based prospective audit and feedback between neonatologists and antimicrobial stewardship teams alone may not be impactful in this setting. Partnerships with neonatologists and surgeons will be key to achieving the target of less than 24 hours of postoperative antimicrobials. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American J...
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Viel-Th ériault, Isabelle Agarwal, Amisha Bariciak, Erika Le Saux, Nicole Thampi, Nisha Tags: Short Communication Source Type: research

Thiol-Disulfide Homeostasis in Neonatal Patients with Urinary Tract Infection
Conclusion The thiol-disulfide homeostasis is an important indicator of oxidative stress during infections. It is valuable to be detected with small amounts of serum in newborns. These molecules can be used to support the diagnosis of UTI in the newborn. Further studies are needed to define the role of thiol-disulfide homeostasis in the UTI of newborn. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Öktem, Ahmet Zenciro ğlu, Ayşegül Dilli, Dilek Bidev, Duygu Özyazıcı, Ahmet Özçelik, Emine Erel, Özcan Tags: Original Article Source Type: research

Effect of Hypothermia on Serum Myelin Basic Protein and Tumor Necrosis Factor- α in Neonatal Hypoxic-Ischemic Encephalopathy
Am J Perinatol DOI: 10.1055/s-0040-1722601 Objective Multiple randomized controlled trials have shown that hypothermia is a safe and effective treatment for neonatal moderate or severe hypoxic-ischemic encephalopathy (HIE). The neuroprotective mechanisms of hypothermia need further study. The aim of this study was to investigate the effect of hypothermia on the serum levels of myelin basic protein (MBP) and tumor necrosis factor-α (TNF-α) as well as neurodevelopmental outcomes in neonatal HIE. Study Design Eighty-five neonates with moderate-to-severe HIE were divided into a hypothermia group (n&...
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Wang, Qiuli Lv, Hongyan Wu, Sujing Song, Junxia Li, Junqin Huo, Haihua Ren, Pengshun Li, Lianxiang Tags: Original Article Source Type: research

Association between Low Cord Serum Cortisol Level and Transient Tachypnea of the Newborn in Late Preterm and Term Neonates Delivered by Elective Cesarean Section
Conclusion Umbilical cord cortisol levels are significantly lower in newborns with transient TTN, and lower cortisol levels are associated with an increased respiratory rate and longer duration of admission. Antenatal glucocorticoids can be recommended for late preterm delivered by CS. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Umran, Raid M.R. Khalil, Roaa M. Tags: Original Article Source Type: research

Attitudes of Argentinean Neonatologists toward Resuscitation of Infants with Trisomies 21, 18, and 13: A Multicenter Survey
Conclusion With improvement in the management and treatment of infants with trisomies 18 and 13, Argentinean neonatologists showed a favorable attitude toward resuscitating them in the delivery room. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Silberberg, Agust ín Etchegaray, Adolfo Ju árez Peñalva, Sofía Villar, Marcelo J. Musante, Gabriel Tags: Original Article Source Type: research

Effectiveness of Dual Medication Therapy (Oral Acetaminophen and Oral Ibuprofen) for the Management of Patent Ductus Arteriosus in Extremely Premature Infants: A Feasibility Trial
Am J Perinatol DOI: 10.1055/s-0040-1722329 Objective The study aimed to evaluate the efficacy of dual medication therapy (DMT) with oral acetaminophen and oral ibuprofen for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA). Study Design In a prospective case–control cohort study (July 2017–May 2019), infants
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Shah, Sanket D. Makker, Kartikeya Nandula, Padma Smotherman, Carmen Kropf, Andrea Hudak, Mark L. Tags: Original Article Source Type: research

Cardiopulmonary Function Abnormalities in Cohort of Adults following Bronchopulmonary Dysplasia as Preterm Infants
Conclusion BPD patients in this study were found to have a burden of cardiorespiratory alterations that persisted into adulthood, with RV performance abnormalities found among patients with obstructive PFT. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Lasry, Ariane Kavabushi, Patrick Canakis, Anne-Marie Luu, Thuy M. Nuyt, Anne-Monique Perreault, Th érèse Simoneau, Jessica Landry, Jennifer Altit, Gabriel Tags: Original Article Source Type: research

Isolated and On Guard: Preparing Neonatal Intensive Care Unit Families for Life with Hydrocephalus
Conclusion Parents expressed interest in the development of tiered NICU counseling tools that would provide evidence-based and family-centric information to (1) initiate connections with community and peer resources and (2) combat the isolation and hypervigilance that characterized their family experience of living with hydrocephalus. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 17, 2021 Category: Perinatology & Neonatology Authors: Dorner, Rebecca A. Boss, Renee D. Burton, Vera J. Raja, Katherine Robinson, Shenandoah Lemmon, Monica E. Tags: Original Article Source Type: research

Nasal Intermittent Positive Pressure Ventilation versus Continuous Positive Airway Pressure and Apnea of Prematurity: A Systematic Review and Meta-Analysis
Conclusion NIPPV was not associated with decrease in AOP frequency, although demonstrated lower odds of developing any AOP. However, definite recommendations cannot be made based on the quality of the published evidence. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 15, 2021 Category: Perinatology & Neonatology Authors: Sabsabi, Bayane Harrison, Ava Banfield, Laura Mukerji, Amit Tags: Original Article Source Type: research