Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of Enicostemma axillare - Swertiamarin on oxidative stress against nicotine-induced liver damage in SD rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure Nachammai Vinaitheerthan Sneha Thakur Ramreddy Godela Sherisha Bhavani Doli Manjula Santhepete Nanjundaiah Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
