Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
A Structure-Based Pharmacophore Modelling Approach to Identify and Design New Neprilysin (NEP) Inhibitors: An in silico-based investigation
Arch Biochem Biophys. 2024 Apr 28:110019. doi: 10.1016/j.abb.2024.110019. Online ahead of print.ABSTRACTNeutral endopeptidase or neprilysin (NEP) cleaves the natriuretic peptides, bradykinin, endothelin, angiotensin II, amyloid β protein, substance P, etc., thus modulating their effects on heart, kidney, and other organs. NEP has a proven role in hypertension, heart disease, renal disease, Alzheimer's, diabetes, and some cancers. NEP inhibitor development has been in focus since the US FDA approved a combination therapy of angiotensin II type 1 receptor inhibitor (valsartan) and NEP inhibitor (sacubitril) for use in heart...
Source: Archives of Biochemistry and Biophysics - April 30, 2024 Category: Biochemistry Authors: Shikha Thakur Apurba Sinhari Anil Bhanudas Gaikwad Hemant R Jadhav Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory
This study demonstrated that the hyperglycaemia-mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.PMID:38686489 | PMC:PMC11058670 | DOI:10.1111/jcmm.18336 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Lihong Lu Minmin Zhu Qichao Wu Zhirong Sun Xiangyuan Chen Changhong Miao Source Type: research
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of Renal Transplant Patients
CONCLUSIONS In addition to age, BMI, and TAC concentration after RT, antibiotic use may be a novel factor affecting PTDM. The use of antibiotics may influence the development of PTDM.PMID:38685698 | DOI:10.12659/AOT.943282 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 30, 2024 Category: Transplant Surgery Authors: Zhenwei Jiang Caomei Xu Huan Hou Xuping Yang Minyan Qian Lian Zuo Peipei Wang Qing Qian Yan Jiang Nan Hu Source Type: research
Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early Diagnosis
CONCLUSION: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.PMID:38686909 | DOI:10.2174/0118715303273741231117060753 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Bai-Yi Liu Dan Zhang Zhu Fan Jing-Jing Jin Cai-Hong Li Rui-Nan Guo Xue-Juan Li Yan Huang Source Type: research
Associations Between Beverage Consumption and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes
CONCLUSION: Higher consumption of ASBs and SSBs was linearly associated with an increased risk of microvascular complications in adults with T2D.PMID:38687598 | DOI:10.1210/clinem/dgae242 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Xiaoyu Lin Kai Zhu Zixin Qiu Rui Li Lin Li Qi Lu Ruyi Li Hancheng Yu Sen Liu Tianyu Guo Kun Yang Yunfei Liao An Pan Gang Liu Source Type: research
Basal Hyperglycemia Contributes More Than Fifty Percent to Time in Range in Pregnant Women with Type 1 Diabetes
CONCLUSIONS: Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling the postprandial hyperglycemia, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.PMID:38686666 | DOI:10.1210/clinem/dgae291 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ping Ling Daizhi Yang Chaofan Wang Xueying Zheng Sihui Luo Xubin Yang Hongrong Deng Wen Xu Jinhua Yan Jianping Weng Source Type: research
The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study
CONCLUSION: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.PMID:38686701 | DOI:10.1210/clinem/dgae119 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Rebeca Eriksen Margaret C White Adem Y Dawed Isabel Garcia Perez Joram M Posma Mark Haid Sapna Sharma Cornelia Prehn Louise E Thomas Robert W Koivula Roberto Bizzotto Andrea Mari Giuseppe N Giordano Imre Pavo Jochen M Schwenk Federico De Masi Konstantinos Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | PMC:PMC11058340 | DOI:10.3346/jkms.2024.39.e140 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | PMC:PMC11058340 | DOI:10.3346/jkms.2024.39.e140 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 30, 2024 Category: General Medicine Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Factors associated with caregiver burden in primary caregivers of older adults with type2 diabetes
CONCLUSIONS: Prevention programs are required to avoid CC and complications, as well as interventions to improve the quality of life of the CPI and patients in care, incorporating strategies to generate and/or increase their family and social support networks.PMID:38688187 | DOI:10.1016/j.aprim.2024.102948 (Source: Atencion Primaria)
Source: Atencion Primaria - April 30, 2024 Category: Primary Care Authors: Ricardo Alejandro S ánchez Bárcenas Daniel L ópez Hernández Leticia Brito-Aranda Brenda Berenice Garc ía Mantilla Mar ía Del Rocío Thompson Bonilla Ernestina Pav ón Delgado Luis Beltr án Lagunes Roberto Dur án Rojo Emmanuel Melgarejo-Estefan Tan Source Type: research
Evaluating the efficacy and safety of therapeutic interventions for corneal neuropathy: A systematic review
Ocul Surf. 2024 Apr 28:S1542-0124(24)00050-8. doi: 10.1016/j.jtos.2024.04.004. Online ahead of print.ABSTRACTCorneal neuropathy involves corneal nerve damage that disrupts ocular surface integrity, negatively impacting quality-of-life from pain and impaired vision. Any ocular or systemic condition that damages the trigeminal nerve can lead to corneal neuropathy. However, the condition currently does not have standardized diagnostic criteria or treatment protocols. The primary aim of this systematic review was to evaluate the efficacy and safety of interventions for treating corneal neuropathy. Randomized controlled trials ...
Source: The Ocular Surface - April 30, 2024 Category: Opthalmology Authors: Rajni Rajan Eve Makrai Ji-Hyun Lee Sumeer Singh Holly R Chinnery Laura E Downie Source Type: research
