Noncoding RNAs in skeletal development and disorders
Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of app... (Source: Biological Research)
Source: Biological Research - April 22, 2024 Category: Biomedical Science Authors: Qing Yao, Tailin He, Jian-You Liao, Rongdong Liao, Xiaohao Wu, Lijun Lin and Guozhi Xiao Tags: Review Source Type: research
Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subc... (Source: Biological Research)
Source: Biological Research - April 4, 2024 Category: Biomedical Science Authors: Elisa Perez-Moreno, Claudia Oyanadel, Adely de la Pe ña, Ronny Hernández, Francisca Pérez-Molina, Claudia Metz, Alfonso González and Andrea Soza Tags: Review Source Type: research
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that... (Source: Biological Research)
Source: Biological Research - April 4, 2024 Category: Biomedical Science Authors: Gonzalo I. G ómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz and Juan A. Tags: Research article Source Type: research
The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans
Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the... (Source: Biological Research)
Source: Biological Research - April 1, 2024 Category: Biomedical Science Authors: Laura Rodr íguez-Castro, Roberto E. Durán, Valentina Méndez, Flavia Dorochesi, Daniela Zühlke, Katharina Riedel and Michael Seeger Tags: Research article Source Type: research
Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function
Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic... (Source: Biological Research)
Source: Biological Research - April 1, 2024 Category: Biomedical Science Authors: Pei Chen, Chaoshuang Ye, Yunke Huang, Bingning Xu, Tianyu Wu, Yuanhang Dong, Yang Jin, Li Zhao, Changchang Hu, Jingxia Mao and Ruijin Wu Tags: Research article Source Type: research
MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal... (Source: Biological Research)
Source: Biological Research - March 23, 2024 Category: Biomedical Science Authors: Karina Ca ñón-Beltrán, Yulia N Cajas, Vasileios Almpanis, Sandra Guisado Egido, Alfonso Gutierrez-Adan, Encina M González and Dimitrios Rizos Tags: Research article Source Type: research
YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions
The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT... (Source: Biological Research)
Source: Biological Research - March 17, 2024 Category: Biomedical Science Authors: Yuanyuan Luo, Lingxiao Zhang, Ning Su, Lerong Liu and Tongfeng Zhao Tags: Research article Source Type: research
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease
Parkinson ’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceo... (Source: Biological Research)
Source: Biological Research - March 16, 2024 Category: Biomedical Science Authors: Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun, Si Chen, Panfeng Yin and Xianchun Wang Tags: Research article Source Type: research
Glial-restricted progenitor cells: a cure for diseased brain?
The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, alway... (Source: Biological Research)
Source: Biological Research - March 12, 2024 Category: Biomedical Science Authors: Piotr Rogujski, Barbara Lukomska, Miroslaw Janowski and Luiza Stanaszek Tags: Review Source Type: research
Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from... (Source: Biological Research)
Source: Biological Research - March 12, 2024 Category: Biomedical Science Authors: Mat ías Gálvez-Silva, Patricio Arros, Camilo Berríos-Pastén, Aura Villamil, Paula I. Rodas, Ingrid Araya, Rodrigo Iglesias, Pamela Araya, Juan C. Hormazábal, Constanza Bohle, Yahua Chen, Yunn-Hwen Gan, Francisco P. Chávez, Rosalba Lagos and Andrés Tags: Short report Source Type: research
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an... (Source: Biological Research)
Source: Biological Research - February 13, 2024 Category: Biomedical Science Authors: Tianqi Li, Rachel W.S. Chan, Raymond H.W. Li, Ernest H.Y. Ng, Songying Zhang and William S.B. Yeung Tags: Research article Source Type: research
Embryo development is impaired by sperm mitochondrial-derived ROS
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat... (Source: Biological Research)
Source: Biological Research - January 30, 2024 Category: Biomedical Science Authors: Yentel Mateo-Otero, Marc Llavanera, Marc Torres-Garrido and Marc Yeste Tags: Research article Source Type: research
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1
Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc... (Source: Biological Research)
Source: Biological Research - January 20, 2024 Category: Biomedical Science Authors: Fei Huang, Guozhen Wei, Hai Wang, Ying Zhang, Wenbin Lan, Yun Xie and Gui Wu Tags: Research article Source Type: research
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ... (Source: Biological Research)
Source: Biological Research - January 13, 2024 Category: Biomedical Science Authors: Huan Liu, Huijuan Kuang, Yiru Wang, Lili Bao, Wanxin Cao, Lu Yu, Meihao Qi, Renfeng Wang, Xiaoshan Yang, Qingyuan Ye, Feng Ding, Lili Ren, Siying Liu, Furong Ma and Shiyu Liu Tags: Research article Source Type: research
Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells
Increasing evidence suggests a double-faceted role of alpha-synuclein ( α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic... (Source: Biological Research)
Source: Biological Research - January 9, 2024 Category: Biomedical Science Authors: Fiona Limanaqi, Silvia Zecchini, Irma Saulle, Sergio Strizzi, Claudia Vanetti, Micaela Garziano, Gioia Cappelletti, Debora Parolin, Sonia Caccia, Daria Trabattoni, Claudio Fenizia, Mario Clerici and Mara Biasin Tags: Research article Source Type: research
