The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease
DISCUSSION: YOAD patients display a different pattern of morbidity up to 10 years prior to diagnosis. Awareness of specific alterations in morbidity may improve efforts toward a timely diagnosis.HIGHLIGHTS: Retrospective, nested case-control study of young onset Alzheimer's disease (YOAD). YOAD cases had a higher morbidity burden than controls. YOAD cases had a higher psychiatric morbidity burden up to 10 years before diagnosis. Altered morbidity patterns could serve as an early warning sign of YOAD.PMID:38294143 | DOI:10.1002/alz.13681 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 31, 2024 Category: Psychiatry Authors: Line Damsgaard Janet Janbek Thomas M Laursen Peter H øgh Karsten Vestergaard Hanne Gottrup Christina Jensen-Dahm Gunhild Waldemar Source Type: research

Importance of cerebrospinal fluid (CSF) collection protocol for the accurate diagnosis of Alzheimer's disease when using CSF biomarkers
Alzheimers Dement. 2024 Jan 30. doi: 10.1002/alz.13721. Online ahead of print.NO ABSTRACTPMID:38288880 | DOI:10.1002/alz.13721 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 30, 2024 Category: Psychiatry Authors: Alicia Algeciras-Schimnich Joshua A Bornhorst Source Type: research

Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings
DISCUSSION: Our data suggest that measuring blood biomarkers related to AD pathology and neurodegeneration from DPSvenous extends the utility of blood-based biomarkers to remote settings with simplified sampling conditions, storage, and logistics.HIGHLIGHTS: A wide array of biomarkers related to Alzheimer's disease (AD) and neurodegeneration were detectable in dried plasma spots (DPSvenous ). DPSvenous biomarkers correlated with standard procedures and cognitive status. DPSvenous biomarkers had a good diagnostic accuracy discriminating amyloid status. Our findings show the potential interchangeability of DPSvenous and plas...
Source: The Journal of Alzheimers Association - January 29, 2024 Category: Psychiatry Authors: Hanna Huber Kaj Blennow Henrik Zetterberg Merc é Boada Andreas Jeromin Haley Weninger Raul Nu ñez-Llaves N úria Aguilera Maribel Ramis Joel Simr én Johanna Nilsson Juan Lantero-Rodriguez Adelina Orellana Fernando Garc ía-Gutiérrez Xavier Morat ó Ni Source Type: research

Social frailty and the incidence of motoric cognitive risk syndrome in older adults
DISCUSSION: Social frailty was associated with an increased risk of incident MCR in older adults.HIGHLIGHTS: Various associations between social factors and motoric cognitive risk syndrome (MCR) have been reported. Social frailty that integrated from multiple social factors was associated with an increased risk of incident MCR. Social frailty should be included in the early screening of individuals to identify those at higher risk of MCR.PMID:38284799 | DOI:10.1002/alz.13696 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 29, 2024 Category: Psychiatry Authors: Hui Zhang Zixin Hu Shuai Jiang Meng Hao Yi Li Yining Liu Xiao-Yan Jiang Li Jin Xiaofeng Wang Source Type: research

Cross-national comparisons of later-life cognitive function using data from the Harmonized Cognitive Assessment Protocol (HCAP): Considerations and recommended best practices
Alzheimers Dement. 2024 Jan 29. doi: 10.1002/alz.13694. Online ahead of print.ABSTRACTThe Harmonized Cognitive Assessment Protocol (HCAP) is a major innovation that provides, for the first time, harmonized data for cross-national comparisons of later-life cognitive functions that are sensitive to linguistic, cultural, and educational differences across countries. However, cognitive function does not lend itself to direct comparison across diverse populations without careful consideration of the best practices for such comparisons. This perspective discusses theoretical and methodological considerations and offers a set of ...
Source: The Journal of Alzheimers Association - January 29, 2024 Category: Psychiatry Authors: Lindsay C Kobayashi Richard N Jones Emily M Brice ño Miguel Arce Renter ía Yuan Zhang Erik Meijer Kenneth M Langa Jinkook Lee Alden L Gross Source Type: research

More than a piece of cake: Noun classifier processing in primary progressive aphasia
This study highlights noun classifiers as linguistic markers to discriminate PPA syndromes in Chinese speakers.HIGHLIGHTS: Noun classifier processing varies in the different primary progressive aphasia (PPA) variants. Specifically, semantic variant PPA (svPPA) and logopenic variant PPA (lvPPA) patients showed significantly lower ability in producing specific classifiers. Compared to lvPPA, svPPA patients were less able to choose the accurate classifiers when presented with choices. In svPPA, classifier production score was positively correlated with gray matter volume over bilateral temporal and left visual association cor...
Source: The Journal of Alzheimers Association - January 29, 2024 Category: Psychiatry Authors: Boon Lead Tee Lorinda Kwan-Chen Li-Ying Ta-Fu Chen Connie Ty Yan Joshua Tsoh Andrew Lung-Tat Chan Adrian Wong Raymond Y Lo Chien Jung Lu Yu Sun Pei-Ning Wang YiChen Lee Ming-Jang Chiu Isabel Elaine Allen Giovanni Battistella Thomas H Bak Yu-Chen Chuang Ad Source Type: research

No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer's disease
Alzheimers Dement. 2024 Jan 25. doi: 10.1002/alz.13709. Online ahead of print.NO ABSTRACTPMID:38273437 | DOI:10.1002/alz.13709 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 26, 2024 Category: Psychiatry Authors: Laura Deecke Jan Homann David Goldecktble Olena Ohlei Valerija Dobricic Johanna Drewelies Ilja Demuth Graham Pawelec Lars Bertram Christina M Lill Source Type: research

Walking the talk for dementia: A unique immersive, embodied, and multi-experiential initiative
Alzheimers Dement. 2024 Jan 26. doi: 10.1002/alz.13644. Online ahead of print.ABSTRACTCoping with dementia requires an integrated approach encompassing personal, health, research, and community domains. Here we describe "Walking the Talk for Dementia," an immersive initiative aimed at empowering people with dementia, enhancing dementia understanding, and inspiring collaborations. This initiative involved 300 participants from 25 nationalities, including people with dementia, care partners, clinicians, policymakers, researchers, and advocates for a 4-day, 40 km walk through the Camino de Santiago de Compostela, Spain. A 2-d...
Source: The Journal of Alzheimers Association - January 26, 2024 Category: Psychiatry Authors: Fernando Aguzzoli Peres Aline Nogueira Haas Angga Dwi Martha Melissa Chan Michelle Steele Maria Teresa Ferretti Ntokozo N Ngcobo Stefania Ilinca Clara Dom ínguez-Vivero Iracema Leroi Nisha Sajnani Eduardo R Zimmer Alex Kornhuber Alexandre Kalache Berrie Source Type: research

Harmonizing florbetapir and PiB PET measurements of cortical A β plaque burden using multiple regions-of-interest and machine learning techniques: An alternative to the Centiloid approach
DISCUSSION: ML improved mcAβ comparability. Additional studies are needed for the generalizability to other amyloid tracers, and to tau PET. Highlights Centiloid is a calibration of the amyloid scale, not harmonization. Centiloid unifies the amyloid scale without improving inter-tracer association (R2 ). Machine learning (ML) can harmonize the amyloid scale by improving R2 . ML harmonization maps multi-regional florbetapir SUVRs to PiB mean-cortical SUVR. Artificial neural network ML increases Centiloid R2 from 86% to 97%.PMID:38276892 | DOI:10.1002/alz.13677 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 26, 2024 Category: Psychiatry Authors: Kewei Chen Valentina Ghisays Ji Luo Yinghua Chen Wendy Lee Teresa Wu Eric M Reiman Yi Su Source Type: research

Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging
We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health.METHODS: We analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease-related dementia (AD/ADRD).RESULTS: In fully adjusted models, having more teeth was associated with l...
Source: The Journal of Alzheimers Association - January 26, 2024 Category: Psychiatry Authors: Tom Rubinstein Adam M Brickman Bin Cheng Sandra Burkett Heekuk Park Medini K Annavajhala Anne-Catrin Uhlemann Howard Andrews Jose Gutierrez Bruce J Paster James M Noble Panos N Papapanou Source Type: research

C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease
DISCUSSION: Reduction of excessive synaptic pruning is an additional beneficial outcome of the suppression of C5a-C5aR1 signaling, further supporting its potential as an effective targeted therapy to treat AD.HIGHLIGHTS: C5aR1 ablation restores long-term potentiation in the Arctic model of AD. C5aR1 ablation rescues region specific excessive pre-synaptic loss. C5aR1 antagonist, PMX205, rescues VGlut1 loss in the Tg2576 model of AD. C1q tagging is not sufficient to induce VGlut1 microglial ingestion. Astrocytes contribute to excessive pre-synaptic loss at late stages of the disease.PMID:38278523 | DOI:10.1002/alz.13682 (Sou...
Source: The Journal of Alzheimers Association - January 26, 2024 Category: Psychiatry Authors: Angela Gomez-Arboledas Maria I Fonseca Enik ö Kramar Shu-Hui Chu Nicole D Schartz Purnika Selvan Marcelo A Wood Andrea J Tenner Source Type: research

Care sequences leading to the diagnosis of Alzheimer's disease and related dementias: An analysis of electronic health records
CONCLUSIONS: Several distinct patterns of care leading to ADRD diagnoses were identified. Integrated care models are needed to promote early identification of ADRD.HIGHLIGHTS: Dementia patients followed distinct care pathways prior to their dementia diagnoses. Key sociodemographic traits contributed to the variation in the sequences of care. Racial differences in the sequencing of care were also found, but only in women.PMID:38270269 | DOI:10.1002/alz.13669 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 25, 2024 Category: Psychiatry Authors: Hanzhang Xu Teah M Bayless Truls Østbye Matthew E Dupre Source Type: research

Down Syndrome Biobank Consortium: A perspective
Alzheimers Dement. 2024 Jan 25. doi: 10.1002/alz.13692. Online ahead of print.ABSTRACTIndividuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals with DS are often excluded. Furthermore, timely diagnosis or management is often not available. Of the genetic causes of AD, people with DS represent the largest cohort. Currently, there is a knowledge gap regarding the underlying neurobiological mechanisms of DS-related AD (DS-AD),...
Source: The Journal of Alzheimers Association - January 25, 2024 Category: Psychiatry Authors: Iban Aldecoa Isabel Barroeta Steven L Carroll Juan Fortea Anah Gilmore Stephen D Ginsberg Samuel J Guzman Eric D Hamlett Elizabeth Head Sylvia E Perez Huntington Potter Laura Molina-Porcel Ruma Raha-Chowdhury Thomas Wisniewski William H Yong Shahid Zaman Source Type: research

Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta-analysis
DISCUSSION: SVD and vascular dementia may be associated with occupational/domestic exposure to hazardous substances. CRD42021297800.PMID:38270898 | DOI:10.1002/alz.13647 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 25, 2024 Category: Psychiatry Authors: Una Clancy Yajun Cheng Amrita Brara Fergus N Doubal Joanna M Wardlaw Source Type: research

Lewy body dementia: Overcoming barriers and identifying solutions
Alzheimers Dement. 2024 Jan 24. doi: 10.1002/alz.13674. Online ahead of print.ABSTRACTDespite its high prevalence among dementias, Lewy body dementia (LBD) remains poorly understood with a limited, albeit growing, evidence base. The public-health burden that LBD imposes is worsened by overlapping pathologies, which contribute to misdiagnosis, and lack of treatments. For this report, we gathered and analyzed public-domain information on advocacy, funding, research outputs, and the therapeutic pipeline to identify gaps in each of these key elements. To further understand the current gaps, we also conducted interviews with le...
Source: The Journal of Alzheimers Association - January 24, 2024 Category: Psychiatry Authors: Kanishka Agarwal Wendi Backler Ece Bayram Leah Bloom Bradley F Boeve Jang-Ho Cha Maria Denslow Tanis J Ferman Douglas Galasko James E Galvin Stephen N Gomperts Michael C Irizarry Kejal Kantarci Harsh Kaushik Matt Kietlinski Aaron Koenig James B Leverenz I Source Type: research