Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis.
Abstract Non-alcoholic steatohepatitis (NASH) is becoming a growing public health problem along with the increase of metabolic syndrome worldwide. Extracellular nucleotides are known to serve as a danger signal by initiating purinergic signaling in many inflammatory disorders, although the role of purinergic signaling in the progression of NASH remains to be clarified. Vesicular nucleotide transporter (VNUT) is a key molecule responsible for vesicular ATP release to initiate purinergic signaling. Here, we studied the role of VNUT in the progression of nonalcoholic steatohepatitis. VNUT was expressed in mouse hepat...
Source: Acta Med Okayama - November 16, 2020 Category: Universities & Medical Training Authors: Tatsushima K, Hasuzawa N, Wang L, Hiasa M, Sakamoto S, Ashida K, Sudo N, Moriyama Y, Nomura M Tags: Biochim Biophys Acta Mol Basis Dis Source Type: research

Anaplastic Lymphoma Kinase Fusion: A Review of Therapeutic Drugs and Treatment Strategies.
Abstract The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epid...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Makimoto G, Ohashi K, Maeda Y, Kiura K Tags: Acta Med Okayama Source Type: research

Clinical Relevance of Serum Prolactin Levels to Inflammatory Reaction in Male Patients.
Abstract To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, ...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Yamamoto K, Hanayama Y, Hasegawa K, Tokumasu K, Miyoshi T, Hagiya H, Ogawa H, Obika M, Itoshima K, Otsuka F Tags: Acta Med Okayama Source Type: research

Three-dimensional Evaluation of Abnormal Gait in Patients with Hip Osteoarthritis.
Abstract Indexes for objectively evaluating abnormal gait in hip osteoarthritis (OA) patients and determining effective interventions are unclear. We analyzed the abnormal gait of hip OA patients by focusing on movements of the trunk and pelvis to establish an effective evaluation index for each direction of motion. We studied 28 patients with secondary hip OA due to developmental dysplasia of the hip and 16 controls. The trunk and pelvic movements during gait were measured in the medial-lateral (x), vertical (y), and back-and-forth (z) directions by a triaxial angular accelerometer. Gait speed, steps, step length...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Homma D, Minato I, Imai N, Miyasaka D, Sakai Y, Horigome Y, Suzuki H, Shimada H, Dohmae Y, Endo N Tags: Acta Med Okayama Source Type: research

Evaluation of Prognosis of Juvenile Differentiated Thyroid Carcinoma.
Abstract Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Tsukioki T, Shien T, Ohtani Y, Fujihara M, Suzuki Y, Kajihara Y, Hatono M, Kawada K, Kochi M, Iwamoto T, Ikeda H, Taira N, Doihara H Tags: Acta Med Okayama Source Type: research

Comprehensive Prospective Analysis of the Factors Contributing to Aspiration Pneumonia Following Endoscopic Submucosal Dissection in Patients with Early Gastric Neoplasms.
Abstract Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data w...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Togo M, Akazawa Y, Akashi T, Yamashita R, Yoshitomi I, Ohba K, Hashimoto S, Iwashita H, Kurogi T, Osada Y, Wada N, Imamura Y, Hashiguchi K, Yamaguchi N, Kondo H, Nakao K Tags: Acta Med Okayama Source Type: research

Oblique Surface Dose Calculation in High-Energy X-ray Therapy.
In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new e...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Narihiro N, Oita M, Takeda Y Tags: Acta Med Okayama Source Type: research

Rapid Disease Progression of Advanced Non-small Cell Lung Cancer Five Months after Cessation of Pembrolizumab.
We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replac...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Hirabae A, Ichihara E, Sunami R, Ota M, Iwamoto Y, Maeda Y, Kiura K Tags: Acta Med Okayama Source Type: research

Polydactyly of the Foot Diagnosed from a Minor Nail Problem.
Abstract Polydactyly is one of the most common foot congenital anomalies. It is often detected immediately after birth, but the diagnosis can sometimes be delayed if the symptoms are less evident. A 2-year-old girl with a complaint of recurrent bleeding from the right toenail was diagnosed with foot polydactyly. She underwent corrective surgery, and her family was satisfied with the outcome. Although the diagnosis of polydactyly may be difficult in cases with minor nail problems, further radiographic evaluation will be needed for the improvement of the patient's quality of life. PMID: 33106699 [PubMed - in pr...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Hiraoka T, Senoo H, Yamazaki Y, Suenobu K, Tsukahara H Tags: Acta Med Okayama Source Type: research

A Giant Thymic Cyst Accompanied by Acute Mediastinitis.
Abstract We encountered a rare case of thymic cyst accompanied by mediastinitis. A 39-year-old Japanese male presented with fever and chest pain. The chest CT revealed a mass composed of a lobular cystic lesion with inflammation, suggesting the onset of mediastinitis. A definitive histological diagnosis was not obtained, and we performed a thymectomy. Pathologically, the thymic cyst was accompanied by multiple cavities, mimicking thymic cysts, caused by the inflammatory abscess. The surrounding adipose tissue showed inflammatory cell infiltrations with chronic fibrosis. These findings indicate that clinicians shou...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Miura A, Shien K, Toji T, Otani S, Yamamoto H, Okazaki M, Sugimoto S, Soh J, Yamane M, Toyooka S Tags: Acta Med Okayama Source Type: research

A Disseminated Fusarium fujikuroi Species Complex Infection Prior to Allogeneic Hematopoietic Stem Cell Transplantation.
Abstract A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Fujishita K, Oka S, Kamei K, Tani K, Fujisawa Y, Kitamura W, Machida T, Imai T Tags: Acta Med Okayama Source Type: research

Combined Laparoscopic and CT Monitoring of the Ice-Ball Margin during Cryoablation for Renal Cell Carcinoma Associated with von Hippel-Lindau Disease: First Case.
We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin d...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Sekito T, Araki M, Hiraki T, Uka M, Komaki T, Matsui Y, Iguchi T, Katayama S, Yoshinaga K, Watari S, Maruyama Y, Mitsui Y, Kubota R, Sadahira T, Nishimura S, Wada K, Takamoto A, Edamura K, Sako T, Kobayashi Y, Watanabe T, Kanazawa S, Nasu Y Tags: Acta Med Okayama Source Type: research

Seronegative Oligoarthritis Preceding Psoriasis by 9.5 Years.
We report a case of psoriatic arthritis where oligoarthritis preceded the skin lesions. A 57-year-old man complained of left third-finger pain. Laboratory examinations were negative for anti-cyclic citrullinated peptide antibodies and rheumatoid factor; he was treated for suspected rheumatoid arthritis. Six years later, X-ray revealed enthesitis of his fingers and wrist joint. At 9.5 years after the initial visit, skin lesions appeared in the left auricular region and buttock and dermatopathology findings indicated psoriasis vulgaris. The final diagnosis was psoriatic arthritis. In cases of seronegative oligoarthritis, pso...
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Tsuchiya J, Kondo N, Fujimoto A, Kondo R, Yamada M, Kuraishi T, Yoda T, Abe R, Endo N Tags: Acta Med Okayama Source Type: research

Study Protocol for Assessing the Efficacy of Compression Therapy Using Stockings and Sleeves to Prevent Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients.
This study's results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients. PMID: 33106704 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - October 1, 2020 Category: Universities & Medical Training Authors: Yamanouchi K, Kuba S, Matsumoto M, Yano H, Morita M, Sakimura C, Otsubo R, Kanetaka K, Nagayasu T, Eguchi S Tags: Acta Med Okayama Source Type: research

Health-Related Quality of Life in Patients on Home Oxygen Therapy with Telemonitoring.
Abstract Home oxygen therapy (HOT) is an important treatment for patients with chronic respiratory diseases. Recently, telemonitoring of HOT has been become available. In the present study, we examined whether telemonitoring of HOT could improve health-related quality of life (HRQOL). Twelve patients receiving HOT participated in this study. The oxygen flow rates, use of the oxygen concentrator, and the values of percutaneous arterial oxygen saturation measured by each patient with a pulse oximeter were checked using a telemonitoring system for a period of one month. Interventions based on the results obtained wer...
Source: Acta Med Okayama - April 30, 2020 Category: Universities & Medical Training Authors: Burioka N, Yamamoto A, Morimoto M, Yamasaki A, Hirayama Y, Takata M Tags: Yonago Acta Med Source Type: research

The Efficacy of Software to Help Patients Understand Drug for Adjuvant Treatment for Breast Cancer: A Pilot Randomized Controlled Trial.
Abstract We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regardin...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Kuba S, Yamanouchi K, Morita M, Sakimura C, Inamasu E, Hatachi T, Otsubo R, Matsumoto M, Yano H, Miyamoto J, Sato S, Nakagawa H, Kanetaka K, Takatsuki M, Nagayasu T, Eguchi S Tags: Acta Med Okayama Source Type: research

Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients.
This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal ...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Kawada Y, Kubo T, Baba Y, Hirota T, Tanioka K, Yamasaki N, Kitaoka H Tags: Acta Med Okayama Source Type: research

Risk of Gynecologic Cancer as Second versus First Primary Cancer in Japan.
This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan-Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previ...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Ogawa C, Nakamura K, Matsuoka H, Matsubara Y, Haraga J, Masuyama H Tags: Acta Med Okayama Source Type: research

Increased Plasma Levels of Platelet Factor 4 and β-thromboglobulin in Women with Recurrent Pregnancy Loss.
Increased Plasma Levels of Platelet Factor 4 and β-thromboglobulin in Women with Recurrent Pregnancy Loss. Acta Med Okayama. 2020 Apr;74(2):115-122 Authors: Kotani S, Kamada Y, Shimizu K, Sakamoto A, Nakatsuka M, Hiramatsu Y, Masuyama H Abstract Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) a...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Kotani S, Kamada Y, Shimizu K, Sakamoto A, Nakatsuka M, Hiramatsu Y, Masuyama H Tags: Acta Med Okayama Source Type: research

The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma.
Abstract The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was ...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Fukuhara R, Shinya T, Fukuma S, Ogawa N, Masaoka Y, Tanaka T, Marunaka H, Arioka T, Hiraki T, Kaji M, Kanazawa S Tags: Acta Med Okayama Source Type: research

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer.
This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal-Wallis test. Late phase attenuation and attenuation of the late minus un...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Fukuma S, Shinya T, Soh J, Fukuhara R, Ogawa N, Higaki F, Tanaka T, Ichihara E, Hiraki T, Toyooka S, Kanazawa S Tags: Acta Med Okayama Source Type: research

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital's 30+-Year Experience.
Abstract Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both signifi...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Isozaki H, Yamamoto Y, Sakai K, Sho T, Ishihara K, Murakami S, Matsumoto S, Takama T Tags: Acta Med Okayama Source Type: research

The Efficacy of Mirabegron for the Relief of Ureteral Stent-Related Symptoms.
Abstract To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for> 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-litho...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Otsuki H, Yamasaki T, Hori S, Aoki H, Kosaka T, Uehara S, Fujio K Tags: Acta Med Okayama Source Type: research

Non-traumatic Atypical Peri-implant Femoral Fracture at the Distal Screw after Short Femoral Nail Fixation for a Pertrochanteric Fracture.
Abstract This is the second report of an atypical peri-implant femoral fracture occurring at the distal screw after intramedullary nail fixation of a pertrochanteric fracture. A 94-year-old Japanese female with a 5-year history of alendronate intake presented with prodromal pain in her right thigh after intramedullary nail fixation. Plain radiographs showed an incomplete noncomminuted transverse fracture at the distal screw, suggesting an atypical peri-implant femoral fracture. The pathogenesis of an atypical peri-implant femoral fracture could be a combined systemic bone metabolism disorder and repetitive overloa...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Yamamoto N, Dan'ura T, Noda T, Ozaki T Tags: Acta Med Okayama Source Type: research

Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case.
Abstract Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested. PMID: 32341591 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: San TH, Ota Y, Fushimi S, Fujisawa M, Yanai H, Toda H, Kunitomo T, Kodama K, Matsukawa A Tags: Acta Med Okayama Source Type: research

Identification of a Novel ACVRL1 Gene Mutation (c.100T > A, p.Cys34Ser) in a Japanese Patient with Possible Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease).
We describe the case of a 50-year-old Japanese man highly suspected of having HHT due to recurrent epistaxis, mucocutaneous telangiectasia, and a family history. Genomic analysis revealed a novel missense mutation of c.100T>A, p.Cys34Ser in the patient's ACVRL1 gene. We used 6 freeware programs to perform an in silico analysis of this mutation. The results demonstrated the mutation's high pathogenicity. PMID: 32341592 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Umemura H, Miura K, Naruse H, Hatta Y, Takei M, Nakayama T Tags: Acta Med Okayama Source Type: research

Incarcerated Amyand's Hernia.
Abstract A 76-year-old Japanese man was transferred to our hospital to undergo rehabilitation after traffic accident-related injuries. Seven days post-admission, he presented with abdominal pain and an 8-cm lump in the right inguinal region. He was diagnosed with an incarcerated inguinal hernia and underwent elective surgery the day after manual reduction. He had a normal vermiform appendix which was observed to have adhered to the right indirect hernia sac. An appendectomy and hernia repair using lightweight mesh were performed. We discuss the surgical management of this rare incarcerated Amyand's hernia and the ...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Okita A, Yoshida O, Murakami M Tags: Acta Med Okayama Source Type: research

Percutaneous Nephrolithotomy under Local Infiltration Anesthesia in Kneeling Prone Position for a Patient with Spinal Deformity.
Abstract Urolithiasis, a common condition in patients with spinal deformity, poses a challenge to surgical procedures and anesthetic management. A 51-year-old Chinese male presented with bilateral complex renal calculi. He was also affected by severe kyphosis deformity and spinal stiffness due to ankylosing spondylitis. Dr. Li performed the percutaneous nephrolithotomy under local infiltration anesthesia with the patient in a kneeling prone position, achieving satisfactory stone clearance with no severe complications. We found this protocol safe and effective to manage kidney stones in patients with spinal deformi...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Yu Z, Lin W, Xu A, Liu C, Li H, Huang P Tags: Acta Med Okayama Source Type: research

Conventional versus Rapid Glucocorticoid Tapering in Severe Systemic Lupus Erythematosus Patients: A Non-Blind, Randomized Controlled Trial.
Abstract Glucocorticoids (GCs) have long played a central role in the treatment of systemic lupus erythematosus (SLE), but these drugs have many adverse effects. We will determine whether rapid weekly GC tapering is non-inferior to conventional biweekly tapering in patients with severe SLE. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the relapse-free survival rate at 52 weeks. The main secondary outcome is the prevalence of the Lupus Low Disease Activity State at 52 weeks. The trial will determine the optimal method of tapering GCs in patients with severe SLE. PMID: ...
Source: Acta Med Okayama - March 31, 2020 Category: Universities & Medical Training Authors: Abe Y, Fujibayashi K, Nishizaki Y, Yanagisawa N, Nojiri S, Kon T, Tada K, Yamaji K, Tamura N Tags: Acta Med Okayama Source Type: research

Insulin allergy brought out 8  years after starting insulin therapy in a subject with type 1 diabetes mellitus.
Insulin allergy brought out 8 years after starting insulin therapy in a subject with type 1 diabetes mellitus. Acta Diabetol. 2020 Feb 20;: Authors: Kimura T, Fushimi Y, Hayashi H, Tatsumi F, Kanda-Kimura Y, Shimoda M, Hirukawa H, Sanada J, Obata A, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H PMID: 32078040 [PubMed - as supplied by publisher] (Source: Acta Med Okayama)
Source: Acta Med Okayama - February 19, 2020 Category: Universities & Medical Training Authors: Kimura T, Fushimi Y, Hayashi H, Tatsumi F, Kanda-Kimura Y, Shimoda M, Hirukawa H, Sanada J, Obata A, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H Tags: Acta Diabetol Source Type: research

The Aging Population and Research into Treatments for Abdominal Aortic Aneurysms.
Abstract Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair a...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Umebayashi R, Uchida HA, Wada J Tags: Acta Med Okayama Source Type: research

Correlations between Depressive Condition and Gastroesophageal Reflux Symptoms in Patients Visiting a Department of General Medicine.
Abstract To clarify the potential relevance of patients' chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Suganami Y, Oka K, Hanayama Y, Honda H, Hamahara J, Obika M, Kariyama K, Kishida M, Otsuka F Tags: Acta Med Okayama Source Type: research

Foveal Structural Analysis of Amblyopic Eyes with Two Types of Fixation Behavior by Spectral-Domain Optical Coherence Tomography.
Abstract We used spectral-domain optical coherence tomography (SD-OCT) to compare the foveal and parafoveal structures of 19 subjects aged 16-58 years (8 men, 11 women): 6 amblyopic patients with eccentric fixation, 5 amblyopic patients with central fixation, and 8 visually normal controls. We obtained foveal horizontal line scans using SD-OCT on all of the patients and controls. The total and layer thicknesses at foveal areas were analyzed. The mean (SD) ages of individuals in the eccentric fixation, central fixation, and control groups were 43.0 (13.9), 42.2 (16.3), and 38.5 (15.5) years, respectively. We observ...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Kishimoto F, Fujii C, Okanouchi T, Ohtsuki H Tags: Acta Med Okayama Source Type: research

Transtibial Pullout Repair Reduces Posterior Extrusion of the Medial Meniscus.
Abstract Medial meniscus posterior root tear causes rapid knee cartilage degradation by inducing posteromedial displacement of the medial meniscus. We evaluated medial meniscus posterior extrusion before and after pullout repair for medial meniscus posterior root tear using magnetic resonance images. Twenty-eight patients with symptomatic medial meniscus posterior root tear were included. The inclusion criteria were: acute (
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Masuda S, Furumatsu T, Okazaki Y, Kamatsuki Y, Okazaki Y, Kodama Y, Hiranaka T, Nakata E, Ozaki T Tags: Acta Med Okayama Source Type: research

The Early Arthroscopic Pullout Repair of Medial Meniscus Posterior Root Tear Is More Effective for Reducing Medial Meniscus Extrusion.
Abstract Clinical studies have demonstrated that transtibial pullout repair led to favorable midterm outcomes in patients with medial meniscus posterior root tears (MMPRTs) although medial meniscal extrusion (MME) continued to be present. It has been unclear whether these residual postoperative MMEs existed after the pullout repair or had progressed at the very short-term evaluation after surgery. We sought to determine which characteristics of patients with MMPRTs influence the incidence of postoperative MME. The cases of 23 patients whose date of injury was known were analyzed. All patients underwent MMPRT pullo...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Kamatsuki Y, Furumatsu T, Miyazawa S, Kodama Y, Hino T, Okazaki Y, Masuda S, Okazaki Y, Noda T, Yamakawa Y, Tetsunaga T, Ozaki T Tags: Acta Med Okayama Source Type: research

Time to Bone Union after Hybrid Closed-Wedge High Tibial Osteotomy.
Abstract Medial open- and lateral closed-wedge high tibial osteotomy (hybrid CWHTO) can overcome the limitations of conventional CWHTO and open-wedge HTO (OWHTO) for medial compartmental osteoarthritis (OA) of the knee. Hybrid CWHTO increases stability by using a rigid locking plate and allows early full weight-bearing. However, the literature contains no information about time to bone union after this new procedure. The aim of this study is to evaluate the time to bone union after hybrid CWHTO. We reviewed 44 knees treated with hybrid CWHTO. Patients were able to stand on both legs on the day after surgery and wa...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Takahara Y, Furumatsu T, Nakashima H, Itani S, Nakamura M, Uchida Y, Kato H, Tsujimura Y, Iwasaki Y, Ochi N Tags: Acta Med Okayama Source Type: research

Two-year Results of Intravitreal Ranibizumab Injections Using a Treat-and-extend Regimen for Macular Edema due to Branch Retinal Vein Occlusion.
Abstract We investigated the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 2-year results of 32 eyes of 32 patients who underwent TAE to treat ME due to BRVO. The patients whose treatment interval extended to ≥ 12 weeks were switched to a pro re nata regimen (PRN). For the patients whose treatment interval was
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Hosogi M, Shiode Y, Morizane Y, Kimura S, Hosokawa M, Doi S, Toshima S, Takahashi K, Fujiwara A, Shiraga F Tags: Acta Med Okayama Source Type: research

Bilateral Anterior Cruciate Ligament Tear Combined with Medial Meniscus Posterior Root Tear.
Abstract The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred> 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thu...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Hiranaka T, Furumatsu T, Okazaki Y, Kamatsuki Y, Masuda S, Okazaki Y, Takihira S, Miyazawa S, Nakata E, Ozaki T Tags: Acta Med Okayama Source Type: research

An Adult Case of Nasal Chondromesenchymal Hamartoma: Imaging Characteristics Including Diffusion-Weighted Images.
Abstract Nasal chondromesenchymal hamartoma (NCMH), a rare, benign, nasal cavity tumor, typically occurs in children. Differential diagnosis is difficult because NCMH often presents with non-specific findings, including cystic components and invasion of the surrounding area on T2-weighted magnetic resonance images. Here, we present a rare adult case of NCMH, with no clear hyperintensity on diffusion-weighted images (DWI), and bone remodeling on the tumor margins on computed tomography. To the best of our knowledge, this is the first report of DWI on NCMH, and these findings, which suggest benign disease, may be us...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Kitayama T, Akaki S, Hisazumi K, Yoshio K, Inoue D, Tajiri N, Shiode T, Kanazawa S, Fujimoto S, Kanai K, Hirata Y Tags: Acta Med Okayama Source Type: research

Reconstruction of Complete Peroneus Longus and Brevis Tendon Ruptures Using a Semitendinosus and Gracilis Tendon Graft.
Abstract The patient was a 40-year-old female who had been treated at our hospital for left peroneal tendonitis due to an ankle sprain 2 years earlier. She re-injured that ankle while dancing. The pain in the lateral left foot soon improved, but she had difficulty standing with the left foot in equinus. Complete peroneus longus and brevis tendon ruptures were diagnosed. The ipsilateral semitendinosus and gracilis tendons were harvested and used to reconstruct the tendons. Three months after surgery, the patient was able to stand in equinus, and at 5 months after surgery she resumed her original level of sports act...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Morimoto Y, Tokuhashi Y Tags: Acta Med Okayama Source Type: research

Two Cases of High Tibial Osteotomy in Patients with Rheumatoid Arthritis Treated with Biologic Disease-modifying Anti-rheumatic Drugs.
We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty. PMID: 31871338 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Takahara Y, Nishida K, Nakashima H, Ochi N, Uchida Y, Kato H, Itani S, Nakamura M, Iwasaki Y, Tsujimura Y Tags: Acta Med Okayama Source Type: research

Local Anesthetic Systemic Toxicity Following General and Epidural Anesthesia in A patient with a History of Muscle Relaxant-induced Anaphylaxis.
Abstract We here report that a 71-year-old Japanese woman with a history of anaphylaxis induced by muscle relaxants had local anesthetic systemic toxicity (LAST) following an abdominal surgery under general anesthesia with combined spinal-epidural anesthesia without muscle relaxants. The total dosages of local anesthetics reached 0.67 mg/kg of ropivacaine and 11.5 mg/kg of lidocaine over 12.5 h to obtain sufficient muscle relaxation for surgery. Regional anesthesia is useful in cases in which muscle relaxants are to be avoided during a surgery. However, especially for a patient with risk factors and prolonged surg...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Kubo A, Shimizu K, Kuroda K, Kanazawa T, Kobayashi M, Morimatsu H Tags: Acta Med Okayama Source Type: research

Phase II Study of Treatment for Newly Diagnosed Multiple Myeloma Patients Over 75 Years Old with Alternating Bortezomib/dexamethasone and Lenalidomide/dexamethasone: the MARBLE Trial.
Abstract Elderly multiple myeloma (MM) patients, who are generally ineligible for transplantation, have high risks of death and treatment discontinuation, and require a regimen incorporating novel agents that balance safety, tolerability, and efficacy. We evaluated alternating bortezomib-dexamethasone and lenalidomide-dexamethasone treatments administered over a 63-day cycle in transplant-ineligible elderly patients with newly diagnosed MM. Subcutaneous bortezomib 1.3 mg/m2 was administered weekly on Days 1, 8, 15, and 22; oral lenalidomide 15 mg daily on Days 36-56; and oral dexamethasone 20 mg on Days 1, 8, 15, ...
Source: Acta Med Okayama - November 30, 2019 Category: Universities & Medical Training Authors: Yokoyama A, Kada A, Saito AM, Sawamura M, Komeno T, Sunami K, Takezako N Tags: Acta Med Okayama Source Type: research

Histidine-rich Glycoprotein Modulates the Blood-vascular System in Septic Condition.
Abstract Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding an...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Wake H Tags: Acta Med Okayama Source Type: research

The Role of High Mobility Group Box-1 in Epileptogenesis.
Abstract High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis. PMID: 31649363 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Fu L, Nishibori M Tags: Acta Med Okayama Source Type: research

Comparison of Two Different Drugs for Overactive Bladder, Solifenacin and Mirabegron: A Prospective Randomized Crossover Study.
Abstract To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of s...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Inoue M, Yokoyama T Tags: Acta Med Okayama Source Type: research

Developing Microsurgery through Experience in Yangon General Hospital, Myanmar.
Abstract Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Yi Yi Cho Thein, Myitzu Win, Moe Thuzar, Matsumoto H, Yamada K, Kimata Y, Leung M Tags: Acta Med Okayama Source Type: research

Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting.
Abstract Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual's bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients' BMD values and changes in the patients' physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We ana...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Ando A, Mitsuhashi T, Honda M, Hanayama Y, Hasegawa K, Obika M, Kataoka H, Otsuka F Tags: Acta Med Okayama Source Type: research

Feasibility of Laparoscopic Radical Cystectomy in Elderly Patients: A Comparative Analysis of Clinical Outcomes in a Single Institution.
In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.05...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Yanagihara Y, Nishida K, Watanabe R, Koyama K, Sawada Y, Noda T, Asai S, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Saika T Tags: Acta Med Okayama Source Type: research

Relationship between Sedentary Behavior and All-cause Mortality in Japanese Chronic Hemodialysis Patients: A Prospective Cohort Study.
Abstract We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups' clinical parameters. We compared the groups' survival rates by using Kaplan-Meier curves an...
Source: Acta Med Okayama - September 30, 2019 Category: Universities & Medical Training Authors: Hishii S, Miyatake N, Nishi H, Katayama A, Ujike K, Koumoto K, Suzuki H, Hashimoto H Tags: Acta Med Okayama Source Type: research