Time from diagnosis to institutionalization and death in people with dementia.
DISCUSSION: The estimates could help to inform patients, their families, and policymakers about probable trajectories. PMID: 32072728 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 21, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Complex interactions underlie racial disparity in the risk of developing Alzheimer's disease dementia.
Authors: Xiong C, Luo J, Coble D, Agboola F, Kukull W, Morris JC Abstract INTRODUCTION: We aim to determine racial disparities and their modifying factors in risk for Alzheimer's disease (AD) dementia among cognitively normal individuals 65 years or older. METHODS: Longitudinal data from the National Alzheimer's Coordinating Center Uniform Data Set on 1229 African Americans (AAs) and 6679 whites were analyzed for the risk of AD using competing risk models with death as a competing event. RESULTS: Major AD risk factors modified racial differences which, when statistically significant, occurred only with olde...
Source: The Journal of Alzheimers Association - February 20, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Impact of deprescribing AChEIs on aggressive behaviors and antipsychotic prescribing.
Authors: Niznik JD, Zhao X, He M, Aspinall SL, Hanlon JT, Nace D, Thorpe JM, Thorpe CT Abstract INTRODUCTION: We evaluated the impact of deprescribing acetylcholinesterase inhibitors (AChEIs) on aggressive behaviors and incident antipsychotic use in nursing home (NH) residents with severe dementia. METHODS: We conducted a retrospective study of Medicare claims, Part D, Minimum Data Set for NH residents aged 65+ with severe dementia receiving AChEIs in 2016. Aggressive behaviors were measured using the aggressive behavior scale (ABS; n = 30,788). Incident antipsychotic prescriptions were evaluated among antipsyc...
Source: The Journal of Alzheimers Association - February 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Spatial navigation ability predicts progression of dementia symptomatology.
Authors: Levine TF, Allison SL, Stojanovic M, Fagan AM, Morris JC, Head D Abstract INTRODUCTION: Spatial navigation deficits are observed in Alzheimer's disease cross-sectionally, but prediction of longitudinal clinical decline has been less examined. METHODS: Cognitive mapping (CM) was assessed in 95 participants and route learning (RL) was assessed in 65 participants at baseline. Clinical progression over an average of 4 to 5 years was assessed using the clinical dementia rating (CDR) scale. Relative predictive ability was compared to episodic memory, hippocampus, and cerebrospinal fluid biomarkers (phosphory...
Source: The Journal of Alzheimers Association - February 12, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.
DISCUSSION: Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD. PMID: 32043733 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 12, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Risk factors for earlier dementia onset in autopsy-confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease.
DISCUSSION: Male sex and APOE ɛ4 alleles increase risk for earlier dementia onset in AD but not LBD. Depression increases risk for earlier dementia onset in AD, LBD, and AD + LBD, but evaluating the course, treatment, and severity is needed in future studies. PMID: 32043803 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 12, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Bill Gates funds $10 million grant to Alzheimer's Association to fuel research for Alzheimer's treatment.
Authors: PMID: 32031316 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 8, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A unified model of dementias and age-related neurodegeneration.
Authors: Fossel M PMID: 31943780 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 18, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial.
Authors: Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, Stevens J, Lines C, Michelson D Abstract INTRODUCTION: We evaluated the clinical profile of the orexin receptor antagonist suvorexant for treating insomnia in patients with mild-to-moderate probable Alzheimer's disease (AD) dementia. METHODS: Randomized, double-blind, 4-week trial of suvorexant 10 mg (could be increased to 20 mg based on clinical response) or placebo in patients who met clinical diagnostic criteria for both probable AD dementia and insomnia. Sleep was assessed by overnight polysomnography in a sleep laboratory. The primar...
Source: The Journal of Alzheimers Association - January 18, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Concordance of Lumipulse cerebrospinal fluid t-tau/A β42 ratio with amyloid PET status.
DISCUSSION: Lumipulse CSF biomarker measures with validated cut-points have clinical utility in identifying AD pathology. PMID: 31914216 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.
DISCUSSION: Our study reports the genetic characterization of a large FTD series and supports an unbiased sequencing screen, irrespective of clinical presentation or family history. PMID: 31914217 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Utility of the global CDR ® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
DISCUSSION: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders. PMID: 31914218 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Tracking disease progression in familial and sporadic frontotemporal lobar degeneration: Recent findings from ARTFL and LEFFTDS.
DISCUSSION: Data from large multisite studies are producing important data on the natural history of f-FTLD that will be critical for planning intervention trials. PMID: 31914219 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's disease.
DISCUSSION: These results, in accordance with a solid pathophysiological rationale, suggest a role for HSV-1 in AD development among subjects with a genetic susceptibility factor, the APOE4 allele. PMID: 31914220 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN).
This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers. METHODS: Mutation carriers and non-carriers from the Dominantly Inherited Alzheimer Network (DIAN) were stratified based on knowledge of mutation status. Rates of change on standard clinical, cognitive, and neuroimaging outcomes were examined. RESULTS: Mutation knowledge had no associations with cognitive decline, clinical progression, amyloid deposition, hippocampal volume, or depression in either carriers or non-carriers. Carriers who learned their status mid-study had slightly higher levels of depression an...
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer.
DISCUSSION: The identified SNPs were rs4298154 (intergenic), within TOMM40/APOE/APOC1, MARK4, CLPTM1, and near the VDAC1/FSTL4 locus. The miRNAs identified in our network have been previously reported to have inverse expression in AD and cancer. PMID: 31914222 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.
CONCLUSION: We demonstrate for the first time a link between MBI and early AD pathology in a cognitively intact elderly population, supporting the use of the MBI-C as a metric to enhance clinical trial enrolment. PMID: 31914223 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Cognitive and physical markers of prodromal dementia: A 12-year-long population study.
Authors: Grande G, Rizzuto D, Vetrano DL, Marseglia A, Vanacore N, Laukka EJ, Welmer AK, Fratiglioni L Abstract INTRODUCTION: The aim is to test whether adding a simple physical test such as walking speed (WS) to the neuropsychological assessment increases the predictive ability to detect dementia. METHODS: The 2546 dementia-free people from the SNAC-K study were grouped into four profiles: (1) healthy profile; (2) isolated cognitive impairment, no dementia (CIND, scoring 1.5 standard deviation below age-specific means on ≥1 cognitive domains); (3) isolated slow WS (
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward.
Authors: Alber J, Goldfarb D, Thompson LI, Arthur E, Hernandez K, Cheng D, DeBuc DC, Cordeiro F, Provetti-Cunha L, den Haan J, Van Stavern GP, Salloway SP, Sinoff S, Snyder PJ Abstract The last decade has seen a substantial increase in research focused on the identification, development, and validation of diagnostic and prognostic retinal biomarkers for Alzheimer's disease (AD). Sensitive retinal biomarkers may be advantageous because they are cost and time efficient, non-invasive, and present a minimal degree of patient risk and a high degree of accessibility. Much of the work in this area thus far has focused on ...
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.
DISCUSSION: f-bvFTD and s-bvFTD cases are clinically similar, suggesting the generalizability of novel biomarkers, therapies, and clinical tools developed in either form to the other. PMID: 31914226 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.
DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD. PMID: 31914227 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Retinal imaging think tank convened by the Alzheimer's Association to examine its promise in the early detection of Alzheimer's.
Authors: Snyder PJ, Snyder HM, Bain LJ PMID: 31914228 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease.
DISCUSSION: The new PSENs/APP mutations indicate heterogeneity in AD pathogenesis between Chinese and other ethnic groups. The low mutation rate suggests the involvement of other genes/factors in Chinese FAD. APOEε4 might be a major gene for some FAD without PSENs/APP mutations. PMID: 31914229 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.
Authors: Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kremers WK, Kukull WA, Litvan I, Lucente D, Lun...
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices.
DISCUSSION: Hippocampal volume is associated with late-life cognitive decline, above and beyond contributions from common neuropathologic indices. PMID: 31914231 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease.
DISCUSSION: neuroAD™ Therapy System provides a low-risk therapeutic benefit for patients with milder AD (baseline ADAS-Cog ≤30) beyond pharmacologic SOC. PMID: 31879235 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 29, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease.
We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD. PMID: 31879236 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 29, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment.
DISCUSSION: Gd does not accumulate in brains of older individuals with a BBB breakdown in the hippocampus. Thus, Gd agents can be used without risk of brain retention within a ∼2-year follow-up to study BBB in the aging human brain in relation to cognition and/or other pathologies. PMID: 31862169 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 23, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Stratifying risk for dementia onset using large-scale electronic health record data: a retrospective cohort study.
DISCUSSION: A cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8 years before diagnosis. PMID: 31859230 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 22, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Brain imaging measurements of fibrillar amyloid- β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele.
CONCLUSIONS: This study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD. PMID: 31831374 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 15, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Neuropsychological decline up to 20  years before incident mild cognitive impairment.
DISCUSSION: The preclinical duration of cognitive and behavioral changes approaches the earliest reported biomarker changes. PMID: 31787561 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 5, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study.
DISCUSSION: MR found robust evidence of a causal association between alcohol consumption and an earlier AAOS, but not alcohol intake and LOAD risk. The protective effect of alcohol dependence is potentially due to survivor bias. PMID: 31786126 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 3, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Incidence of dementia in the oldest-old and its relationship with age: The Monzino 80-plus population-based study.
CONCLUSION: Dementia incidence also keeps rising in nonagenarians and centenarians. Slowing down in growing risk of developing dementia with age is mainly attributable to increasing competing risk of death and resulting selective survival of individuals at lower risk of dementia. PMID: 31786127 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 3, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube.
DISCUSSION: This integrated real-world AD data overview provides an intuitive visual model that facilitates initial assessment and identification of gaps in relevant outcomes data to inform future prospective data collection and matching of data sources and outcomes against research protocols. PMID: 31786128 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 3, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Comorbid amyloid- β pathology affects clinical and imaging features in VCD.
DISCUSSION: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD. PMID: 31786129 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 3, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Incidence of frontotemporal disorders in Olmsted County: A population-based study.
Authors: Turcano P, Stang CD, Mielke MM, Martin PR, Upadhyaya SG, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Savica R Abstract INTRODUCTION: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. METHODS: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995-2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and det...
Source: The Journal of Alzheimers Association - December 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Tau-positron emission tomography correlates with neuropathology findings.
DISCUSSION: Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal. PMID: 31784374 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.
We examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 MAPT, GRN, and C9orf72 family members, including 102 non-mutation carriers, 103 asymptomatic carriers, 43 mildly/questionably symptomatic carriers, and 72 carriers with dementia. RESULTS: Asymptomatic carriers showed similar scores on all clinical measures compared with noncarriers but reduced frontal and temporal volumes. Those with mild/questionable impairment showed decreased verbal recall, fluency, and Trail Making Test performance and impaired mood and self-monitoring. Dementia was associated with impairment i...
Source: The Journal of Alzheimers Association - December 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.
DISCUSSION: Early "subtle cognitive decline" among Aβ+ CN on a sensitive cognitive composite demonstrably increases risk for imminent clinical disease progression and functional impairment. PMID: 31759879 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 26, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).
Authors: González HM, Tarraf W, Fornage M, González KA, Chai A, Youngblood M, Abreu MLA, Zeng D, Thomas S, Talavera GA, Gallo LC, Kaplan R, Daviglus ML, Schneiderman N Abstract Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay ahead in coming decades. The primary purpose of this Perspectives article was t...
Source: The Journal of Alzheimers Association - November 26, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.
DISCUSSION: Our findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium. PMID: 31761478 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 26, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.
DISCUSSION: The Cognigram was well liked in waiting rooms of primary care settings. Assistance from a trained adult and clinic endorsement were keys to success. How the Cognigram performs in a geographically compact, population-dense global setting, such as Brooklyn with high vascular disease risk and a plethora of health disparities, is being tested. PMID: 31753288 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 23, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Corrigendum to "AMYPAD Diagnostic and Patient Management Study: Rationale and design" [Alzheimer's & Dementia 2019;15:388-99].
Corrigendum to "AMYPAD Diagnostic and Patient Management Study: Rationale and design" [Alzheimer's & Dementia 2019;15:388-99]. Alzheimers Dement. 2019 Nov;15(11):1505 Authors: PMID: 31753289 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 23, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results.
DISCUSSION: MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos. PMID: 31753701 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 23, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study.
DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk. PMID: 31718906 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 15, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis.
Authors: Tolar M, Abushakra S, Sabbagh M Abstract Development of disease-modifying treatments for Alzheimer's disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, providing important validation of amyloid as a therapeutic target. However, the inconsistent results observed with aducanumab may be explained by the limited brain penetration and lack of selectivity for the soluble A&beta...
Source: The Journal of Alzheimers Association - November 12, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Intact global cognitive and olfactory ability predicts lack of transition to dementia.
We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. METHODS: In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed. RESULTS: In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 10...
Source: The Journal of Alzheimers Association - November 5, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Individualized clinical management of patients at risk for Alzheimer's dementia.
Authors: Isaacson RS, Hristov H, Saif N, Hackett K, Hendrix S, Melendez J, Safdieh J, Fink M, Thambisetty M, Sadek G, Bellara S, Lee P, Berkowitz C, Rahman A, Meléndez-Cabrero J, Caesar E, Cohen R, Lu PL, Dickson SP, Hwang MJ, Scheyer O, Mureb M, Schelke MW, Niotis K, Greer CE, Attia P, Mosconi L, Krikorian R Abstract INTRODUCTION: Multidomain intervention for Alzheimer's disease (AD) risk reduction is an emerging therapeutic paradigm. METHODS: Patients were prescribed individually tailored interventions (education/pharmacologic/nonpharmacologic) and rated on compliance. Normal cognition/subjective cogni...
Source: The Journal of Alzheimers Association - November 5, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease.
DISCUSSION: These results raise the possibility that C99, rather than Aβ plaques, is responsible for the death of nerve cells in AD. PMID: 31677937 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 5, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.
We examined, in a community-based population (N = 777, aged 50-95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays. RESULTS: Multiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T-tau had the strongest association with cognition in...
Source: The Journal of Alzheimers Association - November 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research