Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Cardiovasc Toxicol. 2023 Aug 7. doi: 10.1007/s12012-023-09802-9. Online ahead of print.ABSTRACTElectronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without n...
Source: Cardiovascular Toxicology - August 7, 2023 Category: Cardiology Authors: Gustaf Lyytinen Amelie Brynedal Erik Anes äter Lukasz Antoniewicz Anders Blomberg H åkan Wallén Jenny A Bosson Linnea Hedman Fariborz Mobarrez Sara Tehrani Magnus Lundb äck Source Type: research
Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Cardiovasc Toxicol. 2023 Aug 7. doi: 10.1007/s12012-023-09802-9. Online ahead of print.ABSTRACTElectronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without n...
Source: Cardiovascular Toxicology - August 7, 2023 Category: Cardiology Authors: Gustaf Lyytinen Amelie Brynedal Erik Anes äter Lukasz Antoniewicz Anders Blomberg H åkan Wallén Jenny A Bosson Linnea Hedman Fariborz Mobarrez Sara Tehrani Magnus Lundb äck Source Type: research
Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Cardiovasc Toxicol. 2023 Aug 7. doi: 10.1007/s12012-023-09802-9. Online ahead of print.ABSTRACTElectronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without n...
Source: Cardiovascular Toxicology - August 7, 2023 Category: Cardiology Authors: Gustaf Lyytinen Amelie Brynedal Erik Anes äter Lukasz Antoniewicz Anders Blomberg H åkan Wallén Jenny A Bosson Linnea Hedman Fariborz Mobarrez Sara Tehrani Magnus Lundb äck Source Type: research
Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Cardiovasc Toxicol. 2023 Aug 7. doi: 10.1007/s12012-023-09802-9. Online ahead of print.ABSTRACTElectronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without n...
Source: Cardiovascular Toxicology - August 7, 2023 Category: Cardiology Authors: Gustaf Lyytinen Amelie Brynedal Erik Anes äter Lukasz Antoniewicz Anders Blomberg H åkan Wallén Jenny A Bosson Linnea Hedman Fariborz Mobarrez Sara Tehrani Magnus Lundb äck Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
