The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Results from the long-term extension of PRIME: A randomized Phase 1b trial of aducanumab
We report cumulative safety and 48-month efficacy results from PRIME. Amyloid-related imaging abnormalities-edema (ARIA-E) were the most common adverse event (AE); 61% of participants with ARIA-E were asymptomatic. Dose titration was associated with a decrease in the incidence of ARIA-E. Aducanumab decreased levels of amyloid beta (Aβ) in a dose- and time-dependent manner.PMID:38567735 | DOI:10.1002/alz.13755 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 3, 2024 Category: Psychiatry Authors: Tianle Chen John O'Gorman Carmen Castrillo-Viguera Rajasimhan Rajagovindan Gioacchino G Curiale Ying Tian Dakshaben Patel Philipp von Rosenstiel Christian von Hehn Stephen Salloway Christoph Hock Roger M Nitsch Samantha Budd Haeberlein Alfred Sandrock Pri Source Type: research

On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries
DISCUSSION: We observed substantial heterogeneity for the APOE-harboring 19q13.32 region with TOMM40/APOE/APOC1 genes. The largest risk effect was seen among African Americans, while Asians showed a surprisingly small risk effect.PMID:38563508 | DOI:10.1002/alz.13796 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 2, 2024 Category: Psychiatry Authors: Sanghun Lee Julian Hecker Georg Hahn Kristina Mullin Alzheimer's Disease Neuroimaging Initiative (ADNI) Sharon M Lutz Rudolph E Tanzi Christoph Lange Dmitry Prokopenko Source Type: research

The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes
DISCUSSION: In this review we describe the role of TAU isoforms in health and disease, and stress the importance of comprehending and studying TAU isoforms in both, physiological and pathological context, in order to develop targeted therapeutic interventions for TAU-associated diseases.HIGHLIGHTS: MAPT splicing is tightly regulated during neuronal maturation and throughout life. TAU isoform expression is development-, cell-type and brain region specific. The contribution of TAU to neurodegeneration might be isoform-specific. Ineffective TAU-based therapies highlight the need for specific targeting strategies.PMID:38556838...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Sarah Buchholz Hans Zempel Source Type: research

The ABC's of Alzheimer risk gene ABCA7
We present latest insights in genetics, expression patterns, and functions of ABCA7.PMID:38556850 | DOI:10.1002/alz.13805 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Lena Duchateau Nicole Wawrzyniak Kristel Sleegers Source Type: research

Minimal clinically important difference in Alzheimer's disease: Rapid review
CONCLUSION: This review identified previously published MCIDs for AD trial endpoints. Input from patients and caregivers will be needed to derive more meaningful endpoints and thresholds.HIGHLIGHTS: This systematic rapid review identified thresholds for minimal clinically important differences (MCIDs) for recently used Alzheimer's disease (AD) trial endpoints: Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Clinical Dementia Rating scale sum of boxes (CDR-SB), integrated Alzheimer's Disease Rating Scale (iADRS), Mini-Mental State Examination (MMSE). MCIDs were higher for more severe stages of AD. Averag...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ryan T Muir Michael D Hill Sandra E Black Eric E Smith Source Type: research

Early-onset dementia and risk of hip fracture and major osteoporotic fractures
DISCUSSION: EOD patients have a higher risk of osteoporotic fractures than cognitively healthy individuals. The use of cholinesterase inhibitors may reduce the risk of hip fracture among EOD patients.HIGHLIGHTS: It is unknown whether early-onset dementia (EOD) increases the risk of fractures. We identified 13,614 individuals with EOD using a nationwide administrative database. Patients with EOD have a higher risk of hip, vertebral, and major osteoporotic fractures. The use of cholinesterase inhibitors may reduce hip fracture among patients with EOD.PMID:38561022 | DOI:10.1002/alz.13815 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Shoya Matsumoto Tatsuya Hosoi Mitsutaka Yakabe Kenji Fujimori Junko Tamaki Shinichi Nakatoh Shigeyuki Ishii Nobukazu Okimoto Masahiro Akishita Masayuki Iki Sumito Ogawa Source Type: research

Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy
In this study, antidepressant use was not associated with long-term dementia risk. Antidepressant use was not associated with cognitive decline or brain atrophy. Our results support safe prescription in an older, cognitively healthy population.PMID:38561253 | DOI:10.1002/alz.13807 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ilse Vom Hofe Bruno H Stricker Meike W Vernooij M Kamran Ikram M Arfan Ikram Frank J Wolters Source Type: research

Structural white matter properties and cognitive resilience to tau pathology
We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties.RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascu...
Source: The Journal of Alzheimers Association - April 1, 2024 Category: Psychiatry Authors: Ting Qiu Zhen-Qi Liu Fran çois Rheault Jon Haitz Legarreta Alex Valcourt Caron Fr édéric St-Onge Cherie Strikwerda-Brown Amelie Metz Mahsa Dadar Jean-Paul Soucy Alexa Pichet Binette R Nathan Spreng Maxime Descoteaux Sylvia Villeneuve PREVENT ‐AD Rese Source Type: research