The Journal of Alzheimers Association 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals
DISCUSSION: Plasma p-tau217 and amyloid PET provide useful information about predicting rates of future cognitive decline in cognitively unimpaired individuals at the population mean level, but not at the individual person level.PMID:38265198 | DOI:10.1002/alz.13651 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 24, 2024 Category: Psychiatry Authors: Clifford R Jack Heather J Wiste Alicia Algeciras-Schimnich Stephen D Weigand Dan J Figdore Val J Lowe Prashanthi Vemuri Jonathan Graff-Radford Vijay K Ramanan David S Knopman Michelle M Mielke Mary M Machulda Julie Fields Christopher G Schwarz Petrice M C Source Type: research
Common infections and neuroimaging markers of dementia in three UK cohort studies
DISCUSSION: We did not find clear evidence for relationships between common infections and markers of dementia risk. Some suggestive findings warrant testing for replication.PMID:38248636 | DOI:10.1002/alz.13613 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 22, 2024 Category: Psychiatry Authors: Rebecca E Green Carole H Sudre Charlotte Warren-Gash Julia Butt Tim Waterboer Alun D Hughes Jonathan M Schott Marcus Richards Nish Chaturvedi Dylan M Williams Source Type: research
Reply to Kljajevic's "Increasing sensitivity of clinical proverb tests for diagnosis of dementia"
Alzheimers Dement. 2024 Jan 22. doi: 10.1002/alz.13689. Online ahead of print.NO ABSTRACTPMID:38253800 | DOI:10.1002/alz.13689 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 22, 2024 Category: Psychiatry Authors: Madhushree Chakrabarty Atanu Biswas Source Type: research
Increasing sensitivity of clinical proverb tests for diagnosis of dementia
Alzheimers Dement. 2024 Jan 22. doi: 10.1002/alz.13688. Online ahead of print.NO ABSTRACTPMID:38253962 | DOI:10.1002/alz.13688 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 22, 2024 Category: Psychiatry Authors: Vanja Kljajevic Source Type: research
Individuals with Alzheimer's disease and low tau burden: Characteristics and implications
We examined characteristics and regional patterns of 397 Aβ+ unimpaired and impaired individuals with low tau (A+T-) in relation to their higher tau counterparts (A+T+).RESULTS: Seventy-one percent of Aβ+ unimpaired and 42% of impaired Aβ+ individuals were categorized as A+T- based on global tau. In impaired individuals only, A+T- status was associated with older age, male sex, and greater cardiovascular risk. α-synuclein was linked to poorer cognition, particularly when tau was low. Tau burden was most frequently elevated in a common set of temporal regions regardless of T+/T- status.DISCUSSION: Low tau is relatively ...
Source: The Journal of Alzheimers Association - January 19, 2024 Category: Psychiatry Authors: Susan M Landau JiaQie Lee Alice Murphy Tyler J Ward Theresa M Harrison Suzanne L Baker Charles DeCarli Danielle Harvey Duygu Tosun Michael W Weiner Robert A Koeppe William J Jagust Alzheimer's Disease Neuroimaging Initiative Source Type: research
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
DISCUSSION rpAD constitutes an extreme subtype of AD with distinct features. GWAS found previously known and novel loci associated with rpAD. Highlights Rapidly progressive Alzheimer's disease (rpAD) was defined with different criteria. Whole genome sequencing identified rare missense variants in rpAD. Novel variants were identified for clinical rpAD on chromosome 21.PMID:38184787 | DOI:10.1002/alz.13655 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Ping Wang Audrey Lynn Kristy Miskimen Yeunjoo E Song Thomas Wisniewski Mark Cohen Brian S Appleby Jiri G Safar Jonathan L Haines Source Type: research
Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function
DISCUSSION: These findings suggest that P460L alters EphA1-dependent forward and reverse signaling, which may impact blood-brain barrier function in LOAD.HIGHLIGHTS: EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.PMID:38184788 | DOI:10.1002/alz.13603 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Helen A Owens Lauren E Thorburn Elisabeth Walsby Owen R Moon Pierre Rizkallah Subuhi Sherwani Caroline L Tinsley Louise Rogers Camilla Cerutti Anne J Ridley Julie Williams Vera Kn äuper Ann Ager Source Type: research
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET
This study shows that an increased parenchymal CSFF is associated with Aβ deposition, suggesting that CSFF could serve as a biomarker for brain glymphatic clearance, which can be used to detect early fluid changes in PVS predisposing individuals to the development of AD.HIGHLIGHTS: Cerebrospinal fluid fraction (CSFF) could be a biomarker of parenchymal perivascular space. CSFF is positively associated with amyloid beta (Aβ) deposition at subject level. CSFF in an Aβ+ region is higher than in an Aβ- region in the posterior cingulate cortex. Correspondence is found between Aβ deposition and glymphatic clearance deficits...
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Liangdong Zhou Thanh D Nguyen Gloria C Chiang Xiuyuan H Wang Ke Xi Tsung-Wei Hu Emily B Tanzi Tracy A Butler Mony J de Leon Yi Li Source Type: research
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
DISCUSSION rpAD constitutes an extreme subtype of AD with distinct features. GWAS found previously known and novel loci associated with rpAD. Highlights Rapidly progressive Alzheimer's disease (rpAD) was defined with different criteria. Whole genome sequencing identified rare missense variants in rpAD. Novel variants were identified for clinical rpAD on chromosome 21.PMID:38184787 | DOI:10.1002/alz.13655 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Ping Wang Audrey Lynn Kristy Miskimen Yeunjoo E Song Thomas Wisniewski Mark Cohen Brian S Appleby Jiri G Safar Jonathan L Haines Source Type: research
Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function
DISCUSSION: These findings suggest that P460L alters EphA1-dependent forward and reverse signaling, which may impact blood-brain barrier function in LOAD.HIGHLIGHTS: EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.PMID:38184788 | DOI:10.1002/alz.13603 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Helen A Owens Lauren E Thorburn Elisabeth Walsby Owen R Moon Pierre Rizkallah Subuhi Sherwani Caroline L Tinsley Louise Rogers Camilla Cerutti Anne J Ridley Julie Williams Vera Kn äuper Ann Ager Source Type: research
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET
This study shows that an increased parenchymal CSFF is associated with Aβ deposition, suggesting that CSFF could serve as a biomarker for brain glymphatic clearance, which can be used to detect early fluid changes in PVS predisposing individuals to the development of AD.HIGHLIGHTS: Cerebrospinal fluid fraction (CSFF) could be a biomarker of parenchymal perivascular space. CSFF is positively associated with amyloid beta (Aβ) deposition at subject level. CSFF in an Aβ+ region is higher than in an Aβ- region in the posterior cingulate cortex. Correspondence is found between Aβ deposition and glymphatic clearance deficits...
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Liangdong Zhou Thanh D Nguyen Gloria C Chiang Xiuyuan H Wang Ke Xi Tsung-Wei Hu Emily B Tanzi Tracy A Butler Mony J de Leon Yi Li Source Type: research
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
DISCUSSION rpAD constitutes an extreme subtype of AD with distinct features. GWAS found previously known and novel loci associated with rpAD. Highlights Rapidly progressive Alzheimer's disease (rpAD) was defined with different criteria. Whole genome sequencing identified rare missense variants in rpAD. Novel variants were identified for clinical rpAD on chromosome 21.PMID:38184787 | DOI:10.1002/alz.13655 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Ping Wang Audrey Lynn Kristy Miskimen Yeunjoo E Song Thomas Wisniewski Mark Cohen Brian S Appleby Jiri G Safar Jonathan L Haines Source Type: research
Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function
DISCUSSION: These findings suggest that P460L alters EphA1-dependent forward and reverse signaling, which may impact blood-brain barrier function in LOAD.HIGHLIGHTS: EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.PMID:38184788 | DOI:10.1002/alz.13603 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Helen A Owens Lauren E Thorburn Elisabeth Walsby Owen R Moon Pierre Rizkallah Subuhi Sherwani Caroline L Tinsley Louise Rogers Camilla Cerutti Anne J Ridley Julie Williams Vera Kn äuper Ann Ager Source Type: research
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET
This study shows that an increased parenchymal CSFF is associated with Aβ deposition, suggesting that CSFF could serve as a biomarker for brain glymphatic clearance, which can be used to detect early fluid changes in PVS predisposing individuals to the development of AD.HIGHLIGHTS: Cerebrospinal fluid fraction (CSFF) could be a biomarker of parenchymal perivascular space. CSFF is positively associated with amyloid beta (Aβ) deposition at subject level. CSFF in an Aβ+ region is higher than in an Aβ- region in the posterior cingulate cortex. Correspondence is found between Aβ deposition and glymphatic clearance deficits...
Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Liangdong Zhou Thanh D Nguyen Gloria C Chiang Xiuyuan H Wang Ke Xi Tsung-Wei Hu Emily B Tanzi Tracy A Butler Mony J de Leon Yi Li Source Type: research
Sleep and circadian rhythm disruptions in behavioral variant frontotemporal dementia
DISCUSSION: Patients with bvFTD showed longer sleep duration, lower sleep quality, and rest-activity rhythm alterations. Actigraphy could serve as a cost-effective and accessible tool for ecologically monitoring changes in sleep duration in bvFTD patients.HIGHLIGHTS: We assessed sleep and circadian rhythms in behavioral variant frontotemporal dementia (bvFTD) using actigraphy. Patients with bvFTD show increased sleep duration and reduced sleep quality. Patients with bvFTD show rest-activity alterations in the morning and early afternoon. Sleep duration is associated with reduced cortical thickness in frontal regions. These...
Source: The Journal of Alzheimers Association - January 6, 2024 Category: Psychiatry Authors: Marco Filardi Valentina Gnoni Ludovica Tamburrino Salvatore Nigro Daniele Urso Davide Vilella Benedetta Tafuri Alessia Giugno Roberto De Blasi Stefano Zoccolella Giancarlo Logroscino Source Type: research
