Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumu...
Source: Cardiovascular Toxicology - July 4, 2023 Category: Cardiology Authors: Talita Cristina Rodrigues Pereira Thiago Montes Fidale Lucas Costa Guimar ães Simone Ramos Deconte Gustavo Cavinato Herrera Ant ônio Vicente Mundim Eduardo de Sales Cabral Paulo Ricardo Lopes Fernanda Rodrigues de Souza Luiz Duarte de Ulh ôa Rocha Jún Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Cardiovascular Harmful Effects of Recommended Daily Doses (13 µg/kg/day), Tolerable Upper Intake Doses (0.14 mg/kg/day) and Twice the Tolerable Doses (0.28 mg/kg/day) of Copper
The objective of this study was to evaluate the effects of exposure to the recommended daily dose (13 µg/kg/day), upper tolerable dose (0.14 mg/kg/day) and twice the upper tolerable dose (0.28 mg/kg/day) via i.p. over 4 weeks on the vascular reactivity of aortic rings and the contraction of LV papillary muscles of male Wistar rats. It was also determined whether the antioxidant peptide from egg white hydrolysate (EWH) prevents these effects. Copper exposure at the doses evaluated did not change weight gain of male Wistar rats, the reactivity of the aortic rings or the cardiac mass. The dose of 0.13 µg/kg/day did not redu...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Filipe Martinuzo Filetti Ingridy Reinholz Grafites Schereider Giulia Alessandra Wiggers Marta Miguel Dalton Valentim Vassallo Maylla Ronacher Sim ões Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Cardiovascular Harmful Effects of Recommended Daily Doses (13 µg/kg/day), Tolerable Upper Intake Doses (0.14 mg/kg/day) and Twice the Tolerable Doses (0.28 mg/kg/day) of Copper
The objective of this study was to evaluate the effects of exposure to the recommended daily dose (13 µg/kg/day), upper tolerable dose (0.14 mg/kg/day) and twice the upper tolerable dose (0.28 mg/kg/day) via i.p. over 4 weeks on the vascular reactivity of aortic rings and the contraction of LV papillary muscles of male Wistar rats. It was also determined whether the antioxidant peptide from egg white hydrolysate (EWH) prevents these effects. Copper exposure at the doses evaluated did not change weight gain of male Wistar rats, the reactivity of the aortic rings or the cardiac mass. The dose of 0.13 µg/kg/day did not redu...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Filipe Martinuzo Filetti Ingridy Reinholz Grafites Schereider Giulia Alessandra Wiggers Marta Miguel Dalton Valentim Vassallo Maylla Ronacher Sim ões Source Type: research
