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Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
DISCUSSION: Increasing genetic diversity promotes resilience to AD-related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD.HIGHLIGHTS: Genetic diversity's impact on AD in mice was explored. Diverse F1 mouse strains were used for AD study, via the Collaborative Cross. Strain-specific variations in AD pathology, glia, and transcription were found. Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified. Correlations with human AD transcriptomics were observed.PMID:38426...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Neelakshi Soni Lindsay A Hohsfield Kristine M Tran Shimako Kawauchi Amber Walker Dominic Javonillo Jimmy Phan Dina Matheos Celia Da Cunha Asli Uyar Giedre Milinkeviciute Angela Gomez-Arboledas Katelynn Tran Catherine C Kaczorowski Marcelo A Wood Andrea J Source Type: research

Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study
DISCUSSION: SCI sensitivity (63.4%) and specificity (92.5%) against dementia were comparable with similar metrics for the NHATS probable dementia measure against the "gold-standard" Aging, Demographics, and Memory Study-based dementia criteria, implying that population-based surveys may afford cost-effective opportunities for dementia surveillance to assess risk and inform policy.HIGHLIGHTS: The prevalence of subjective cognitive impairment (SCI) is generally higher than that of a validated measure of probable dementia, particularly within the youngest age group, females, Whites, and persons with a college or higher degree...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Linda C Chyr Jennifer L Wolff Julie M Zissimopoulos Emmanuel F Drabo Source Type: research

Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease
DISCUSSION: Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.PMID:38421123 | DOI:10.1002/alz.13733 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 29, 2024 Category: Psychiatry Authors: Coco Newton Marianna Pope Catarina Rua Richard Henson Zilong Ji Neil Burgess Christopher T Rodgers Matthias Stangl Maria-Eleni Dounavi Andrea Castegnaro Ivan Koychev Paresh Malhotra Thomas Wolbers Karen Ritchie Craig W Ritchie John O'Brien Li Su Dennis Ch Source Type: research

The Bio-Hermes Study: Biomarker database developed to investigate blood-based and digital biomarkers in community-based, diverse populations clinically screened for Alzheimer's disease
DISCUSSION: Blood-based biomarkers are highly associated with amyloid PET/CSF results in diverse populations enrolled at clinical trial sites.HIGHLIGHTS: Amyloid beta (Aβ)42/Aβ40, phosphorylated tau (p-tau)181, and p-tau 217 blood-based biomarkers predicted brain amyloid positivity. P-tau 217 was the strongest predictor of brain amyloid positivity. Biomarkers from diverse ethnic, racial, and clinical cohorts predicted brain amyloid positivity. Community-based populations have similar Alzheimer's disease (AD) biomarker levels as other populations. A prescreen process with blood-based assays may reduce the number of AD tri...
Source: The Journal of Alzheimers Association - February 28, 2024 Category: Psychiatry Authors: Richard C Mohs Douglas Beauregard John Dwyer Jennifer Gaudioso Jason Bork Tamiko MaGee-Rodgers Mickeal N Key Diana R Kerwin Lynn Hughes Cyndy B Cordell Bio-Hermes Collaborative Group Source Type: research

U.S. dementia care spending by state: 2010-2019
DISCUSSION: The cost of informal care varied substantially by state and is expected to grow through at least 2050.HIGHLIGHTS: In the United States in 2019, foregone wages due to informal dementia care was $58 billion. Replacing informal dementia care with health aides would have cost $230 billion. These costs vary dramatically by state, even when assessed per prevalent case. These costs are expected to nearly double by 2050.PMID:38411287 | DOI:10.1002/alz.13746 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 27, 2024 Category: Psychiatry Authors: Amy Lastuka Michael R Breshock Theresa A McHugh William T Sogge Vivianne Swart Joseph L Dieleman Source Type: research

Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease
DISCUSSION: Increased plasma C3 in AD are associated with amyloid pathology, possibly reflecting a defense response for Aβ clearance. Further studies on Aβ-binding proteins will enhance understanding of Aβ mechanisms in blood.PMID:38411315 | DOI:10.1002/alz.13734 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 27, 2024 Category: Psychiatry Authors: Kyu Hwan Shim Danyeong Kim Min Ju Kang Jung-Min Pyun Young Ho Park Young Chul Youn Kyung Won Park Kyoungho Suk Ho-Won Lee B árbara Fernandes Gomes Henrik Zetterberg Seong Soo A An SangYun Kim Alzheimer's Disease All Markers (ADAM) Research group Source Type: research

Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change
DISCUSSION: Neighborhood disadvantage appears to be associated with decreased cognitive reserve. This association is modified by education but is independent of the major dementia-associated neuropathologies.PMID:38400524 | DOI:10.1002/alz.13736 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 24, 2024 Category: Psychiatry Authors: Boram Kim Isabel Yannatos Kaitlin Blam Douglas Wiebe Sharon X Xie Corey T McMillan Dawn Mechanic-Hamilton David A Wolk Edward B Lee Source Type: research

Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies
DISCUSSION: Patient- and proxy-reported quality of life (QoL) should be assessed separately in advanced DLB. Some symptoms associated with QoL have available therapeutic options. Research is needed regarding strategies to optimally improve QoL in DLB.HIGHLIGHTS: Patient and proxy quality of life (QoL) ratings had moderate correlation in advanced dementia with Lewy bodies. Daytime sleepiness affected patient- and proxy-reported QoL. Behavioral symptoms affected patient- and proxy-reported QoL. Autonomic symptom burden affected patient-reported QoL. Dementia severity, dependence, and caregiver experiences affected proxy rati...
Source: The Journal of Alzheimers Association - February 24, 2024 Category: Psychiatry Authors: Melissa J Armstrong Brian LaBarre Kaitlin Sovich Susan M Maixner Henry L Paulson Carol Manning Julie A Fields Angela Lunde Leah Forsberg Bradley F Boeve James E Galvin Angela S Taylor Zhigang Li Source Type: research

Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
DISCUSSION: LC analysis indicates that amyloid reduction is associated with improved clinical outcomes and supports its use as a surrogate biomarker in clinical trials.HIGHLIGHTS: We used latent class (LC) analysis to test amyloid reduction as a surrogate biomarker. Despite similar baseline characteristics, the amyloid-reduction class exhibited remarkably better outcomes compared to the amyloid-growth class across multiple measures. LC analysis proves valuable in testing amyloid reduction as a surrogate biomarker in clinical trials lacking significant treatment effects.PMID:38400532 | DOI:10.1002/alz.13735 (Source: The Jou...
Source: The Journal of Alzheimers Association - February 24, 2024 Category: Psychiatry Authors: Guoqiao Wang Yan Li Chengjie Xiong Tammie L S Benzinger Brian A Gordon Jason Hassenstab Andrew J Aschenbrenner Eric McDade David B Clifford Jorge J Libre-Guerra Xinyu Shi Catherine J Mummery Christopher H van Dyck James J Lah Lawrence S Honig Gregg Day Jo Source Type: research

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research
Alzheimers Dement. 2024 Feb 24. doi: 10.1002/alz.13742. Online ahead of print.ABSTRACTThe fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address training gaps in preclinical translational studies for Alzheimer's disease (AD). In addition to providing fundamental knowledge and hands-on skills essential for executing rigorous in vivo studies that are designed to facilitate translation, each year the workshop aims to provide insight on state...
Source: The Journal of Alzheimers Association - February 24, 2024 Category: Psychiatry Authors: Michael Sasner Kristen D Onos Paul R Territo Stacey J Sukoff Rizzo Source Type: research