Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway
Cardiovasc Toxicol. 2023 Sep 13. doi: 10.1007/s12012-023-09805-6. Online ahead of print.ABSTRACTCoronary artery disease (CAD) as a major cardiovascular disease is the leading global cause of mortality, Klotho/FGF23 axis involved in development of cardiovascular disease, while the function and underlying mechanism of Klotho/FGF23 axis in CAD is unclear. Blood samples from 67 CAD patients with coronary artery bypass graft (CABG) surgery were collected, and the level of Klotho and FGF23 of those patients was measured by using an ELISA kit. Cardiomyocyte was isolated from 0 to 3 days Sprague Dawley (SD) rats. Expression of Klo...
Source: Cardiovascular Toxicology - September 13, 2023 Category: Cardiology Authors: Zheng Jia Qian Liu Ying Xie Jie Wei Xiaolin Sun Fandi Meng Bin Zhao Zhenkun Yu Li Zhao Zhengjiang Xing Source Type: research
Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Cardiovasc Toxicol. 2023 Sep 8. doi: 10.1007/s12012-023-09806-5. Online ahead of print.ABSTRACTBased on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity. However, key immune-related transcriptional markers linked to doxorubicin-induced cardiotoxicity in breast cancer patients have not been thoroughly investigated. We used GSE40447, GSE76314, and TCGA BRCA cohorts to perform this study. Then, we performed various bioinformatics approaches to identify the key immune-related transcriptional markers and their association with doxorubicin-...
Source: Cardiovascular Toxicology - September 8, 2023 Category: Cardiology Authors: Daiqin Xiong Jianhua Yang Dongfeng Li Jie Wang Source Type: research
Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Cardiovasc Toxicol. 2023 Sep 8. doi: 10.1007/s12012-023-09806-5. Online ahead of print.ABSTRACTBased on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity. However, key immune-related transcriptional markers linked to doxorubicin-induced cardiotoxicity in breast cancer patients have not been thoroughly investigated. We used GSE40447, GSE76314, and TCGA BRCA cohorts to perform this study. Then, we performed various bioinformatics approaches to identify the key immune-related transcriptional markers and their association with doxorubicin-...
Source: Cardiovascular Toxicology - September 8, 2023 Category: Cardiology Authors: Daiqin Xiong Jianhua Yang Dongfeng Li Jie Wang Source Type: research
Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Cardiovasc Toxicol. 2023 Sep 8. doi: 10.1007/s12012-023-09806-5. Online ahead of print.ABSTRACTBased on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity. However, key immune-related transcriptional markers linked to doxorubicin-induced cardiotoxicity in breast cancer patients have not been thoroughly investigated. We used GSE40447, GSE76314, and TCGA BRCA cohorts to perform this study. Then, we performed various bioinformatics approaches to identify the key immune-related transcriptional markers and their association with doxorubicin-...
Source: Cardiovascular Toxicology - September 8, 2023 Category: Cardiology Authors: Daiqin Xiong Jianhua Yang Dongfeng Li Jie Wang Source Type: research
Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Cardiovasc Toxicol. 2023 Sep 8. doi: 10.1007/s12012-023-09806-5. Online ahead of print.ABSTRACTBased on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity. However, key immune-related transcriptional markers linked to doxorubicin-induced cardiotoxicity in breast cancer patients have not been thoroughly investigated. We used GSE40447, GSE76314, and TCGA BRCA cohorts to perform this study. Then, we performed various bioinformatics approaches to identify the key immune-related transcriptional markers and their association with doxorubicin-...
Source: Cardiovascular Toxicology - September 8, 2023 Category: Cardiology Authors: Daiqin Xiong Jianhua Yang Dongfeng Li Jie Wang Source Type: research
Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research
Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research
COMP Improves Ang-II-Induced Atrial Fibrillation via TGF- β Signaling Pathway
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09799-1. Online ahead of print.ABSTRACTCartilage oligomeric matrix protein (COMP) regulates transforming growth factor-β (TGF-β) signaling pathway, which has been proved to be associated with skin fibrosis and pulmonary fibrosis. Atrial fibrosis is a major factor of atrial fibrillation (AF). Nevertheless, the interaction between COMP and TGF-β as well as their role in AF remains undefined. The purpose of this study is to clarify the role of COMP in AF and explore its potential mechanism. The hub gene of AF was identified from two datasets using bioinformatics. Fur...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: XiaoBi Cai Mingliang Li Ying Zhong Wenkun Yang Zhu Liang Source Type: research
Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09803-8. Online ahead of print.ABSTRACTThe ancient use of herbs for the treatment of various human diseases have been documented, with several scientific literatures supporting the use of medicinal plants. There is however a major concern about the phyto-constituents in the plants that performs the healing function and the mechanism by which it works for different ailments are still a research prospect. Cardiometabolic disease (CMD) is no doubt becoming more frequent globally and this is due to poor approach in therapy, contrary effects linked with intensive control,...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: Cecilia Oluwamodupe Adesola Oluwaseun Adeleye Source Type: research
COMP Improves Ang-II-Induced Atrial Fibrillation via TGF- β Signaling Pathway
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09799-1. Online ahead of print.ABSTRACTCartilage oligomeric matrix protein (COMP) regulates transforming growth factor-β (TGF-β) signaling pathway, which has been proved to be associated with skin fibrosis and pulmonary fibrosis. Atrial fibrosis is a major factor of atrial fibrillation (AF). Nevertheless, the interaction between COMP and TGF-β as well as their role in AF remains undefined. The purpose of this study is to clarify the role of COMP in AF and explore its potential mechanism. The hub gene of AF was identified from two datasets using bioinformatics. Fur...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: XiaoBi Cai Mingliang Li Ying Zhong Wenkun Yang Zhu Liang Source Type: research
Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09803-8. Online ahead of print.ABSTRACTThe ancient use of herbs for the treatment of various human diseases have been documented, with several scientific literatures supporting the use of medicinal plants. There is however a major concern about the phyto-constituents in the plants that performs the healing function and the mechanism by which it works for different ailments are still a research prospect. Cardiometabolic disease (CMD) is no doubt becoming more frequent globally and this is due to poor approach in therapy, contrary effects linked with intensive control,...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: Cecilia Oluwamodupe Adesola Oluwaseun Adeleye Source Type: research
COMP Improves Ang-II-Induced Atrial Fibrillation via TGF- β Signaling Pathway
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09799-1. Online ahead of print.ABSTRACTCartilage oligomeric matrix protein (COMP) regulates transforming growth factor-β (TGF-β) signaling pathway, which has been proved to be associated with skin fibrosis and pulmonary fibrosis. Atrial fibrosis is a major factor of atrial fibrillation (AF). Nevertheless, the interaction between COMP and TGF-β as well as their role in AF remains undefined. The purpose of this study is to clarify the role of COMP in AF and explore its potential mechanism. The hub gene of AF was identified from two datasets using bioinformatics. Fur...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: XiaoBi Cai Mingliang Li Ying Zhong Wenkun Yang Zhu Liang Source Type: research
Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases
Cardiovasc Toxicol. 2023 Aug 16. doi: 10.1007/s12012-023-09803-8. Online ahead of print.ABSTRACTThe ancient use of herbs for the treatment of various human diseases have been documented, with several scientific literatures supporting the use of medicinal plants. There is however a major concern about the phyto-constituents in the plants that performs the healing function and the mechanism by which it works for different ailments are still a research prospect. Cardiometabolic disease (CMD) is no doubt becoming more frequent globally and this is due to poor approach in therapy, contrary effects linked with intensive control,...
Source: Cardiovascular Toxicology - August 16, 2023 Category: Cardiology Authors: Cecilia Oluwamodupe Adesola Oluwaseun Adeleye Source Type: research
