Histidine-rich Glycoprotein Modulates the Blood-vascular System in Septic Condition.
Abstract Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding an...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Wake H Tags: Acta Med Okayama Source Type: research

The Role of High Mobility Group Box-1 in Epileptogenesis.
Abstract High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis. PMID: 31649363 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Fu L, Nishibori M Tags: Acta Med Okayama Source Type: research

Comparison of Two Different Drugs for Overactive Bladder, Solifenacin and Mirabegron: A Prospective Randomized Crossover Study.
Abstract To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of s...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Inoue M, Yokoyama T Tags: Acta Med Okayama Source Type: research

Developing Microsurgery through Experience in Yangon General Hospital, Myanmar.
Abstract Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Yi Yi Cho Thein, Myitzu Win, Moe Thuzar, Matsumoto H, Yamada K, Kimata Y, Leung M Tags: Acta Med Okayama Source Type: research

Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting.
Abstract Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual's bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients' BMD values and changes in the patients' physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We ana...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Ando A, Mitsuhashi T, Honda M, Hanayama Y, Hasegawa K, Obika M, Kataoka H, Otsuka F Tags: Acta Med Okayama Source Type: research

Feasibility of Laparoscopic Radical Cystectomy in Elderly Patients: A Comparative Analysis of Clinical Outcomes in a Single Institution.
In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.05...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Yanagihara Y, Nishida K, Watanabe R, Koyama K, Sawada Y, Noda T, Asai S, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Saika T Tags: Acta Med Okayama Source Type: research

Relationship between Sedentary Behavior and All-cause Mortality in Japanese Chronic Hemodialysis Patients: A Prospective Cohort Study.
Abstract We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups' clinical parameters. We compared the groups' survival rates by using Kaplan-Meier curves an...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Hishii S, Miyatake N, Nishi H, Katayama A, Ujike K, Koumoto K, Suzuki H, Hashimoto H Tags: Acta Med Okayama Source Type: research

"Active Guide" Brochure Reduces Sedentary Behavior of Elderly People: A Randomized Controlled Trial.
"Active Guide" Brochure Reduces Sedentary Behavior of Elderly People: A Randomized Controlled Trial. Acta Med Okayama. 2019 Oct;73(5):427-432 Authors: Owari Y, Suzuki H, Miyatake N Abstract The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the "Active Guide" brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people w...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Owari Y, Suzuki H, Miyatake N Tags: Acta Med Okayama Source Type: research

Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia.
In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)re...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Tamada S, Mitsui T, Ohira A, Tani K, Maki J, Eguchi T, Eto E, Hayata K, Masuyama H Tags: Acta Med Okayama Source Type: research

Risk Factors for Postoperative Hematoma after Chest Wall Contouring for Female-to-Male Transsexuals: A Clinical Study.
Abstract Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematom...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Watanabe T, Sakurai T, Mukai Y, Kimata Y, Namba Y Tags: Acta Med Okayama Source Type: research

Acute Prevertebral Abscesses Caused by Bacterial-infected Traumatic Tooth Fractures.
We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fract...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Matsunaga K, Takemaru M, Yamashiro K, Yoshihara-Hirata C, Inohara K, Shimoe Y, Tanaka A, Kuriyama M, Takashiba S Tags: Acta Med Okayama Source Type: research

A Granulation Polyp in the Colon Masquerading as Metastatic Cancer.
Abstract A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were obser...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Iwamuro M, Takahara M, Yamazaki T, Tanaka T, Kondo Y, Hiraoka S, Okada H Tags: Acta Med Okayama Source Type: research

Twist Knot: A New Sliding Noose in Adjustable Suture Strabismus Surgery.
Abstract To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the "twist knot" and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Shibata K, Hamasaki I, Shimizu T, Kono R, Ohtsuki H, Morizane Y, Shiraga F Tags: Acta Med Okayama Source Type: research

Phase II Trial Using Romidepsin after Gemcitabine, Dexamethasone, and Cisplatin Therapy in Elderly Transplant-Ineligible Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma: Study Protocol.
Abstract Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in th...
Source: Acta Med Okayama - October 1, 2019 Category: Universities & Medical Training Authors: Yamasaki S, Kada A, Nagai H, Yoshida I, Choi I, Saito AM, Iwasaki H Tags: Acta Med Okayama Source Type: research

Nodal Merkel Cell Carcinoma in Head and Neck Lesions with an Unknown Primary: A Case Report in Light of the Literature.
We report a unique case of nodal MCC in head and neck lesions with an unknown primary. A 70-year-old woman was admitted to our department with a right submandibular mass. Fine needle aspiration biopsy was performed and indicated malignancy. F-18-fluorodeoxyglucose positron emission tomography (PET) demonstrated abnormal accumulation in the right submandibular lymph node, right palatine tonsil, and right thyroid gland. For diagnostics and treatment, bilateral selective neck lymph node dissection, right tonsillectomy, and right thyroidectomy were performed. Histopathological examination revealed that most parts of the subman...
Source: Acta Med Okayama - September 1, 2019 Category: Universities & Medical Training Authors: Ikeda R, Ohta N, Fukaya S, Shoji F, Suzuki T, Noguchi N, Kakuta R, Hayashi K, Kiba T, Murakami K, Nakamura Y Tags: Yonago Acta Med Source Type: research

Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2 ε.
Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug 29;:158515 Authors: Mustafiz SSB, Uyama T, Morito K, Takahashi N, Kawai K, Hussain Z, Tsuboi K, Araki N, Yamamoto K, Tanaka T, Ueda N Abstract N-Acyl-phosphatidylethanolamines (NAPEs) are known to be precursors of bioactive N-acylethanolamines (NAEs), including the endocannabinoid arachidonoylethanolamide (anandamide) and anti-inflammatory palmitoylethanolamide. In mammals, NAPEs are produced by N-acyltransferases, which transfer a...
Source: Acta Med Okayama - August 29, 2019 Category: Universities & Medical Training Authors: Mustafiz SSB, Uyama T, Morito K, Takahashi N, Kawai K, Hussain Z, Tsuboi K, Araki N, Yamamoto K, Tanaka T, Ueda N Tags: Biochim Biophys Acta Mol Cell Biol Lipids Source Type: research

Dynamic Reorganization of Microtubule and Glioma Invasion.
Abstract Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliom...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Otani Y, Ichikawa T, Kurozumi K, Date I Tags: Acta Med Okayama Source Type: research

Tuberosity-overlapping Fixation of the Humeral Shaft in Humeral Head Replacement Surgery.
Abstract The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union ...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Hiranaka T, Nishida K, Konishiike T, Ozaki T, Mikasa M Tags: Acta Med Okayama Source Type: research

Impact of Disease Complexity on Cardiovascular Events after the Transition to an Adult Congenital Heart Disease Specialized Medical Unit.
Abstract The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients' appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Takahashi S, Akagi T, Toh N, Takaya Y, Nakagawa K, Nishii N, Ito H Tags: Acta Med Okayama Source Type: research

Construction and Characterization of a PGN_0297 Mutant of Porphyromonas gingivalis: Evidence of the Contribution of PGN_0297 to Gingipain Activity.
Abstract The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism's virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene ...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Ono S, Nakayama M, Tachibana M, Shahriar ASM, Heling W, Takashiba S, Ohara N Tags: Acta Med Okayama Source Type: research

Therapeutic Outcomes of 15 Postoperative Bronchopleural Fistulas Including Seven Endoscopic Interventions.
Abstract Therapeutic approaches to bronchopleural fistula (BPF) closure after lung resection are surgical or endoscopic interventions. We evaluated therapeutic outcomes to determine the optimal approach. We reviewed 15 patients who had developed BPF after lung resection for thoracic malignant diseases at our institution in the 10 years since 2008. The patients were 11 men and 4 women (mean age 68 years). We performed one pneumonectomy, 6 lobectomies, 7 segmentectomies, and one partial resection for malignant diseases. The median interval from lung resection to the BPF diagnosis was 46 days. The BPF-associated mort...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Ueno T, Maki Y, Sugimoto R, Suehisa H, Yamashita M, Harada D, Kozuki T, Nogami N Tags: Acta Med Okayama Source Type: research

The Efficacy and Safety of Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma.
Abstract Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) ...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Kuwaki K, Nouso K, Miyashita M, Makino Y, Hagihara H, Moriya A, Adachi T, Wada N, Yasunaka Y, Yasunaka T, Takeuchi Y, Onishi H, Nakamura S, Ikeda F, Shiraha H, Takaki A, Okada H Tags: Acta Med Okayama Source Type: research

Evaluation of Treatment Response in Prostate Cancer and Renal Cell Carcinoma Patients Using 11C-choline PET/CT Findings.
Abstract We investigated the effectiveness of 11C-choline-positron emission tomography/computed tomography (PET/CT) for evaluating treatment response in patients with prostate cancer or renal cell carcinoma. We performed 34 11C-choline PET/CT scans before/after a combined total of 17 courses of treatment in 6 patients with prostate cancer and 2 with renal cell carcinoma. The 17 treatments including hormonal therapy, radiotherapy, chemotherapy, radium-223, molecular target therapy, radiofrequency ablation, transcatheter arterial embolization, and cancer immunotherapy yielded 1 (5.9%) complete metabolic response (CM...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Kitajima K, Yamamoto S, Nakanishi Y, Yamada Y, Hashimoto T, Suzuki T, Go S, Kanematsu A, Nojima M, Fujiwara M, Kaida H, Tsurusaki M, Kanda T, Tamaki Y, Yamakado K Tags: Acta Med Okayama Source Type: research

Significance of Microcalcifications on Mammography in the Surgical Treatment of Breast Cancer Patients with a Preoperative Diagnosis of Ductal Carcinoma in Situ by Core Needle Biopsy.
Abstract To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) cat...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Isozaki H, Yamamoto Y, Murakami S, Matsumoto S, Takama T Tags: Acta Med Okayama Source Type: research

Characteristics of Grouped Discharge Waveforms Observed in Long-term Masseter Muscle Electromyographic Recording: A Preliminary Study.
Abstract We investigated the characteristics of grouped discharge (GD) waveforms obtained from long-term masseter electromyogram (EMG) recording in 6 female temporomandibular disorder (TMD) patients with myofascial pain and 6 healthy females. The EMG measurement was performed from the morning of the experiment day until the subject woke up the next day. We observed a significantly larger number of GD waveforms in the TMD group compared to the control group (p=0.002). Our results indicate that the existence of GD waveforms in masseter EMGs might be a predictor of future TMD with myofascial pain. PMID: 31439959...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Maeda N, Kodama N, Manda Y, Kawakami S, Oki K, Minagi S Tags: Acta Med Okayama Source Type: research

A Case of Primary Colonic Signet Ring Cell Carcinoma in a Young Man which Preoperatively Mimicked Phlebosclerotic Colitis.
Abstract A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely simil...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Watanabe A, Kadowaki Y, Hattori K, Ohmori M, Tsukayama H, Kubota N, Okumoto T, Ishido N, Okino T Tags: Acta Med Okayama Source Type: research

A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis.
Abstract Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present m...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Mifune-Morioka T, Uchida HA, Fukushima K, Watanabe M, Ouchi C, Mise K, Kawakita C, Kano Y, Onishi A, Toma K, Eguchi J, Wada N, Ikeda F, Sasaki E, Suganami Y, Kishida M, Sugiyama H, Okada H, Wada J Tags: Acta Med Okayama Source Type: research

Lateral Lumbar Interbody Fusion with Percutaneous Pedicle Screw in Combination with Microendoscopic Laminectomy in the Lateral Position for Lumbar Canal Stenosis.
Abstract A minimally invasive surgical (MIS) procedure is an ideal surgical procedure. Many MIS techniques have been reported in spinal surgery. In clinical practice, we often encounter two-level canal stenosis cases, in which one level shows instability and the other does not. In such a case, fusion surgery for one level and decompression surgery for the other level is ideal. LLIF/OLIF approached from the lateral side has been reported effective. MIS decompression techniques in the lateral decubitus position have never been reported. We devised a surgical method that can accomplish both fixation and decompression...
Source: Acta Med Okayama - August 1, 2019 Category: Universities & Medical Training Authors: Oda Y, Yamauchi T, Tanaka M Tags: Acta Med Okayama Source Type: research

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry.
Abstract Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatme...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Sakamoto S, Kawai H, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K, Mizuki Y, Takaki M, Yamada N Tags: Acta Med Okayama Source Type: research

Geriatric Trauma in Patients ≧85 Years Old in an Urban District of Japan.
Abstract Japan's population has been skewing toward the elderly, but the outcomes of advanced elderly trauma are not clear. Here we compared the outcomes of very elderly trauma patients (≧85 years old) with those of 65- to 84-year-old trauma patients. We retrospectively reviewed the medical records of patients treated at Hyogo Emergency Medical Center from August 2010 to August 2016; 631 patients were entered in the study. We divided them into the younger geriatrics (YG group, 65-84 years old: n=534) and older geriatrics (OG group, ≧85 years old: n=97). The group's patient characteristics, mortality, 1-year su...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Nishimura T, Naito H, Matsuyama S, Ishihara S, Nakao A, Nakayama S Tags: Acta Med Okayama Source Type: research

Laparoscopic Rectosigmoid Colon Vaginoplasty in Male-to-Female Transsexuals: Experience in Japan.
In this study, we examined the safety and effectiveness of rectosigmoid colon vaginoplasty in the Japanese population. We retrospectively surveyed 18 male-to-female transsexuals who underwent laparoscopic rectosigmoid colon vaginoplasty at the Okayama University Hospital Gender Center between October 2012 and December 2017. One patient had developed an anastomotic leak and 2 patients experienced vaginal prolapse, which needed revision surgery. Both adverse outcomes were comparable with those from previous studies. The anastomotic leak was managed adequately with conservative treatment. To avoid vaginal prolapse, it is impo...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Mukai Y, Sakurai T, Watanabe T, Sako T, Sugimoto M, Kimata Y, Mori Y, Nagasaka T, Namba Y Tags: Acta Med Okayama Source Type: research

Spiral Trajectory Modulation of Rheotaxic Motile Human Sperm in Cylindrical Microfluidic Channels of Different Inner Diameters.
Abstract We investigated the relationship between human sperm rheotaxis and motile sperm trajectories by using poly-(dimethylsiloxane) (PDMS)-based cylindrical microfluidic channels with inner diameters of 100 μm, 50 μm, and 70 μm, which corresponded to the inner diameter of the human isthmus, the length of a sperm and a diameter intermediate between the two, respectively. We counted the number of rheotaxic sperm and sperm with spiral motion. We also analyzed motile sperm trajectories. As the cylindrical channel diameter was decreased, the percentage of sperm cells exhibiting rheotaxis, the percentage of ...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Nishina S, Matsuura K, Naruse K Tags: Acta Med Okayama Source Type: research

Post-traumatic Articular Cartilage Lesions Increase at Second-look Arthroscopy Following Primary Anterior Cruciate Ligament Reconstruction.
In this study, we assessed changes in cartilage lesions by arthroscopic findings following anatomical double-bundle ACLR and at post-operative second-look arthroscopy about 14 months later. We retrospectively evaluated 37 knees in cases with patients
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Sugiu K, Furumatsu T, Kodama Y, Kamatsuki Y, Okazaki Y, Okazaki Y, Hiranaka T, Ozaki T Tags: Acta Med Okayama Source Type: research

Lights-out Surgery for Strabismus Using a Heads-Up 3D Vision System.
We report the 2 cases' results and evaluate the novel method. The surgeries were performed without problem even though the microscope's light source was not used. The patients' photophobia was alleviated. Lights-out surgery is a potentially useful modality for strabismus surgery. PMID: 31235970 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Hamasaki I, Shibata K, Shimizu T, Kono R, Morizane Y, Shiraga F Tags: Acta Med Okayama Source Type: research

Prevalence of and Risk Factors for the Progression of Upper Cervical Lesions in Patients with Rheumatoid Arthritis.
Abstract We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) w...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Horita M, Nishida K, Hashizume K, Sugimoto Y, Nasu Y, Nakahara R, Harada R, Ozaki T Tags: Acta Med Okayama Source Type: research

Safety of Surgical Treatment for Elderly Patients with Gallbladder Carcinoma.
Abstract Gallbladder carcinoma (GBC) is a common malignancy with a poor prognosis. With the average life expectancy increasing globally, the incidence of GBC is predicted to increase as well. We investigated the safety and feasibility of surgical treatment for elderly patients with GBC. We retrospectively compared clinical pathological data and treatment outcomes in 45 consecutive GBC patients (23 patients ≥ 75 years [elderly group] and 22 patients
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Utsumi M, Aoki H, Nishimura S, Une Y, Kashima H, Kimura Y, Taniguchi F, Arata T, Katsuda K, Tanakaya K Tags: Acta Med Okayama Source Type: research

Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Middle or Lower Esophageal Cancer Using Elective Nodal Irradiation: Comparison with 3D Conformal Radiotherapy.
The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Yoshio K, Wakita A, Mitsuhashi T, Kitayama T, Hisazumi K, Inoue D, Tajiri N, Shiode T, Akaki S, Kanazawa S Tags: Acta Med Okayama Source Type: research

Improvement of Open Bite and Stomatognathic Function in an Axenfeld- Rieger Syndrome Patient by Orthodontic Sectional Arch Mechanics: Clinical Considerations and the Risk of Orthodontic Tooth Movement.
Abstract Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient's orthodontic trea...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Seki D, Takeshita N, Seiryu M, Deguchi T, Takano-Yamamoto T Tags: Acta Med Okayama Source Type: research

Sudden, Sharp Turn in an AIDS Patient's Course Following the Onset of Fulminant Type 1 Diabetes.
Abstract A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and wa...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Shimoyama Y, Umegaki O, Ooi Y, Shigemoto S, Agui T, Kadono N, Minami T Tags: Acta Med Okayama Source Type: research

Contrast-enhanced Computed Tomography-Guided Percutaneous Cryoablation of Renal Cell Carcinoma in a Renal Allograft: First Case in Asia.
We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up. PMID: 31235976 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Tsuboi I, Araki M, Fujiwara H, Iguchi T, Hiraki T, Arichi N, Kawamura K, Maruyama Y, Mitsui Y, Sadahira T, Kubota R, Nishimura S, Sako T, Takamoto A, Wada K, Kobayashi Y, Watanabe T, Yanai H, Kitagawa M, Tanabe K, Sugiyama H, Wada J, Shiina H, Kanazawa S, Tags: Acta Med Okayama Source Type: research

A Case of Nager Syndrome Diagnosed Before Birth.
In this report, we describe a case in which micrognathia of the fetus was suspected based on the observation of upper limb shortening during detailed B mode and 3D/4D ultrasonographic observation, and combined fetal MRI and 3D-CT led to a prenatal diagnosis of Nager syndrome. Upon birth, because severe micrognathia caused airway obstruction and made it difficult to spread the larynx for intubation, effective ventilation could not be carried out and a tracheostomy was necessary. Since a differential diagnosis of Nager syndrome can be made based on the fact that micrognathia typically co-occurs with upper limb shortening, it...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Hayata K, Masuyama H, Eto E, Mitsui T, Tamada S, Eguchi T, Maki J, Tani K, Ohira A, Washio Y, Yoshimoto J, Hasegawa K Tags: Acta Med Okayama Source Type: research

Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry.
Abstract Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metaboli...
Source: Acta Med Okayama - June 1, 2019 Category: Universities & Medical Training Authors: Makimoto G, Nishimori H, Kondo R, Yanai H, Sugimoto M, Oda N, Kubo T, Hotta K, Tabata M, Kiura K, Maeda Y Tags: Acta Med Okayama Source Type: research

Effect of Self-perceived Fatigue on Balance and Functional Mobility in Middle-Aged Obese Women.
tin C Abstract The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Ercan S, Başkurt F, Başkurt Z, Çetin C Tags: Acta Med Okayama Source Type: research

Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit.
This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubin...
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Iida A, Naito H, Yorifuji T, Zamami Y, Yamada A, Koga T, Imai T, Sendo T, Nakao A, Ichiba S Tags: Acta Med Okayama Source Type: research

Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx.
In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer. PMID: 31015745 [PubMed - in process] (Source: Acta Med Okayama)
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Abe M, Iwamuro M, Kawahara Y, Kanzaki H, Kawano S, Tanaka T, Tsumura M, Makino T, Noda Y, Marunaka H, Nishizaki K, Okada H Tags: Acta Med Okayama Source Type: research

Unintentional Injury Deaths among Children: A Descriptive Study Using Medico-legal Documents in Okayama Prefecture, Japan (2001-2015).
Abstract According to the World Health Organization's World Report, approx. 950,000 children and young people
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Yamasaki Y, Tamiya N, Yamamoto H, Miyaishi S Tags: Acta Med Okayama Source Type: research

Thyroid Function Decline and Diet in Female High School Long-distance Runners.
Abstract We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects' height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects' intake of energy and nutrients based on meals provided at the subjects' dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol...
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Iwasaki Y, Miyahara K, Miyatake N, Nakatsuka M Tags: Acta Med Okayama Source Type: research

Collagen XVIII Deposition in the Basement Membrane Zone beneath the Newly Forming Epidermis during Wound Healing in Mice.
Abstract The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in ...
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Maeba T, Yonezawa T, Ono M, Tomono Y, Heljasvaara R, Pihlajaniemi T, Inagawa K, Oohashi T Tags: Acta Med Okayama Source Type: research

Prolonged Tachycardia with Higher Heart Rate Is Associated with Higher ICU and In-hospital Mortality.
Abstract Tachycardia is common in intensive care units (ICUs). It is unknown whether tachycardia or prolonged tachycardia affects patient outcomes. We investigated the association between tachycardia and mortality in critically ill patients. This retrospective cohort study's primary outcome was patient mortality in the ICU and the hospital. We stratified the patients (n=476) by heart rate (HR) as LowHR, MediumHR, and HighHR groups. We also stratified them by their durations of HR>100 (prolonged HR; tachycardia): MildT, ModerateT, and SevereT groups. We determined the six groups' mortality. The ICU mortality rat...
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Hayashi M, Taniguchi A, Kaku R, Fujimoto S, Isoyama S, Manabe S, Yoshida T, Suzuki S, Shimizu K, Morimatsu H, Momota R Tags: Acta Med Okayama Source Type: research

Clinical Characteristics of Severe Refractory Asthma Associated with the Effectiveness of Bronchial Thermoplasty.
Abstract We investigated the clinical characteristics of refractory asthma associated with the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated data from 10 patients who underwent BT between June 2016 and December 2017 at Okayama Medical Center. The following were measured before and 6 months post-BT: forced expiratory volume in 1.0 s (FEV1), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) level, blood eosinophil counts (Eosi), Asthma Quality of Life Questionnaire (AQLQ) score, and preventive medication use. At baseline, the mean post-bronchodilator FEV1 was 80.9% of the pr...
Source: Acta Med Okayama - April 1, 2019 Category: Universities & Medical Training Authors: Minami D, Kayatani H, Sato K, Fujiwara K, Shibayama T, Yonei T, Sato T Tags: Acta Med Okayama Source Type: research