The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.PMID:34668644 | DOI:10.1002/alz.12492 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Tiia Ngandu Jenni Lehtisalo Saana Korkki Alina Solomon Nicola Coley Riitta Antikainen Lars B äckman Tuomo H änninen Jaana Lindstr öm Tiina Laatikainen Teemu Paajanen Satu Havulinna Markku Peltonen Anna Stigsdotter Neely Timo Strandberg Jaakko Tuomileht Source Type: research

Concussion and long-term cognitive function among rugby players-The BRAIN Study
CONCLUSIONS: Overall there was no association between concussion and cognitive function; however, a significant interaction with age revealed an association in older participants.PMID:34668650 | DOI:10.1002/alz.12455 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Valentina Gallo Damien M McElvenny Giulia Seghezzo Simon Kemp Elizabeth Williamson Kirsty Lu Saba Mian Laura James Catherine Hobbs Donna Davoren Nigel Arden Madeline Davies Andrea Malaspina Michael Loosemore Keith Stokes Matthew Cross Sebastian Crutch Hen Source Type: research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.PMID:34668644 | DOI:10.1002/alz.12492 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Tiia Ngandu Jenni Lehtisalo Saana Korkki Alina Solomon Nicola Coley Riitta Antikainen Lars B äckman Tuomo H änninen Jaana Lindstr öm Tiina Laatikainen Teemu Paajanen Satu Havulinna Markku Peltonen Anna Stigsdotter Neely Timo Strandberg Jaakko Tuomileht Source Type: research

Concussion and long-term cognitive function among rugby players-The BRAIN Study
CONCLUSIONS: Overall there was no association between concussion and cognitive function; however, a significant interaction with age revealed an association in older participants.PMID:34668650 | DOI:10.1002/alz.12455 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Valentina Gallo Damien M McElvenny Giulia Seghezzo Simon Kemp Elizabeth Williamson Kirsty Lu Saba Mian Laura James Catherine Hobbs Donna Davoren Nigel Arden Madeline Davies Andrea Malaspina Michael Loosemore Keith Stokes Matthew Cross Sebastian Crutch Hen Source Type: research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.PMID:34668644 | DOI:10.1002/alz.12492 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Tiia Ngandu Jenni Lehtisalo Saana Korkki Alina Solomon Nicola Coley Riitta Antikainen Lars B äckman Tuomo H änninen Jaana Lindstr öm Tiina Laatikainen Teemu Paajanen Satu Havulinna Markku Peltonen Anna Stigsdotter Neely Timo Strandberg Jaakko Tuomileht Source Type: research

Concussion and long-term cognitive function among rugby players-The BRAIN Study
CONCLUSIONS: Overall there was no association between concussion and cognitive function; however, a significant interaction with age revealed an association in older participants.PMID:34668650 | DOI:10.1002/alz.12455 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Valentina Gallo Damien M McElvenny Giulia Seghezzo Simon Kemp Elizabeth Williamson Kirsty Lu Saba Mian Laura James Catherine Hobbs Donna Davoren Nigel Arden Madeline Davies Andrea Malaspina Michael Loosemore Keith Stokes Matthew Cross Sebastian Crutch Hen Source Type: research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.PMID:34668644 | DOI:10.1002/alz.12492 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Tiia Ngandu Jenni Lehtisalo Saana Korkki Alina Solomon Nicola Coley Riitta Antikainen Lars B äckman Tuomo H änninen Jaana Lindstr öm Tiina Laatikainen Teemu Paajanen Satu Havulinna Markku Peltonen Anna Stigsdotter Neely Timo Strandberg Jaakko Tuomileht Source Type: research

Concussion and long-term cognitive function among rugby players-The BRAIN Study
CONCLUSIONS: Overall there was no association between concussion and cognitive function; however, a significant interaction with age revealed an association in older participants.PMID:34668650 | DOI:10.1002/alz.12455 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Valentina Gallo Damien M McElvenny Giulia Seghezzo Simon Kemp Elizabeth Williamson Kirsty Lu Saba Mian Laura James Catherine Hobbs Donna Davoren Nigel Arden Madeline Davies Andrea Malaspina Michael Loosemore Keith Stokes Matthew Cross Sebastian Crutch Hen Source Type: research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
DISCUSSION: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.PMID:34668644 | DOI:10.1002/alz.12492 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Tiia Ngandu Jenni Lehtisalo Saana Korkki Alina Solomon Nicola Coley Riitta Antikainen Lars B äckman Tuomo H änninen Jaana Lindstr öm Tiina Laatikainen Teemu Paajanen Satu Havulinna Markku Peltonen Anna Stigsdotter Neely Timo Strandberg Jaakko Tuomileht Source Type: research

Concussion and long-term cognitive function among rugby players-The BRAIN Study
CONCLUSIONS: Overall there was no association between concussion and cognitive function; however, a significant interaction with age revealed an association in older participants.PMID:34668650 | DOI:10.1002/alz.12455 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2021 Category: Psychiatry Authors: Valentina Gallo Damien M McElvenny Giulia Seghezzo Simon Kemp Elizabeth Williamson Kirsty Lu Saba Mian Laura James Catherine Hobbs Donna Davoren Nigel Arden Madeline Davies Andrea Malaspina Michael Loosemore Keith Stokes Matthew Cross Sebastian Crutch Hen Source Type: research

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists
Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12474. Online ahead of print.ABSTRACTMedications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is associated with synaptic loss and results in cognitive decline and behavioral changes. Among diabetes medications, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) promote protective effects on vascular, microglial, and neuronal functions. In this review, we present evidence from animal...
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Hussein N Yassine Victoria Solomon Angad Thakral Nasim Sheikh-Bahaei Helena C Chui Meredith N Braskie Lon S Schneider Konrad Talbot Source Type: research

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Duygu Tosun Zeynep Demir Dallas P Veitch Daniel Weintraub Paul Aisen Clifford R Jack William J Jagust Ronald C Petersen Andrew J Saykin Leslie M Shaw John Q Trojanowski Michael W Weiner Alzheimer's Disease Neuroimaging Initiative Source Type: research

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists
Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12474. Online ahead of print.ABSTRACTMedications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is associated with synaptic loss and results in cognitive decline and behavioral changes. Among diabetes medications, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) promote protective effects on vascular, microglial, and neuronal functions. In this review, we present evidence from animal...
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Hussein N Yassine Victoria Solomon Angad Thakral Nasim Sheikh-Bahaei Helena C Chui Meredith N Braskie Lon S Schneider Konrad Talbot Source Type: research

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Duygu Tosun Zeynep Demir Dallas P Veitch Daniel Weintraub Paul Aisen Clifford R Jack William J Jagust Ronald C Petersen Andrew J Saykin Leslie M Shaw John Q Trojanowski Michael W Weiner Alzheimer's Disease Neuroimaging Initiative Source Type: research

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists
Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12474. Online ahead of print.ABSTRACTMedications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is associated with synaptic loss and results in cognitive decline and behavioral changes. Among diabetes medications, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) promote protective effects on vascular, microglial, and neuronal functions. In this review, we present evidence from animal...
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Hussein N Yassine Victoria Solomon Angad Thakral Nasim Sheikh-Bahaei Helena C Chui Meredith N Braskie Lon S Schneider Konrad Talbot Source Type: research

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Duygu Tosun Zeynep Demir Dallas P Veitch Daniel Weintraub Paul Aisen Clifford R Jack William J Jagust Ronald C Petersen Andrew J Saykin Leslie M Shaw John Q Trojanowski Michael W Weiner Alzheimer's Disease Neuroimaging Initiative Source Type: research

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists
Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12474. Online ahead of print.ABSTRACTMedications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is associated with synaptic loss and results in cognitive decline and behavioral changes. Among diabetes medications, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) promote protective effects on vascular, microglial, and neuronal functions. In this review, we present evidence from animal...
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Hussein N Yassine Victoria Solomon Angad Thakral Nasim Sheikh-Bahaei Helena C Chui Meredith N Braskie Lon S Schneider Konrad Talbot Source Type: research

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Duygu Tosun Zeynep Demir Dallas P Veitch Daniel Weintraub Paul Aisen Clifford R Jack William J Jagust Ronald C Petersen Andrew J Saykin Leslie M Shaw John Q Trojanowski Michael W Weiner Alzheimer's Disease Neuroimaging Initiative Source Type: research

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists
Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12474. Online ahead of print.ABSTRACTMedications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is associated with synaptic loss and results in cognitive decline and behavioral changes. Among diabetes medications, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) promote protective effects on vascular, microglial, and neuronal functions. In this review, we present evidence from animal...
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Hussein N Yassine Victoria Solomon Angad Thakral Nasim Sheikh-Bahaei Helena C Chui Meredith N Braskie Lon S Schneider Konrad Talbot Source Type: research

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 14, 2021 Category: Psychiatry Authors: Duygu Tosun Zeynep Demir Dallas P Veitch Daniel Weintraub Paul Aisen Clifford R Jack William J Jagust Ronald C Petersen Andrew J Saykin Leslie M Shaw John Q Trojanowski Michael W Weiner Alzheimer's Disease Neuroimaging Initiative Source Type: research

The impact of diabetes on cognitive impairment and its progression to dementia
CONCLUSIONS: Diabetes characterized by poor glycemic control or cardiovascular complications is related to a greater risk of the development and progression of cognitive impairment. Inflammation may play a role in these relationships.PMID:34636485 | DOI:10.1002/alz.12482 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 12, 2021 Category: Psychiatry Authors: Abigail Dove Ying Shang Weili Xu Giulia Grande Erika J Laukka Laura Fratiglioni Anna Marseglia Source Type: research

Recently decreased association of air pollution with cognitive impairment in a population-based aging cohort and in a mouse model
Alzheimers Dement. 2021 Oct 7. doi: 10.1002/alz.12471. Online ahead of print.NO ABSTRACTPMID:34617667 | DOI:10.1002/alz.12471 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 7, 2021 Category: Psychiatry Authors: Jennifer A Ailshire Caleb E Finch Source Type: research

Commentary: Global Alzheimer's disease and Alzheimer's disease related dementia research funding organizations support and engage the research community throughout the COVID-19 pandemic
Alzheimers Dement. 2021 Oct 1. doi: 10.1002/alz.12472. Online ahead of print.ABSTRACTThe COVID-19 pandemic has disproportionately affected more vulnerable populations, including those living with dementia. Over 50 million individuals worldwide are living with Alzheimer's disease (AD) or other dementia, and it is crucial to continue the fight against the condition during the global pandemic. Since the start of mandated lockdowns in March 2020, charity and non-profit organizations that fund AD and related dementia research continue to respond to the needs of the AD research community, ensuring the momentum continues and acce...
Source: The Journal of Alzheimers Association - October 1, 2021 Category: Psychiatry Authors: Emily A Meyers Philippe Amouyel Diane E Bovenkamp Maria C Carrillo Geraldine Drexel De Buchy Magali Dumont Howard Fillit Lauren Friedman Gregor Henderson-Begg Jakub Hort Andrew Murtishaw Richard Oakley Ma ï Panchal Sharyn L Rossi Rosa M Sancho Linda Thie Source Type: research

Diversity in Alzheimer's disease drug trials: The importance of eligibility criteria
DISCUSSION: Ethnoracially diverse participants continue to be underrepresented in AD clinical trials. Several recommendations are provided to broaden eligibility criteria.PMID:34590409 | DOI:10.1002/alz.12433 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Sanne Franzen Jade Emily Smith Esther van den Berg Monica Rivera Mindt Rozemarijn L van Bruchem-Visser Erin L Abner Lon S Schneider Niels D Prins Ganesh M Babulal Janne M Papma Source Type: research

Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report
CONCLUSIONS: This consensus guidance should prove useful for the protocol development and conduct of clinical trials, and may further provide a platform for the development of education materials that may help guide appropriate clinical trial participation decisions for potential trial participants and the general public.PMID:34590417 | DOI:10.1002/alz.12461 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Greg A Jicha Erin L Abner Steven E Arnold Maria C Carrillo Hiroko H Dodge Steven D Edland Keith N Fargo Howard H Feldman Larry B Goldstein James Hendrix Ruth Peters Julie M Robillard Lon S Schneider Jodi R Titiner Christopher J Weber Clinical Trial Advanc Source Type: research

Pulmonary function is associated with cognitive decline and structural brain differences
Alzheimers Dement. 2021 Sep 30. doi: 10.1002/alz.12479. Online ahead of print.ABSTRACTThe association of poor pulmonary function (PF) with cognitive trajectories and structural brain differences remains unclear. Within the Rush Memory and Aging Project, 1377 dementia-free subjects were followed up to 21 years. PF was assessed with a composite score measured at baseline. Global and domain-specific cognitive function was assessed annually constructed from 19 cognitive tests. A subsample of 351 participants underwent brain magnetic resonance imaging to investigate the cross-sectional association between PF and structural brai...
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Jiao Wang Ruixue Song Abigail Dove Xiuying Qi Jun Ma Erika J Laukka David A Bennett Weili Xu Source Type: research

Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease
DISCUSSION: CSF apoB markedly associates with early tau dysregulation in asymptomatic subjects and identifies at-risk individuals predisposed to develop visuospatial cognitive decline over time.PMID:34590423 | DOI:10.1002/alz.12442 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Cynthia Picard Nathalie Nilsson Anne Labont é Daniel Auld Pedro Rosa-Neto Alzheimer's Disease Neuroimaging Initiative Nicholas J Ashton Henrik Zetterberg Kaj Blennow John C B Breitner Sylvia Villeneuve Judes Poirier PREVENT-AD research group Source Type: research

Diversity in Alzheimer's disease drug trials: The importance of eligibility criteria
DISCUSSION: Ethnoracially diverse participants continue to be underrepresented in AD clinical trials. Several recommendations are provided to broaden eligibility criteria.PMID:34590409 | DOI:10.1002/alz.12433 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Sanne Franzen Jade Emily Smith Esther van den Berg Monica Rivera Mindt Rozemarijn L van Bruchem-Visser Erin L Abner Lon S Schneider Niels D Prins Ganesh M Babulal Janne M Papma Source Type: research

Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report
CONCLUSIONS: This consensus guidance should prove useful for the protocol development and conduct of clinical trials, and may further provide a platform for the development of education materials that may help guide appropriate clinical trial participation decisions for potential trial participants and the general public.PMID:34590417 | DOI:10.1002/alz.12461 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Greg A Jicha Erin L Abner Steven E Arnold Maria C Carrillo Hiroko H Dodge Steven D Edland Keith N Fargo Howard H Feldman Larry B Goldstein James Hendrix Ruth Peters Julie M Robillard Lon S Schneider Jodi R Titiner Christopher J Weber Clinical Trial Advanc Source Type: research

Pulmonary function is associated with cognitive decline and structural brain differences
Alzheimers Dement. 2021 Sep 30. doi: 10.1002/alz.12479. Online ahead of print.ABSTRACTThe association of poor pulmonary function (PF) with cognitive trajectories and structural brain differences remains unclear. Within the Rush Memory and Aging Project, 1377 dementia-free subjects were followed up to 21 years. PF was assessed with a composite score measured at baseline. Global and domain-specific cognitive function was assessed annually constructed from 19 cognitive tests. A subsample of 351 participants underwent brain magnetic resonance imaging to investigate the cross-sectional association between PF and structural brai...
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Jiao Wang Ruixue Song Abigail Dove Xiuying Qi Jun Ma Erika J Laukka David A Bennett Weili Xu Source Type: research

Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease
DISCUSSION: CSF apoB markedly associates with early tau dysregulation in asymptomatic subjects and identifies at-risk individuals predisposed to develop visuospatial cognitive decline over time.PMID:34590423 | DOI:10.1002/alz.12442 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 30, 2021 Category: Psychiatry Authors: Cynthia Picard Nathalie Nilsson Anne Labont é Daniel Auld Pedro Rosa-Neto Alzheimer's Disease Neuroimaging Initiative Nicholas J Ashton Henrik Zetterberg Kaj Blennow John C B Breitner Sylvia Villeneuve Judes Poirier PREVENT-AD research group Source Type: research

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DISCUSSION: ADNI has had a profound impact in improving clinical trials for AD.PMID:34581485 | DOI:10.1002/alz.12422 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Dallas P Veitch Michael W Weiner Paul S Aisen Laurel A Beckett Charles DeCarli Robert C Green Danielle Harvey Clifford R Jack William Jagust Susan M Landau John C Morris Ozioma Okonkwo Richard J Perrin Ronald C Petersen Monica Rivera-Mindt Andrew J Saykin Source Type: research

Scientific meetings highlight collaboration and discovery
Alzheimers Dement. 2021 Sep;17(9):1583-1584. doi: 10.1002/alz.12467.NO ABSTRACTPMID:34581491 | DOI:10.1002/alz.12467 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Source Type: research

Personalized prediction of progression in pre-dementia patients based on individual biomarker profile: A development and validation study
DISCUSSION: The biomarker profile allows prediction of personalized trajectories of future cognitive progression. This enables accurate personalized prognosis in clinical care and better selection of patient populations for clinical trials. A web-based application for prediction of patients' future cognitive progression is available online.PMID:34581496 | DOI:10.1002/alz.12363 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Line K ühnel Vincent Bouteloup J érémie Lespinasse Genevi ève Chêne Carole Dufouil Jos é Luis Molinuevo Lars Lau Raket MEMENTO study group and the Alzheimer's Disease Neuroimaging Initiative Source Type: research

The costs of developing treatments for Alzheimer's disease: A retrospective exploration
DISCUSSION: Measures to reduce expenditures while moving toward disease-modifying therapies that alleviate the rising burden of AD require continued investment from industry, government, and academia.PMID:34581499 | DOI:10.1002/alz.12450 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Jeffrey L Cummings Dana P Goldman Nicholas R Simmons-Stern Eric Ponton Source Type: research

Current directions in tau research: Highlights from Tau 2020
Alzheimers Dement. 2021 Sep 28. doi: 10.1002/alz.12452. Online ahead of print.ABSTRACTStudies supporting a strong association between tau deposition and neuronal loss, neurodegeneration, and cognitive decline have heightened the allure of tau and tau-related mechanisms as therapeutic targets. In February 2020, leading tau experts from around the world convened for the first-ever Tau2020 Global Conference in Washington, DC, co-organized and cosponsored by the Rainwater Charitable Foundation, the Alzheimer's Association, and CurePSP. Representing academia, industry, government, and the philanthropic sector, presenters and at...
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Claire Sexton Heather Snyder Dirk Beher Adam L Boxer Pat Brannelly Jean-Pierre Brion Luc Bu ée Angela M Cacace Ga ël Chételat Martin Citron Sarah L DeVos Kristophe Diaz Howard H Feldman Bess Frost Alison M Goate Michael Gold Bradley Hyman Keith Johnson Source Type: research

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DISCUSSION: ADNI has had a profound impact in improving clinical trials for AD.PMID:34581485 | DOI:10.1002/alz.12422 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Dallas P Veitch Michael W Weiner Paul S Aisen Laurel A Beckett Charles DeCarli Robert C Green Danielle Harvey Clifford R Jack William Jagust Susan M Landau John C Morris Ozioma Okonkwo Richard J Perrin Ronald C Petersen Monica Rivera-Mindt Andrew J Saykin Source Type: research

Scientific meetings highlight collaboration and discovery
Alzheimers Dement. 2021 Sep;17(9):1583-1584. doi: 10.1002/alz.12467.NO ABSTRACTPMID:34581491 | DOI:10.1002/alz.12467 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Source Type: research

Personalized prediction of progression in pre-dementia patients based on individual biomarker profile: A development and validation study
DISCUSSION: The biomarker profile allows prediction of personalized trajectories of future cognitive progression. This enables accurate personalized prognosis in clinical care and better selection of patient populations for clinical trials. A web-based application for prediction of patients' future cognitive progression is available online.PMID:34581496 | DOI:10.1002/alz.12363 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Line K ühnel Vincent Bouteloup J érémie Lespinasse Genevi ève Chêne Carole Dufouil Jos é Luis Molinuevo Lars Lau Raket MEMENTO study group and the Alzheimer's Disease Neuroimaging Initiative Source Type: research

The costs of developing treatments for Alzheimer's disease: A retrospective exploration
DISCUSSION: Measures to reduce expenditures while moving toward disease-modifying therapies that alleviate the rising burden of AD require continued investment from industry, government, and academia.PMID:34581499 | DOI:10.1002/alz.12450 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Jeffrey L Cummings Dana P Goldman Nicholas R Simmons-Stern Eric Ponton Source Type: research

Current directions in tau research: Highlights from Tau 2020
Alzheimers Dement. 2021 Sep 28. doi: 10.1002/alz.12452. Online ahead of print.ABSTRACTStudies supporting a strong association between tau deposition and neuronal loss, neurodegeneration, and cognitive decline have heightened the allure of tau and tau-related mechanisms as therapeutic targets. In February 2020, leading tau experts from around the world convened for the first-ever Tau2020 Global Conference in Washington, DC, co-organized and cosponsored by the Rainwater Charitable Foundation, the Alzheimer's Association, and CurePSP. Representing academia, industry, government, and the philanthropic sector, presenters and at...
Source: The Journal of Alzheimers Association - September 28, 2021 Category: Psychiatry Authors: Claire Sexton Heather Snyder Dirk Beher Adam L Boxer Pat Brannelly Jean-Pierre Brion Luc Bu ée Angela M Cacace Ga ël Chételat Martin Citron Sarah L DeVos Kristophe Diaz Howard H Feldman Bess Frost Alison M Goate Michael Gold Bradley Hyman Keith Johnson Source Type: research