The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes
DISCUSSION: In this review we describe the role of TAU isoforms in health and disease, and stress the importance of comprehending and studying TAU isoforms in both, physiological and pathological context, in order to develop targeted therapeutic interventions for TAU-associated diseases.HIGHLIGHTS: MAPT splicing is tightly regulated during neuronal maturation and throughout life. TAU isoform expression is development-, cell-type and brain region specific. The contribution of TAU to neurodegeneration might be isoform-specific. Ineffective TAU-based therapies highlight the need for specific targeting strategies.PMID:38556838...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Sarah Buchholz Hans Zempel Source Type: research

The ABC's of Alzheimer risk gene ABCA7
We present latest insights in genetics, expression patterns, and functions of ABCA7.PMID:38556850 | DOI:10.1002/alz.13805 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Lena Duchateau Nicole Wawrzyniak Kristel Sleegers Source Type: research

Minimal clinically important difference in Alzheimer's disease: Rapid review
CONCLUSION: This review identified previously published MCIDs for AD trial endpoints. Input from patients and caregivers will be needed to derive more meaningful endpoints and thresholds.HIGHLIGHTS: This systematic rapid review identified thresholds for minimal clinically important differences (MCIDs) for recently used Alzheimer's disease (AD) trial endpoints: Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Clinical Dementia Rating scale sum of boxes (CDR-SB), integrated Alzheimer's Disease Rating Scale (iADRS), Mini-Mental State Examination (MMSE). MCIDs were higher for more severe stages of AD. Averag...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ryan T Muir Michael D Hill Sandra E Black Eric E Smith Source Type: research

Early-onset dementia and risk of hip fracture and major osteoporotic fractures
DISCUSSION: EOD patients have a higher risk of osteoporotic fractures than cognitively healthy individuals. The use of cholinesterase inhibitors may reduce the risk of hip fracture among EOD patients.HIGHLIGHTS: It is unknown whether early-onset dementia (EOD) increases the risk of fractures. We identified 13,614 individuals with EOD using a nationwide administrative database. Patients with EOD have a higher risk of hip, vertebral, and major osteoporotic fractures. The use of cholinesterase inhibitors may reduce hip fracture among patients with EOD.PMID:38561022 | DOI:10.1002/alz.13815 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Shoya Matsumoto Tatsuya Hosoi Mitsutaka Yakabe Kenji Fujimori Junko Tamaki Shinichi Nakatoh Shigeyuki Ishii Nobukazu Okimoto Masahiro Akishita Masayuki Iki Sumito Ogawa Source Type: research

Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy
In this study, antidepressant use was not associated with long-term dementia risk. Antidepressant use was not associated with cognitive decline or brain atrophy. Our results support safe prescription in an older, cognitively healthy population.PMID:38561253 | DOI:10.1002/alz.13807 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ilse Vom Hofe Bruno H Stricker Meike W Vernooij M Kamran Ikram M Arfan Ikram Frank J Wolters Source Type: research

Structural white matter properties and cognitive resilience to tau pathology
We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties.RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascu...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ting Qiu Zhen-Qi Liu Fran çois Rheault Jon Haitz Legarreta Alex Valcourt Caron Fr édéric St-Onge Cherie Strikwerda-Brown Amelie Metz Mahsa Dadar Jean-Paul Soucy Alexa Pichet Binette R Nathan Spreng Maxime Descoteaux Sylvia Villeneuve PREVENT ‐AD Rese Source Type: research

Histories of neighborhood socioeconomic status contribute to race differences in later-life cognition
DISCUSSION: Disinvestment in neighborhoods may be particularly salient in race disparities in cognitive function.HIGHLIGHTS: Race is implicated in the likelihood of living in more disadvantaged neighborhoods. Historical trends in neighborhood disadvantage are associated with cognitive function in older adulthood. Identifying patterns of neighborhood change may inform neighborhood-level interventions.PMID:38552138 | DOI:10.1002/alz.13786 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 29, 2024 Category: Psychiatry Authors: Ketlyne Sol Emily P Morris Ji Hyun Lee Afsara B Zaheed Jordan D Palms Kiana Scambray Philippa Clarke Laura B Zahodne Source Type: research

Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort
DISCUSSION: In this behavioral neurology cohort, αSyn-SAA had excellent diagnostic performance for cortical LBD. In amygdala- and brainstem-predominant cases, sensitivity was lower, but positivity was associated with anatomical spread, suggesting αSyn-SAA detects early LBD progression in these cohorts.HIGHLIGHTS: A cerebrospinal fluid alpha-synuclein assay detects cortical LBD with high sensitivity/specificity. Positivity in prodromal stages of LBD was associated with early cortical spread. The assay provides precision diagnosis of LBD that could support clinical trials. The assay can also identify LBD co-pathology, whic...
Source: The Journal of Alzheimers Association - March 28, 2024 Category: Psychiatry Authors: Niyatee Samudra D Luke Fischer Steven Lenio Argentina Lario Lago Peter A Ljubenkov Julio C Rojas William W Seeley Salvatore Spina Adam M Staffaroni Jonathan Tablante Fattin Wekselman Jennifer Lamoureux Luis Concha-Marambio Lea T Grinberg Adam L Boxer Lawr Source Type: research

Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD-risk-enriched cohorts
This study presents normative standards for cognitive measures sensitive to pre-clinical changes. Future directions will investigate potential clinical applications of longitudinal normative standards.HIGHLIGHTS: Quantile regression was used to construct longitudinal norms for cognitive tests. Poorer percentile scores were related to concurrent diagnosis and Alzheimer's disease biomarkers. A ShinyApp was built to display test scores and norms and flag low performance.PMID:38539269 | DOI:10.1002/alz.13774 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 28, 2024 Category: Psychiatry Authors: Erin M Jonaitis Bruce P Hermann Kimberly D Mueller Lindsay R Clark Lianlian Du Tobey J Betthauser Karly Cody Carey E Gleason Bradley T Christian Sanjay Asthana Richard J Chappell Nathaniel A Chin Sterling C Johnson Rebecca E Langhough Source Type: research

Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort
DISCUSSION: In this behavioral neurology cohort, αSyn-SAA had excellent diagnostic performance for cortical LBD. In amygdala- and brainstem-predominant cases, sensitivity was lower, but positivity was associated with anatomical spread, suggesting αSyn-SAA detects early LBD progression in these cohorts.HIGHLIGHTS: A cerebrospinal fluid alpha-synuclein assay detects cortical LBD with high sensitivity/specificity. Positivity in prodromal stages of LBD was associated with early cortical spread. The assay provides precision diagnosis of LBD that could support clinical trials. The assay can also identify LBD co-pathology, whic...
Source: The Journal of Alzheimers Association - March 28, 2024 Category: Psychiatry Authors: Niyatee Samudra D Luke Fischer Steven Lenio Argentina Lario Lago Peter A Ljubenkov Julio C Rojas William W Seeley Salvatore Spina Adam M Staffaroni Jonathan Tablante Fattin Wekselman Jennifer Lamoureux Luis Concha-Marambio Lea T Grinberg Adam L Boxer Lawr Source Type: research

Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD-risk-enriched cohorts
This study presents normative standards for cognitive measures sensitive to pre-clinical changes. Future directions will investigate potential clinical applications of longitudinal normative standards.HIGHLIGHTS: Quantile regression was used to construct longitudinal norms for cognitive tests. Poorer percentile scores were related to concurrent diagnosis and Alzheimer's disease biomarkers. A ShinyApp was built to display test scores and norms and flag low performance.PMID:38539269 | DOI:10.1002/alz.13774 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 28, 2024 Category: Psychiatry Authors: Erin M Jonaitis Bruce P Hermann Kimberly D Mueller Lindsay R Clark Lianlian Du Tobey J Betthauser Karly Cody Carey E Gleason Bradley T Christian Sanjay Asthana Richard J Chappell Nathaniel A Chin Sterling C Johnson Rebecca E Langhough Source Type: research

Gene networks and systems biology in Alzheimer's disease: Insights from multi-omics approaches
Alzheimers Dement. 2024 Mar 27. doi: 10.1002/alz.13790. Online ahead of print.ABSTRACTDespite numerous studies in the field of dementia and Alzheimer's disease (AD), a comprehensive understanding of this devastating disease remains elusive. Bulk transcriptomics have provided insights into the underlying genetic factors at a high level. Subsequent technological advancements have focused on single-cell omics, encompassing techniques such as single-cell RNA sequencing and epigenomics, enabling the capture of RNA transcripts and chromatin states at a single cell or nucleus resolution. Furthermore, the emergence of spatial omic...
Source: The Journal of Alzheimers Association - March 27, 2024 Category: Psychiatry Authors: Negin Rahimzadeh Shushrruth Sai Srinivasan Jing Zhang Vivek Swarup Source Type: research

The shift in the fatty acid composition of the circulating lipidome in Alzheimer's disease
DISCUSSION: The circulating LFA is involved in the pathogenesis and progression of AD.HIGHLIGHTS: The lipidome fatty acid profile in CSF and plasma was markedly different. Higher levels of vaccenic acid and lower levels of oleic acid in plasma were associated with greater risk of Alzheimer's disease. In plasma, higher levels of oleic acid were associated with a reduced risk of MCI-to-AD progression. Higher levels of docosahexaenoic acid in CSF were associated with a lower risk of MCI-to-AD progression. Higher levels of docosahexaenoic acid in plasma were associated with a greater rate of MCI-to-AD progression.PMID:38534027...
Source: The Journal of Alzheimers Association - March 27, 2024 Category: Psychiatry Authors: Farida Dakterzada Mariona Jov é Jos é Luís Cantero Nat àlia Mota-Martorell Reinald Pamplona Gerard Pi ñoll-Ripoll Source Type: research