The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study
DISCUSSION: HTN+/DM+ and HTN+/DM- increased AD risk compared to HTN-/DM-, but pathological differences between groups suggest targeted therapies may be warranted based on cardiovascular risk profiles.HIGHLIGHTS: AD risk was studied in hypertensive (HTN+) individuals with/without diabetes (DM+/-). HTN+/DM+ and HTN+/DM- both had an increased risk of AD compared to HTN-/DM-. Post mortem analysis identified neuropathological differences between HTN+/DM+ and HTN+/DM-. In HTN+/DM+, AD risk was greater in those with AD neuropathology and CAA. In HTN+/DM-, AD risk was greater in those with cerebrovascular neuropathology.PMID:38425...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Myuri Ruthirakuhan Walter Swardfager Lisa Xiong Bradley J MacIntosh Jennifer S Rabin Krista L Lanct ôt Julie Ottoy Joel Ramirez Julia Keith Sandra E Black Source Type: research

Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence
Alzheimers Dement. 2024 Mar 1. doi: 10.1002/alz.13716. Online ahead of print.ABSTRACTWearable digital technologies capable of measuring everyday behaviors could improve the early detection of dementia-causing diseases. We conducted two systematic reviews following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to establish the evidence base for measuring navigation and gait, two everyday behaviors affected early in AD and non-AD disorders and not adequately measured in current practice. PubMed and Web of Science databases were searched for studies on asymptomatic and early-stage symp...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Giedr ė Čepukaitytė Coco Newton Dennis Chan Source Type: research

Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
DISCUSSION: Increasing genetic diversity promotes resilience to AD-related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD.HIGHLIGHTS: Genetic diversity's impact on AD in mice was explored. Diverse F1 mouse strains were used for AD study, via the Collaborative Cross. Strain-specific variations in AD pathology, glia, and transcription were found. Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified. Correlations with human AD transcriptomics were observed.PMID:38426...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Neelakshi Soni Lindsay A Hohsfield Kristine M Tran Shimako Kawauchi Amber Walker Dominic Javonillo Jimmy Phan Dina Matheos Celia Da Cunha Asli Uyar Giedre Milinkeviciute Angela Gomez-Arboledas Katelynn Tran Catherine C Kaczorowski Marcelo A Wood Andrea J Source Type: research

Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study
DISCUSSION: SCI sensitivity (63.4%) and specificity (92.5%) against dementia were comparable with similar metrics for the NHATS probable dementia measure against the "gold-standard" Aging, Demographics, and Memory Study-based dementia criteria, implying that population-based surveys may afford cost-effective opportunities for dementia surveillance to assess risk and inform policy.HIGHLIGHTS: The prevalence of subjective cognitive impairment (SCI) is generally higher than that of a validated measure of probable dementia, particularly within the youngest age group, females, Whites, and persons with a college or higher degree...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Linda C Chyr Jennifer L Wolff Julie M Zissimopoulos Emmanuel F Drabo Source Type: research

Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease
DISCUSSION: Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.PMID:38421123 | DOI:10.1002/alz.13733 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 29, 2024 Category: Psychiatry Authors: Coco Newton Marianna Pope Catarina Rua Richard Henson Zilong Ji Neil Burgess Christopher T Rodgers Matthias Stangl Maria-Eleni Dounavi Andrea Castegnaro Ivan Koychev Paresh Malhotra Thomas Wolbers Karen Ritchie Craig W Ritchie John O'Brien Li Su Dennis Ch Source Type: research

The Bio-Hermes Study: Biomarker database developed to investigate blood-based and digital biomarkers in community-based, diverse populations clinically screened for Alzheimer's disease
DISCUSSION: Blood-based biomarkers are highly associated with amyloid PET/CSF results in diverse populations enrolled at clinical trial sites.HIGHLIGHTS: Amyloid beta (Aβ)42/Aβ40, phosphorylated tau (p-tau)181, and p-tau 217 blood-based biomarkers predicted brain amyloid positivity. P-tau 217 was the strongest predictor of brain amyloid positivity. Biomarkers from diverse ethnic, racial, and clinical cohorts predicted brain amyloid positivity. Community-based populations have similar Alzheimer's disease (AD) biomarker levels as other populations. A prescreen process with blood-based assays may reduce the number of AD tri...
Source: The Journal of Alzheimers Association - February 28, 2024 Category: Psychiatry Authors: Richard C Mohs Douglas Beauregard John Dwyer Jennifer Gaudioso Jason Bork Tamiko MaGee-Rodgers Mickeal N Key Diana R Kerwin Lynn Hughes Cyndy B Cordell Bio-Hermes Collaborative Group Source Type: research