Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study
CONCLUSIONS: A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.PMID:34310004 | DOI:10.1002/alz.12343 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Ruixue Song Kuan-Yu Pan Hui Xu Xiuying Qi Aron S Buchman David A Bennett Weili Xu Source Type: research

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study
Alzheimers Dement. 2021 Jul 26. doi: 10.1002/alz.12404. Online ahead of print.ABSTRACTINTRODUCTION: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations.METHODS: Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform.RESULTS: In unadjusted models, NfL was significantly associated with age (P
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Sid O'Bryant Melissa Petersen James Hall Leigh Johnson Kristine Yaffe Meredith Braskie Arthur W Toga Robert A Rissman HABLE study team Source Type: research

Virtual conferences broadcast research advances in 2021
Alzheimers Dement. 2021 Jul 26. doi: 10.1002/alz.12420. Online ahead of print.NO ABSTRACTPMID:34310023 | DOI:10.1002/alz.12420 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Source Type: research

Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype
We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.RESULTS: More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poore...
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Andr ée-Ann Baril Alexa S Beiser Erlan Sanchez Vincent Mysliwiec Susan Redline Daniel J Gottlieb George T O'Connor Mitzi M Gonzales Dibya Himali Sudha Seshadri Jayandra J Himali Matthew P Pase Source Type: research

Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men
We examined associations of variants comprised of the TOMM40 rs8106922 and APOE rs405509, rs440446, and ε2-encoding rs7412 polymorphisms with AD in a sample of 2862 AD-affected and 169,516 AD-unaffected non-carriers of the ε4 allele.RESULTS: Association of the ε2/ε3 heterozygote of men with AD is 38% (P = 1.65 × 10-2 ) more beneficial when it is accompanied by rs8106922 major allele homozygote and rs405509 and rs440446 heterozygotes than by rs8106922 heterozygote and rs405509 and rs440446 major allele homozygotes. No difference in the beneficial associations of these two most common &e...
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Alexander M Kulminski Ian Philipp Yury Loika Liang He Irina Culminskaya Source Type: research

Detection of Alzheimer's disease amyloid beta 1-42, p-tau, and t-tau assays
CONCLUSION: CSF t-tau/Aβ42 and p-tau/Aβ42 ratios are very robust indicators of AD. For individual biomarkers, the intended use should determine which cut point is chosen.PMID:34310035 | DOI:10.1002/alz.12406 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Argonde C van Harten Heather J Wiste Stephen D Weigand Michelle M Mielke Walter K Kremers Udo Eichenlaub Roy B Dyer Alicia Algeciras-Schimnich David S Knopman Clifford R Jack Ronald C Petersen Source Type: research

Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans
DISCUSSION: A healthy lifestyle was associated with a slower cognitive decline in African and European Americans.PMID:34310036 | DOI:10.1002/alz.12435 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Klodian Dhana Lisa L Barnes Xiaoran Liu Puja Agarwal Pankaja Desai Kristin R Krueger Thomas M Holland Shannon Halloway Neelum T Aggarwal Denis A Evans Kumar B Rajan Source Type: research

Comparing data-driven and hypothesis-driven MRI-based predictors of cognitive impairment in individuals from the Atherosclerosis Risk in Communities (ARIC) study
CONCLUSIONS: Overall, the AD-PS scores were the stronger MRI-derived predictors of incident cognitive impairment in cognitively non-impaired individuals.PMID:34310039 | DOI:10.1002/alz.12427 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Ramon Casanova Fang-Chi Hsu Ryan T Barnard Andrea M Anderson Rajesh Talluri Christopher T Whitlow Timothy M Hughes Michael Griswold Kathleen M Hayden Rebecca F Gottesman Lynne E Wagenknecht Alzheimer's Disease Neuroimaging Initiative Source Type: research

Slowly progressive behavioral frontotemporal dementia syndrome in a family co-segregating the C9orf72 expansion and a Synaptophysin mutation
DISCUSSION: Our results strengthened previous suggestive evidence that the phenotypes associated with C9orf72 repeat expansion are variable and probably influenced by additional genetic modifiers. We hypothesized that the pathogenic variant in the SYP gene might have modified the typical phenotype associated with the C9orf72 mutation.PMID:34310040 | DOI:10.1002/alz.12409 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Joana Prota Liara Rizzi Luciana Bonadia Leonardo Cruz de Souza Paulo Caramelli Rodrigo Secolin Iscia Lopes-Cendes Marcio L F Balthazar Source Type: research

Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial
DISCUSSION: Diet response during middle age may highlight early pathophysiological processes that increase AD risk.PMID:34310044 | DOI:10.1002/alz.12421 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Siobhan Hoscheidt Ashley H Sanderlin Laura D Baker Youngkyoo Jung Samuel Lockhart Derek Kellar Christopher Whitlow Angela J Hanson Seth Friedman Thomas Register James B Leverenz Suzanne Craft Source Type: research

Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project
CONCLUSION: These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.PMID:34310061 | DOI:10.1002/alz.12441 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Merc è Boada Adri án Rodrigo Frank Jessen Bengt Wimblad Milika Kramberger Pieter Jelle Visser Rafael Sim ó Octavio Rodr íguez-Gomez Andreea Ciudin Jean Georges Annete Dumas Peggy Maguire David Krivec Anders Wimo Sergi Valero Montserrat Alegret Laura J Source Type: research

Comparison of CSF phosphorylated tau 181 and 217 for cognitive decline
DISCUSSION: There are subtle differences for CSF p-tau217 and p-tau181 as prognostic AD markers.PMID:34310832 | DOI:10.1002/alz.12415 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 26, 2021 Category: Psychiatry Authors: Michelle M Mielke Jeremiah A Aakre Alicia Algeciras-Schimnich Nicholas K Proctor Mary M Machulda Udo Eichenlaub David S Knopman Prashanthi Vemuri Jonathan Graff-Radford Clifford R Jack Ronald C Petersen Jeffrey L Dage Source Type: research

Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial
DISCUSSION: Age- and geo-targeted mass mailing of infographic materials was the most effective approach in recruiting older adults with amnestic MCI into an 18-month exercise trial.PMID:34297895 | DOI:10.1002/alz.12401 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 23, 2021 Category: Psychiatry Authors: Aladdin H Shadyab Andrea Z LaCroix Howard H Feldman Christopher H van Dyck Ozioma C Okonkwo Steven P Tam J Kaci Fairchild Kathleen A Welsh-Bohmer Genevieve Matthews Daniel Bennett Alexandre A Shadyab Kimberly A Schafer Rosemary H Morrison Sean A Kipperman Source Type: research

Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants
DISCUSSION: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.PMID:34288382 | DOI:10.1002/alz.12416 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 21, 2021 Category: Psychiatry Authors: Jonathan S Stevenson Lei Clifton El żbieta Kuźma Thomas J Littlejohns Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial
CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.PMID:34255432 | DOI:10.1002/alz.12279 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Authors: Shireen Sindi Ingemar K åreholt Tiia Ngandu Anna Rosenberg Jenni Kulmala Lena Johansson Hanna Wetterberg Johan Skoog Linnea Sj öberg Hui-Xin Wang Laura Fratiglioni Ingmar Skoog Miia Kivipelto Source Type: research

ISTAART PIAs reflect on lessons learned from the virtual AAIC 2020
Alzheimers Dement. 2021 Jul;17(7):1257-1258. doi: 10.1002/alz.12407.NO ABSTRACTPMID:34255433 | DOI:10.1002/alz.12407 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 13, 2021 Category: Psychiatry Source Type: research

Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease
Alzheimers Dement. 2021 Jul 5. doi: 10.1002/alz.12389. Online ahead of print.ABSTRACTThe morphological plasticity of microglia has fascinated neuroscientists for 100 years. Attempts to classify functional phenotypes are hampered by similarities between endogenous brain microglia and peripheral myeloid cells that can enter the brain under pathological conditions. Recent advances in single-cell -omic methodologies have led to an explosion of data regarding gene expression in microglia. Herein, we review the diversity of microglial phenotypes in healthy brains, aging, and Alzheimer's disease (AD); identify knowledge gaps in t...
Source: The Journal of Alzheimers Association - July 5, 2021 Category: Psychiatry Authors: Delphine Boche Marcia N Gordon Source Type: research

Plasma IL-12/IFN- γ axis predicts cognitive trajectories in cognitively unimpaired older adults
DISCUSSION: Immune dysregulation is implicated in early-stage cognitive decline, and greater IL-12/IFN-γ axis activation may be protective against cognitive decline and early-stage AD progression.PMID:34160128 | DOI:10.1002/alz.12399 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 23, 2021 Category: Psychiatry Authors: Hyun-Sik Yang Can Zhang Becky C Carlyle Sherri Y Zhen Bianca A Trombetta Aaron P Schultz Jeremy J Pruzin Colleen D Fitzpatrick Wai-Ying W Yau Dylan R Kirn Dorene M Rentz Steven E Arnold Keith A Johnson Reisa A Sperling Jasmeer P Chhatwal Rudolph E Tanzi Source Type: research

Beyond attention, executive function & amp; memory-Re-socializing cerebral small vessel disease
Alzheimers Dement. 2021 Jun 22. doi: 10.1002/alz.12391. Online ahead of print.NO ABSTRACTPMID:34156144 | DOI:10.1002/alz.12391 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 22, 2021 Category: Psychiatry Authors: Matthias L Schroeter Source Type: research

Response to Schroeter ML, Letter, Small vessel disease and social cognition
Alzheimers Dement. 2021 Jun 22. doi: 10.1002/alz.12402. Online ahead of print.NO ABSTRACTPMID:34156150 | DOI:10.1002/alz.12402 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 22, 2021 Category: Psychiatry Authors: Olivia K Hamilton Joanna M Wardlaw Source Type: research

Beyond attention, executive function & amp; memory-Re-socializing cerebral small vessel disease
Alzheimers Dement. 2021 Jun 22. doi: 10.1002/alz.12391. Online ahead of print.NO ABSTRACTPMID:34156144 | DOI:10.1002/alz.12391 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 22, 2021 Category: Psychiatry Authors: Matthias L Schroeter Source Type: research

Response to Schroeter ML, Letter, Small vessel disease and social cognition
Alzheimers Dement. 2021 Jun 22. doi: 10.1002/alz.12402. Online ahead of print.NO ABSTRACTPMID:34156150 | DOI:10.1002/alz.12402 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 22, 2021 Category: Psychiatry Authors: Olivia K Hamilton Joanna M Wardlaw Source Type: research

Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma A β42/Aβ40 and p-tau
DISCUSSION: A combination of plasma Aβ42/Aβ40 and p-tau217 discriminated Aβ status with relatively high accuracy, whereas p-tau217 showed strongest associations with Aβ pathology in MCI but not in CU.PMID:34151519 | DOI:10.1002/alz.12395 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 21, 2021 Category: Psychiatry Authors: Shorena Janelidze Sebastian Palmqvist Antoine Leuzy Erik Stomrud Inge M W Verberk Henrik Zetterberg Nicholas J Ashton Pedro Pesini Leticia Sarasa Jos é Antonio Allué Charlotte E Teunissen Jeffrey L Dage Kaj Blennow Niklas Mattsson-Carlgren Oskar Hansson Source Type: research