Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease
Cardiovasc Toxicol. 2023 Nov 20. doi: 10.1007/s12012-023-09815-4. Online ahead of print.ABSTRACTThe developments in HIV treatments have increased the life expectancy of people living with HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as relevant as ever. PLWH are at increased risk of CVD, and our understanding of the underlying mechanisms is continually increasing. HIV infection is associated with elevated levels of multiple proinflammatory molecules, including IL-6, IL-1β, VCAM-1, ICAM-1, TNF-α, TGF-β, osteopontin, sCD14, hs-CRP, and D-dimer. Other currently examined mechanisms incl...
Source: Cardiovascular Toxicology - November 20, 2023 Category: Cardiology Authors: Agnieszka Lembas Andrzej Za łęski Micha ł Peller Tomasz Miku ła Alicja Wierci ńska-Drapało Source Type: research
Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Cardiovasc Toxicol. 2023 Nov 16. doi: 10.1007/s12012-023-09812-7. Online ahead of print.ABSTRACTArsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and de...
Source: Cardiovascular Toxicology - November 16, 2023 Category: Cardiology Authors: Laila Khaleda Syeda Kishuara Begum Md Abdur Rahman Apu Rahee Hasan Chowdhury Md Jibran Alam Amit Datta Md Zillur Rahman Nazmul Hosain Mohammad Al-Forkan Source Type: research
Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Cardiovasc Toxicol. 2023 Nov 16. doi: 10.1007/s12012-023-09812-7. Online ahead of print.ABSTRACTArsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and de...
Source: Cardiovascular Toxicology - November 16, 2023 Category: Cardiology Authors: Laila Khaleda Syeda Kishuara Begum Md Abdur Rahman Apu Rahee Hasan Chowdhury Md Jibran Alam Amit Datta Md Zillur Rahman Nazmul Hosain Mohammad Al-Forkan Source Type: research
Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Cardiovasc Toxicol. 2023 Nov 16. doi: 10.1007/s12012-023-09812-7. Online ahead of print.ABSTRACTArsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and de...
Source: Cardiovascular Toxicology - November 16, 2023 Category: Cardiology Authors: Laila Khaleda Syeda Kishuara Begum Md Abdur Rahman Apu Rahee Hasan Chowdhury Md Jibran Alam Amit Datta Md Zillur Rahman Nazmul Hosain Mohammad Al-Forkan Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
