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Echocardiographic measures of the left heart and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study
This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.METHODS: Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.RESULT...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: He-Ying Hu Hao Hu Jing Jiang Yan-Lin Bi Yan Sun Ya-Nan Ou Lan Tan Jin-Tai Yu Source Type: research

Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD
DISCUSSION: FCLC-MTL is implicated in Aβ-related cortical atrophy, suggesting that LC-MTL connectivity could confer neuroprotective effects in preclinical AD.HIGHLIGHTS: Novelty-related functional magnetic resonance imaging (fMRI) LC-medial temporal lobe (MTL) connectivity links to longitudinal Aβ-dependent atrophy. This relationship extended to higher Braak stage regions with increasing Aβ burden. Longitudinal MTL atrophy mediated the LC-MTL connectivity-cognition relationship. Our findings mirror the animal data on MTL atrophy following NE signal dysfunction.PMID:38676563 | DOI:10.1002/alz.13839 (Source: The Journal o...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Christoph Schneider Prokopis C Prokopiou Kathryn V Papp Nina Engels-Dom ínguez Stephanie Hsieh Truley A Juneau Aaron P Schultz Dorene M Rentz Reisa A Sperling Keith A Johnson Heidi I L Jacobs Source Type: research

Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia
Alzheimers Dement. 2024 Apr 27. doi: 10.1002/alz.13812. Online ahead of print.NO ABSTRACTPMID:38676574 | DOI:10.1002/alz.13812 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Pasquale Gallina Francesco Lolli Berardino Porfirio Source Type: research

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease
DISCUSSION: Several of our findings were consistent with results in humans, showing glycerophospholipids reduction in serum of apolipoprotein E (apoE) ε4 carriers and replicating the serum metabolic imprint of the APOE ε4 genotype. Our work thus represents a significant step toward translating metabolic dysregulation from model organisms to human AD.HIGHLIGHTS: This was a metabolomic assessment of two mouse models relevant to Alzheimer's disease. Mouse models exhibit broad sex-specific metabolic differences, similar to human study cohorts. The early-onset 5XFAD mouse model primarily alters brain metabolites while the lat...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Ravi S Pandey Mattias Arnold Richa Batra Jan Krumsiek Kevin P Kotredes Dylan Garceau Harriet Williams Michael Sasner Gareth R Howell Rima Kaddurah-Daouk Gregory W Carter Source Type: research

Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity.HIGHLIGHTS: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-syn...
Source: The Journal of Alzheimers Association - April 26, 2024 Category: Psychiatry Authors: Johannes Levin Simone Baiardi Corinne Quadalti Marcello Rossi Angela Mammana Jonathan V öglein Alexander Bernhardt Richard J Perrin Mathias Jucker Oliver Preische Anna Hofmann G ünter U Höglinger Nigel J Cairns Erin E Franklin Patricio Chrem Carlos Cru Source Type: research

Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Mateus Rozalem Aranha Victor Montal Hilde van den Brink Jordi Pegueroles Maria Carmona-Iragui Laura Videla Lucia Maure Blesa Bessy Benejam Javier Arranz S ílvia Valldeneu Isabel Barroeta Susana Fern ández Laia Ribas Daniel Alcolea Sof ía González-Orti Source Type: research

Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease
DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research