Evaluating the efficacy and safety of therapeutic interventions for corneal neuropathy: A systematic review
Ocul Surf. 2024 Apr 28:S1542-0124(24)00050-8. doi: 10.1016/j.jtos.2024.04.004. Online ahead of print.ABSTRACTCorneal neuropathy involves corneal nerve damage that disrupts ocular surface integrity, negatively impacting quality-of-life from pain and impaired vision. Any ocular or systemic condition that damages the trigeminal nerve can lead to corneal neuropathy. However, the condition currently does not have standardized diagnostic criteria or treatment protocols. The primary aim of this systematic review was to evaluate the efficacy and safety of interventions for treating corneal neuropathy. Randomized controlled trials ...
Source: The Ocular Surface - April 30, 2024 Category: Opthalmology Authors: Rajni Rajan Eve Makrai Ji-Hyun Lee Sumeer Singh Holly R Chinnery Laura E Downie Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early Diagnosis
CONCLUSION: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.PMID:38686909 | DOI:10.2174/0118715303273741231117060753 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Bai-Yi Liu Dan Zhang Zhu Fan Jing-Jing Jin Cai-Hong Li Rui-Nan Guo Xue-Juan Li Yan Huang Source Type: research
Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure?
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.PMID:38686683 | DOI:10.14503/THIJ-23-8210 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Xiaoqing Xi Jinfeng Cai Chen Zhang Xuefei Wang Source Type: research
Bioequivalence of Related GelShield < sup > Ⓡ < /sup > Sustained-Release Formulations of Metformin: A Pooled Pharmacokinetic Analysis
Clin Ther. 2024 Apr 29:S0149-2918(24)00077-8. doi: 10.1016/j.clinthera.2024.03.011. Online ahead of print.ABSTRACTPURPOSE: GlucophageⓇ (Merck Healthcare KGaA, Darmstadt, Germany) is the originator brand of metformin hydrochloride, an oral antidiabetic drug. Metformin is recommended in guidelines as first-line treatment of type 2 diabetes mellitus and increasingly in related insulin-resistant conditions, such as prediabetes and polycystic ovary syndrome. The GelShieldⓇ sustained-release formulation tablet of GlucophageⓇ has been improved from the historic version marketed in 2000. Bioequivalence has been demonstrated ...
Source: Clinical Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Axel Krebs-Brown Kerstin M G Brand Marco A F Nogueira Filho Sumedh Gaikwad Yvonne Schnaars Source Type: research
