Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart
In conclusion, PET MPs promoted cardiomyocyte apoptosis by inducing oxidative stress and activating mitochondria-mediated apoptotic processes, ultimately leading to myocardial fibrosis. This study provides ideas for the prevention of PET MP toxicity and promotes thinking about enhancing plastic pollution control.PMID:38369677 | DOI:10.1007/s12012-024-09837-6 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 18, 2024 Category: Cardiology Authors: Tao Lu Desheng Li Xiaoqing Yuan Zhenzhen Wang Zhuang Shao Xiaotian Feng Chen Yang Huan Liu Guanqing Zhang Yue Wang Xiaohan Liu Ling Zhou Maolei Xu Source Type: research
Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart
In conclusion, PET MPs promoted cardiomyocyte apoptosis by inducing oxidative stress and activating mitochondria-mediated apoptotic processes, ultimately leading to myocardial fibrosis. This study provides ideas for the prevention of PET MP toxicity and promotes thinking about enhancing plastic pollution control.PMID:38369677 | DOI:10.1007/s12012-024-09837-6 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 18, 2024 Category: Cardiology Authors: Tao Lu Desheng Li Xiaoqing Yuan Zhenzhen Wang Zhuang Shao Xiaotian Feng Chen Yang Huan Liu Guanqing Zhang Yue Wang Xiaohan Liu Ling Zhou Maolei Xu Source Type: research
Heavy Metal Scavenger Metallothionein Rescues Against Cold Stress-Evoked Myocardial Contractile Anomalies Through Regulation of Mitophagy
Cardiovasc Toxicol. 2024 Feb 14. doi: 10.1007/s12012-023-09823-4. Online ahead of print.ABSTRACTCold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold stress-induced cardiac anomalies. Our present study evaluated the effect of heavy metal antioxidant metallothionein on cold stress (4 °C)-induced in cardiac remodeling and contractile anomalies and cell signaling involved including regulation of autophagy and mitophagy. Cold stress (3 weeks) prompted interstitial fibrosis, mitochondrial damage (mitochon...
Source: Cardiovascular Toxicology - February 15, 2024 Category: Cardiology Authors: Zhaohui Pei Yayuan Xiong Shasha Jiang Rui Guo Wei Jin Jun Tao Zhenzhong Zhang Yingmei Zhang Yunzeng Zou Yan Gong Jun Ren Source Type: research
Heavy Metal Scavenger Metallothionein Rescues Against Cold Stress-Evoked Myocardial Contractile Anomalies Through Regulation of Mitophagy
Cardiovasc Toxicol. 2024 Feb 14. doi: 10.1007/s12012-023-09823-4. Online ahead of print.ABSTRACTCold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold stress-induced cardiac anomalies. Our present study evaluated the effect of heavy metal antioxidant metallothionein on cold stress (4 °C)-induced in cardiac remodeling and contractile anomalies and cell signaling involved including regulation of autophagy and mitophagy. Cold stress (3 weeks) prompted interstitial fibrosis, mitochondrial damage (mitochon...
Source: Cardiovascular Toxicology - February 15, 2024 Category: Cardiology Authors: Zhaohui Pei Yayuan Xiong Shasha Jiang Rui Guo Wei Jin Jun Tao Zhenzhong Zhang Yingmei Zhang Yunzeng Zou Yan Gong Jun Ren Source Type: research
Heavy Metal Scavenger Metallothionein Rescues Against Cold Stress-Evoked Myocardial Contractile Anomalies Through Regulation of Mitophagy
Cardiovasc Toxicol. 2024 Feb 14. doi: 10.1007/s12012-023-09823-4. Online ahead of print.ABSTRACTCold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold stress-induced cardiac anomalies. Our present study evaluated the effect of heavy metal antioxidant metallothionein on cold stress (4 °C)-induced in cardiac remodeling and contractile anomalies and cell signaling involved including regulation of autophagy and mitophagy. Cold stress (3 weeks) prompted interstitial fibrosis, mitochondrial damage (mitochon...
Source: Cardiovascular Toxicology - February 15, 2024 Category: Cardiology Authors: Zhaohui Pei Yayuan Xiong Shasha Jiang Rui Guo Wei Jin Jun Tao Zhenzhong Zhang Yingmei Zhang Yunzeng Zou Yan Gong Jun Ren Source Type: research
Comparative In Vitro Study of the Cytotoxic Effects of Doxorubicin's Main Metabolites on Cardiac AC16 Cells Versus the Parent Drug
In conclusion, our findings suggest that metabolism may not be a pivotal factor in mediating DOX's cardiotoxic effects.PMID:38347287 | DOI:10.1007/s12012-024-09829-6 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 12, 2024 Category: Cardiology Authors: Ana Reis-Mendes Cl áudia Vitorino-Oliveira Mariana Ferreira F élix Carvalho Fernando Remi ão Em ília Sousa Maria de Lourdes Bastos Vera Marisa Costa Source Type: research
Effects of Electronic Cigarette Vaping on Cardiac and Vascular Function, and Post-myocardial Infarction Remodeling in Rats
Cardiovasc Toxicol. 2024 Feb 10. doi: 10.1007/s12012-024-09835-8. Online ahead of print.ABSTRACTThe effect of electronic cigarette (E-cig) vaping on cardiac and vascular function during the healing phase of myocardial infarction (MI), and post-MI remodeling was investigated. Sprague Dawley rats were subjected to left coronary artery ligation to induce MI. One week later, rats were randomized to receive either 12 weeks of exposure to purified air (n = 37) or E-cig vapor (15 mg/ml of nicotine) (n = 32). At 12 weeks, cardiac and vascular function, and post-MI remodeling were assessed. Baseline blood flow in the femoral artery...
Source: Cardiovascular Toxicology - February 10, 2024 Category: Cardiology Authors: Wangde Dai Jianru Shi Prabha Siddarth Juan Carreno Michael T Kleinman David A Herman Rebecca J Arechavala Samantha Renusch Irene Hasen Amanda Ting Robert A Kloner Source Type: research
Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection
Cardiovasc Toxicol. 2024 Feb 7. doi: 10.1007/s12012-023-09824-3. Online ahead of print.ABSTRACTAortic dissection (AD) is a severe vascular disease with high rates of mortality and morbidity. However, the underlying molecular mechanisms of AD remain unclear. Differentially expressed genes (DEGs) were screened by bioinformatics methods. Alterations of histopathology and inflammatory factor levels in β-aminopropionitrile (BAPN)-induced AD mouse model were evaluated through Hematoxylin-Eosin (HE) staining and Enzyme-linked immunosorbent assay (ELISA), respectively. Reverse transcription quantitative real-time polymerase chain...
Source: Cardiovascular Toxicology - February 7, 2024 Category: Cardiology Authors: Jianxian Xiong Linyuan Wang Xin Xiong Yongzhi Deng Source Type: research
Management of Fluoropyrimidine-Induced Cardiac Adverse Outcomes Following Cancer Treatment
Cardiovasc Toxicol. 2024 Feb 7. doi: 10.1007/s12012-024-09834-9. Online ahead of print.ABSTRACTAdvancements in cancer treatments have improved survival rates but have also led to increased cardiotoxicities, which can cause adverse cardiovascular events or worsen pre-existing conditions. Herein, cardiotoxicity is a severe adverse effect of 5-fluorouracil (5-FU) therapy in cancer patients, with reported incidence rates ranging from 1 to 20%. Some studies have also suggested subclinical effects and there are reports which have documented instances of cardiac arrest or sudden death during 5-FU treatment, highlighting the impor...
Source: Cardiovascular Toxicology - February 7, 2024 Category: Cardiology Authors: Mohsen Rajaeinejad Peyvand Parhizkar-Roudsari Mehran Khoshfetrat Mohammad Hassan Kazemi-Galougahi Reza Mosaed Rasta Arjmand Seyed Abolfazl Mohsenizadeh Babak Arjmand Source Type: research
Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death
Cardiovasc Toxicol. 2024 Feb 6. doi: 10.1007/s12012-024-09836-7. Online ahead of print.ABSTRACTCardiac myocyte death is an essential initiator of the pathogenesis and progression of various etiological cardiomyopathies, including diabetic cardiomyopathy (DCM), a disease that has been reported since 1972. Cardiac cell death has been detected in the hearts of patients with diabetes and in animal models, and the role of cell death in the pathogenesis of DCM has been extensively investigated. The first review by the authors, specifically focusing on "Cell death and diabetic cardiomyopathy," was published in the journal, Cardio...
Source: Cardiovascular Toxicology - February 6, 2024 Category: Cardiology Authors: Lu Cai Yi Tan Brian Holland Kupper Wintergerst Source Type: research
Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF- κB/IκB/IκKB Signaling Pathway in Wistar Rats
This study evaluated the potential protective effect of fermented rooibos tea (RTE) on sodium fluoride (NaF)-induced cardiorenal toxicity in rats. Male Wistar rats (n = 56) were randomly allocated into one of seven equal groups: control, NaF (100 mg/kg orally), NaF + RTE (2%, w/v), NaF + RTE (4%, w/v), NaF + lisinopril (10 mg/kg orally), 2% RTE, and 4% RTE. The experiment lasted for 14 days and RTE was administered to the rats as their sole source of drinking fluid. NaF induced cardiorenal toxicity indicated by elevated level of urea, creatinine, LDH, creatinine kinase-MB, and cardiac troponin I in the serum, accompanied b...
Source: Cardiovascular Toxicology - February 5, 2024 Category: Cardiology Authors: Olawale Razaq Ajuwon Toyosi Abiodun Adeleke Basiru Olaitan Ajiboye Akeem Olalekan Lawal Ibukun Folorunso Bartholomew Brai Fisayo Abraham Bamisaye John Adeolu Falode Ikenna Maximillian Odoh Kabirat Iyabode Adegbite Oluwasayo Bosede Adegoke Source Type: research
Comparison of Protective Effect of Tri-circulator and Coenzyme Q10 on Myocardial Injury and the Mechanism Study by Zebrafish Model
Cardiovasc Toxicol. 2024 Feb 5. doi: 10.1007/s12012-024-09828-7. Online ahead of print.ABSTRACTTri-Circulator (TC) is a product comprising coenzyme Q10 (CoQ10), Salvia miltiorrhiza, and Panax notoginseng. Individually, each of these constituents has demonstrated protective effects on myocardial injury. The purpose of this study is to evaluate the protective efficacy of TC on heart function and compare the differential effects between CoQ10 and TC. Two myocardial injury models of zebrafish, the hypoxia-reoxygenation model (H/R) and the isoproterenol (ISO, a β-receptor agonist) model, were used in this experiment. The zebra...
Source: Cardiovascular Toxicology - February 5, 2024 Category: Cardiology Authors: Yuan Xiao Ranjing Wang Shang Kong Tingting Zhao Yongli Situ Hong Nie Source Type: research
Evaluation of Environmental Contamination by Heavy Metals and Relationship with Cardiovascular Risk in a Population of Barcarena-PA
In this study, the objective was to evaluate clinical-epidemiological and biochemical parameters in relation to the overall risk score (ERG) of developing CVDs in 112 individuals aged 30 to 74 years living in the city of Barcarena-PA. The results of heavy metal contamination and biochemical parameters were applied in the ERG calculation. A significance level of p < 0.05 was adopted in the statistical tests. The values were high for chromium (Cr) (45.8%) and aluminum (Al) (98.6%). As for the ERG for CVDs, they obtained low risk (42%), medium risk (40%), and high risk (18%). In individuals with high ERG, a significant ass...
Source: Cardiovascular Toxicology - February 3, 2024 Category: Cardiology Authors: Nahide Pinto Rodrigues Helenize Catarina Moreira Costalat Ronaldo Magno Rocha Rosane do Socorro Pompeu de Loiola Tereza Cristina de Oliveira Corvelo Source Type: research
Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling
In conclusion, ZFX knockdown protected mice from hypoxia-induced PAH injury. ZFX knockdown dramatically reduced RVSP and RV/(LV + S) in hypoxia-treated mice.PMID:38310188 | DOI:10.1007/s12012-023-09822-5 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 3, 2024 Category: Cardiology Authors: Ling Tang Xiao Zhou Aili Guo Lizhang Han Silin Pan Source Type: research
Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice
This study demonstrated that Simvastatin, an FDA approved and easily accessible drug, may be beneficial in lowering the prevalence of alcohol-induced cardiovascular diseases (especially in adolescents) which will have a huge financial implication on health systems worldwide.PMID:38261135 | PMC:PMC10838240 | DOI:10.1007/s12012-023-09821-6 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - January 23, 2024 Category: Cardiology Authors: Makgotso Nchodu Alice Efuntayo Robin du Preez Hasiena Ali Oladiran I Olateju Source Type: research
