Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies
Cardiovasc Toxicol. 2023 Jul 21. doi: 10.1007/s12012-023-09800-x. Online ahead of print.ABSTRACTThe advent of BCR-ABL tyrosine kinase inhibitors (TKIs) targeted therapy revolutionized the treatment of chronic myeloid leukemia (CML) patients. Mitochondria are the key organelles for the maintenance of myocardial tissue homeostasis. However, cardiotoxicity associated with BCR-ABL1 TKIs can directly or indirectly cause mitochondrial damage and dysfunction, playing a pivotal role in cardiomyocytes homeostatic system and putting the cancer survivors at higher risk. In this review, we summarize the cardiotoxicity caused by BCR-AB...
Source: Cardiovascular Toxicology - July 21, 2023 Category: Cardiology Authors: Sheng Sun Jiqiu Qin Wenhao Liao Xiang Gao Zhoubiao Shang Dehua Luo Shaoquan Xiong Source Type: research
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with...
Source: Cardiovascular Toxicology - July 17, 2023 Category: Cardiology Authors: Murat Cimci Bahadir Batar Merve Bostanci Eser Durmaz Bahadir Karayel Damla Raimoglou Mehmet Guven Bilgehan Karadag Source Type: research
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with...
Source: Cardiovascular Toxicology - July 17, 2023 Category: Cardiology Authors: Murat Cimci Bahadir Batar Merve Bostanci Eser Durmaz Bahadir Karayel Damla Raimoglou Mehmet Guven Bilgehan Karadag Source Type: research
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with...
Source: Cardiovascular Toxicology - July 17, 2023 Category: Cardiology Authors: Murat Cimci Bahadir Batar Merve Bostanci Eser Durmaz Bahadir Karayel Damla Raimoglou Mehmet Guven Bilgehan Karadag Source Type: research
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with...
Source: Cardiovascular Toxicology - July 17, 2023 Category: Cardiology Authors: Murat Cimci Bahadir Batar Merve Bostanci Eser Durmaz Bahadir Karayel Damla Raimoglou Mehmet Guven Bilgehan Karadag Source Type: research
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with...
Source: Cardiovascular Toxicology - July 17, 2023 Category: Cardiology Authors: Murat Cimci Bahadir Batar Merve Bostanci Eser Durmaz Bahadir Karayel Damla Raimoglou Mehmet Guven Bilgehan Karadag Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
