Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
Cardiovasc Toxicol. 2023 Oct 3. doi: 10.1007/s12012-023-09809-2. Online ahead of print.ABSTRACTA growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on three bioisosteric 7-azaindazole-based candidate inhibitors namely FD269, FD268 and FD274 that give same order of inhibitory concentration 50% (IC50) magnitude against PI3Ks, in this work, we proposed to systematically evaluate the SCR of 7-azaindazole-based PI3K inhibitors designed by bioisosteric approach. The 24-h lethal c...
Source: Cardiovascular Toxicology - October 3, 2023 Category: Cardiology Authors: Tianze Wu Yi Chen Chengbin Yang Mingzhu Lu Fang Geng Jianhua Guo Yan Pi Yun Ling Jun Xu Tong Cai Lei Lu Yaming Zhou Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Cardiovasc Toxicol. 2023 Sep 22. doi: 10.1007/s12012-023-09808-3. Online ahead of print.ABSTRACTSalidroside shows an inhibitory effect on myocardial ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains to be explored. The present work analyzes the mechanism that drives salidroside to ameliorate I/R-induced human cardiomyocyte injury. Human cardiomyocytes were subjected to I/R treatment to simulate a myocardial infarction cell model. Cell viability, cell proliferation, and cell apoptosis were analyzed by CCK-8 assay, EdU assay, and flow cytometry analysis, respectively. RNA expression levels of circ_...
Source: Cardiovascular Toxicology - September 22, 2023 Category: Cardiology Authors: Yuyang Yang Fangqian Liang Jingyuan Gao Jian Li Chunhua Jiang Wei Xie Shujuan Wu Ya Wang Jing Yi Source Type: research
Δ < sup > 9 < /sup > -Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
This study highlights important differences in the timeline of cardiopulmonary response to THC following the most common preclinical routes of administration.PMID:37728714 | DOI:10.1007/s12012-023-09810-9 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - September 20, 2023 Category: Cardiology Authors: Lucas T Laudermilk Julie A Marusich Jenny L Wiley Source Type: research
Δ < sup > 9 < /sup > -Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
This study highlights important differences in the timeline of cardiopulmonary response to THC following the most common preclinical routes of administration.PMID:37728714 | DOI:10.1007/s12012-023-09810-9 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - September 20, 2023 Category: Cardiology Authors: Lucas T Laudermilk Julie A Marusich Jenny L Wiley Source Type: research
Δ < sup > 9 < /sup > -Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
This study highlights important differences in the timeline of cardiopulmonary response to THC following the most common preclinical routes of administration.PMID:37728714 | DOI:10.1007/s12012-023-09810-9 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - September 20, 2023 Category: Cardiology Authors: Lucas T Laudermilk Julie A Marusich Jenny L Wiley Source Type: research
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
