The Journal of Alzheimers Association 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity.HIGHLIGHTS: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-syn...
Source: The Journal of Alzheimers Association - April 26, 2024 Category: Psychiatry Authors: Johannes Levin Simone Baiardi Corinne Quadalti Marcello Rossi Angela Mammana Jonathan V öglein Alexander Bernhardt Richard J Perrin Mathias Jucker Oliver Preische Anna Hofmann G ünter U Höglinger Nigel J Cairns Erin E Franklin Patricio Chrem Carlos Cru Source Type: research
Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Mateus Rozalem Aranha Victor Montal Hilde van den Brink Jordi Pegueroles Maria Carmona-Iragui Laura Videla Lucia Maure Blesa Bessy Benejam Javier Arranz S ílvia Valldeneu Isabel Barroeta Susana Fern ández Laia Ribas Daniel Alcolea Sof ía González-Orti Source Type: research
Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease
DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research
Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial
We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).METHODS: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.RESULTS: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive im...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Takashi Sakurai Taiki Sugimoto Hiroyasu Akatsu Takehiko Doi Yoshinori Fujiwara Akihiro Hirakawa Fumie Kinoshita Masafumi Kuzuya Sangyoon Lee Nanae Matsumoto Koichiro Matsuo Makoto Michikawa Akinori Nakamura Susumu Ogawa Rei Otsuka Kenji Sato Hiroyuki Shim Source Type: research
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease
DISCUSSION: Our results suggest that WMH may be associated with AD-intrinsic processes of degeneration, in addition to vascular mechanisms.HIGHLIGHTS: We studied white matter hyperintensities (WMHs) and WMH-connected cortical changes. WMHs are associated with more severe regional cortical degeneration. Findings suggest WMHs may be associated with Alzheimer's disease-intrinsic processes of degeneration.PMID:38648354 | DOI:10.1002/alz.13845 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Junfang Zhang Haijuan Chen Jie Wang Qi Huang Xiaomeng Xu Wenjing Wang Wei Xu Yihui Guan Jun Liu Joanna M Wardlaw Yulei Deng Fang Xie Binyin Li Source Type: research
Overrepresentation of APOE ε4 carriers in genome-wide association studies of memory function and memory decline
Alzheimers Dement. 2024 Apr 22. doi: 10.1002/alz.13824. Online ahead of print.NO ABSTRACTPMID:38648376 | DOI:10.1002/alz.13824 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Md Shafiqur Rahman Source Type: research
Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Mateus Rozalem Aranha Victor Montal Hilde van den Brink Jordi Pegueroles Maria Carmona-Iragui Laura Videla Lucia Maure Blesa Bessy Benejam Javier Arranz S ílvia Valldeneu Isabel Barroeta Susana Fern ández Laia Ribas Daniel Alcolea Sof ía González-Orti Source Type: research
Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease
DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research
Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial
We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).METHODS: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.RESULTS: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive im...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Takashi Sakurai Taiki Sugimoto Hiroyasu Akatsu Takehiko Doi Yoshinori Fujiwara Akihiro Hirakawa Fumie Kinoshita Masafumi Kuzuya Sangyoon Lee Nanae Matsumoto Koichiro Matsuo Makoto Michikawa Akinori Nakamura Susumu Ogawa Rei Otsuka Kenji Sato Hiroyuki Shim Source Type: research
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease
DISCUSSION: Our results suggest that WMH may be associated with AD-intrinsic processes of degeneration, in addition to vascular mechanisms.HIGHLIGHTS: We studied white matter hyperintensities (WMHs) and WMH-connected cortical changes. WMHs are associated with more severe regional cortical degeneration. Findings suggest WMHs may be associated with Alzheimer's disease-intrinsic processes of degeneration.PMID:38648354 | DOI:10.1002/alz.13845 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Junfang Zhang Haijuan Chen Jie Wang Qi Huang Xiaomeng Xu Wenjing Wang Wei Xu Yihui Guan Jun Liu Joanna M Wardlaw Yulei Deng Fang Xie Binyin Li Source Type: research
Overrepresentation of APOE ε4 carriers in genome-wide association studies of memory function and memory decline
Alzheimers Dement. 2024 Apr 22. doi: 10.1002/alz.13824. Online ahead of print.NO ABSTRACTPMID:38648376 | DOI:10.1002/alz.13824 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Md Shafiqur Rahman Source Type: research
Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Mateus Rozalem Aranha Victor Montal Hilde van den Brink Jordi Pegueroles Maria Carmona-Iragui Laura Videla Lucia Maure Blesa Bessy Benejam Javier Arranz S ílvia Valldeneu Isabel Barroeta Susana Fern ández Laia Ribas Daniel Alcolea Sof ía González-Orti Source Type: research
Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease
DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research
