Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.
DISCUSSION: Our association of MYH11, FZD3, SORCS3, and GOLGA8B with dementia is supported by independent functional studies in human subjects, model systems, and associations with shared risk factors for stroke and dementia. PMID: 32966694 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 25, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Synaptic impairment: The new battlefield of Alzheimer's disease.
Authors: Francesco DL, Koch G PMID: 32946657 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 21, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Correction of microtubule defects within A β plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition.
Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimers Dement. 2020 Sep 11;: Authors: Yao Y, Nzou G, Alle T, Tsering W, Maimaiti S, Trojanowski JQ, Lee VM, Ballatore C, Brunden KR Abstract The hallmark pathologies of the Alzheimer's disease (AD) brain are amyloid beta (Aβ)-containing senile plaques and neurofibrillary tangles formed from the microtubule (MT)-binding tau protein. Tau becomes hyperphosphorylated and disengages from MTs in AD, with evidence of resulting MT structure/function defects. Bra...
Source: The Journal of Alzheimers Association - September 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease.
Authors: Abstract Temporarily withdrawn pending completion of publication embargo. PMID: 32920957 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans.
Authors: Abstract Temporarily withdrawn pending completion of publication embargo. PMID: 32920988 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
DISCUSSION: Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort. PMID: 32921000 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Epidemiology of early onset dementia and its clinical presentations in the province of Modena, Italy.
Authors: Chiari A, Vinceti G, Adani G, Tondelli M, Galli C, Fiondella L, Costa M, Molinari MA, Filippini T, Zamboni G, Vinceti M Abstract INTRODUCTION: Patients with early onset dementia (EOD), defined as dementia with symptom onset at age
Source: The Journal of Alzheimers Association - September 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Long-term risk of dementia following hospitalization due to physical diseases: A multicohort study.
DISCUSSION: In addition to conventional risk factors, several physical diseases may increase the long-term risk of dementia. PMID: 32886434 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 6, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Prevalence and incidence of dementia in an older Chinese population over two decades: The role of education.
We examined the changes in dementia prevalence and incidence by comparing data from Shanghai Epidemiological Survey of Dementia and Alzheimer's disease (SESD) and Shanghai Aging Study (SAS) conducted two decades apart. FINDINGS: The dementia prevalence and incidence in total participants in SAS were higher than that in SESD (prevalence: 6.44% vs 2.30%, P 
Source: The Journal of Alzheimers Association - September 6, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Circulating metabolites are associated with brain atrophy and white matter hyperintensities.
DISCUSSION: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials. PMID: 32886448 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 6, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia.
DISCUSSION: Findings suggest that APOE may interact with tau independently of Aβ and that elevated MTL tau confers negative cognitive consequences in Aβ-negative ε4 carriers. PMID: 32886451 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - September 6, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Rhode Island chosen as fifth site for U.S. study of lifestyle interventions to reduce risk of cognitive decline.
Authors: PMID: 32860650 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 30, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease.
DISCUSSION: Refining the molecular mechanisms connecting tau, Aβ, and apoE with cerebrovascular pathologies is critical for greater understanding of AD pathogenesis and establishing effective therapeutic interventions for the disease. PMID: 32827351 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 24, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Education differentially contributes to cognitive reserve across racial/ethnic groups.
We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. METHODS: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. RESULTS: Hig...
Source: The Journal of Alzheimers Association - August 24, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies.
Authors: Frisoni GB, Molinuevo JL, Altomare D, Carrera E, Barkhof F, Berkhof J, Delrieu J, Dubois B, Kivipelto M, Nordberg A, Schott JM, van der Flier WM, Vellas B, Jessen F, Scheltens P, Ritchie C Abstract Empirical evidence suggests that a fair proportion of dementia cases are preventable, that some preventive actions can be taken immediately, and others may soon be implemented. Primary prevention may target cognitively normal persons with modifiable risk factors through lifestyle and multiple domain interventions (including general cardiovascular health). While the effect on individuals may be modest, it might h...
Source: The Journal of Alzheimers Association - August 22, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

APOE and dementia - resequencing and genotyping in 105,597 individuals.
DISCUSSION: We found that genetically low apoE levels increase and genetically high levels decrease risk, beyond ɛ2/ɛ3/ɛ4. This underscores that dementia risk more likely relates to variants affecting levels of apoE. PMID: 32808727 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 20, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Preparing the health-care system to pay for new Alzheimer's drugs.
Authors: Lin PJ, Cohen JT, Neumann PJ Abstract Biogen's announcement last fall that it will seek U.S. Food and Drug Administration approval for its Alzheimer's disease (AD) treatment, aducanumab, 7 months after the drug was declared a failure, buoyed patients and families, but put health payers and policymakers on alert. Whether aducanumab succeeds, other disease-modifying therapies for AD will follow, and the health-care system is unprepared for the reimbursement and access challenges. Novel AD therapies are much needed, but we cannot assume substantial cost offsets. With forethought and preparation, however, the ...
Source: The Journal of Alzheimers Association - August 20, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
DISCUSSION: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD. PMID: 32808747 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 20, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Does thiamine protect the brain from iron overload and alcohol-related dementia?
Authors: Listabarth S, König D, Vyssoki B, Hametner S Abstract Alcohol-related dementia (ARD) is a common and severe co-morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood-brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and ...
Source: The Journal of Alzheimers Association - August 20, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Dementia risk scores as surrogate outcomes for lifestyle-based multidomain prevention trials-rationale, preliminary evidence and challenges.
DISCUSSION: Dementia risk scores and their z-score versions show potential as surrogate outcomes. How changes in risk scores affect dementia remains to be determined. PMID: 32803862 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 19, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status.
DISCUSSION: Associations between different oral hypoglycemic drugs and memory change were not consistent between cognitively normal elderly and those with AD dementia. APOE ε4 genotype modified some relationships. PMID: 32803865 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 19, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.
DISCUSSION: Decreased lean mass was an indicator of increased dementia risk in older adults. Studies should test whether preventing lean mass loss in older adults reduces dementia risk. PMID: 32803916 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 19, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Authors: Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P Abstract We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, o...
Source: The Journal of Alzheimers Association - August 14, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays. Alzheimers Dement. 2020 Aug 04;: Authors: Boulo S, Kuhlmann J, Andreasson U, Brix B, Venkataraman I, Herbst V, Rutz S, Manuilova E, Vandijck M, Dekeyser F, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Pinski G, Trapmann S, Schimmel H, Emons H, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstichele H, Stoops E, Leinenbach A, Bittner T, Jenkins RG, Kostanjevecki V, Lewczuk P, Gobom J, Zetterberg H, Zegers I, Blennow K Abstract INTRODUCTION: Reference materials based on huma...
Source: The Journal of Alzheimers Association - August 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.
Authors: Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, Burgess JD, Ertekin-Taner N, Petersen RC, Wang L, Qi Z, He A, Neuhaus I, Patel V, Foroud T, Faber KM, Lovestone S, Simmons A, Weiner MW, Saykin AJ, Alzheimer's Disease Neuroimaging Initiative Abstract INTRODUCTION: Abnormal gene expression patterns may contribute to the onset and progression of late-onset Alzheimer's disease (LOAD). METHODS: We performed transcriptome-wide meta-analysis (N = 1440) of blood-based microarray gene expression profiles as well as neuroimaging and cerebrospinal fluid (CSF) endop...
Source: The Journal of Alzheimers Association - August 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Lifestyle, multi-omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study.
This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data. PMID: 32776666 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage.
This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage. METHODS: We conducted a two-stage-sectional study (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation stage: AD, 73; aMCI, 71; controls, 72), a study including preclinical AD (160) and controls (160), and a confirmation study in familial AD (mutation carriers: 59; non-mutation carriers: 62). RESULTS: The concentrations of growth associated protein 43 (GAP43), neurogranin, synaptosome associated protein 25 (SNAP25), and synaptotagmin 1 were lower in AD than in controls (P 
Source: The Journal of Alzheimers Association - August 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Hearing loss and microstructural integrity of the brain in a dementia-free older population.
CONCLUSION: Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes. PMID: 32743902 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 5, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Association launches webinar series for researchers.
Authors: PMID: 32743933 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - August 5, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia.
We present the results of the 5th CCCDTD, which convened in October 2019, to address topics chosen by the steering committee to reflect advances in the field, and build on previous guidelines. Topics included: (1) utility of the National Institute on Aging research framework for clinical Alzheimer's disease (AD) diagnosis; (2) updating diagnostic criteria for vascular cognitive impairment, and its management; (3) dementia case finding and detection; (4) neuroimaging and fluid biomarkers in diagnosis; (5) use of non-cognitive markers of dementia for better dementia detection; (6) risk reduction/prevention; (7) psychosocial ...
Source: The Journal of Alzheimers Association - July 31, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

AD risk score for the early phases of disease based on unsupervised machine learning.
Authors: Wang Z, Tang Z, Zhu Y, Pettigrew C, Soldan A, Gross A, Albert M Abstract INTRODUCTION: Identifying cognitively normal individuals at high risk for progression to symptomatic Alzheimer's disease (AD) is critical for early intervention. METHODS: An AD risk score was derived using unsupervised machine learning. The score was developed using data from 226 cognitively normal individuals and included cerebrospinal fluid, magnetic resonance imaging, and cognitive measures, and validated in an independent cohort. RESULTS: Higher baseline AD progression risk scores (hazard ratio = 2.70, P
Source: The Journal of Alzheimers Association - July 31, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

No difference in dementia prediction between apolipoprotein E4 and the ischemic score.
We examined whether the Hachinski Ischemic Scale (HIS) can predict dementia in elderly. METHODS: We leveraged data of the Canadian Study of Health and Aging. First, we examined the association of HIS with incident dementia. Next, we compared HIS to apolipoprotein E (APOE ɛ4) in prediction of dementia. We trained the HIS and APOE ɛ4 models in the training dataset and used the trained models for dementia prediction in the validation dataset. RESULTS: A higher HIS level was associated with a higher odds of dementia (odds ratio = 1.64, 95% confidence interval [CI]: 1.41 to 1.90, P 
Source: The Journal of Alzheimers Association - July 31, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Health-care use and cost for multimorbid persons with dementia in the National Health and Aging Trends Study.
CONCLUSIONS: Among older adults with dementia, proactive and ambulatory care that includes informal caregivers along with primary and specialty providers, may offer promise to decrease use and costs for chronic kidney disease, ischemic heart disease, atrial fibrillation, depression, and hypertension. PMID: 32729984 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 31, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau.
DISCUSSION: These data extend previous studies by showing an association of decreased plasmalogen indices with AD, mild cognitive impairment (MCI), cognition, and CSF tau. Future studies are needed to better define mechanistic relationships, and to test the effects of interventions designed to replete serum plasmalogens. PMID: 32715599 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Validation of online functional measures in cognitively impaired older adults.
DISCUSSION: The results support the validity of online assessments and their greater utilization in healthcare and research settings. Online SP-reported functional decline is an indicator of dementia and AD risk. PMID: 32715602 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Can active life mitigate the impact of diabetes on dementia and brain aging?
DISCUSSION: AL could mitigate the deleterious impact of diabetes on dementia, potentially by limiting the loss of brain tissue volume. PMID: 32715606 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Authors: Vidoni ED, Choi IY, Lee P, Reed G, Zhang N, Pleen J, Mahnken JD, Clutton J, Becker A, Sherry E, Bothwell R, Anderson H, Harris RA, Brooks W, Wilkins HM, Mosconi L, Burns JM, Swerdlow RH Abstract INTRODUCTION: Brain bioenergetics are defective in Alzheimer's disease (AD). Preclinical studies find oxaloacetate (OAA) enhances bioenergetics, but human safety and target engagement data are lacking. METHODS: We orally administered 500 or 1000 mg OAA, twice daily for 1 month, to AD participants (n = 15 each group) and monitored safety and tolerability. To assess brain metabolism engagement, we performed fluor...
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study.
Authors: Boada M, López OL, Olazarán J, Núñez L, Pfeffer M, Paricio M, Lorites J, Piñol-Ripoll G, Gámez JE, Anaya F, Kiprov D, Lima J, Grifols C, Torres M, Costa M, Bozzo J, Szczepiorkowski ZM, Hendrix S, Páez A Abstract INTRODUCTION: This phase 2b/3 trial examined the effects of plasma exchange (PE) in patients with mild-to-moderate Alzheimer's disease (AD). METHODS: Three hundred forty-seven patients (496 screened) were randomized (1:1:1:1) into three PE treatment arms with different doses of albumin and intravenous immunoglobulin replacement (6-week period of ...
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Dietary fatty acids and risk of Alzheimer's disease and related dementias: Observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP).
Authors: Gustafson DR, Bäckman K, Scarmeas N, Stern Y, Manly JJ, Mayeux R, Gu Y Abstract INTRODUCTION: High dietary intake of long chain, polyunsaturated fatty acids is associated with lower Alzheimer's disease (AD) risk. METHODS: Washington Heights-Hamilton Heights-Inwood Columbia Aging Project is a multiethnic, prospective observational study of aging and dementia among elderly (≥ 65 years). Dietary intake was measured using a food frequency questionnaire. Dietary short-, medium-, and long-chain fatty acid intakes were categorized by number of carbons and double bonds. Consensus AD diagnoses were...
Source: The Journal of Alzheimers Association - July 28, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.
Authors: Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GY, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kramer J, Kukull W, Lucente D, Lungu C, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Tatton N, Taylor J, Toga A, Trojano...
Source: The Journal of Alzheimers Association - July 14, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study.
This study tested the self-reported sleep characteristics associated with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in cognitively intact older adults. METHODS: The linear and non-linear regression analyses were conducted in 736 cognitively normal participants (mean [standard deviation; SD] age, 62.3 [10.5] years, range 40 to 88 years, 59% female) who had measurements of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tTau proteins and sleep characteristics, after adjusting for age, gender, education, apolipoprotein E gene (APOE) ε4 status, and general cognition. RESULTS: Greater da...
Source: The Journal of Alzheimers Association - July 14, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.
Authors: Brenowitz WD, Kaup AR, Yaffe K Abstract INTRODUCTION: We created a summary score for multiple sensory (multisensory) impairment and evaluated its association with dementia. METHODS: We studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were asses...
Source: The Journal of Alzheimers Association - July 14, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Shift work and incidence of dementia: A Danish Nurse Cohort study.
We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those workin...
Source: The Journal of Alzheimers Association - July 13, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

New manual aims to create common standards for dementia diagnosis across Latin America.
Authors: PMID: 32643872 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 11, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.
Authors: Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenb...
Source: The Journal of Alzheimers Association - July 7, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A prognostic model for overall survival in sporadic Creutzfeldt-Jakob disease.
DISCUSSION: We developed the first prognostic model for overall survival of sCJD patients based on readily available information only. The developed score chart serves as a hands-on prediction tool for clinical practice. PMID: 32614136 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - July 4, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
DISCUSSION: We uncovered the significance of neuronal apoE receptor sortilin in facilitating neuroprotective actions of brain lipids, and its relevance for AD risk seen with apoE4. PMID: 32588544 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 27, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub-clinical cognitive decline in late middle age.
DISCUSSION: Combining nEV biomarkers can identify individuals with age-associated cognitive decline. PMID: 32588967 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 27, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.
DISCUSSION: We demonstrated common genetic signatures for LOAD and PTSD and suggested immune response as a common pathway for these diseases. PMID: 32588970 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 27, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A randomized controlled trial of amyloid positron emission tomography results disclosure in mild cognitive impairment.
DISCUSSION: These findings point to the possibility that both MCI patients and caregivers may need emotional support after the disclosure of amyloid scan results. PMID: 32588971 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - June 27, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research