Applicability of Augmented Reality in an Organ Transplantation.
Abstract Augmented reality (AR) delivers virtual information or some of its elements to the real world. This technology, which has been used primarily for entertainment and military applications, has vigorously entered medicine, especially in radiology and surgery, yet has never been used in organ transplantation. AR could be useful in training transplant surgeons, promoting organ donations, graft retrieval and allocation, and microscopic diagnosis of rejection, treatment of complications, and post-transplantation neoplasms. The availability of AR display tools such as Smartphone screens and head-mounted goggles, ...
Source: Annals of Transplantation - July 31, 2020 Category: Transplant Surgery Authors: Kosieradzki M, Lisik W, Gierwiało R, Sitnik R Tags: Ann Transplant Source Type: research

Effect of Concentration/Dose Ratio in De Novo Kidney Transplant Recipients Receiving LCP-Tacrolimus or Immediate-Release Tacrolimus: Post Hoc Analysis of a Phase 3 Clinical Trial.
CONCLUSIONS Although within metabolizer subgroups, attainment of target trough concentrations in the first week differed between LCPT and IR-Tac, these results suggest that, regardless of metabolizer phenotype, clinical outcomes do not differ between these formulations when dose adjustments are made. PMID: 32719307 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - July 28, 2020 Category: Transplant Surgery Authors: Suwelack B, Bunnapradist S, Meier-Kriesche U, Stevens DR, Procaccianti C, Morganti R, Budde K Tags: Ann Transplant Source Type: research

Kidney Transplantation in the Times of COVID-19 - A Literature Review.
In this study, we aim to review the published literature of kidney transplant recipients who encountered COVID-19. A literature review was performed using PubMed, ScienceDirect, and World Health Organization databases to identify relevant English-language articles published up to May 7, 2020. There were 24 articles that reported 129 kidney transplant recipients who encountered COVID-19. The age mean was 54.2 years with 73.7% as males. The most commonly reported presentations in order were fever (82.3%), cough (58%), shortness of breath (33.2%), and fatigue (30.7%). Acute kidney injury was observed in 34.1% of patients. Kid...
Source: Annals of Transplantation - July 24, 2020 Category: Transplant Surgery Authors: Imam A, Abukhalaf SA, Imam R, Abu-Gazala S, Merhav H, Khalaileh A Tags: Ann Transplant Source Type: research

Efficacy and Safety of Weight Reduction of the Donor in Hepatic Steatosis for Living Donor Liver Transplantation.
This study investigated the efficacy and clinical outcome of simple weight reduction of steatosis for donors undergoing living-donor liver transplantation (LDLT). MATERIAL AND METHODS We defined two groups: the reduction group, which included donors with>30% macrovesicular steatosis and body mass index (BMI)>25 kg/m², and the conventional group, which included donors with. PMID: 32690857 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - July 21, 2020 Category: Transplant Surgery Authors: Chung JH, Ryu JH, Yang KH, Choi BH, Park Y, Lee TB, Shim JR, Ko HJ, Cho SH Tags: Ann Transplant Source Type: research

Kidney Transplantation and "Sex Mismatch": A 10-Year Single-Center Analysis.
Kidney Transplantation and "Sex Mismatch": A 10-Year Single-Center Analysis. Ann Transplant. 2020 Jul 17;25:e921117 Authors: Graňák K, Kováčiková L, Skálová P, Vnučák M, Miklušica J, Laca Ľ, Mokáň M, Dedinská I Abstract BACKGROUND The effect of a relative disproportion in the size of a transplanted kidney (KT) on graft function and survival is well documented. However, the importance of the H-Y antigen (male donor and female recipient) has not been unambiguously confirmed. MATERIAL AND METHODS Our retrospective analysis cons...
Source: Annals of Transplantation - July 17, 2020 Category: Transplant Surgery Authors: Graňák K, Kováčiková L, Skálová P, Vnučák M, Miklušica J, Laca Ľ, Mokáň M, Dedinská I Tags: Ann Transplant Source Type: research

Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats.
CONCLUSIONS A hepatic IRI model caused zone 3-based LI and SII, which were attenuated by intraportal administration of milrinone. PMID: 32661218 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - July 14, 2020 Category: Transplant Surgery Authors: Nakanuma S, Tajima H, Takamura H, Sakai S, Gabata R, Okazaki M, Shinbashi H, Ohbatake Y, Makino I, Hayashi H, Miyashita T, Fushida S, Ohta T Tags: Ann Transplant Source Type: research

Preparation of a Novel Transplant Material, Zirconium Oxide (ZrO ₂) Nanotubes, and Characterizations Research.
CONCLUSIONS Zirconium nanotubes were successfully synthesized and demonstrated good structural characteristics, which can be applied to transplanting and treating caries. PMID: 32647105 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - July 10, 2020 Category: Transplant Surgery Authors: Wang C, Wang Y, Zhang G, Chen Y, Han X, Liang L, Xu Y, Xu L Tags: Ann Transplant Source Type: research

Should Pre-Transplant Hemoglobin A1c Be Used to Predict Post-Transplant Compliance in End-Stage Renal Disease Patients Undergoing Kidney Transplantation?
CONCLUSIONS In diabetic ESRD patients selected for renal transplantation, elevated pre-transplant HbA1c levels, defined as HbA1c>7.7%, are not predictive of post-transplant medication compliance. We advocate that this group of patients should not be denied transplant solely on their elevated pre-transplant HbA1c. PMID: 32587234 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - June 26, 2020 Category: Transplant Surgery Authors: Terranella SL, Poirier J, Chan EY, Hertl M, Olaitan OK Tags: Ann Transplant Source Type: research

Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation.
This study aims to provide data for the development of liver function recovery after liver transplantation by dynamically analyzing metabolites of bile acids pathway in serum. MATERIAL AND METHODS A comprehensive metabolomics profiling of serum of 9 liver transplantation patients before transplantation, on the 1st, 3rd, and 7th days after liver transplantation, and healthy individuals were performed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Multivariate data and dynamic analysis were used to search for biomarkers between the metabolomics profiles present in perioperative liver transplantation ...
Source: Annals of Transplantation - June 23, 2020 Category: Transplant Surgery Authors: Sui W, Gan Q, Liu F, Ou M, Wang B, Liao S, Lai L, Chen H, Yang M, Dai Y Tags: Ann Transplant Source Type: research

Safety and Efficacy of Right Retroperitoneal Laparoscopic Live Donor Nephrectomy: A Retrospective Single-Center Study.
CONCLUSIONS Right retroperitoneal laparoscopic live donor nephrectomy is safe and effective for renal transplant in living-related renal transplant by laparoscopic excision and extraction of the right kidney with vena cava flap. PMID: 32555124 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - June 19, 2020 Category: Transplant Surgery Authors: Fu Y, Hu Y, Wang W, Gao B, Wang G, Lian X, Zhou H, Wang Y Tags: Ann Transplant Source Type: research

Minimally Invasive Surgery Is Feasible in Patients with Liver and Kidney Transplantation.
CONCLUSIONS Laparoscopic and non-laparoscopic MIS surgery are feasible and safe for abdominal organ transplant patients and are helpful for timely intervention in cases with acute abdomen. No adjustment of immunosuppressant is usually needed, as oral intake can be resumed very soon after surgery. PMID: 32541640 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Hsu DW, Chang CM, Hsu CS, Yin WY Tags: Ann Transplant Source Type: research

Heart Transplant Using Hepatitis C-Seropositive and Viremic Organs in Seronegative Recipients.
CONCLUSIONS We describe 10 HCV-seronegative patients who received HCV-seropositive donor hearts at our institution, with excellent short-term outcomes, even in those who received nucleic acid testing positive organs. DAA can be effective in treating hepatitis C viremia before and after OHT, with excellent recipient survival. Large clinical studies are needed to further evaluate the long-term outcomes of DAA therapy in patients after heart transplantation. PMID: 32527989 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - June 12, 2020 Category: Transplant Surgery Authors: Zhu Y, Shudo Y, Lee R, Woo YJ Tags: Ann Transplant Source Type: research

Pregnancy Outcomes Following Pediatric Liver Transplantation: A Single-Center Experience in Japan.
CONCLUSIONS Planned pregnancies in LT recipients can lead to the birth of a healthy baby and no influence on either the allograft or the recipient. However, unplanned pregnancies in LT recipients, such as recipients who take MMF or have allograft liver dysfunction, may have an adverse influence on the fetus. PMID: 32513910 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - June 9, 2020 Category: Transplant Surgery Authors: Naya I, Sanada Y, Katano T, Miyahara G, Hirata Y, Yamada N, Okada N, Onishi Y, Sakuma Y, Sata N Tags: Ann Transplant Source Type: research

Effect of Hyperbaric Oxygen on Tissue Damage and Expression of Adhesion Molecules and C3 in a Rat Model of Renal Ischemia-Reperfusion Injury After Kidney Transplantation.
Abstract BACKGROUND The aim of this study was to investigate the protective effect and mechanism of hyperbaric oxygen (HBO) in a rat model of renal ischemia-reperfusion injury following kidney transplantation. MATERIAL AND METHODS Sprague Dawley rats were randomly divided into 3 groups (n=18): sham group, kidney transplantation group, and HBO treatment group. Six rats in each group were sacrificed at 1, 3, and 5 hours after reperfusion, and serum and renal tissue were then collected. The serum creatinine levels and histopathological changes of the renal tissue were detected. ICAM-1, VCAM-1, and C3 expression level...
Source: Annals of Transplantation - June 5, 2020 Category: Transplant Surgery Authors: Zhao F, Wang X, Liang T, Bao D, Wang Y, Du Y, Li H, Du J, Chen A, Fu Z, Xie Z, Liang G Tags: Ann Transplant Source Type: research

Influence of Body Mass Index ≥30 on Pure Laparoscopic Donor Right Hepatectomy.
This study aimed to investigate the influence of donor obesity (BMI ≥30 kg/m²) on and clinical outcomes after PLDRH. MATERIAL AND METHODS Records of all living donors who underwent PLDRH between November 2015 and May 2018 and open conventional donor right hepatectomy (CDRH) between January 2011 and October 2015 at Seoul National University Hospital were retrospectively reviewed. The donors were divided into 3 groups: PLDRH BMI ≥30, PLDRH BMI
Source: Annals of Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Hong SK, Suh KS, Cho JH, Lee JM, Yi NJ, Lee KW Tags: Ann Transplant Source Type: research

Outcomes with Tacrolimus-Based Immunosuppression After Kidney Transplantation from Standard- and Extended-Criteria Donors - A Post Hoc Analysis of the Prospective OSAKA Study.
Abstract BACKGROUND This post hoc analysis of data from the prospective OSAKA study evaluated the efficacy and safety of prolonged- and immediate-release tacrolimus in patients who received kidneys from extended-criteria (ECD) and standard-criteria (SCD) donors. MATERIAL AND METHODS Within the ECD and SCD groups, patients were randomized to one of 4 tacrolimus-based regimens (initial dose): Arm 1, immediate-release tacrolimus (0.2 mg/kg/day); Arm 2, prolonged-release tacrolimus (0.2 mg/kg/day); Arm 3, prolonged-release tacrolimus (0.3 mg/kg/day); Arm 4, prolonged-release tacrolimus (0.2 mg/kg/day) plus basiliximab...
Source: Annals of Transplantation - May 29, 2020 Category: Transplant Surgery Authors: Albano L, Banas B, Lehner F, Glyda M, Viklicky O, Schleibner S, Brown M, Kamar N Tags: Ann Transplant Source Type: research

Postoperative Serum Lactate Levels for In-Hospital Mortality Prediction Among Heart Transplant Recipients.
CONCLUSIONS Serum lactate level measurement upon ICU admission can be used as a predictive parameter for in-hospital mortality among heart transplant recipients. Values greater than 7.0 mmol/L can predict in-hospital mortality with 90% accuracy. PMID: 32451373 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - May 26, 2020 Category: Transplant Surgery Authors: Kędziora A, Wierzbicki K, Piątek J, Hymczak H, Górkiewicz-Kot I, Milaniak I, Tomsia P, Sobczyk D, Drwiła R, Kapelak B Tags: Ann Transplant Source Type: research

Bacterial and Fungal Infections After Liver Transplantation: Microbial Epidemiology, Risk Factors for Infection and Death with Infection.
CONCLUSIONS We found that 39.3% of recipients had at least 1 bacterial or fungal infection after LT. Shortening the length of hospital stay and early withdrawal of mechanical ventilation will reduce the risk of infection after LT. Patients with liver failure should be more vigilant against postoperative infection. Once an infection occurs, immediate assessment of the postoperative MELD score, early diagnosis of septic shock, and active search for pathogenic evidence for precise treatment will help improve patient prognosis. Routine screening for CRAB colonization before surgery will facilitate empirical use of effective an...
Source: Annals of Transplantation - May 19, 2020 Category: Transplant Surgery Authors: Zhang W, Wang W, Kang M, Wu S, Liu Y, Liao Q, Xiao Y, Ma Y, Xie Y Tags: Ann Transplant Source Type: research

Developing an Organ Donation Curriculum for Medical Undergraduates in China Based on Theory of Planned Behavior: A Delphi Method Study.
CONCLUSIONS This study identified the contents of an organ donation curriculum for medical undergraduates in China, which would be useful for researchers and instructors in medical education. Determining the fundamental content of a donation-related curriculum is an indispensable step for implementation of organ donation education and promotion of organ donation. PMID: 32409628 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - May 15, 2020 Category: Transplant Surgery Authors: Lei L, Lin L, Deng J, Dong H, Luo Y Tags: Ann Transplant Source Type: research

Comparison of Cardioprotective Effects of Propofol versus Sevoflurane in Pediatric Living Donor Liver Transplantation.
Abstract BACKGROUND Our study compared the myocardiac protective effect of propofol vs. sevoflurane in pediatric patients receiving living donor liver transplantation (LDLT) surgery. MATERIAL AND METHODS We randomly and equally divided 120 children who underwent LDLT into a sevoflurane group and a propofol group. Preoperative, intraoperative, and postoperative data were collected and compared between the 2 groups. The concentrations of cTnI, CK-MB, IL-6, TNF-alpha, and HMGB1 at 5 min after induction (T0), 30 min in the anhepatic period (T1), and 3 h after reperfusion (T2), and at the end of surgery (T3) were measu...
Source: Annals of Transplantation - May 12, 2020 Category: Transplant Surgery Authors: Weng Y, Yuan S, Li H, Yu W Tags: Ann Transplant Source Type: research

Toll-Like Receptor 3 Activator Preconditioning Enhances Modulatory Function of Adipose ‑Derived Mesenchymal Stem Cells in a Fully MHC-Mismatched Murine Model of Heterotopic Heart Transplantation.
CONCLUSIONS These results show that short-term TLR3 agonist preconditioning enhances the immunomodulatory efficacy of ADSCs, which can induce the generation of Tregs and upregulate the expression of FGL2, thereby improving the outcome of patients receiving organ transplantation. PMID: 32366814 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - May 5, 2020 Category: Transplant Surgery Authors: Bao Z, Li J, Zhang P, Pan Q, Liu B, Zhu J, Jian Q, Jia D, Yi C, Moeller CJ, Liu H Tags: Ann Transplant Source Type: research

Serial Peripheral Blood Gene Expression Profiling to Assess Immune Quiescence in Kidney Transplant Recipients with Stable Renal Function.
CONCLUSIONS Our results indicate the value of serial TruGraf testing in those transplant centers that do not perform surveillance biopsies as part of their standard of care. The high negative predictive value indicates the ability of TruGraf to confirm immune quiescence with a high degree of probability in patients with a Transplant eXcellence (TX) result, without the need to perform a surveillance biopsy. PMID: 32341330 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 28, 2020 Category: Transplant Surgery Authors: Peddi VR, Patel PS, Schieve C, Rose S, First MR Tags: Ann Transplant Source Type: research

First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia.
CONCLUSIONS NMP provides a potential tool for preservation and assessment of ECD livers in China. PMID: 32312947 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 21, 2020 Category: Transplant Surgery Authors: Zhang Z, Ju W, Tang Y, Wang L, Zhu C, Gao N, Zhao Q, Huang S, Wang D, Yang L, Han M, Xiong W, Wu L, Chen M, Zhang Y, Zhu Y, Sun C, Zhu X, Guo Z, He X Tags: Ann Transplant Source Type: research

A Retrospective Cohort Study of the Effect of Gout on Mortality Among Patients with a History of Kidney Transplantation.
CONCLUSIONS Among patients with a history of kidney transplantation, gout did not have an independent effect on all-cause mortality. However, gout was a predictor of mortality among patients with no comorbidities, suggesting that gout is an early warning sign of poor health in kidney transplantation patients. PMID: 32284525 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 14, 2020 Category: Transplant Surgery Authors: Li JW, Suh M, Brigham MD, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Miyasato G Tags: Ann Transplant Source Type: research

Everolimus-Eluting Second-Generation Stents for Treatment of De Novo Lesions in Patients with Cardiac Allograft Vasculopathy.
CONCLUSIONS In the analyzed population, invasive strategy with second-generation everolimus-eluting stents for de novo lesions in cardiac allograft vasculopathy resulted in a low rate of binary restenosis, low late lumen loss, and no deaths during the 6-month follow-up. PMID: 32253369 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Pyka Ł, Hawranek M, Szyguła-Jurkiewicz B, Desperak P, Szczurek W, Lekston A, Gąsior M, Zembala MO, Pawlak S, Zembala M, Przybyłowski P Tags: Ann Transplant Source Type: research

Prophylaxis of Hepatitis B Virus (HBV) Re-Infection in Liver Transplantation: Is the Reappearance of Hepatitis B Surface Antigen (HBsAg) Significant?
Abstract The recurrence of hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) was in the past a primary cause of organ loss or mortality. Currently, post-OLT prophylaxis with anti-HBs immunoglobulins plus a nucleos(t)ide analogue has virtually abolished the risk of re-infection. Some studies have proposed to simplify prophylaxis by discontinuing immunoglobulins while continuing the analogue alone. This review analysed the available studies, focusing on the recurrence of HBsAg in serum and its biological effects. In all, 16 studies were retrieved, mainly observational or retrospective, e...
Source: Annals of Transplantation - March 31, 2020 Category: Transplant Surgery Authors: Brancaccio G, Gaeta GB Tags: Ann Transplant Source Type: research

Optimizing Organ Donation: Expert Opinion from Austria, Germany, Spain and the U.K.
CONCLUSIONS Expert opinions from different professional backgrounds from different European health care systems reach a broad consensus on the most relevant issues for the improvement of organ donation. PMID: 32179731 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - March 17, 2020 Category: Transplant Surgery Authors: Becker F, Roberts KJ, Nadal M, Zink M, Stiegler P, Pemberger S, Castellana TP, Kellner C, Murphy N, Kaltenborn A, Tuffs A, Amelung V, Krauth C, Bayliss J, Schrem HH Tags: Ann Transplant Source Type: research

Recipient Hepatic Tumor-Associated Immunologic Infiltrates Predict Outcomes After Liver Transplantation for Hepatocellular Carcinoma.
Abstract BACKGROUND Transplantation of the liver entails a state of altered recipient immunologic competence. There are only scarce data concerning the impact of host immunologic factors on the outcome of liver transplant recipients in the context of hepatocellular carcinoma (HCC). MATERIAL AND METHODS Our study focused on evaluating the presence of tumor necrosis and frequency levels of angiopoietins and monocytes/macrophages subtypes in the host liver prior to liver transplantation (LTX) and their association with recurrence, graft rejection, survival, and clinical prognosis after LTX. Formation of tumor necrosi...
Source: Annals of Transplantation - March 13, 2020 Category: Transplant Surgery Authors: Atanasov G, Dino K, Schierle K, Dietel C, Aust G, Pratschke J, Seehofer D, Schmelzle M, Hau HM Tags: Ann Transplant Source Type: research

Clinical Outcome of Residual Liver Volume and Hepatic Steatosis After Right-Lobe Living-Donor Hepatectomy.
Abstract BACKGROUND We examine how residual liver volume (RLV) and hepatic steatosis (HS) of living liver donors affect the regeneration process and clinical outcomes. MATERIAL AND METHODS We longitudinally studied 58 donors who underwent right-lobe hepatectomy during the period February 2014 to February 2015 at a single medical institution. The patients were classified based on RLV (30-35%, 35-40%, 40-50%) subgroups and HS (
Source: Annals of Transplantation - March 10, 2020 Category: Transplant Surgery Authors: Hsieh CE, Lin KH, Hsu YL, Chou CT, Chen CB, Lin PY, Lin CC, Hung YJ, Weng LC, Chen YL Tags: Ann Transplant Source Type: research

Diffusion Weighted Magnetic Resonance Imaging in the Assessment of Renal Function and Parenchymal Changes in Chronic Kidney Disease: A Preliminary Study.
ski P Abstract BACKGROUND The aim of this study was to evaluate the feasibility of using intravoxel incoherent motion (IVIM) imaging for noninvasive assessment of pathologic changes in chronic kidney disease (CKD). MATERIAL AND METHODS Thirty-four patients with CKD and 20 healthy volunteers were examined on a 1.5 T magnetic resonance imaging (MRI) unit. The examination consisted of morphologic sequences and diffusion-weighted echo-planar sequence with 10 b values. Diffusion parameters were calculated with the use of mono- (apparent diffusion coefficient, ADC) and bi-exponential model: pure diffusion coefficient (D...
Source: Annals of Transplantation - March 3, 2020 Category: Transplant Surgery Authors: Sułkowska K, Palczewski P, Furmańczyk-Zawiska A, Perkowska-Ptasińska A, Wójcik D, Szeszkowski W, Durlik M, Gołębiowski M, Małkowski P Tags: Ann Transplant Source Type: research

Efficacy and Safety of a Quadruple Regimen Compared with Triple Regimens in Patients with Mycophenolic Acid-Related Gastrointestinal Complications After Renal Transplantation: A Short-Term Single-Center Study.
CONCLUSIONS This quadruple regimen may be equivalent to regimens containing standard-dose tacrolimus, corticosteroids plus either low-dose EC-MPS or standard-dose MZR in improving GI symptoms after kidney transplant, and is also advantageous for kidney function, graft rejection, and the rates of adverse events. PMID: 32107364 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 28, 2020 Category: Transplant Surgery Authors: Peng Z, Xian W, Sun H, Li E, Geng L, Tian J Tags: Ann Transplant Source Type: research

Effects of Delayed Hypothermic Machine Perfusion on Kidney Grafts with a Preliminary Period of Static Cold Storage and a Total Cold Ischemia Time of Over 24 Hours.
CONCLUSIONS A delayed and extended HMP can recover the graft hemodynamic function, maintain some metabolic activity, and stabilize the accumulated ischemic damage due to a preliminary SCS. PMID: 32094320 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 25, 2020 Category: Transplant Surgery Authors: Adani GL, Pravisani R, Crestale S, Baccarani U, Scott CA, D'Alì L, DeMaglio G, Tulissi P, Vallone C, Isola M, Righi E, Pizzolito S, Di Loreto C, Risaliti A Tags: Ann Transplant Source Type: research

Effect of Rewarming on Leukocyte-Endothelial Interaction After Deep Hypothermic Preservation.
CONCLUSIONS Hypothermia exerts a protective effect consisting of reduced leukocyte-endothelial interaction. Rewarming after hypothermic preservation, however, causes considerable upregulation of leukocyte infiltration. Downregulation of JAM-A may play a role in modulating TEM during hypothermia and rewarming. We conclude that the rewarming process is an essential but underestimated aspect during transplantation. PMID: 32080161 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 21, 2020 Category: Transplant Surgery Authors: Bogert NV, Werner I, Kornberger A, Vahl CF, Beiras-Fernandez A Tags: Ann Transplant Source Type: research

Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China.
This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients during outpatient follow-up. MATERIAL AND METHODS A retrospective cross-sectional study was performed in 124 liver transplant patients during outpatient follow-up. All participants completed a general demographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Generalized Anxiety Disorder-7 scale (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the perceived social support scale (PSSS). RESULTS The mean global PSQI score was 6.57 (SD, 4.28), which was significantly higher than the mean score ...
Source: Annals of Transplantation - February 18, 2020 Category: Transplant Surgery Authors: Zhu X, Ming Y, Liu J, Liu L, Cheng K, Mao P Tags: Ann Transplant Source Type: research

Attitudes and Awareness Towards Organ Donation Among Parents of Pediatric Brain Death Patients in a Pediatric Intensive Care Unit in Eastern Turkey.
CONCLUSIONS The most important reasons relevant to parents' organ donation refusal are the parents' low level of education and insufficient information about brain death and organ donation. The unwillingness to allow impairment of their child's internal organ integrity and thinking that their child would be in pain at the time of organ donation were the most common reasons. PMID: 32054824 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 14, 2020 Category: Transplant Surgery Authors: Yeşilbaş O Tags: Ann Transplant Source Type: research

Evolution of Laparoscopic Donor Nephrectomy Techniques and Outcomes: A Single-Center Experience with More than 1000 Cases.
This study retrospectively reviews 1132 patients who underwent 4 different laparoscopic living-donor nephrectomies: hand-assisted laparoscopic nephrectomy (HALDN), pure laparoscopic donor nephrectomy (PLDN), laparoendoscopic single-site plus 1-port donor nephrectomy (LESSOP-DN), and mini laparoscopic donor nephrectomy (MLDN). RESULTS The mean estimated blood loss (EBL) for the HALDN group was meaningfully higher than those of LESSOP-DN and MLDN (57.5±52.2 mL versus 21.0±30.0 mL versus 18.2±28.7 mL) (P
Source: Annals of Transplantation - February 11, 2020 Category: Transplant Surgery Authors: Cho SJ, Moon HW, Kang SM, Choi SW, Kim KS, Choi YS, Hong SH, Ha US, Lee JY, Kim SW, Kim JC, Cho HJ Tags: Ann Transplant Source Type: research

Individualized Preconditioning for ABO-Incompatible Living-Donor Kidney Transplantation: An Initial Report of 48 Cases from China.
Abstract BACKGROUND ABO-incompatible (ABOi) living-donor kidney transplantation (KTx) is well established in developed countries, but not yet in China. MATERIAL AND METHODS We developed individualized preconditioning protocols for ABOi KTx based on initial ABO antibody titers. After propensity score matching of ABOi with ABO-compatible (ABOc) KTx, post-transplant outcomes were compared. RESULTS Between September 2014 and June 2018, 48 ABOi living-donor KTx candidates received individualized preconditioning, and all underwent subsequent KTx (median initial ABO titers: 16 for IgM and 16 for IgG). Thirty-one recipien...
Source: Annals of Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Wang XD, Liu JP, Fan Y, Song TR, Shi YY, Li YM, Lv YH, Li XH, Huang ZL, Lin T Tags: Ann Transplant Source Type: research

Diagnosis and Treatment of Renal Artery Stenosis in China in the Era of Donation After Cardiac Death.
CONCLUSIONS The incidence of TRAS with hypertensive cerebrovascular accident DCD-originated kidneys is relatively high, which is a warning to kidney transplant physicians. Digital subtraction angiography (DSA) is the most reliable diagnostic means of TRAS and can be performed concurrently with intervention therapy. If the donor has severe atherosclerosis, plaques that are visible to the unaided eye in the renal artery trunk should be removed as completely as possible. PMID: 32015300 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 4, 2020 Category: Transplant Surgery Authors: Wang Q, Li X, Liu Z, Xu J, Han Y, Yu T, Chen S, Tang Y, Liu Y, Li X Tags: Ann Transplant Source Type: research

Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders.
CONCLUSIONS Accurate diagnosis and appropriate treatment for psychiatric disorders by psychiatrists and psychologists are important during LDLT donor follow-up. Minimization of physiological complications might be important to prevent postoperative psychiatric complications in LDLT donors. PMID: 32001667 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 31, 2020 Category: Transplant Surgery Authors: Shizuku M, Kamei H, Kimura H, Kurata N, Jobara K, Yoshizawa A, Ishizuka K, Okada A, Kishi S, Ozaki N, Ogura Y Tags: Ann Transplant Source Type: research

Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation.
Abstract BACKGROUND Kidney injury is a complication among children undergoing liver transplantation (pLTx). Cystatin C serum concentration seems to be superior to creatinine-based determination of kidney injury in adults and children. Near-infrared spectroscopy (NIRS) technology provides non-invasive and real-time measurement of renal tissue oxygenation. Here, we compared renal tissue oximetry (rSrO₂) with conventional diagnostic criteria cystatin C and creatinine concentration in children undergoing pLTx. MATERIAL AND METHODS rSrO₂ was measured intraoperatively in children undergoing pLTx over the left kidney...
Source: Annals of Transplantation - January 28, 2020 Category: Transplant Surgery Authors: Sinner B, Banas M, Brunete-Lorenzo C, Zant R, Knoppke B, Scherer MN, Graf BM, Lunz D Tags: Ann Transplant Source Type: research

Different Routes of Proton Pumps Inhibitors Co-Administration have Significant Impact on Mycophenolate Acid (MPA) Serum Levels in Heart Transplant Recipients.
Abstract BACKGROUND Antiproliferative drugs including mycophenolate mofetil (MMF) are widely accepted part of an immunosuppressive therapy following heart transplantation. Proton pump inhibitors (PPIs) are routinely administered after cardiac surgery procedures including transplantation. They may also have impact on mycophenolate acid (MPA) serum levels. MATERIAL AND METHODS There were 30 consecutive patients (28 male and 2 female patients) with a mean age of 45±12 years who were enrolled into this study. MPA serum levels were studied; PPIs were intravenously and orally administered. RESULTS The mean MPA pl...
Source: Annals of Transplantation - January 24, 2020 Category: Transplant Surgery Authors: Urbanowicz T, Straburzyńska-Migaj E, Casadei V, Bociański M, Jemielity M Tags: Ann Transplant Source Type: research

Perioperative Pleural Drainage in Liver Transplantation: A Retrospective Analysis from a High-Volume Liver Transplant Center.
PV Abstract BACKGROUND Pleural effusions represent a common complication after liver transplantation (LT) and chest drain (CD) placement is frequently necessary. MATERIAL AND METHODS In this retrospective cohort study, adult LT recipients between 2009 and 2016 were analyzed for pleural effusion formation and its treatment within the first 10 postoperative days. The aim of the study was to compare different settings of CD placement with regard to intervention-related complications. RESULTS Overall, 597 patients met the inclusion criteria, of which 361 patients (60.5%) received at least 1 CD within the study period...
Source: Annals of Transplantation - January 17, 2020 Category: Transplant Surgery Authors: Wiering L, Sponholz F, Brandl A, Dziodzio T, Jara M, Dargie R, Eurich D, Schmelzle M, Sauer IM, Aigner F, Kotsch K, Pratschke J, Öllinger R, Ritschl PV Tags: Ann Transplant Source Type: research

Applicability of Hypothermic Oxygenate Machine Perfusion Preservation for Split-Liver Transplantation in a Porcine Model: An Experimental Study.
CONCLUSIONS Splitting the liver under machine perfusion preservation may help restore the function and reduce ischemia-reperfusion injury. PMID: 31932575 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 14, 2020 Category: Transplant Surgery Authors: Ishii D, Matsuno N, Gochi M, Otani M, Shonaka T, Takahashi H, Nishikawa Y, Yoshikawa R, Obara H, Miyamoto K, Furukawa H Tags: Ann Transplant Source Type: research

Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver.
CONCLUSIONS Preoperative intentional treatment for FL was effective. Early graft function and donor postoperative course were comparable in the 2 groups. These results suggest that well-treated steatotic grafts can be used without jeopardizing donor safety. PMID: 31919339 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 10, 2020 Category: Transplant Surgery Authors: Fujii Y, Kawamura N, Zaitsu M, Watanabe M, Goto R, Kamiyama T, Taketomi A, Shimamura T Tags: Ann Transplant Source Type: research

Knowledge Does Not Correlate with Behavior toward Deceased Organ Donation: A Cross-Sectional Study in Japan.
CONCLUSIONS For hospital staff in Japanese medical facilities, high knowledge about organ donation and transplantation was not associated with donor registration, but was associated with willingness to become an organ donor. PMID: 31896742 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - January 3, 2020 Category: Transplant Surgery Authors: Murakami M, Fukuma S, Ikezoe M, Izawa S, Watanabe H, Yamaguchi H, Kitazawa A, Takahashi K, Natsukawa S, Fukuhara S Tags: Ann Transplant Source Type: research

The Conversional Efficacy of Ex Vivo Lung Perfusion and Clinical Outcomes in Patients Undergoing Transplantation of Donor Lungs by Ex Vivo Lung Perfusion: A Meta-Analysis.
CONCLUSIONS: The pooled results indicated that EVLP could be used to assess and improve high-risk donor lungs and had non-inferior postoperative outcomes compared with the standard cold storage. EVLP not only increased the utilization of marginal donors, but also could extend preservation time and reduce the total ischemia time of donors. PMID: 31879416 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - December 27, 2019 Category: Transplant Surgery Authors: Luo Q, Zhu L, Wang Y, Wang L, Lv W, Hu J Tags: Ann Transplant Source Type: research

Hemashield Vascular Graft Is a Preferable Prosthetic Graft for Middle Hepatic Vein Reconstruction in Living Donor Liver Transplantation.
CONCLUSIONS MHV reconstruction using Hemashield vascular grafts demonstrated higher short-term patency rates than those associated with ringed Gore-Tex vascular grafts. We suggest that the Hemashield vascular graft is one of the best prosthetic materials for MHV reconstruction. PMID: 31844037 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - December 17, 2019 Category: Transplant Surgery Authors: Park GC, Hwang S, Ha TY, Song GW, Jung DH, Ahn CS, Moon DB, Kim KH, Yoon YI, Cho HD, Kwon JH, Chung YK, Kang SH, Jung IJ, Choi JU, Lee SG Tags: Ann Transplant Source Type: research

Post-Reperfusion Syndrome in Liver Transplantation: Does a Caval Blood Flush Vent Help?
CONCLUSIONS Pre-reperfusion caval venting in liver transplantation (in addition to a portal vent and a chilled LR/albumin portal flush solution) appears to have favorable hemodynamic effects. The literature on this technique is sparse and larger studies are needed. PMID: 31831725 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - December 13, 2019 Category: Transplant Surgery Authors: Stoll WD, Hand WR, Chavin KD, Felton DH, Wolf BO, Davis GP, Harvey NR, Whiteley JR, Mester RA, Bolin ED Tags: Ann Transplant Source Type: research

Impact of Increased Duration of Trimethoprim-Sulfamethoxazole Prophylaxis for Pneumocystis Pneumonia After Renal Transplant.
CONCLUSIONS Extending the duration of TMP-SMX prophylaxis was not associated with change in frequency of UTIs or multi-drug-resistant UTIs, nor was it associated with increased adverse events. TMP-SMX is an effective PCP prophylaxis, and these data support recommendations to extend the duration of prophylaxis after transplant. PMID: 31806862 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - December 6, 2019 Category: Transplant Surgery Authors: Chapman FA, Dickerson JE, Daly C, Clancy M, Geddes C Tags: Ann Transplant Source Type: research

An Update on Early Urological Complications in Kidney Transplantation: A National Cohort Study.
CONCLUSIONS Many living- and deceased-donor KTX recipients have early urological complications. MUCs did not affect long-term graft or patient survival. PMID: 31792196 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - December 3, 2019 Category: Transplant Surgery Authors: Bruintjes MHD, d'Ancona FCH, Zhu X, Hoitsma AJ, Warlé MC Tags: Ann Transplant Source Type: research