N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
Cardiovasc Toxicol. 2024 Apr 17. doi: 10.1007/s12012-024-09853-6. Online ahead of print.ABSTRACTThe challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition, widespread clinical use, and potential abuse. In response, healthcare professionals have primarily concentrated on mitigating the hallucinogenic and respiratory depressant consequences of opioid overdose to minimize associated risks. However, it is crucial to acknowledge that most opioids possess the capacity to prolong the QT interval, particularly in cases of overdose, thereby pot...
Source: Cardiovascular Toxicology - April 17, 2024 Category: Cardiology Authors: Jiale Hu Yongfei Song Xiaoyan Huang Chongrong Li Xiaojun Jin Lichao Cen Chuanjin Zhang Beilei Ding Jiangfang Lian Source Type: research
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
Cardiovasc Toxicol. 2024 Apr 17. doi: 10.1007/s12012-024-09853-6. Online ahead of print.ABSTRACTThe challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition, widespread clinical use, and potential abuse. In response, healthcare professionals have primarily concentrated on mitigating the hallucinogenic and respiratory depressant consequences of opioid overdose to minimize associated risks. However, it is crucial to acknowledge that most opioids possess the capacity to prolong the QT interval, particularly in cases of overdose, thereby pot...
Source: Cardiovascular Toxicology - April 17, 2024 Category: Cardiology Authors: Jiale Hu Yongfei Song Xiaoyan Huang Chongrong Li Xiaojun Jin Lichao Cen Chuanjin Zhang Beilei Ding Jiangfang Lian Source Type: research
Could Pan-Immune-Inflammation Value be a Marker for the Diagnosis of Coronary Slow Flow Phenomenon?
This study investigated the predictive value of PIV for diagnosing CSFP in comparison to other inflammation-based markers. A total of 214 patients, 109 in the CSFP group and 105 in the normal coronary flow (NCF) group, were retrospectively included in the study. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction frame count method. In addition to PIV, other inflammatory markers such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were calculated for the patients. The average age of patients was 50.3 ± 8.4, with a male ratio of 55.1%. C...
Source: Cardiovascular Toxicology - April 15, 2024 Category: Cardiology Authors: Mustafa Kaplangoray Kenan Toprak Edhem Deveci Cuneyt Caglayan Ebru Şahin Source Type: research
Could Pan-Immune-Inflammation Value be a Marker for the Diagnosis of Coronary Slow Flow Phenomenon?
This study investigated the predictive value of PIV for diagnosing CSFP in comparison to other inflammation-based markers. A total of 214 patients, 109 in the CSFP group and 105 in the normal coronary flow (NCF) group, were retrospectively included in the study. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction frame count method. In addition to PIV, other inflammatory markers such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were calculated for the patients. The average age of patients was 50.3 ± 8.4, with a male ratio of 55.1%. C...
Source: Cardiovascular Toxicology - April 15, 2024 Category: Cardiology Authors: Mustafa Kaplangoray Kenan Toprak Edhem Deveci Cuneyt Caglayan Ebru Şahin Source Type: research
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets. We investigated the observational and causal associations of 92 inflammatory proteins, which were measured using affinity-based proteomic assays. Firstly, the case-control cohort identified differential proteins associated with the occurrence and progression of CAVS. Subsequently, we delved into exploring the causal impacts of these associated proteins through Mendelian randomization. This involved utilizing genetic instruments derived from cis-protein quantitative loci identified in genome-wide association st...
Source: Cardiovascular Toxicology - April 8, 2024 Category: Cardiology Authors: Rui Lin Yuexin Zhu Weiyao Chen Zhiao Wang Yuan Wang Jie Du Source Type: research
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets. We investigated the observational and causal associations of 92 inflammatory proteins, which were measured using affinity-based proteomic assays. Firstly, the case-control cohort identified differential proteins associated with the occurrence and progression of CAVS. Subsequently, we delved into exploring the causal impacts of these associated proteins through Mendelian randomization. This involved utilizing genetic instruments derived from cis-protein quantitative loci identified in genome-wide association st...
Source: Cardiovascular Toxicology - April 8, 2024 Category: Cardiology Authors: Rui Lin Yuexin Zhu Weiyao Chen Zhiao Wang Yuan Wang Jie Du Source Type: research
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets. We investigated the observational and causal associations of 92 inflammatory proteins, which were measured using affinity-based proteomic assays. Firstly, the case-control cohort identified differential proteins associated with the occurrence and progression of CAVS. Subsequently, we delved into exploring the causal impacts of these associated proteins through Mendelian randomization. This involved utilizing genetic instruments derived from cis-protein quantitative loci identified in genome-wide association st...
Source: Cardiovascular Toxicology - April 8, 2024 Category: Cardiology Authors: Rui Lin Yuexin Zhu Weiyao Chen Zhiao Wang Yuan Wang Jie Du Source Type: research
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets. We investigated the observational and causal associations of 92 inflammatory proteins, which were measured using affinity-based proteomic assays. Firstly, the case-control cohort identified differential proteins associated with the occurrence and progression of CAVS. Subsequently, we delved into exploring the causal impacts of these associated proteins through Mendelian randomization. This involved utilizing genetic instruments derived from cis-protein quantitative loci identified in genome-wide association st...
Source: Cardiovascular Toxicology - April 8, 2024 Category: Cardiology Authors: Rui Lin Yuexin Zhu Weiyao Chen Zhiao Wang Yuan Wang Jie Du Source Type: research
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets. We investigated the observational and causal associations of 92 inflammatory proteins, which were measured using affinity-based proteomic assays. Firstly, the case-control cohort identified differential proteins associated with the occurrence and progression of CAVS. Subsequently, we delved into exploring the causal impacts of these associated proteins through Mendelian randomization. This involved utilizing genetic instruments derived from cis-protein quantitative loci identified in genome-wide association st...
Source: Cardiovascular Toxicology - April 8, 2024 Category: Cardiology Authors: Rui Lin Yuexin Zhu Weiyao Chen Zhiao Wang Yuan Wang Jie Du Source Type: research
The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?
This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case-control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94-0.99, P = 0.04). The association remained significant after adjustment for age, gender, s...
Source: Cardiovascular Toxicology - April 1, 2024 Category: Cardiology Authors: Mahdi Mousavi Mele Atefeh Tahavorgar Zahra Salimi Ali Shaker Seyed Ali Askarpour Mohammad Keshavarz Mohammadian Seyed Reza Mirshafaei Zahra Saeedirad Mahdie Torkaman Zahra Mahmoudi Shirin Tajadod Sara Khoshdooz Saeid Doaei Akram Kooshki Maryam Gholamaliza Source Type: research
The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?
This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case-control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94-0.99, P = 0.04). The association remained significant after adjustment for age, gender, s...
Source: Cardiovascular Toxicology - April 1, 2024 Category: Cardiology Authors: Mahdi Mousavi Mele Atefeh Tahavorgar Zahra Salimi Ali Shaker Seyed Ali Askarpour Mohammad Keshavarz Mohammadian Seyed Reza Mirshafaei Zahra Saeedirad Mahdie Torkaman Zahra Mahmoudi Shirin Tajadod Sara Khoshdooz Saeid Doaei Akram Kooshki Maryam Gholamaliza Source Type: research
The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?
This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case-control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94-0.99, P = 0.04). The association remained significant after adjustment for age, gender, s...
Source: Cardiovascular Toxicology - April 1, 2024 Category: Cardiology Authors: Mahdi Mousavi Mele Atefeh Tahavorgar Zahra Salimi Ali Shaker Seyed Ali Askarpour Mohammad Keshavarz Mohammadian Seyed Reza Mirshafaei Zahra Saeedirad Mahdie Torkaman Zahra Mahmoudi Shirin Tajadod Sara Khoshdooz Saeid Doaei Akram Kooshki Maryam Gholamaliza Source Type: research
The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?
This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case-control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94-0.99, P = 0.04). The association remained significant after adjustment for age, gender, s...
Source: Cardiovascular Toxicology - April 1, 2024 Category: Cardiology Authors: Mahdi Mousavi Mele Atefeh Tahavorgar Zahra Salimi Ali Shaker Seyed Ali Askarpour Mohammad Keshavarz Mohammadian Seyed Reza Mirshafaei Zahra Saeedirad Mahdie Torkaman Zahra Mahmoudi Shirin Tajadod Sara Khoshdooz Saeid Doaei Akram Kooshki Maryam Gholamaliza Source Type: research
