Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy
In this study, we established a zinc overload model by treating rat cardiomyocyte H9c2 cells with Zn2+ at different concentrations. Our results showed that zinc overload increased LDH and reactive oxygen species (ROS) levels, leading to cell death, mitochondrial membrane potential decrease and impaired mitochondrial function and dynamics. Furthermore, zinc overload activated the PINK1/Parkin signaling pathway and induced mitochondrial autophagy via ROS, while NAC inhibited mitophagy and weakened the activation of PINK1/Parkin pathway, thereby preserving mitochondrial biogenesis. In addition, our data also showed that Mfn2 ...
Source: Cardiovascular Toxicology - October 16, 2023 Category: Cardiology Authors: Ying Yang Pei Wang Jiabao Guo Tingting Ma Youcheng Hu Luyao Huang Bohan Xing Yonggui He Jinkun Xi Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Development and Validation of a Nomogram Model for the Risk of Cardiac Death in Patients Treated with Chemotherapy for Esophageal Cancer
Cardiovasc Toxicol. 2023 Oct 7. doi: 10.1007/s12012-023-09807-4. Online ahead of print.ABSTRACTThe primary cause of mortality in esophageal cancer survivors is cardiac death. Early identification of cardiac mortality risk during chemotherapy for esophageal cancer is crucial for improving the prognosis. We developed and validated a nomogram model to identify patients with high cardiac mortality risk after chemotherapy for esophageal cancer for early screening and clinical decision-making. We randomly allocated 37,994 patients with chemotherapy-treated esophageal cancer into two groups using a 7:3 split ratio: model training...
Source: Cardiovascular Toxicology - October 7, 2023 Category: Cardiology Authors: Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Yingdong Li Source Type: research
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
Cardiovasc Toxicol. 2023 Oct 3. doi: 10.1007/s12012-023-09809-2. Online ahead of print.ABSTRACTA growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on three bioisosteric 7-azaindazole-based candidate inhibitors namely FD269, FD268 and FD274 that give same order of inhibitory concentration 50% (IC50) magnitude against PI3Ks, in this work, we proposed to systematically evaluate the SCR of 7-azaindazole-based PI3K inhibitors designed by bioisosteric approach. The 24-h lethal c...
Source: Cardiovascular Toxicology - October 3, 2023 Category: Cardiology Authors: Tianze Wu Yi Chen Chengbin Yang Mingzhu Lu Fang Geng Jianhua Guo Yan Pi Yun Ling Jun Xu Tong Cai Lei Lu Yaming Zhou Source Type: research
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
Cardiovasc Toxicol. 2023 Oct 3. doi: 10.1007/s12012-023-09809-2. Online ahead of print.ABSTRACTA growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on three bioisosteric 7-azaindazole-based candidate inhibitors namely FD269, FD268 and FD274 that give same order of inhibitory concentration 50% (IC50) magnitude against PI3Ks, in this work, we proposed to systematically evaluate the SCR of 7-azaindazole-based PI3K inhibitors designed by bioisosteric approach. The 24-h lethal c...
Source: Cardiovascular Toxicology - October 3, 2023 Category: Cardiology Authors: Tianze Wu Yi Chen Chengbin Yang Mingzhu Lu Fang Geng Jianhua Guo Yan Pi Yun Ling Jun Xu Tong Cai Lei Lu Yaming Zhou Source Type: research
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
Cardiovasc Toxicol. 2023 Oct 3. doi: 10.1007/s12012-023-09809-2. Online ahead of print.ABSTRACTA growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on three bioisosteric 7-azaindazole-based candidate inhibitors namely FD269, FD268 and FD274 that give same order of inhibitory concentration 50% (IC50) magnitude against PI3Ks, in this work, we proposed to systematically evaluate the SCR of 7-azaindazole-based PI3K inhibitors designed by bioisosteric approach. The 24-h lethal c...
Source: Cardiovascular Toxicology - October 3, 2023 Category: Cardiology Authors: Tianze Wu Yi Chen Chengbin Yang Mingzhu Lu Fang Geng Jianhua Guo Yan Pi Yun Ling Jun Xu Tong Cai Lei Lu Yaming Zhou Source Type: research
