Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: "What Are the Tools Needed for the Job?" and "Do We Have Them?"
Cardiovasc Toxicol. 2024 Mar 31. doi: 10.1007/s12012-024-09850-9. Online ahead of print.ABSTRACTCigarette smoking is positively and robustly associated with cardiovascular disease (CVD), including hypertension, atherosclerosis, cardiac arrhythmias, stroke, thromboembolism, myocardial infarctions, and heart failure. However, after more than a decade of ENDS presence in the U.S. marketplace, uncertainty persists regarding the long-term health consequences of ENDS use for CVD. New approach methods (NAMs) in the field of toxicology are being developed to enhance rapid prediction of human health hazards. Recent technical advanc...
Source: Cardiovascular Toxicology - March 31, 2024 Category: Cardiology Authors: Mark Chandy Thomas Hill Nerea Jimenez-Tellez Joseph C Wu S Emma Sarles Edward Hensel Qixin Wang Irfan Rahman Daniel J Conklin Source Type: research
Genetically Predicted Apolipoprotein E Levels with the Risk of Panvascular Diseases: A Mendelian Randomization Study
Cardiovasc Toxicol. 2024 Mar 27. doi: 10.1007/s12012-024-09846-5. Online ahead of print.ABSTRACTThe aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations ...
Source: Cardiovascular Toxicology - March 27, 2024 Category: Cardiology Authors: Yi-Ming Shi Dian Ou Jia-Ting Li Le Bao Xiao-Dan Liu Wei Zhang Huang Ding Source Type: research
Genetically Predicted Apolipoprotein E Levels with the Risk of Panvascular Diseases: A Mendelian Randomization Study
Cardiovasc Toxicol. 2024 Mar 27. doi: 10.1007/s12012-024-09846-5. Online ahead of print.ABSTRACTThe aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations ...
Source: Cardiovascular Toxicology - March 27, 2024 Category: Cardiology Authors: Yi-Ming Shi Dian Ou Jia-Ting Li Le Bao Xiao-Dan Liu Wei Zhang Huang Ding Source Type: research
Genetically Predicted Apolipoprotein E Levels with the Risk of Panvascular Diseases: A Mendelian Randomization Study
Cardiovasc Toxicol. 2024 Mar 27. doi: 10.1007/s12012-024-09846-5. Online ahead of print.ABSTRACTThe aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations ...
Source: Cardiovascular Toxicology - March 27, 2024 Category: Cardiology Authors: Yi-Ming Shi Dian Ou Jia-Ting Li Le Bao Xiao-Dan Liu Wei Zhang Huang Ding Source Type: research
Genetically Predicted Apolipoprotein E Levels with the Risk of Panvascular Diseases: A Mendelian Randomization Study
Cardiovasc Toxicol. 2024 Mar 27. doi: 10.1007/s12012-024-09846-5. Online ahead of print.ABSTRACTThe aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations ...
Source: Cardiovascular Toxicology - March 27, 2024 Category: Cardiology Authors: Yi-Ming Shi Dian Ou Jia-Ting Li Le Bao Xiao-Dan Liu Wei Zhang Huang Ding Source Type: research
Acute High-Output Heart Failure with Pulmonary Hypertension and Severe Liver Injury Caused by Amlodipine Poisoning: A Case Report
We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally. The patient's circulatory function and right ventricular dysfunction gradually improved after large doses of vasopressors and detoxification measures. However, her bilirubin and transaminase levels incr...
Source: Cardiovascular Toxicology - March 26, 2024 Category: Cardiology Authors: Chenlong Wang Qingcheng Zhu Dingyu Tan Joseph Walline Yachao Wang Source Type: research
BMSCs-derived Exosome CISH Alleviates Myocardial Infarction by Inactivating the NF- κB Pathway to Stimulate Macrophage M2 Polarization
Cardiovasc Toxicol. 2024 Mar 21. doi: 10.1007/s12012-024-09847-4. Online ahead of print.ABSTRACTCurrent myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI m...
Source: Cardiovascular Toxicology - March 21, 2024 Category: Cardiology Authors: Minzhi Ouyang Yang Yang Guolong Yu Jiling Zhao Yi Peng Source Type: research
BMSCs-derived Exosome CISH Alleviates Myocardial Infarction by Inactivating the NF- κB Pathway to Stimulate Macrophage M2 Polarization
Cardiovasc Toxicol. 2024 Mar 21. doi: 10.1007/s12012-024-09847-4. Online ahead of print.ABSTRACTCurrent myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI m...
Source: Cardiovascular Toxicology - March 21, 2024 Category: Cardiology Authors: Minzhi Ouyang Yang Yang Guolong Yu Jiling Zhao Yi Peng Source Type: research
BMSCs-derived Exosome CISH Alleviates Myocardial Infarction by Inactivating the NF- κB Pathway to Stimulate Macrophage M2 Polarization
Cardiovasc Toxicol. 2024 Mar 21. doi: 10.1007/s12012-024-09847-4. Online ahead of print.ABSTRACTCurrent myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI m...
Source: Cardiovascular Toxicology - March 21, 2024 Category: Cardiology Authors: Minzhi Ouyang Yang Yang Guolong Yu Jiling Zhao Yi Peng Source Type: research
BMSCs-derived Exosome CISH Alleviates Myocardial Infarction by Inactivating the NF- κB Pathway to Stimulate Macrophage M2 Polarization
Cardiovasc Toxicol. 2024 Mar 21. doi: 10.1007/s12012-024-09847-4. Online ahead of print.ABSTRACTCurrent myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI m...
Source: Cardiovascular Toxicology - March 21, 2024 Category: Cardiology Authors: Minzhi Ouyang Yang Yang Guolong Yu Jiling Zhao Yi Peng Source Type: research
BMSCs-derived Exosome CISH Alleviates Myocardial Infarction by Inactivating the NF- κB Pathway to Stimulate Macrophage M2 Polarization
Cardiovasc Toxicol. 2024 Mar 21. doi: 10.1007/s12012-024-09847-4. Online ahead of print.ABSTRACTCurrent myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI m...
Source: Cardiovascular Toxicology - March 21, 2024 Category: Cardiology Authors: Minzhi Ouyang Yang Yang Guolong Yu Jiling Zhao Yi Peng Source Type: research
Development and Validation of Machine Learning Algorithms to Predict 1-Year Ischemic Stroke and Bleeding Events in Patients with Atrial Fibrillation and Cancer
In this study, we leveraged machine learning (ML) approach to develop and validate new assessment tools for predicting stroke and bleeding among patients with atrial fibrillation (AFib) and cancer. We conducted a retrospective cohort study including patients who were newly diagnosed with AFib with a record of cancer from the 2012-2018 Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The ML algorithms were developed and validated separately for each outcome by fitting elastic net, random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM), and neural network models with tenfol...
Source: Cardiovascular Toxicology - March 19, 2024 Category: Cardiology Authors: Bang Truong Jingyi Zheng Lori Hornsby Brent Fox Chiahung Chou Jingjing Qian Source Type: research
Development and Validation of Machine Learning Algorithms to Predict 1-Year Ischemic Stroke and Bleeding Events in Patients with Atrial Fibrillation and Cancer
In this study, we leveraged machine learning (ML) approach to develop and validate new assessment tools for predicting stroke and bleeding among patients with atrial fibrillation (AFib) and cancer. We conducted a retrospective cohort study including patients who were newly diagnosed with AFib with a record of cancer from the 2012-2018 Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The ML algorithms were developed and validated separately for each outcome by fitting elastic net, random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM), and neural network models with tenfol...
Source: Cardiovascular Toxicology - March 19, 2024 Category: Cardiology Authors: Bang Truong Jingyi Zheng Lori Hornsby Brent Fox Chiahung Chou Jingjing Qian Source Type: research
Association Between Cancer and Cardiovascular Toxicity: A Nationwide Cross-Sectional Study on NHANES 1999-2018
Cardiovasc Toxicol. 2024 Mar 11. doi: 10.1007/s12012-024-09845-6. Online ahead of print.ABSTRACTThere is a dearth of evidence pertaining to the relationship of cardiovascular disease (CVD) and its subtype with adjudicated cancer, thereby limiting our understanding of the heightened risk of CVD resulting from long-term complications of cancer and its therapies. The aim of this study was to quantify the risks of CVD and its subtypes in adult cancer survivors compared with cancer-free controls in a nationwide cross-sectional study on Continuous National Health and Nutrition Examination Survey (NHANES). We included 44,442 part...
Source: Cardiovascular Toxicology - March 11, 2024 Category: Cardiology Authors: Ruihuan Shen Tong Zou Source Type: research
Association Between Cancer and Cardiovascular Toxicity: A Nationwide Cross-Sectional Study on NHANES 1999-2018
Cardiovasc Toxicol. 2024 Mar 11. doi: 10.1007/s12012-024-09845-6. Online ahead of print.ABSTRACTThere is a dearth of evidence pertaining to the relationship of cardiovascular disease (CVD) and its subtype with adjudicated cancer, thereby limiting our understanding of the heightened risk of CVD resulting from long-term complications of cancer and its therapies. The aim of this study was to quantify the risks of CVD and its subtypes in adult cancer survivors compared with cancer-free controls in a nationwide cross-sectional study on Continuous National Health and Nutrition Examination Survey (NHANES). We included 44,442 part...
Source: Cardiovascular Toxicology - March 11, 2024 Category: Cardiology Authors: Ruihuan Shen Tong Zou Source Type: research
