The Journal of Alzheimers Association 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.20-year depressive symptoms, dementia, and structural neuropathology in older women
DISCUSSION: There are heterogeneous profiles of depressive symptoms and dementia risk. Common neuropathological factors may contribute to both depression and dementia. Highlights The progression of depressive symptoms and concurrent dementia risk is heterogeneous. Emerging depressive symptoms may be a prodromal symptom of dementia. Cerebrovascular disease and AD are potentially shared neuropathological factors.PMID:38591250 | DOI:10.1002/alz.13781 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 9, 2024 Category: Psychiatry Authors: Andrew J Petkus Xinhui Wang Diana Younan Lauren E Salminen Susan M Resnick Stephen R Rapp Mark A Espeland Margaret Gatz Keith F Widaman Ramon Casanova Helena Chui Ryan T Barnard Sarah A Gaussoin Joseph S Goveas Kathleen M Hayden Victor W Henderson Bonnie Source Type: research
Automatic classification of AD pathology in FTD phenotypes using natural speech
DISCUSSION: Brief naturalistic speech samples can be used for screening FTD patients for underlying ADNC in vivo. This work supports the future development of digital assessment tools for FTD.HIGHLIGHTS: We trained machine learning classifiers for frontotemporal dementia patients using natural speech. We grouped participants by neuropathological diagnosis (autopsy) or cerebrospinal fluid biomarkers. Classifiers well distinguished underlying pathology (Alzheimer's disease vs. frontotemporal lobar degeneration) in patients. We identified important features through an explainable artificial intelligence approach. This work la...
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Sunghye Cho Christopher A Olm Sharon Ash Sanjana Shellikeri Galit Agmon Katheryn A Q Cousins David J Irwin Murray Grossman Mark Liberman Naomi Nevler Source Type: research
Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hA β-KI) mice
DISCUSSION: These findings highlight a sex-dependent variation in the microbiomes of hAβ-KI mice and underscore the importance of considering the microbiome when designing studies that use murine models for AD.HIGHLIGHTS: Microbial diversity and the abundance of several species differed in human amyloid beta knock-in (hAβ-KI) females but not males. Correlations to Alzheimer's disease (AD) genotype were stronger for the microbiome than the metabolome. Microbiomes from hAβ-KI mice were distinct from 3xTg-AD mice. Cage effects accounted for most of the variance in the microbiome and metabolome.PMID:38572865 | DOI:10.1002/a...
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Sage J B Dunham Julio Avelar-Barragan Jason A Rothman Eric D Adams Gina Faraci Stefania Forner Shimako Kawauchi Andrea J Tenner Kim N Green Frank M LaFerla Grant R MacGregor Mark Mapstone Katrine L Whiteson Source Type: research
Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study
DISCUSSION: Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.PMID:38574374 | DOI:10.1002/alz.13761 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Ariane Bollack Lyduine E Collij David V állez García Mahnaz Shekari Daniele Altomare Pierre Payoux Bruno Dubois Oriol Grau-Rivera Merc è Boada Marta Marqui é Agneta Nordberg Zuzana Walker Philip Scheltens Michael Sch öll Robin Wolz Jonathan M Schott Source Type: research
Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations
We report the successful generation of genetically engineered marmosets harboring knock-in point mutations in the PSEN1 gene. PSEN1 marmosets and their germline offspring recapitulate the early emergence of AD-related biomarkers. Studies as early in life as possible in PSEN1 marmosets will enable the identification of primate-specific mechanisms that drive disease progression.PMID:38574388 | DOI:10.1002/alz.13806 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Gregg E Homanics Jung Eun Park Lauren Bailey David J Schaeffer Lauren Schaeffer Jie He Shuoran Li Tingting Zhang Annat Haber Catrina Spruce Anna Greenwood Takeshi Murai Laura Schultz Lauren Mongeau Seung-Kwon Ha Julia Oluoch Brianne Stein Sang Ho Choi Has Source Type: research
Data-driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset
DISCUSSION: Our data-driven methods outperformed consensus diagnosis by providing more precise information about progression risk and revealing heterogeneity in cognition and progression risk within the NACC "normal cognition" group.PMID:38574399 | DOI:10.1002/alz.13793 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Emily C Edmonds Kelsey R Thomas Steven Z Rapcsak Shannon L Lindemer Lisa Delano-Wood David P Salmon Mark W Bondi Source Type: research
Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology
DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease-specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia.PMID:38574400 | DOI:10.1002/alz.13791 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Kristiana Xhima Julie Ottoy Erin Gibson Katherine Zukotynski Christopher Scott Ginelle J Feliciano Sabrina Adamo Phillip H Kuo Michael J Borrie Howard Chertkow Richard Frayne Robert Laforce Michael D Noseworthy Frank S Prato Demetrios J Sahlas Eric E Smit Source Type: research
Plasma oxysterols are associated with serum lipids and dementia risk in older women
DISCUSSION: Less favorable lipid profiles were associated with higher oxysterol levels. A higher ratio of 24-OHC/27-OHC may contribute to dementia risk in APOE3 and APOE4+ carriers.PMID:38574442 | DOI:10.1002/alz.13811 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Michelle M Dunk Stephen R Rapp Kathleen M Hayden Mark A Espeland Ramon Casanova JoAnn E Manson Aladdin H Shadyab Robert Wild Ira Driscoll Source Type: research
Automatic classification of AD pathology in FTD phenotypes using natural speech
DISCUSSION: Brief naturalistic speech samples can be used for screening FTD patients for underlying ADNC in vivo. This work supports the future development of digital assessment tools for FTD.HIGHLIGHTS: We trained machine learning classifiers for frontotemporal dementia patients using natural speech. We grouped participants by neuropathological diagnosis (autopsy) or cerebrospinal fluid biomarkers. Classifiers well distinguished underlying pathology (Alzheimer's disease vs. frontotemporal lobar degeneration) in patients. We identified important features through an explainable artificial intelligence approach. This work la...
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Sunghye Cho Christopher A Olm Sharon Ash Sanjana Shellikeri Galit Agmon Katheryn A Q Cousins David J Irwin Murray Grossman Mark Liberman Naomi Nevler Source Type: research
Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hA β-KI) mice
DISCUSSION: These findings highlight a sex-dependent variation in the microbiomes of hAβ-KI mice and underscore the importance of considering the microbiome when designing studies that use murine models for AD.HIGHLIGHTS: Microbial diversity and the abundance of several species differed in human amyloid beta knock-in (hAβ-KI) females but not males. Correlations to Alzheimer's disease (AD) genotype were stronger for the microbiome than the metabolome. Microbiomes from hAβ-KI mice were distinct from 3xTg-AD mice. Cage effects accounted for most of the variance in the microbiome and metabolome.PMID:38572865 | DOI:10.1002/a...
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Sage J B Dunham Julio Avelar-Barragan Jason A Rothman Eric D Adams Gina Faraci Stefania Forner Shimako Kawauchi Andrea J Tenner Kim N Green Frank M LaFerla Grant R MacGregor Mark Mapstone Katrine L Whiteson Source Type: research
Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study
DISCUSSION: Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.PMID:38574374 | DOI:10.1002/alz.13761 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Ariane Bollack Lyduine E Collij David V állez García Mahnaz Shekari Daniele Altomare Pierre Payoux Bruno Dubois Oriol Grau-Rivera Merc è Boada Marta Marqui é Agneta Nordberg Zuzana Walker Philip Scheltens Michael Sch öll Robin Wolz Jonathan M Schott Source Type: research
Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations
We report the successful generation of genetically engineered marmosets harboring knock-in point mutations in the PSEN1 gene. PSEN1 marmosets and their germline offspring recapitulate the early emergence of AD-related biomarkers. Studies as early in life as possible in PSEN1 marmosets will enable the identification of primate-specific mechanisms that drive disease progression.PMID:38574388 | DOI:10.1002/alz.13806 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Gregg E Homanics Jung Eun Park Lauren Bailey David J Schaeffer Lauren Schaeffer Jie He Shuoran Li Tingting Zhang Annat Haber Catrina Spruce Anna Greenwood Takeshi Murai Laura Schultz Lauren Mongeau Seung-Kwon Ha Julia Oluoch Brianne Stein Sang Ho Choi Has Source Type: research
Data-driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset
DISCUSSION: Our data-driven methods outperformed consensus diagnosis by providing more precise information about progression risk and revealing heterogeneity in cognition and progression risk within the NACC "normal cognition" group.PMID:38574399 | DOI:10.1002/alz.13793 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Emily C Edmonds Kelsey R Thomas Steven Z Rapcsak Shannon L Lindemer Lisa Delano-Wood David P Salmon Mark W Bondi Source Type: research
Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology
DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease-specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia.PMID:38574400 | DOI:10.1002/alz.13791 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Kristiana Xhima Julie Ottoy Erin Gibson Katherine Zukotynski Christopher Scott Ginelle J Feliciano Sabrina Adamo Phillip H Kuo Michael J Borrie Howard Chertkow Richard Frayne Robert Laforce Michael D Noseworthy Frank S Prato Demetrios J Sahlas Eric E Smit Source Type: research
