The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds
Cardiovasc Toxicol. 2023 Dec 18. doi: 10.1007/s12012-023-09820-7. Online ahead of print.ABSTRACTDoxorubicin (DOX) is commonly used for the treatment of various types of cancer, however can cause serious side effects, including cardiotoxicity. The mechanisms involved in DOX-induced cardiac damage are complex and not yet fully understood. One mechanism is the disruption of cardiac metabolism, which can impair cardiac function. The mammalian target of rapamycin (mTOR) is a key regulator of cardiac energy metabolism, and dysregulation of mTOR signaling has been implicated in DOX-induced cardiac dysfunction. Natural compounds (...
Source: Cardiovascular Toxicology - December 18, 2023 Category: Cardiology Authors: Fatemeh Yarmohammadi Mahvash Hesari Dareuosh Shackebaei Source Type: research
Four ‑Dimensional Echocardiographic Evaluation of Cardiac Iron Overload in Patients with Beta-Thalassemia Major
Cardiovasc Toxicol. 2023 Dec 18. doi: 10.1007/s12012-023-09813-6. Online ahead of print.ABSTRACTCardiac magnetic resonance imaging is the gold standard to detect cardiac iron overload in patients with beta-thalassemia. The aim of this study was to evaluate cardiac iron overload using four-dimensional transthoracic echocardiography in thalassemia patients with and without cardiac involvement detected by T2* value and to compare the two techniques. This cross-sectional and observational study was conducted in 44 patients diagnosed with thalassemia major. Left ventricular systolic function was assessed using four-dimensional ...
Source: Cardiovascular Toxicology - December 18, 2023 Category: Cardiology Authors: Ahmet Burak Fedai Ugur Nadir Karakulak Elifcan Aladag Nilgun Sayinalp Source Type: research
On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles
Cardiovasc Toxicol. 2023 Dec 18. doi: 10.1007/s12012-023-09814-5. Online ahead of print.ABSTRACTLead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms...
Source: Cardiovascular Toxicology - December 18, 2023 Category: Cardiology Authors: Ilzira A Minigaliyeva Svetlana V Klinova Marina P Sutunkova Yuliya V Ryabova Irene E Valamina Ivan G Shelomentsev Tatiana N Shtin Tatiana V Bushueva Yuri L Protsenko Alexander A Balakin Ruslan V Lisin Daniil A Kuznetsov Boris A Katsnelson Liubov V Toropov Source Type: research
The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds
Cardiovasc Toxicol. 2023 Dec 18. doi: 10.1007/s12012-023-09820-7. Online ahead of print.ABSTRACTDoxorubicin (DOX) is commonly used for the treatment of various types of cancer, however can cause serious side effects, including cardiotoxicity. The mechanisms involved in DOX-induced cardiac damage are complex and not yet fully understood. One mechanism is the disruption of cardiac metabolism, which can impair cardiac function. The mammalian target of rapamycin (mTOR) is a key regulator of cardiac energy metabolism, and dysregulation of mTOR signaling has been implicated in DOX-induced cardiac dysfunction. Natural compounds (...
Source: Cardiovascular Toxicology - December 18, 2023 Category: Cardiology Authors: Fatemeh Yarmohammadi Mahvash Hesari Dareuosh Shackebaei Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
