Dementia: Paradigm shifting into high gear.
Authors: Hachinski V Abstract Redressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug "silver bullet". Dementia of late onset is not a disease, but an amalgam of interactive pathologies on the shifting background of aging, requiring multimodal targeting. Cerebrovascular diseases coexist and coact with all major neurodegenerative pathologies, increasing two-fold the likelihood that the...
Source: The Journal of Alzheimers Association - April 15, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study.
Authors: Lleó A, Alcolea D, Martínez-Lage P, Scheltens P, Parnetti L, Poirier J, Simonsen AH, Verbeek MM, Rosa-Neto P, Slot RER, Tainta M, Izaguirre A, Reijs BLR, Farotti L, Tsolaki M, Vandenbergue R, Freund-Levi Y, Verhey FRJ, Clarimón J, Fortea J, Frolich L, Santana I, Molinuevo JL, Lehmann S, Visser PJ, Teunissen CE, Zetterberg H, Blennow K Abstract INTRODUCTION: Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. METHODS: We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses wer...
Source: The Journal of Alzheimers Association - April 12, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease.
DISCUSSION: Biologists can use these freely-available tools to obtain a comprehensive, information-rich view of the pathways in AD. PMID: 30935898 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 3, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Erratum to "Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome" [Alzheimer's & Dementia 2019;15:76-92.].
Erratum to "Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome" [Alzheimer's & Dementia 2019;15:76-92.]. Alzheimers Dement. 2019 Mar 21;: Authors: PMID: 30905591 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 26, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial.
DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. PMID: 30894299 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 23, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A randomized clinical trial to evaluate home-based assessment of people over 75  years old.
DISCUSSION: Relatively low efficiency of internet-based assessment compared with testing by live-assessors has implications for internet-based recruitment and assessment efforts currently proposed for diverse populations. PMID: 30872114 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Impact of Helicobacter pylori and/or Helicobacter pylori-related metabolic syndrome on incidence of all-cause and Alzheimer's dementia.
Authors: Kountouras J, Doulberis M, Polyzos SA, Katsinelos T, Vardaka E, Kountouras C, Arapoglou S, Exadaktylos AK, Deretzi G, Tsolaki M, Boziki M, Katsinelos P PMID: 30872115 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Primary age-related tauopathy (PART) and Alzheimer's disease (AD).
Authors: Jellinger KA PMID: 30853463 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum.
DISCUSSION: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker. PMID: 30853464 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.
DISCUSSION: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake. PMID: 30853465 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Detecting both current and prior Helicobacter pylori infection is important to assess its impact on dementia.
Authors: Roubaud-Baudron C, Mégraud F, Salles N, Dartigues JF, Letenneur L PMID: 30853466 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia.
DISCUSSION: Self-reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases. PMID: 30852157 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 12, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.
DISCUSSION: Early abnormalities in CSF tTau, pTau, SNAP-25, VILIP-1, and YKL-40 suggest that synaptic damage, neuronal injury, and neuroinflammation begin shortly after the commencement of brain amyloid accumulation. PMID: 30846386 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 10, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Parkinsonism in MCI or mild Alzheimer's disease.
Authors: Jellinger KA PMID: 30827873 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 6, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Brain arterial dilatation and the risk of Alzheimer's disease.
DISCUSSION: Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD. PMID: 30827874 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 6, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline.
Authors: Zhang F, Zhong R, Li S, Fu Z, Wang R, Wang T, Huang Z, Le W Abstract OBJECTIVE: The present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alzheimer's disease (AD). BACKGROUND AND RATIONALE: Sleep disturbance is common in patients with AD. It is not known if it can occur at the early stage of AD and if EEG recording may help identify the early sign of the disease. HISTORICAL EVOLUTION: Sleep disturbance in AD has generally been considered as late consequence of the neurodegenerative process. A growing body of evidence has ...
Source: The Journal of Alzheimers Association - March 4, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study.
DISCUSSION: Preliminary evidence suggests that protective effects of the MIND diet are geographically generalizable. Additional prospective studies are needed in diverse samples to determine the relative effects of the MIND and the Mediterranean diets against cognitive decline. PMID: 30826160 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 4, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Incidence of dementia after age 90 in a multiracial cohort.
DISCUSSION: Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude. PMID: 30797730 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 26, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort.
DISCUSSION: Despite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies. PMID: 30792090 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 24, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Hospitalization, surgery, and incident dementia.
DISCUSSION: We confirm hospitalization as a risk factor for dementia, with repeated hospitalizations a more important risk factor than surgery. PMID: 30777379 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 21, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

GeneMatch: A novel recruitment registry using at-home APOE genotyping to enhance referrals to Alzheimer's prevention studies.
Authors: Langbaum JB, Karlawish J, Roberts JS, Wood EM, Bradbury A, High N, Walsh TL, Gordon D, Aggarwal R, Davis P, Stowell C, Trisko L, Langlois CM, Reiman EM, Tariot PN Abstract INTRODUCTION: Recruitment for Alzheimer's disease (AD) prevention research studies is challenging because of lack of awareness among cognitively healthy adults coupled with the high screen fail rate due to participants not having a genetic risk factor or biomarker evidence of the disease. Participant recruitment registries offer one solution for efficiently and effectively identifying, characterizing, and connecting potential eligible vo...
Source: The Journal of Alzheimers Association - February 20, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset.
DISCUSSION: Duration of each preclinical stage can be estimated in ADAD, facilitating better planning of prevention trials with the EYO cutoffs under the recently released FDA guidance. The generalization of these results to sporadic AD warrants further investigation. PMID: 30773445 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 20, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Clinical and cortical decline in the aphasic variant of Alzheimer's disease.
DISCUSSION: Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non-Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials. PMID: 30765195 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
We report a family with a novel variant in PSEN1. METHODS: We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing. RESULTS: Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 ...
Source: The Journal of Alzheimers Association - February 14, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Erratum to "Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies" [Alzheimer's & Dementia 2018;14:707-22.].
Erratum to "Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies" [Alzheimer's & Dementia 2018;14:707-22.]. Alzheimers Dement. 2019 Feb;15(2):319 Authors: PMID: 30736960 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 11, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Erratum to "Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults" [Alzheimer's & Dementia 2018;14:1640-50.].
Erratum to "Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults" [Alzheimer's & Dementia 2018;14:1640-50.]. Alzheimers Dement. 2019 Feb;15(2):319 Authors: PMID: 30736961 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 11, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Early versus late MCI: Improved MCI staging using a neuropsychological approach.
CONCLUSIONS: Our novel neuropsychological approach improved the staging of MCI by (1) capturing individuals at an early symptomatic stage, (2) minimizing false-positive cases, and (3) identifying a late MCI group further along the disease trajectory. PMID: 30737119 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 11, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Alzheimer's disease and glaucoma: Look-alike neurodegenerative diseases.
Authors: Wostyn P, Van Dam D, De Deyn PP PMID: 30713020 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 6, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Longitudinal study of hearing loss and subjective cognitive function decline in men.
We examined the relation between self-reported hearing loss, hearing aid use, and risk of subjective cognitive function (SCF) decline. METHODS: We conducted an 8-year (2008-2016) longitudinal study of 10,107 men aged ≥62 years who reported their hearing status in 2006 and had no subjective cognitive concerns in 2008. Change in SCF scores was assessed by a 6-item questionnaire, and subjective decline was defined as new report of at least one SCF concern during follow-up. RESULTS: Hearing loss was associated with higher risk of SCF decline. Compared with no hearing loss, the multivariable-adjusted relative ri...
Source: The Journal of Alzheimers Association - February 4, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

"Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia".
"Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". Alzheimers Dement. 2019 Jan;15(1):153-157 Authors: Jagust W, Jack CR, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Sperling R PMID: 30642435 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Authors: Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler...
Source: The Journal of Alzheimers Association - January 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The National Institute on Aging and Alzheimer's Association research framework: A commentary from the Cochrane Dementia and Cognitive Improvement Group.
Authors: McCleery J, Flicker L, Richard E, Quinn TJ PMID: 30642437 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The 2018 NIA-AA research framework: Recommendation and comments.
Authors: Louie R PMID: 30642438 [PubMed - in process] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 17, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease.
DISCUSSION: Optimized tau PET classifiers may diagnose AD with high accuracy, but both tau PET and structural brain MRI capture partly unique information relevant for the clinical deterioration in AD. PMID: 30639421 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 15, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Artificially low mild cognitive impairment to normal reversion rate in Alzheimer's Disease Neuroimaging Initiative.
We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative (ADNI). METHODS: CN and MCI participants were identified as remaining stable, progressing, or reverting at 1-year of follow-up (Year 1). Application of ADNI's MCI criteria at Year 1 and Alzheimer's disease biomarkers by group were examined. RESULTS: The MCI-to-CN reversion rate was 3.0%. When specific components were examined, 22.5% of stable MCI participants had normal memory performance at Year 1 and their Alzheimer's disease biomarkers were consistent with the ...
Source: The Journal of Alzheimers Association - January 7, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Genetic screen in a large series of patients with primary progressive aphasia.
DISCUSSION: Our results show that while pathogenic variants within the most common dementia genes were rarely associated with PPA, these were found almost exclusively in GRN and C9orf72, suggesting that PPA is more TDP43- than tau-related in our series. This is consistent with the finding that PPA frequency in dominantly inherited dementias is the highest in kindreds with GRN variants. PMID: 30599136 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.
Authors: Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M...
Source: The Journal of Alzheimers Association - December 19, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia.
DISCUSSION: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. PMID: 30555032 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 19, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Dietary changes and cognition over 2  years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).
DISCUSSION: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition. PMID: 30527596 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 12, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease.
DISCUSSION: Our results provide new insight into AP composition. We demonstrate unexpected differences between AD, non-AD, and APP/PS1 mouse APs, which may relate to different pathological processes. PMID: 30502339 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 8, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome.
DISCUSSION: Our findings address uncertainties around the development of randomized controlled trials to delay cognitive decline in DS. Such trials are essential to reduce the high burden of dementia in people with DS and could serve as proof-of-principle trials for some drug targets. PMID: 30503169 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 8, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
DISCUSSION: Our study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case-control study. PMID: 30503768 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 8, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016.
Authors: Sommerlad A, Perera G, Singh-Manoux A, Lewis G, Stewart R, Livingston G PMID: 30476466 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 28, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia.
DISCUSSION: The WHELD intervention has clinical and economic benefits when used in residents with clinically significant agitation. PMID: 30470592 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 26, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.
We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease. METHODS: Nine middle-aged (mean = 11.2 years) and nine aged (mean = 21.7 years) female vervet/African green monkeys underwent cerebrospinal fluid collection, gait speed measurement, and neuroimaging before neuropathologic assessment. RESULTS: β-amyloid plaques were identified in all aged vervets and paired helical filament tau immunoreactivity was observed in all animals. Cerebrospinal fluid β-amyloid42 and gait speed correlated negatively wit...
Source: The Journal of Alzheimers Association - November 25, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease.
DISCUSSION: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning. PMID: 30465754 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 23, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
DISCUSSION: In vitro phagocytosis of hPSC monocytes and tMGs was not affected by the TREM2+/R47H mutation but was significantly impaired in TREM2+/- and TREM2-/- progeny. PMID: 30442540 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 19, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach.
We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence-based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N-of-1 effectiveness (trial registered at ClinicalTrials.gov NCT03687710). Prior preliminary results suggest that the clinical practice of AD risk reduction is feasible, with measurable improvements in cognition and biomarkers of AD risk. We propose using these early findings as a foundation to evaluate the...
Source: The Journal of Alzheimers Association - November 19, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.
DISCUSSION: Exploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia. PMID: 30439332 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 16, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.
Authors: Oppedal K, Ferreira D, Cavallin L, Lemstra AW, Ten Kate M, Padovani A, Rektorova I, Bonanni L, Wahlund LO, Engedal K, Nobili F, Kramberger M, Taylor JP, Hort J, Snædal J, Blanc F, Walker Z, Antonini A, Westman E, Aarsland D, Alzheimer's Disease Neuroimaging Initiative Abstract INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior at...
Source: The Journal of Alzheimers Association - November 16, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research