Hearing impairment and missing cognitive test scores in a population-based study of older adults: The Atherosclerosis Risk in Communities neurocognitive study
DISCUSSION: Older adults with hearing impairment are less likely to complete cognitive testing, thereby underestimating the hearing impairment-cognition relationship.PMID:33844443 | DOI:10.1002/alz.12339 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 12, 2021 Category: Psychiatry Authors: Jennifer A Deal Alden L Gross A Richey Sharrett Alison G Abraham Josef Coresh Michelle Carlson Michael Griswold Thomas Mosley Melinda C Power Pradeep Ramulu Nicholas S Reed Frank R Lin Bonnielin K Swenor Source Type: research

Functional decline in the aphasic variant of Alzheimer's disease
DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.PMID:33829622 | DOI:10.1002/alz.12331 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Stacey Moeller Jaiashre Sridhar Adam Martersteck Christina Coventry Alan Kuang Hui Zhang Sandra Weintraub M-Marsel Mesulam Emily Rogalski Source Type: research

Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates
DISCUSSION: Dysregulated calcium signaling confers risk for tau pathology and provides a potential therapeutic target.PMID:33829643 | DOI:10.1002/alz.12325 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Dibyadeep Datta Shannon N Leslie Min Wang Yury M Morozov Shengtao Yang SueAnn Mentone Caroline Zeiss Alvaro Duque Pasko Rakic Tamas L Horvath Christopher H van Dyck Angus C Nairn Amy F T Arnsten Source Type: research

Functional decline in the aphasic variant of Alzheimer's disease
DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.PMID:33829622 | DOI:10.1002/alz.12331 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Stacey Moeller Jaiashre Sridhar Adam Martersteck Christina Coventry Alan Kuang Hui Zhang Sandra Weintraub M-Marsel Mesulam Emily Rogalski Source Type: research

Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates
DISCUSSION: Dysregulated calcium signaling confers risk for tau pathology and provides a potential therapeutic target.PMID:33829643 | DOI:10.1002/alz.12325 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Dibyadeep Datta Shannon N Leslie Min Wang Yury M Morozov Shengtao Yang SueAnn Mentone Caroline Zeiss Alvaro Duque Pasko Rakic Tamas L Horvath Christopher H van Dyck Angus C Nairn Amy F T Arnsten Source Type: research

Functional decline in the aphasic variant of Alzheimer's disease
DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.PMID:33829622 | DOI:10.1002/alz.12331 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Stacey Moeller Jaiashre Sridhar Adam Martersteck Christina Coventry Alan Kuang Hui Zhang Sandra Weintraub M-Marsel Mesulam Emily Rogalski Source Type: research

Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates
DISCUSSION: Dysregulated calcium signaling confers risk for tau pathology and provides a potential therapeutic target.PMID:33829643 | DOI:10.1002/alz.12325 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Dibyadeep Datta Shannon N Leslie Min Wang Yury M Morozov Shengtao Yang SueAnn Mentone Caroline Zeiss Alvaro Duque Pasko Rakic Tamas L Horvath Christopher H van Dyck Angus C Nairn Amy F T Arnsten Source Type: research

Functional decline in the aphasic variant of Alzheimer's disease
DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.PMID:33829622 | DOI:10.1002/alz.12331 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Stacey Moeller Jaiashre Sridhar Adam Martersteck Christina Coventry Alan Kuang Hui Zhang Sandra Weintraub M-Marsel Mesulam Emily Rogalski Source Type: research

Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates
DISCUSSION: Dysregulated calcium signaling confers risk for tau pathology and provides a potential therapeutic target.PMID:33829643 | DOI:10.1002/alz.12325 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 8, 2021 Category: Psychiatry Authors: Dibyadeep Datta Shannon N Leslie Min Wang Yury M Morozov Shengtao Yang SueAnn Mentone Caroline Zeiss Alvaro Duque Pasko Rakic Tamas L Horvath Christopher H van Dyck Angus C Nairn Amy F T Arnsten Source Type: research

Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology
DISCUSSION: TES criteria provided good evidence to rule out, but limited evidence to rule in, CTE pathology. Requiring cognitive symptoms in revised criteria and using AD biomarkers may improve CTE pathology prediction.PMID:33826224 | DOI:10.1002/alz.12338 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 7, 2021 Category: Psychiatry Authors: Jesse Mez Michael L Alosco Daniel H Daneshvar Nicole Saltiel Zachary Baucom Bobak Abdolmohammadi Madeline Uretsky Raymond Nicks Brett M Martin Joseph N Palmisano Christopher J Nowinski Philip Montenigro Todd M Solomon Ian Mahar Jonathan D Cherry Victor E Source Type: research

Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort
Alzheimers Dement. 2021 Apr 3. doi: 10.1002/alz.12292. Online ahead of print.ABSTRACTBACKGROUND: We classified non-demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological and imaging profiles.MATERIALS AND METHODS: From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut-offs of 1000 pg/mL for amyloid beta (Aß)1-42 and 27 pg/mL for p-tau181 were validated using Gaussian mixture models. Given strong correlation of p-tau and t-tau (R2 = 0.98, P
Source: The Journal of Alzheimers Association - April 3, 2021 Category: Psychiatry Authors: Silvia Ingala Casper De Boer Larissa A Masselink Ilaria Vergari Luigi Lorenzini Kaj Blennow Ga ël Chételat Carol Di Perri Michael Ewers Wiesje M van der Flier Nick C Fox Juan Domingo Gispert Sven Haller Jos é Luís Molinuevo Graciela Muniz-Terrera Henr Source Type: research

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development
DISCUSSION: Downstream analyses of these novel loci highlight synaptic function, in contrast to common AD-associated variants, which implicate innate immunity and amyloid processing. These loci have not been associated previously with AD, emphasizing the ability of WGS to identify AD-associated rare variants, particularly outside of the exome.PMID:33797837 | DOI:10.1002/alz.12319 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Dmitry Prokopenko Sarah L Morgan Kristina Mullin Oliver Hofmann Brad Chapman Rory Kirchner Alzheimer's Disease Neuroimaging Initiative (ADNI) Sandeep Amberkar Inken Wohlers Christoph Lange Winston Hide Lars Bertram Rudolph E Tanzi Source Type: research

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Alzheimers Dement. 2021 Apr 2. doi: 10.1002/alz.12321. Online ahead of print.ABSTRACTNeurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a dynamic lifespan of maturity that associates with progressive neuronal dysfunction and cognitive deficits. As neurofibrillary tangles mature, the biology of the neuron undergoes extensive changes that may impact biomarker recognition and therapeutic targeting. Neurofibrillary tangle maturity encompasses three levels: pretangles, mature tangles, and ghost tangles. In this review, we detail distinct and overlapping characteristics observed in the hum...
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Christina M Moloney Val J Lowe Melissa E Murray Source Type: research

AMYQ: An index to standardize quantitative amyloid load across PET tracers
DISCUSSION: AMYQ is a new MRI-independent index for standardizing and quantifying amyloid load across tracers.PMID:33797846 | DOI:10.1002/alz.12317 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Jordi Pegueroles Victor Montal Alexandre Bejanin Eduard Vilaplana Mateus Aranha Miguel Angel Santos-Santos Daniel Alcolea Ignasi Carri ó Valle Camacho Rafael Blesa Alberto Lle ó Juan Fortea Alzheimer Disease Neuroimaging Initiative Australian Imaging, B Source Type: research

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development
DISCUSSION: Downstream analyses of these novel loci highlight synaptic function, in contrast to common AD-associated variants, which implicate innate immunity and amyloid processing. These loci have not been associated previously with AD, emphasizing the ability of WGS to identify AD-associated rare variants, particularly outside of the exome.PMID:33797837 | DOI:10.1002/alz.12319 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Dmitry Prokopenko Sarah L Morgan Kristina Mullin Oliver Hofmann Brad Chapman Rory Kirchner Alzheimer's Disease Neuroimaging Initiative (ADNI) Sandeep Amberkar Inken Wohlers Christoph Lange Winston Hide Lars Bertram Rudolph E Tanzi Source Type: research

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Alzheimers Dement. 2021 Apr 2. doi: 10.1002/alz.12321. Online ahead of print.ABSTRACTNeurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a dynamic lifespan of maturity that associates with progressive neuronal dysfunction and cognitive deficits. As neurofibrillary tangles mature, the biology of the neuron undergoes extensive changes that may impact biomarker recognition and therapeutic targeting. Neurofibrillary tangle maturity encompasses three levels: pretangles, mature tangles, and ghost tangles. In this review, we detail distinct and overlapping characteristics observed in the hum...
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Christina M Moloney Val J Lowe Melissa E Murray Source Type: research

AMYQ: An index to standardize quantitative amyloid load across PET tracers
DISCUSSION: AMYQ is a new MRI-independent index for standardizing and quantifying amyloid load across tracers.PMID:33797846 | DOI:10.1002/alz.12317 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 2, 2021 Category: Psychiatry Authors: Jordi Pegueroles Victor Montal Alexandre Bejanin Eduard Vilaplana Mateus Aranha Miguel Angel Santos-Santos Daniel Alcolea Ignasi Carri ó Valle Camacho Rafael Blesa Alberto Lle ó Juan Fortea Alzheimer Disease Neuroimaging Initiative Australian Imaging, B Source Type: research

Replication study of plasma proteins relating to Alzheimer's pathology
This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.METHODS: Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.RESULTS: Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN varian...
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Liu Shi Laura M Winchester Sarah Westwood Alison L Baird Sneha N Anand Noel J Buckley Abdul Hye Nicholas J Ashton Isabelle Bos Stephanie J B Vos Mara Ten Kate Philip Scheltens Charlotte E Teunissen Rik Vandenberghe Silvy Gabel Karen Meersmans Sebastiaan E Source Type: research

Plasma P-tau181 to A β42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease
DISCUSSION: Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.PMID:33792168 | DOI:10.1002/alz.12332 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Joyce R Chong Nicholas J Ashton Thomas K Karikari Tomotaka Tanaka Francis N Saridin Anthonin Reilhac Edward G Robins Ying-Hwey Nai Henri Vrooman Saima Hilal Henrik Zetterberg Kaj Blennow Mitchell K P Lai Christopher P Chen Source Type: research

Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative
This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.PMID:33792187 | DOI:10.1002/alz.12326 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Caishui Yang Xin Li Junying Zhang Yaojing Chen He Li Dongfeng Wei Peng Lu Ying Liang Zhen Liu Ni Shu Fang Wang Qing Guan Wuhai Tao Qingshan Wang Jianjun Jia Lin Ai Ruixue Cui Yanping Wang Dantao Peng Wei Zhang Kewei Chen Xiaomin Wang Jizong Zhao Yongyan W Source Type: research

Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD)
DISCUSSION: The LBD-MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI-DLB.PMID:33793069 | DOI:10.1002/alz.12334 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: James E Galvin Stephanie Chrisphonte Iris Cohen Keri K Greenfield Michael J Kleiman Claudia Moore Mary Lou Riccio Amie Rosenfeld Niurka Shkolnik Marcia Walker Lun-Ching Chang Magdalena I Tolea Source Type: research

Replication study of plasma proteins relating to Alzheimer's pathology
This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.METHODS: Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.RESULTS: Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN varian...
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Liu Shi Laura M Winchester Sarah Westwood Alison L Baird Sneha N Anand Noel J Buckley Abdul Hye Nicholas J Ashton Isabelle Bos Stephanie J B Vos Mara Ten Kate Philip Scheltens Charlotte E Teunissen Rik Vandenberghe Silvy Gabel Karen Meersmans Sebastiaan E Source Type: research

Plasma P-tau181 to A β42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease
DISCUSSION: Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.PMID:33792168 | DOI:10.1002/alz.12332 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Joyce R Chong Nicholas J Ashton Thomas K Karikari Tomotaka Tanaka Francis N Saridin Anthonin Reilhac Edward G Robins Ying-Hwey Nai Henri Vrooman Saima Hilal Henrik Zetterberg Kaj Blennow Mitchell K P Lai Christopher P Chen Source Type: research

Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative
This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.PMID:33792187 | DOI:10.1002/alz.12326 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2021 Category: Psychiatry Authors: Caishui Yang Xin Li Junying Zhang Yaojing Chen He Li Dongfeng Wei Peng Lu Ying Liang Zhen Liu Ni Shu Fang Wang Qing Guan Wuhai Tao Qingshan Wang Jianjun Jia Lin Ai Ruixue Cui Yanping Wang Dantao Peng Wei Zhang Kewei Chen Xiaomin Wang Jizong Zhao Yongyan W Source Type: research

Quantifying progression in primary progressive aphasia with structural neuroimaging
CONCLUSION: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.PMID:33787063 | DOI:10.1002/alz.12323 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 31, 2021 Category: Psychiatry Authors: Jolina Lombardi Benjamin Mayer Elisa Semler Sarah Anderl-Straub Ingo Uttner Jan Kassubek Janine Diehl-Schmid Adrian Danek Johannes Levin Klaus Fassbender Klaus Fliessbach Anja Schneider Hans-J ürgen Huppertz Holger Jahn Alexander Volk Johannes Kornhuber Source Type: research

Register for May AAIC ® Satellite Symposium and second Latinos & amp; Alzheimer's symposium
Alzheimers Dement. 2021 Mar 31. doi: 10.1002/alz.12337. Online ahead of print.NO ABSTRACTPMID:33788391 | DOI:10.1002/alz.12337 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 31, 2021 Category: Psychiatry Source Type: research

Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study
DISCUSSION: Differential associations between specific ophthalmic conditions and dementia subtypes may elucidate pathophysiologic pathways. Lack of association between glaucoma and dementia was most surprising from these analyses.PMID:33788406 | DOI:10.1002/alz.12313 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 31, 2021 Category: Psychiatry Authors: Phillip H Hwang Will T Longstreth Stephen M Thielke Courtney E Francis Marco Carone Lewis H Kuller Annette L Fitzpatrick Source Type: research

The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau
Alzheimers Dement. 2021 Mar 31. doi: 10.1002/alz.12316. Online ahead of print.ABSTRACTThe core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between-center differences in pre-analytical procedures may contribute to variability in measurements across laboratories. To resolve this issue, a workgroup was led by the Alzheimer's Association with experts from both academia and industry. The aim of th...
Source: The Journal of Alzheimers Association - March 31, 2021 Category: Psychiatry Authors: Oskar Hansson Richard Batrla Britta Brix Maria C Carrillo Veronika Corradini Rebecca M Edelmayer Rianne N Esquivel Christina Hall John Lawson Nathalie Le Bastard Jos é Luis Molinuevo Laura K Nisenbaum Sandra Rutz Salvatore J Salamone Charlotte E Teunisse Source Type: research

Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study
We examined the relationship between different types of mid-life loneliness and the development of dementia and AD.METHODS: Loneliness was assessed in cognitively normal adults using one item from the Center for Epidemiologic Studies Depression Scale. We defined loneliness as no loneliness, transient loneliness, incident loneliness,or persistent loneliness, and applied Cox regression models and Kaplan-Meier plots with dementia and AD as outcomes (n = 2880).RESULTS: After adjusting for demographics, social network, physical health, and apolipoprotein E ε4, persistent loneliness was associated with higher (hazard rat...
Source: The Journal of Alzheimers Association - March 24, 2021 Category: Psychiatry Authors: Samia C Akhter-Khan Qiushan Tao Ting Fang Alvin Ang Indira Swetha Itchapurapu Michael L Alosco Jesse Mez Ryan J Piers David C Steffens Rhoda Au Wei Qiao Qiu Source Type: research

2021 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report discusses the challenges of providing equitable health care for people with dementia in the United States. An estimated 6.2 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Official death certificates recorded 121,499 deaths from AD in 2019, the...
Source: The Journal of Alzheimers Association - March 23, 2021 Category: Psychiatry Source Type: research

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank
DISCUSSION: These findings underscore the importance of blood pressure control in midlife to mitigate dementia risk.PMID:33749976 | DOI:10.1002/alz.12320 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 22, 2021 Category: Psychiatry Authors: Rainer Malik Marios K Georgakis Julia Neitzel Kristiina Rannikm äe Michael Ewers Sudha Seshadri Cathie L M Sudlow Martin Dichgans Source Type: research

A novel tau-based rhesus monkey model of Alzheimer's pathogenesis
DISCUSSION: These results highlight the initial stages of tau seeding and propagation in a primate model, a more powerful translational approach for the development of new therapies for AD.PMID:33734581 | DOI:10.1002/alz.12318 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 18, 2021 Category: Psychiatry Authors: Danielle Beckman Paramita Chakrabarty Sean Ott Amanda Dao Eric Zhou William G Janssen Kristine Donis-Cox Scott Muller Jeffrey H Kordower John H Morrison Source Type: research

Deepen into sleep and wake patterns across Alzheimer's disease phenotypes
Alzheimers Dement. 2021 Mar 12. doi: 10.1002/alz.12304. Online ahead of print.ABSTRACTAlthough, the clinical variants of Alzheimer's disease (AD) show distinct patterns of cognitive and behavioral decline, disease progression, and neuropathological features, it is unclear if this clinical heterogeneity extends to sleep-wake patterns. Sleep and wake disturbances are frequent in typical AD, often preceding memory loss and negatively impacting the quality of life of patients and caregivers alike. Still, sleep and wake disorders are often misdiagnosed and undertreated in typical AD. Better characterization of sleep-wake featur...
Source: The Journal of Alzheimers Association - March 12, 2021 Category: Psychiatry Authors: Neus Falg às Christine M Walsh Thomas C Neylan Lea T Grinberg Source Type: research

Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias
Alzheimers Dement. 2021 Mar 12. doi: 10.1002/alz.12305. Online ahead of print.ABSTRACTWhile heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2 S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2 S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2 S metabolites and MRI to evaluate indicators of m...
Source: The Journal of Alzheimers Association - March 12, 2021 Category: Psychiatry Authors: Elizabeth Disbrow Karen Y Stokes Christina Ledbetter James Patterson Roger Kelley Sibile Pardue Tyler Reekes Lana Larmeu Vinita Batra Shuai Yuan Urska Cvek Marjan Trutschl Phillip Kilgore J Steven Alexander Christopher G Kevil Source Type: research

Cardiovascular risk and midlife cognitive decline in the Study of Women's Health Across the Nation
DISCUSSION: Midlife may be a critical period for intervening on cardiovascular risk factors to prevent or delay later life cognitive impairment and ADRD.PMID:33710770 | DOI:10.1002/alz.12300 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 12, 2021 Category: Psychiatry Authors: Carol A Derby Franya Hutchins Gail A Greendale Karen A Matthews Barbara Sternfeld Susan A Everson-Rose Rasa Kazlauskaite Rachel A Whitmer Maria M Brooks Source Type: research

Extrapyramidal signs and Alzheimer's disease prognosis in a multiethnic, community-based sample of demented elders
DISCUSSION: Our results partially confirm previous studies on predominantly White, clinic-based samples. Further research is needed to better understand the etiological role of EPS in AD.PMID:33710771 | DOI:10.1002/alz.12309 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 12, 2021 Category: Psychiatry Authors: Anton J Kociolek Kayri K Fernandez Zhezhen Jin Stephanie Cosentino Carolyn W Zhu Yian Gu Yaakov Stern Source Type: research

Deepen into sleep and wake patterns across Alzheimer's disease phenotypes
Alzheimers Dement. 2021 Mar 12. doi: 10.1002/alz.12304. Online ahead of print.ABSTRACTAlthough, the clinical variants of Alzheimer's disease (AD) show distinct patterns of cognitive and behavioral decline, disease progression, and neuropathological features, it is unclear if this clinical heterogeneity extends to sleep-wake patterns. Sleep and wake disturbances are frequent in typical AD, often preceding memory loss and negatively impacting the quality of life of patients and caregivers alike. Still, sleep and wake disorders are often misdiagnosed and undertreated in typical AD. Better characterization of sleep-wake featur...
Source: The Journal of Alzheimers Association - March 12, 2021 Category: Psychiatry Authors: Neus Falg às Christine M Walsh Thomas C Neylan Lea T Grinberg Source Type: research