Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early Diagnosis
CONCLUSION: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.PMID:38686909 | DOI:10.2174/0118715303273741231117060753 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Bai-Yi Liu Dan Zhang Zhu Fan Jing-Jing Jin Cai-Hong Li Rui-Nan Guo Xue-Juan Li Yan Huang Source Type: research
Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure?
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.PMID:38686683 | DOI:10.14503/THIJ-23-8210 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Xiaoqing Xi Jinfeng Cai Chen Zhang Xuefei Wang Source Type: research
Bioequivalence of Related GelShield < sup > Ⓡ < /sup > Sustained-Release Formulations of Metformin: A Pooled Pharmacokinetic Analysis
Clin Ther. 2024 Apr 29:S0149-2918(24)00077-8. doi: 10.1016/j.clinthera.2024.03.011. Online ahead of print.ABSTRACTPURPOSE: GlucophageⓇ (Merck Healthcare KGaA, Darmstadt, Germany) is the originator brand of metformin hydrochloride, an oral antidiabetic drug. Metformin is recommended in guidelines as first-line treatment of type 2 diabetes mellitus and increasingly in related insulin-resistant conditions, such as prediabetes and polycystic ovary syndrome. The GelShieldⓇ sustained-release formulation tablet of GlucophageⓇ has been improved from the historic version marketed in 2000. Bioequivalence has been demonstrated ...
Source: Clinical Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Axel Krebs-Brown Kerstin M G Brand Marco A F Nogueira Filho Sumedh Gaikwad Yvonne Schnaars Source Type: research
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Ren Fail. 2024 Dec;46(1):2344655. doi: 10.1080/0886022X.2024.2344655. Epub 2024 Apr 29.ABSTRACTThe association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eB...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Zhoucang Zhang Jiarui Li Jiaxiang Ding Shenglei Zhang Mei Wang Jinsheng Xu Source Type: research
Construction and Validation Study of a Model for Predicting the Risk of Pulmonary Complications in Elderly Patients with Multiple Rib Fractures
CONCLUSIONS: The column-line diagram model of pulmonary complications in patients with MRF constructed in this study showed good discriminative and calibration performance in both internal and external validation, which is helpful for clinicians to identify individuals at high risk of pulmonary complications as early as possible, and thus can be recommended for clinical use.PMID:38687856 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Chenchen Yang Hengfa Ge Aifeng Gong Source Type: research
Prediction and causal inference of hyperuricemia using gut microbiota
This study aimed to determine the relationship between HUA and GM. The microbiome of 224 men and 254 women aged 40 years was analyzed through next-generation sequencing and machine learning. We obtained GM data through 16S rRNA-based sequencing of the fecal samples, finding that alpha-diversity by Shannon index was significantly low in the HUA group. Linear discriminant effect size analysis detected a high abundance of the genera Collinsella and Faecalibacterium in the HUA and non-HUA groups. Based on light gradient boosting machine learning, we propose that HUA can be predicted with high AUC using four clinical characteri...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Yuna Miyajima Shigehiro Karashima Ren Mizoguchi Masaki Kawakami Kohei Ogura Kazuhiro Ogai Aoi Koshida Yasuo Ikagawa Yuta Ami Qiunan Zhu Hiromasa Tsujiguchi Akinori Hara Shin Kurihara Hiroshi Arakawa Hiroyuki Nakamura Ikumi Tamai Hidetaka Nambo Shigefumi O Source Type: research
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Atherosclerosis. 2024 Apr 17:117545. doi: 10.1016/j.atherosclerosis.2024.117545. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance and relative insulin deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher levels of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low levels of HDL cholesterol, elevated number of small, dense LDL, and increased non-HDL cholesterol, results from an increased synthesis and impaired clearance ...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Lorenzo Luciani Matteo Pedrelli Paolo Parini Source Type: research
The current landscape for diabetes treatment: Preventing diabetes-associated CV risk
Atherosclerosis. 2024 Apr 23:117560. doi: 10.1016/j.atherosclerosis.2024.117560. Online ahead of print.ABSTRACTDespite the risk of atherosclerosis has progressively declined over the past few decades, subjects with type 2 diabetes mellitus (T2DM) continue to experience substantial excess of atherosclerotic cardiovascular disease (ASCVD)-related events. Therefore, there is urgent need to treat ASCVD disease in T2DM earlier, more intensively, and with greater precision. Many factors concur to increase the risk of atherosclerosis, and multifactorial intervention remains the basis for effective prevention or reduction of ather...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Angela Dardano Cristina Bianchi Monia Garofolo Stefano Del Prato Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Glycemic and lipid control in patients with diabetes at time of myocardial infarction
CONCLUSION: We highlighted the poor glycemic and lipid control in high-risk CV patients. There is an urgent need to develop multidisciplinary approaches to optimize CV risk factors control to reduce myocardial infarction and strokes.PMID:38685473 | DOI:10.1016/j.pharma.2024.04.010 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 30, 2024 Category: Drugs & Pharmacology Authors: Christelle Lacqua H éloïse Adam Marianne Zeller Lucie Vadot Florence Bichat Maud Maza Yves Cottin Mathieu Boulin Source Type: research
SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs
Cardiovasc Toxicol. 2024 Apr 30. doi: 10.1007/s12012-024-09858-1. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of CVDs has been extensively studied, the role of mitochondrial dysfunction in CVD development has yet to be investigated. Diabetic cardiomyopathy, ischemic-reperfusion injury, and heart failure are some of the CVDs resulting from mitochondrial dysfunction Recent evidence from the research states that any dysfunction of mitochondria has an impact on metabolic alteration, eventually caus...
Source: Cardiovascular Toxicology - April 30, 2024 Category: Cardiology Authors: K P Divya Navjot Kanwar P V Anuranjana Gautam Kumar Fathima Beegum Krupa Thankam George Nitesh Kumar K Nandakumar Abhinav Kanwal Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | PMC:PMC11058340 | DOI:10.3346/jkms.2024.39.e140 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 30, 2024 Category: Biomedical Science Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Moving from insulin substitution to the treatment of the underlying autoimmune disease in type 1 diabetes
Horm Res Paediatr. 2024 Apr 30. doi: 10.1159/000539120. Online ahead of print.ABSTRACTCurrently a paradigm change occurs in type 1 diabetes from insulin substitution to the treatment of the underlying autoimmune disease. Teplizumab, a humanized monoclonal anti CD3 antibody, is the first FDA approved disease modifying treatment of preclinical stage 2 diabetes. Research of drugs like Golimumab, a monoclonal antibody specific for TNF alpha, baricitinib, a tyrosine kinase inhibitor, or frexalimab, a monoclonal antibody against the CD40-Ligand, is still ongoing. Repurposing drugs that have been used in other indications like th...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jantje Weiskorn Thomas Danne Source Type: research
Experimental laboratory models as tools for understanding modifiable dementia risk
Alzheimers Dement. 2024 Apr 30. doi: 10.1002/alz.13834. Online ahead of print.ABSTRACTExperimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This re...
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Duncan Sinclair Alison J Canty Jenna M Ziebell Adele Woodhouse Jessica M Collins Sharn Perry Eddy Roccati Maneesh Kuruvilla Jacqueline Leung Rachel Atkinson James C Vickers Anthony L Cook Anna E King Source Type: research
